3LD6,3G1Q,1X8V,2W0A,3L4D,3KHM,2X2N


Conserved Protein Domain Family
CYP51-like

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cd11042: CYP51-like 
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cytochrome P450 family 51 and similar cytochrome P450s
This family is composed of cytochrome P450 51 (CYP51 or sterol 14alpha-demethylase) and related cytochrome P450s. CYP51 is the only cytochrome P450 enzyme with a conserved function across animals, fungi, and plants, in the synthesis of essential sterols. In mammals, it is expressed in many different tissues, with highest expression in testis, ovary, adrenal gland, prostate, liver, kidney, and lung. In fungi, CYP51 is a significant drug target for treatment of human protozoan infections. In plants, it functions within a specialized defense-related metabolic pathway. CYP51 is also found in several bacterial species. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410668
Aligned: 42 rows
Threshold Bit Score: 393.505
Created: 13-Jan-2010
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 25 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:3LD6: Human lanosterol 14alpha-demethylase binds heme; contacts at 4A
    View structure with Cn3D
  • Structure:1X8V: Mycobacterium tuberculosis sterol 14alpha-demethylase (CYP51) binds heme; contacts at 4A
    View structure with Cn3D
  • Structure:3KHM: Trypanosoma cruzi sterol 14alpha-demethylase (CYP51) binds heme; contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                    #                     #  #      #
3LD6_A     40 AYEKY---GPVFSFTMVGkTFTYLLG-SDAAALLFNSKNEDLnaeDVYSRLTTPVFgkgvaydvpnpvFLEQKKMLKSGL 115 human
3L4D_A     32 AKKKY---GGIFTMNICGnRITVVGD-VHQHSKFFTPRNEILsprEVYSFMVPVFGegvaya-apyprMREQLNFLAEEL 106 Leishmania infantum
3KHM_A     36 CKRDLk--SGVFTISIGGqRVTIVGD-PHEHSRFFSPRNEILsprEVYTIMTPVFGegvaya-apyprMREQLNFLAEEL 111 Trypanosoma cruzi
2X2N_A     45 CKRQLk--SGIFTINIVGkRVTIVGD-PHEHSRFFLPRNEVLsprEVYSFMVPVFGegvaya-apyprMREQLNFLAEEL 120 Trypanosoma brucei
ABP64518   36 LKRGYrskGRLFAMNFMGqRMNVMLG-PEHNRFFFEETDKLLsirESMPFFLKMFSpefy----sfaeMDEYLRQRSIIM 110 Novosphingobium ar...
EEQ30371   65 SGKKY---GQVFQINLLL-TNTIWLNsPALNKEYLFAREDVWsfgDGMGVFLNKVVvp---------nFFDQLRVLVGSL 131 Microsporum canis ...
CAK48260   56 ATARC---GPVFQINLLLtKIVMLRG-AQLNRFYLDTREEVWsfgDGMGLFLEKVVvp---------gYLSHLKEMVSSL 122 Aspergillus niger
EDM78481  206 GQREH---GPVFAVALGPwRCAVVSG-PEANAVFYGRTDHELlteGPYAYLRKMFGrvgltq-tpkdyVAERHILRAPFK 280 Plesiocystis pacif...
CAM03199   23 AERGYaecGEAFSVRIPGwTAHMFIG-PEHNRFFFSETDRRLsirTAYPFFVRMFDpafy----ffagDDEYRRQRALVL 97  Saccharopolyspora ...
ADA69248   48 FYKGYqelGNVFTVNIPK-PIVVVTG-SEYHQWFYNETDKSLniaKGYEILKYTIGevflt--askeqYKKQRIFLPIIF 123 Nostoc sp. 'Peltig...
Feature 1                                                                                     
3LD6_A    116 NIahf-----kqhVSIIEKETKEYFESWGESGekn--vfeALSELIILTASHCLhgkeir-sqlneKVAQLYADLDGGFS 187 human
3L4D_A    107 TVakf-----qnfAPSIQHEVRKFMKANWNKDegeinildDCSAMIINTACQCLfgedlrkrldarQFAQLLAKMESCLI 181 Leishmania infantum
3KHM_A    112 TIakf-----qnfVPAIQHEVRKFMAENWKEDegvinlleDCGAMIINTACQCLfgedlrkrlnarHFAQLLSKMESSLI 186 Trypanosoma cruzi
2X2N_A    121 TIakf-----qnfVPAIQHEVRKFMAANWDKDegeinlleDCSTMIINTACQCLfgedlrkrldarRFAQLLAKMESSLI 195 Trypanosoma brucei
ABP64518  111 PRfkaas--mkqyVPVMVEESLNLVERLGEEGefd--lipTLGPVVMDIAAHSFmgrefh-eklghEFFELFRDFSGGME 185 Novosphingobium ar...
EEQ30371  132 SRgisnnaamshyTDLAGIETEKAIASWANRKepla-lfkDTSYIVHKTIVQCMmgpdf--ydaadELFDLLHVMEANLG 208 Microsporum canis ...
CAK48260  123 NRgvirsialehyTRIAGEEARKIATNWAEKPdie--vfeQMSRYTHRVIVRCLmgqdfy-dhhldELLDLLHRMEADIG 199 Aspergillus niger
EDM78481  281 ARlme------gnLGVIDEVVLRFIDGLDDAGefd--lvpTVEGLLQEISARVLmgedfh-armdaEFWALYGDLAAGLD 351 Plesiocystis pacif...
CAM03199   98 PRfqgrq--lenyVATMVDEVCELDRALGNSGefd--lvrTMGPLVMRIAARAFlgrefs-arlenGFFEKFRRFSAGMD 172 Saccharopolyspora ...
ADA69248  124 GRern-----lgyLNAMNYEVDVWLDRLGESGemd--imdEMRLVTRSIAGHAFaganfr-delgsEFWEAYSDIAKSVS 195 Nostoc sp. 'Peltig...
Feature 1                                                                                   # 
3LD6_A    188 HAAWllpgw--lplpsFRRRDRAHREIKDIFYKAIQKRrqsq----ekiDDILQTLLDATykdgrplTDDEVAGMLIGLL 261 human
3L4D_A    182 PAAVflpwilklplpqSYRCRDARAELQDILSEIIIARekeeaqkdtntSDLLAGLLGAVyrdgtrmSQHEVCGMIVAAM 261 Leishmania infantum
3KHM_A    187 PAAVfmpwllrlplpqSARCREARAELQKILGEIIVARekeeaskdnntSDLLGGLLKAVyrdgtrmSLHEVCGMIVAAM 266 Trypanosoma cruzi
2X2N_A    196 PAAVflpillklplpqSARCHEARTELQKILSEIIIARkaaavnkdsstSDLLSGLLSAVyrdgtpmSLHEVCGMIVAAM 275 Trypanosoma brucei
ABP64518  186 FVLPlwlp-----tpkMVKSQRAKRKLHAILQSWIDKRraap----ldpPDFFQTMIETKypdgrpvPDEIIRHLILLLV 256 Novosphingobium ar...
EEQ30371  209 SIWNfilpew-lphpaAKKLWDARDRTKEIFNVRLAARekepe-kwkkeLDYISYTLRDPvt---ahLKDKYSALHTVLM 283 Microsporum canis ...
CAK48260  200 HPFHfllpnw-vphgpARRLHHARDRMAAIFNERLQAReqnpe-kwqdsLDYIAYTLKDSrt---ahLRQYFAAHHTLLM 274 Aspergillus niger
EDM78481  352 QALPpwlp-----lprFIRRDIARARLHRKLGALIEERrelsr-qgrqpEDLLQALVDARledgsvlPVERVVDYVLALV 425 Plesiocystis pacif...
CAM03199  173 PVMAgwlp-----lphLVRSRFAKRELHRLMGELIRQRrrsp----vepGDFLQTLIEARyddgevvPDRVLINLILLFS 243 Saccharopolyspora ...
ADA69248  196 IILPpdwp-----lprYKRRDRARAKIRSILGRLCQQRrqap----eayDDVISLLLNTPlddgtylDDQKAADLWLGLI 266 Nostoc sp. 'Peltig...
Feature 1      ##  ##  #                                                      #    #   # #    
3LD6_A    262 LAGQHTSSTTSAWMGFFLARDK--TLQKKCYLEQKtvcgenlpp-ltydqlkdLNLLDRCIKETLRLRPPiMIMMRMART 338 human
3L4D_A    262 FAGQHTSTITTTWSLLHLMDPRnkRHLAKLHQEIDefpaqln----ydnvmeeMPFAEQCARESIRRDPPlVMLMRKVLK 337 Leishmania infantum
3KHM_A    267 FAGQHTSTITTSWSMLHLMHPKnkKWLDKLHKEIDefpaqln----ydnvmdeMPFAERCVRESIRRDPPlLMVMRMVKA 342 Trypanosoma cruzi
2X2N_A    276 FAGQHTSSITTTWSMLHLMHPAnvKHLEALRKEIEefpaqln----ynnvmdeMPFAERCARESIRRDPPlLMLMRKVMA 351 Trypanosoma brucei
ABP64518  257 WAGHETTAGQVSWALADLLQNP--DYQKVLRGEISsllggsdgrdlgweqavaMEKMDLALRETERLHPVaYMLSRKARA 334 Novosphingobium ar...
EEQ30371  284 FAAHTSTVAGVAWTIIELLRNP--HYLERLRKELEanpn-----------pdeSEFLGALMKETVRHYVA-FNDLRFTRQ 349 Microsporum canis ...
CAK48260  275 FAAHTSTVASIAWTVLELLRNP--THLEALKTALAtdad-----------ihrSPTLIATLKETSRRYSG-VNMIRWARQ 340 Aspergillus niger
EDM78481  426 FAGFETTTGHAAWGVILLLQHR--VHLERIRGQVDvalegver--idrkalatLAPVRDALRETERIMPVaDRHVRQADA 501 Plesiocystis pacif...
CAM03199  244 WAGHETTTGHISWAVIDLLRNP--EALRKVLEETHgvlgsrsfgeltlsdvgkLKYLGHALHETERLHPVaFTMARTAAE 321 Saccharopolyspora ...
ADA69248  267 FAGNDTTARQAAWCVLLTLQHP--NILARLQTEVEvlndsid-----amsfrsLPLTFQVIDETVRLKPSaDMLLRVTEQ 339 Nostoc sp. 'Peltig...
Feature 1                                                                         ###  ###### 
3LD6_A    339 Pqt--------vAGYTIPPGHQVCVSPTVNQRLKDSWvERLDFNPDRYlqdnpa------sgekfAYVPFGAGRHRCIGE 404 human
3L4D_A    338 Pvq--------vGKYVVPEGDIIACSPLLSHQDEEAFpNPREWNPERNmkl-----------vdgAFCGFGAGVHKCIGE 398 Leishmania infantum
3KHM_A    343 Evk--------vGSYVVPKGDIIACSPLLSHHDEEAFpNPRLWDPERDekv------------dgAFIGFGAGVHKCIGQ 402 Trypanosoma cruzi
2X2N_A    352 Dvk--------vGSYVVPKGDIIACSPLLSHHDEEAFpEPRRWDPERDekv------------egAFIGFGAGVHKCIGQ 411 Trypanosoma brucei
ABP64518  335 Die--------rDGYVIRKGEFVLLAPSVSHRMEETFrNPDAYDPERFnpanpd-----aqiesnSLIGFGGGVHRCAGV 401 Novosphingobium ar...
EEQ30371  350 Pktltn--adskKAITIPAGTMVSISPYITHHDPSIWeNPNEYLPERWindpnlqk-kmnegnniRYLPFGAGSHRCPGE 426 Microsporum canis ...
CAK48260  341 PhqlpadaapgkGNIVVPENCIVSISPYLTHHDPETYaDPHIWDPTRWleggrlsetqksnrsevTYFPFGAGCHRCPGE 420 Aspergillus niger
EDM78481  502 Pve--------iGGYTIPAGWLLMSGVALTHRMPELYaEPEVYDPQRFergeg--------kgkfTLVGFGGGSHRCTGV 565 Plesiocystis pacif...
CAM03199  322 Afe--------yAGYRIPEGAMLMISPAVTHRLPGLYpEPDRFRPERFqdnp---------kdtrYLVGFGGGVHRCLGV 384 Saccharopolyspora ...
ADA69248  340 Evq--------vGDYQIPAGWRVVIAAGSSHYLESKFsNPPLFDPDRFskerse------gkdqyAIMGFGGGGRKCPGM 405 Nostoc sp. 'Peltig...
Feature 1      ##                                                     
3LD6_A    405 NFAYVQIKTIWSTMLRLYEfdl--idgYFPTVNytt-------mihTPENPVIRYK 451 human
3L4D_A    399 KFGLLQVKTVLATVLRDYDfel---lgPLPEPNyhtm-----vvgpTASQCRVKYI 446 Leishmania infantum
3KHM_A    403 KFALLQVKTILATAFREYDfql--lrdEVPDPDyhtm-----vvgpTLNQCLVKYT 451 Trypanosoma cruzi
2X2N_A    412 KFGLLQVKTILATAFRSYDfql--lrdEVPDPDyhtm-----vvgpTASQCRVKYI 460 Trypanosoma brucei
ABP64518  402 NFARMEMKVLVAILLQNFDmel---mdEVRPIAgas-------tywPAQPCRVRYR 447 Novosphingobium aromaticivorans DSM 12444
EEQ30371  427 KMALMMMRTIVAKIVMTCDmdwpaggaNQNTTDldfak---igspwLKGDIRVKIQ 479 Microsporum canis CBS 113480
CAK48260  421 QMAGMIAREMVAHMVKTYDvrw---ssTGPPEDfeqldfsrvgsawLKGDARVTVK 473 Aspergillus niger
EDM78481  566 TLAYNEMTILLARLVQRLElel--vapKVPEIAdtm-------gvlGPEPTRVGYR 612 Plesiocystis pacifica SIR-1
CAM03199  385 HFAYLEMTIALAHLFREFEf-------ELLDTNprpvpg--ahtkwPRSPCRVRYV 431 Saccharopolyspora erythraea NRRL 2338
ADA69248  406 NFAKSEMAIILAKLLRNYDl-------TLLTPNpktisv--lggapRPSPTRISYQ 452 Nostoc sp. 'Peltigera membranacea cyanobiont'

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