1PVU,1K0Z


Conserved Protein Domain Family
PvuII-like
?
cd22351: PvuII-like 
Click on image for an interactive view with Cn3D
Restriction endonuclease PvuII and similar nucleases
The type II restriction endonuclease PvuII recognizes and cleaves the DNA sequence 5'-CAG|CTG-3' leaving blunt ends (| denotes the cleavage site). It belongs to a superfamily of nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI.
Links
?
Statistics
?
PSSM-Id: 411755
Aligned: 21 rows
Threshold Bit Score: 202.494
Created: 28-Mar-2011
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active sitehomodimer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1K0Z: Proteus vulgaris restriction endonuclease PvuII active site binds praseodymium and sulfate ions, contact at 4A
    - View structure with Cn3D
  • Citation:PMID 7664066
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                              #         # #             
1PVU_A         4 DLNKLLELWPHIQEYQDLALKHgi-nDIFQDNGGKLLQVLLITGLTVLPgregNDAVDnagQEYELKSInid--ltKGFS 80  Proteus vulgaris
1K0Z_A         4 DLNKLLELWPHIQEYQDLALKHgi-nDIFQDNGGKLLQVLLITGLTVLPgregNDAVDnagQEYELKSInid--ltKGFS 80  Proteus vulgaris
WP_009266549  11 EIAKIEQLWRNLNELDQMAHAYgi-sDIFQDNGAKVLQQLIYLNMSILPgregNDCIStsgTEWEMKSInle-tsaSGFS 88  Lachnospiraceae...
WP_066130582  11 EIAKINRLWANLTELNKLAKTYgi-pDIFQDNGAKVLQQLIYLNMSILPgregNDCISasgTEWEMKSInle-tsaSGFS 88  Gemella asaccha...
WP_024733770  11 KIDCFNDMWSKLDDIEELAKTYqi-aDIAQDNNLKLLQTLVLFDFDNQPgregSDAIDrygHAWELKTVnid--ltSSFS 87  Clostridiales
AMO44142       8 RYAEIESLWPGVEAMQNLAEQYgi-kDIFQDAGGKMLQLAIATGLDLIPgrtgPDAQDrmgNLYEVKTIdms-gkgSGFT 85  Roseobacter pha...
BAU10642      45 DLERLQTAFEGVRALQELAREYei-tDIFQDNGGKVLQVLILLGLKISPgregNDAIDaegNEYELKTLnrslnknAGVT 123 Leptolyngbya sp...
SEB02229      11 KLVNLNVMWENLKVLSSFAKQEfgidDIFQDNDGKVMQQLTILNFTNLDgregNDGMDengVEWEMKSVnin--ktSSIS 88  Paenibacillus s...
WP_056986580  11 DIQKLEGLWKKLVDLEDLAKSRgi-nDIFQDNGAKVLQQLIISNMKFLPgregNDAEDrngVEWEFKSVnid-tsaRGFS 88  Pediococcus dam...
WP_117461841   8 DKTSVDILWMQLRTLQDMAKEYgi-sNIFQDNGAEILQQLIYLNMKAVPgregNDGIDangCEWEMKSLdis-kgnAGIT 85  Subdoligranulum...

Feature 1                    #                                                                   
1PVU_A        81 THHHMNPVIIAKYRq-VPWIFAIYRGIAIEAIYRLEpk-dLEFYYDKWERKWYSDGHk-----dINNPKIPVKYVMEHGT 153 Proteus vulgaris
1K0Z_A        81 THHHMNPVIIAKYRq-VPWIFAIYRGIAIEAIYRLEpk-dLEFYYDKWERKWYSDGHk-----dINNPKIPVKYVMEHGT 153 Proteus vulgaris
WP_009266549  89 TNHHTTHDIIAKYRq-VPWTFAIYYGINLAEMYVMTpe-mLEPLYQHWEAKLQTMTH-------LNNPKIPVKYVREHGI 159 Lachnospiraceae...
WP_066130582  89 TNHHTTHYIIAKYRq-VPWTFAIYHGITLTEMYVMTps-mLEPLYQHWEEKLQTMAH-------LNNPKIPVKYVRENGI 159 Gemella asaccha...
WP_024733770  88 TNHHTNLERINVFRq-ERWLFSSYKGIILQEVYVVNpr-hLETYFSKWEQSVKEKIAanienahLNNPKIPLKYVKEVGT 165 Clostridiales
AMO44142      86 TNHHLTRDTIARYRn-RRFVFAMYDKITLHEAYLVEpd-aLEPVFQKWERTLRTQSH-------INNPKIPVEGIRELGT 156 Roseobacter pha...
BAU10642     124 THHHLNRDILAKYRavKAWYIAIYEGIELIEIYKVSpe-mLEIKFSEWERKLDQIDS-------INNPKIPMRLIRQGEL 195 Leptolyngbya sp...
SEB02229      89 THHHLNTKIIEKYRk-VPWSIAVYRGVELLEIYAIHpyklNEEYFNKWELSVINHNRq------LNNPKINLEFVRREGT 161 Paenibacillus s...
WP_056986580  89 TDHHTTVNLLDRFNs-VPWLFSIYKGIHLQEMYVVSpg-gLDEWVAKQKAGLTKHWKtnk-dyeLNNPKISIKYVKSHGI 165 Pediococcus dam...
WP_117461841  86 TNHHLNAAIIEKYRt-VPWSVAIYDGIHLQKIYVVGne-qLEPLFSRWEEQLQTVES-------INNPKIPLAYIEEHGI 156 Subdoligranulum...

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap