5FV4,1JMY,1AQL,5V5V,3BIX,3BE8,6I2T,6SCJ


Conserved Protein Domain Family
COesterase

?
pfam00135: COesterase 
Click on image for an interactive view with Cn3D
Carboxylesterase family
Statistics
?
PSSM-Id: 395084
Aligned: 54 rows
Threshold Bit Score: 430.19
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5FV4_A    5 SPPVVDTAQ----GRVLGKYVSLEGLAq---PVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCCQDPVAG 77   pig
O01302   15 VCKRVQLSS----GTIEGKILNISYSPlgnqSATVFLGIPFVEPPIGDLRYRKPRPPKSWEGVLVTNEYKSACMSNATKT 90   Caenorhabditis elegans
Q8T016   27 QQTHIKLEQ----GDLIGLKVFPDGTRg---AVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTI 99   fruit fly
Q9VPZ5   48 DDPVIFARLfdrdARVEGFRNPST-------GIYSFLGMHYAEPPVGPLRYSRPVY-KRLAGDFNATKHGPPCIQPHPQF 119  fruit fly
Q9VP25   38 ETATVTVELyngqGTVLGNYAYTAWTDr---AFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCPVITNLD 114  fruit fly
P33438   58 QEAVVQAPEv---GQILGISGHKTIANr---PVNAFLGIRYGTVGGGLARFQAAQP-IGYQGRVNATVQSPNCAQFPELD 130  fruit fly
Q9VLJ1   71 QEPKVFTTTvpdlGRLRGRTLTTDWTGq---KIMQFLDIPYGKA----ERFRPAEPAPSWKGVLPAHRPHAGCPSIQDLI 143  fruit fly
Q9VLJ2   32 KDTIVELPTl---GSIQGKILETAWTKr---EVLQFVDVRYAEPPTGLHRFKAPRPIEPWEDVMDATAEKIGCPSVVSMD 105  fruit fly
P21837   32 GDNEVLLSD----GAIRGTVTD---------THRVFYGIPFARPPIDELRYEDPQPPKPWSYVRDGTKQRDQCIQDCKLG 98   Dictyostelium disco...
P18142   30 DASIVVTQF----GAIKGIVED---------THRVFYGVPFAQPPVNQLRWENPIDLKPWENVRETLTQKSQCAQKCNLG 96   Dictyostelium disco...
5FV4_A   78 QMTSDLFTnrkerlipeFSEDCLYLNIYTPADLTKRGRL--PVMVWIHGGGLVVGGAST--YDGLALAAHE-----NVVV 148  pig
O01302   91 YKNKFGGP---------ISEDCLYLNVLTneycLENKNC--SVMMIVHGGGYLTESAST--FNPEILINNFvgqgrNIVV 157  Caenorhabditis elegans
Q8T016  100 YDESSDGSmpr---svsTDEDCLYLNIWTPESGMRYGKL--PIVVIVTGEEFA-YDWPRnrINGLDLAGE------GIVV 167  fruit fly
Q9VPZ5  120 PQRII------------GDEDCLLLNVYTPQM-PDETTGl-PVFVWIHPGGYRYGSAAQ--YDATPMAQR------GAIV 177  fruit fly
Q9VP25  115 SQMSDA-----------ELEDCLTLSVYT----KNLSASq-PVMFYIYGGGFYNGSSED--HPPNYLLEK------DVVL 170  fruit fly
P33438  131 RLRLSESRg-------eNVDDCLTLDIYA----PEGANQl-PVLVFVHGEMLFDGGSEE--AQPDYVLEK------DVLL 190  fruit fly
Q9VLJ1  144 VFAKLEEDg-------fDVEDCLRLSVNT----KAMEGKslPVMVYIHGDFFYDGDSVE--AAPGYLLEH------DVVL 204  fruit fly
Q9VLJ2  106 SLRRLDDVl--------DVEDCLTMTITT----PNVTSRl-PVLVYIHGEYLYEGSNSE--APPDYLLEK------DVVL 164  fruit fly
P21837   99 KGSCSEVG---------TSEDCLYLDVFIPRT-VNPGSKv-PVMVFIPGGAFTQGTGSCplYDGLKFANS------SVIV 161  Dictyostelium disco...
P18142   97 PGVCSPIG---------TSEDCLYLDVFTPKD-ATPNSKy-PVIVYIPGGAFSVGSGSVplYDATKFAQS------SVIV 159  Dictyostelium disco...
5FV4_A  149 VAIQYRLGIWGFFSTGD--EHSRGNWGHLDQVAALHWVQENIANFGGDPGSVTIFGESAGGESVSVLVLS-PLAK--NLF 223  pig
O01302  158 VTFNYRLGLFSFGQFNG--DRGDKNFGLYDMIESVNWVRREIENFGGNKNRITLAGHSAGASMIVAFTSS-PLTK--GLV 232  Caenorhabditis elegans
Q8T016  168 VSVQYRNNIYGWLSLGEqhRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATL-EDSS---QV 243  fruit fly
Q9VPZ5  178 VAPQYRLGSLGIMGDGT--KQFDGNLAMFDLAAALRWVTDYISYFGGNPKQVQAIGHGSGAASAMYLSMS-PTSRsaGDV 254  fruit fly
Q9VP25  171 VVPQYRVGALGWLSTYT--EELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLS-PKTGd-nMF 246  fruit fly
P33438  191 VSINYRLAPFGFLSALT--DELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSgRAGN---LF 265  fruit fly
Q9VLJ1  205 VSVRYRLGPFGFLSTLT--DEMPGNAAVTDIILALKWVQQHIASFGGDPQRVTLFGQVGGAALVNVLTLS-PAVPa-GLF 280  fruit fly
Q9VLJ2  165 VTPQYRLGPFGFLSTKT--DEIPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLS-PVVQr-GLF 240  fruit fly
P21837  162 VNVNYRLGVLGFLCT----GLLSGNFGFLDQVMALDWVQENIEVFGGDKNQVTIYGESAGAFSVAAHLSS-EKSE--GKF 234  Dictyostelium disco...
P18142  160 VNINYRLGVLGFMGT----DLMHGNYGFLDQIKALEWVYNNIGSFGGNKEMITIWGESAGAFSVSAHLTS-TYSR--QYF 232  Dictyostelium disco...
5FV4_A  224 HRAISESGVAFTAGLVRKD----MKAAAKQIAVLAGC--------KTTTSA----VFVHCLRQKSEDELLDLTLKmkffa 287  pig
O01302  233 HQQIIMSA----PMTNMSKk--sNFKGMTVMAQMVGClseeigfnKLSEEQv--eNTYSCLRKKSAQQILDAQlwllqn- 303  Caenorhabditis elegans
Q8T016  244 KQLVLMSPGPIMR-ALGQNhqkwIVETGQVLVQKLGCq------fEEAQRR----QLMGCLRRKSREDLLRAYES----- 307  fruit fly
Q9VPZ5  255 HGVVAMSGTALSQYAMDKE----PVQSVQEVAKINGC--------PTGNEL----EIVNCLRSKSAEDIIKNDDKvqter 318  fruit fly
Q9VP25  247 KRAIVQSGSIFASWAINKD----PKAQSRRICIQLGC-----------SGCeqhdQLVKCIQKAKVIDILKATASe---- 307  fruit fly
P33438  266 QQLILQSGTALNPYLIDNQ----PLDTLSTFARLARCpp-----pSINPSAqglkPLYDCLARLPTSQLVAAFEQlllqn 336  fruit fly
Q9VLJ1  281 HRVIYQSGTALSPAFITDA----PLGATKAIGRIAGC-----------KQStkvdQLNKCLNRLNATMLLAAFSVhgenq 345  fruit fly
Q9VLJ2  241 HQVIYHSGSAIMPIFLEED----PRKHAQEIAKKADC--------KMVTVR----DLNTCLMELTALELLTAFMEhalek 304  fruit fly
P21837  235 HRAILSS----TPYTVGLKsqtvARGFAGRFSSKIGCd----------------lEDIDCHRSKSPEEILAIQKElglai 294  Dictyostelium disco...
P18142  233 NAAISSS----SPLTVGLKdkttARGNANRFATNVGCn----------------iEDLTCLRGKSMDEILDAQEKvgltf 292  Dictyostelium disco...
5FV4_A  288 ldlh---gdpreshpFLTTvVDG---------VLLP--K-MPE-EILAekdfnTVPYIVGINKQEFGWLLPTMMGFP--- 348  pig
O01302  304 ----------styflGAPP-IDE---------HFLT--D-YPE-NLYAsksiyPINTLIGTTTLEVEESSYIIDPAF--- 356  Caenorhabditis elegans
Q8T016  308 --------------------VYNhgngssqlgVILP--EgLPLeQRLRnk--tLPPVLLGITSNEGAFLQDYWLDVA--- 360  fruit fly
Q9VPZ5  319 lagralvkgltgnvgFQPH-IESeddgralpsLIVG----EPE-QQLKssnfsGIPLLTGVTKHETANSVTVETIEKvfg 392  fruit fly
Q9VP25  308 --------------sFSPI-VGDl-------hGILP--Q-QPS-ELVKsy-rrQIPILTGFTQHDGSFVLASYYDAL--- 357  fruit fly
P33438  337 ehlgltqlggfklvvGDPL-------------GFLP--S-HPA-SLATns-slALPMIIGATKDASAFIVSRIYDQL--- 395  fruit fly
Q9VLJ1  346 pslsggayggvqlviGGPS-------------GILP--E-HPG-RLLAaekfqAYPTMGGSVKHGGTFMLRDIFADI--- 405  fruit fly
Q9VLJ2  305 sdlgightggiqftiGGPS-------------GVLP--K-HPY-DLMLet-nfSYPAMGGCPKNAGSRVLNEIVDND--- 363  fruit fly
P21837  295 gdk-----ildaftiWSPV-VDG-----------INvnE-QPL-TMIKqgtthDVPTIIGDNQDEAILFVYMTYKNV--- 352  Dictyostelium disco...
P18142  293 gdk-----ildaftiWSPV-IDG---------DIIP--M-QPL-TAVKegktyDVPTIIGNVKHEAIPFIYSFFQDS--- 350  Dictyostelium disco...
5FV4_A  349 ------LSEGKLDQKTATSLLWKSYPIAn--------iPEELTPVATDKYL-----GGTDDPVKKKDLFLDLMGDVVFGV 409  pig
O01302  357 --------ADKKVELLENLCDHIGYVLYe--------ePETFSKKCQKQYM-------------NGNSSMNLSNEMEFYT 407  Caenorhabditis elegans
Q8T016  361 ------REGQVALHKYINHTLLPNVMRAlesv---geeSSTQLAAIRWRYFn----GKGEGVSHLLAGMQRLLSESLYEL 427  fruit fly
Q9VPZ5  393 saeqflGSLSDSLNKLTSFLKIDKLTGQiakpe-lpglTSVLTPTLQDVWKv----PQALNVDQVLSKVVESTTDVLFNL 467  fruit fly
Q9VP25  358 ------AAKVANVSSLSVRQFSQGINDLvn-------dTSGLTDNILNRLLfkpqaLNSHDHSAAVSSYFDLTTNIFMKS 424  fruit fly
P33438  396 ----------ARLQSRNVSDYIDVVLRHtappsehrlwKQWALREIFTPIQ-----EQTASLQTVAPGLLELSNYILYRA 460  fruit fly
Q9VLJ1  406 ------FNETILDDTMTGRQYIDTIIEQangadpsgswKEFSDEEIFTQND-----VKNGTFKRLTPGLIDLCSTISLKN 474  fruit fly
Q9VLJ2  364 ------FEGKIPDDEYNTYNYIDHVIRQtvgtdktmllTSFVTHDFFNRNL-----MENGTFDTLIPRLIDVAGTLNHKL 432  fruit fly
P21837  353 ------VIPSSYRTMVHVLF------------------GIANGNKVLEHY------PLPGFLKDSRPILSKLLTDYLFRC 402  Dictyostelium disco...
P18142  351 ------VGIDYYRVLV-AIV------------------FPLNAMKILPLY------PAAPRGQDSRPILSELITDYLFRC 399  Dictyostelium disco...
5FV4_A  410 PSVTVARQHR--DAGAP--TYMYEFQYRPSFSSDk---------kP--------KTVIGDH--GDEIFS------VFGAP 460  pig
O01302  408 PAIDFADSHT--SGNTK--VFLYSYDYRGAG--------------Payd--rylEVRSPHH--SEDLIY------VFGTH 459  Caenorhabditis elegans
Q8T016  428 PYSRILELL---NGTTS---YAYVFDHSHSMDMRgr----------------rnLFGGASH--SSDLPL------LLGPS 477  fruit fly
Q9VPZ5  468 PAVLTTQVW---SRLAP--AFMYSFEYNGTKSKGinfl----kglPivsetahdKPETVGH--GDEIGYmfdandIFGNP 536  fruit fly
Q9VP25  425 PVITLATKMYtqQRSTP--VYVYSFEYEGTYTRFgyefg--nshyP--------FNGGVHH--SNDNIY------LFATH 484  fruit fly
P33438  461 PVINSISQS---YRSVP--AYLYTFDYRGEHHRFghl------snP--------LPFGVDAslSDDSVY------LFPYP 515  fruit fly
Q9VLJ1  475 PVLLVLQAN---AKKLPnsTYLYSFDYEGEQNRYatged-eanfvP--------FDMGVSL--TDDNLY------LFPWP 534  fruit fly
Q9VLJ2  433 PVLLALNMN---NKHNPdnTFLYSFDYAGEFNRYkemdeetnlqsP--------FKAGVSL--TDEALY------LFPYP 493  fruit fly
P21837  403 PGRYHVSKSAq-ANESP--IYHYQYKQVLSGGHSfeac-----------------eglVCH--GTELPM------VFNTY 454  Dictyostelium disco...
P18142  400 PDRYHTVTNAk-KLSSP--TYHYHYVHVKSTGHSldac-----------------ddkVCH--GTELSL------FFNSY 451  Dictyostelium disco...
5FV4_A  461 FLRGD----APEE-EVSLSKTVMKFWANFARSGNPNG----EGLPHWPMY---DQEEGYLQIGVNT----------QAAK 518  pig
O01302  460 RG-------IFAPkDYIIEKIYSGMFADFVNFENPLP----SGDQKWNQYt--KENREHFLINFDKnfi-----tpGMRD 521  Caenorhabditis elegans
Q8T016  478 LFQQIarrrFSGE-EEQLCRKIRGAFANFIKNGNPTPg---RIYDGWLPYn--KENPFVYSLGEQAk------------- 538  fruit fly
Q9VPZ5  537 MEETR----LTSAeDLKVRNNLIDLLVKFANKDKEEG----GKSSIFQSVt--GKATPFIKIDTKLq------------- 593  fruit fly
Q9VP25  485 PLEGQ---------DTQMSQKMVDVWTSFAIEGVPRN---------LSPLs--SASGPYNKLNLEVtkgddlldtlTAAI 544  fruit fly
P33438  516 PEASRln-----plDRSLSRALVTMWVNFATTGVPNP-----SSGVWPQAt--SEYGPFLRFTNNQq------------- 570  fruit fly
Q9VLJ1  535 RFLA-----LNSNrDLKVARRMVALWTSFATTGVPQA----PGLPAWPAMn--DETGPYMKIDRTVsfgdnyldeyRIav 603  fruit fly
Q9VLJ2  494 EHVTRl-----SRpDQSMAHRMVELWTNFVISGNPLGs---ARVGYWPPMt--TLYGPYMRIDDTMtiggnyftefSATL 563  fruit fly
P21837  455 ESALDl---DLEEeEEEFAEQLNNYFVNFIKYSNPSHpnglPTPKVWNPTtktTNTSLVMKLGFEVk-----------DL 520  Dictyostelium disco...
P18142  452 ELMGEr---LDND-EKELAIDINNYIVNFATTHNPNTg--lDVPVQWRQVtstQNSTLILETTIETk-----------DT 514  Dictyostelium disco...
5FV4_A  519 RLKGEEVAFW 528  pig
O01302  522 NYYTEAYEFW 531  Caenorhabditis elegans
Q8T016  539 TPQTGSVDEA 548  fruit fly
Q9VPZ5  594 --TSNDFRFc 601  fruit fly
Q9VP25  545 ddpdngrlqr 554  fruit fly
P33438  571 SPLELDPHFG 580  fruit fly
Q9VLJ1  604 eeakhgynlv 613  fruit fly
Q9VLJ2  564 sdeeqghsli 573  fruit fly
P21837  521 ITNDPKCDLF 530  Dictyostelium discoideum
P18142  515 FTNDPKCNAL 524  Dictyostelium discoideum
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap