2YCB,2XR1,3AF5


Conserved Protein Domain Family
arCOG00543

?
TIGR03675: arCOG00543 
Click on image for an interactive view with Cn3D
arCOG00543 universal archaeal KH-domain/beta-lactamase-domain protein
This family of proteins is universal in the archaea and consistsof an N-terminal type-1 KH-domain (pfam00013) a central beta-lactamase-domain (pfam00753) with a C-terminal motif associated with RNA metabolism (pfam07521). KH-domains are associated with RNA-binding, so taken together, this protein is a likely metal-dependent RNAase. This family was defined as arCOG01782.
Statistics
?
PSSM-Id: 274718
Aligned: 23 rows
Threshold Bit Score: 931.277
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2YCB_A         6 LEEIKRTIMQRLPERVQVAKVEFEGPEVVIYTKNPEIITEn-gNLIRDIAKDIRKRIIIRSDRSVLMDPEKAIRKIHEIV 84  Methanothermoba...
WP_010901037   7 IEETKNIFNRLYPDN-KITDIDYEGPTIVVYTKDPELFAKr-dDLVRQIAQEIRRRIAIRSDPSILLPEDQARESIEKII 84  Thermoplasma ac...
WP_011177488   7 LSEAKAIFDRLYPDN-KISEVDYEGPTIVVYTKDEELFSKr-dDIARQIAQELRRRIAVRPDPSIMLDEDTAEKLIKEII 84  Picrophilus tor...
WP_011277529   4 RLNIVNAIYNGMPKEAGISKIDFEGPEIAVYVRNPAVVd---gETVKKIAKEIKKRVVVKADPKSRKDKEETKEIIKNIV 80  Sulfolobus acid...
WP_011839227  11 RAELLKRILREIPPDLVLTNIEFEGPEIVLYVRNRKAIAKy-lDLVKNIAKKVRKRVVIRADPDVRLPPEKAKEKILEIV 89  Staphylothermus...
WP_011822707   2 KKIALTIMEQLTPKYIQVSRIEFEGPEIAIYVRNPKALAEh-pEVAKEIAKKLKKRIVIRTDPSVRRSEKETIEVIKNLV 80  Hyperthermus bu...
WP_011019595  15 KKKVMERVEEVLPSDVVVTDVDFEGPEVVLYTNSPHSFVKddsDLVTRLAKALRKRVKIRPNPAALSPAKEAKKVILKII 94  Methanopyrus ka...
WP_010865809  20 KQLIMEIYNSL--RSADIASIEFEGPEIAVYIRNPKFIVEn-eNVVKDLARKLRKRIVVRTHPKSRKSMEYTIKFIRENV 96  Aeropyrum pernix
WP_011751983   8 aREIRETIASNVPKEAEITKVDFEGPKVAIYTKRPQVFLEndgELVKRIAKTIKKRVIVRGDPESRLNEGSAEEFIKKAV 87  Thermofilum pen...
WP_011007526   3 FVEIENKVKAIL-SGIEIVKVNYEGPNLCIYVKRPTEDVI---DMIGEVAKTLKKRVILRVDPSNRASEKTASKVIREVL 78  Pyrobaculum aer...
2YCB_A        85 PEEAKI--TNISFDDVTCEVIIEARKPGLVIGKYGSTSREIVKNTGWAPKILRTPP-----ISSE---IIERIRRTLRKN 154 Methanothermoba...
WP_010901037  85 PKEAGL--EDIYFEPDTGEVIIELDEPSIVTARGTDYVQEIKSRTQWSPRIVRAPP-----MYSR---TVKEVREFMREV 154 Thermoplasma ac...
WP_011177488  85 PDEAGL--KDIYFEPDTGEAVIELDEPSIVT-RNQEVMVNIKSRTKWSPRIVRAPP-----MYSR---TVKEMREFLRSV 153 Picrophilus tor...
WP_011277529  81 PQEAQI--IDIKFDDELGEVLIKAKKPGLVIGKGGSIQQKIFAETYWRPIIVREPP-----LKSR---TYDGVLTHIYNE 150 Sulfolobus acid...
WP_011839227  90 PKDAGVdpNGIVFDHTRGEVWIKAEKPGLIVGRGSYIRHYILAETGWRPEPQRASP-----LESK---VLKVIMSNLLKE 161 Staphylothermus...
WP_011822707  81 PPEAGI--KEIKFDHVLGEVIIKAEKVGLVYGKGQSIYNKVLAETGWRMNVVRIPP-----VDPKdlsTLNKIIDYMLSQ 153 Hyperthermus bu...
WP_011019595  95 PEEAGVseRDLLFLD-TGEVVIFSKKPGLVIGKRGKNVHRISRDTGWVPRIYRQPP-----IPSK---TVNTTRRLILSD 165 Methanopyrus ka...
WP_010865809  97 PPDVGI--VDIQFDDVLGEVRVIAEKPGKLMGRGKVFRNLVLAETGWRLEVYRKPL-----LQSG---LLDSVLRHLQRH 166 Aeropyrum pernix
WP_011751983  88 PPEAGL--KNVYFNDVTGEVELEVLYPEKI---PPEVLNRVFFETLWTPRVLRKPP-----VHSR---TVSEIRELYRAS 154 Thermofilum pen...
WP_011007526  79 ---SDV--EDVVFENN-GDVYIYLAKP-LREKEIKSATREIFVKTGWRAVIESGVPkdrvkLPTH---EIVGVRHIFHSA 148 Pyrobaculum aer...
2YCB_A       155 SKERKKILQQLGNRIHQKPK----YDNDWARLTAMGGFREVGRSCLYLQTPNSRVLLDCG-V-NVaGg--DDKNSYPYLN 226 Methanothermoba...
WP_010901037 155 KQERREFLHNLGVKLSGPPM----VGETWVRLTALGGHSEVGRSATLVSTKNSKVLIDCG-MmNV-GpdaDPWDAAPYLY 228 Thermoplasma ac...
WP_011177488 154 KKERKEFLHNLGIKLTTPVM----PGETWIRITALGGHREVGRSATLISTNNSKILVDCGmI-NV-NdpdHPWEEAPYLY 227 Picrophilus tor...
WP_011277529 151 TEYRAKALRVFGERIHRDIL----FKDRFVRITGLGGFNEVGRSAVLVETPESKILLDVG-L-NP-Sv-sYGEKLFPRID 222 Sulfolobus acid...
WP_011839227 162 SDYRLRFLRKLGERIHRDVI----FKNNYVRITALGGFMEVGRSAILVETRESRVLLDLG-I-NV-GagtDYDRAYPFID 234 Staphylothermus...
WP_011822707 154 SSYRLEFLRSSGERIHRGVI----FENRYVRITALGGFMEVGRSAILIETSESKILLDVG-I-NP-Sg--IGYNLYPRLD 224 Hyperthermus bu...
WP_011019595 166 -DSRRKFLRNVSARIFCGRTrsrgTESRWARVSALGGFQEVGRSSLFLHTEESRVLLDCG-V-NV-Aa--NGTDAYPHFN 239 Methanopyrus ka...
WP_010865809 167 AEERRRALRDIGERIFRDTL----IGTRHVRVVGLGSFGEVGRSAILVDTGESKVLLDAG-L-SP-Sg--YGPDSYPYYW 237 Aeropyrum pernix
WP_011751983 155 KQERIDFLRKLGYKVYRKPI----FPADRVRIVSLGAFHEVGRSAVLVQTPEANILLDAG-L-KP-Tg--NGDEL-PLFD 224 Thermofilum pen...
WP_011007526 149 YAQRMELMESLARYIHQEPV----VKEGPITVTFLGAAMEVGRSAILVSTTESNVLLDCG-L-KP-A---QNDEEFPLLD 218 Pyrobaculum aer...
2YCB_A       227 VPEFT-LDSLDAVIITHAHLDHSGFLPYLYHYGY---DGPVYCTAPTRDLMTLLQLDHIDIAHREDEPLPFNVKHVKKSV 302 Methanothermoba...
WP_010901037 229 VPEVQpLSTIDAVILTHAHLDHSGLLPLLFKYGY---DGPVYMTPPTRDLAALLQNDYIKVARMEGGKVPYESKYIREEL 305 Thermoplasma ac...
WP_011177488 228 VPEIQpFSSLDAVILTHAHLDHSGLVPLLYKYGY---DGPLYTTAPTRDLAALLQNDYIKVAHSEGHKISYESKHIREML 304 Picrophilus tor...
WP_011277529 223 IDQVK-LEDIDAVVITHAHLDHCGMVPLLFKYGY---EGPVYMTPPTRDIMALAQLDALDVAEKEGRPIPYTAKEVRREL 298 Sulfolobus acid...
WP_011839227 235 IDQLN-LSELDAVIVTHAHLDHIGLVPLLYKYGY---RGPLYVTKPTRELMVIMIKDLIEVTQREGKYLPYSEKDLMTTI 310 Staphylothermus...
WP_011822707 225 IDQLN-LEELDAVVVTHAHLDHIGLVPYLFKYGY---RGPVYATKPTRDLMVLLLLDLLDIMQRSGQKPPYTQQEVKKMI 300 Hyperthermus bu...
WP_011019595 240 VPEFR-MDDLDAIVITHAHLDHCGFLPYFYRHKViesRVPVYCTPPTRDLMYLLLTDYIKVLEKRGQEPPYTEKDVKKVI 318 Methanopyrus ka...
WP_010865809 238 SPEFR-VDELDAVVISHAHLDHVGTLPLLFKYGF---RGPVYATPPTRDIMIIVLRDLINLMRKAQGEPPFEPRDVEKAL 313 Aeropyrum pernix
WP_011751983 225 LPEFD-LESLDAVVITHAHLDHVGALPVLFKYGY---KGPVYMTEPTLHLSKLLFEDYIKVAQREGKNELYSMRDVNSLL 300 Thermofilum pen...
WP_011007526 219 L--ID-IDRLDAVVLTHAHMDHVGCLPFLFKYGY---KGPVYMTDPTKYQAFILLSDYVELKEREGLQPSYSKADIETVI 292 Pyrobaculum aer...
2YCB_A       303 KHTITLDYGEVTDIAPDIRLTLHNAGHILGSAMAHLHIGDGQHNMVYTGDFKYEQ------SRLLEAAANRFPRIETLVM 376 Methanothermoba...
WP_010901037 306 KHTITLRYGETTDITRDMRLTFYNAGHILGSASGHLHIGDGLYNVVLSGDVKFEK------TWLFNPANNKFPRAETFMT 379 Thermoplasma ac...
WP_011177488 305 KHTIALKYNETTDITPDVRLTLYNAGHILGSASVHLHIGDGLYNIVLSGDQKFEK------TWLFNPAVNRFPRVETFMI 378 Picrophilus tor...
WP_011277529 299 LHTITLDYGEVTDIAPDVKLTFYNAGHILGSAMAHLHIGEGLHNVVYTGDFKYAR------TKLLDKANDEFIRVDTMIM 372 Sulfolobus acid...
WP_011839227 311 LHTIPLEYGDVTDVAPDIKVTMYNAGHILGSAIVHLHIGMGLHNIVYTGDFKYAP------TRLLNRAEDKFPRVETLIM 384 Staphylothermus...
WP_011822707 301 LHTIPLDYGEVTDIAPDMKLTFYNAGHILGSAIAHIHIGEGLHNIVYTGDFKFGR------TRLLDKAHTEFPRVETLIM 374 Hyperthermus bu...
WP_011019595 319 KRTITIDYREPTDITPDMSITFYNAGHILGSASVHVFLQDKGHNFVYTGDINPTP------SRLLEGADNRFKRVDSMVV 392 Methanopyrus ka...
WP_010865809 314 TRLIPVNYNTVTDVAPDIKMTFINAGHILGSSMVHLHIGQGLYNILYTADFKFYRikndrsTRLLPPAEYSFQRVEALIM 393 Aeropyrum pernix
WP_011751983 301 LNTYTLSYGEVTDIAPEIRLTFYRAGHILGSAMVHLHIGEGLINIVYTGDMKYAR------TMLLDPAYNKFPRAEVLII 374 Thermofilum pen...
WP_011007526 293 YHTITLDYEEVTDIAPDIKLTFYDAGHEIGSAMAHLHIGNGRYNILYTGDFKYGK------TRLLNRAANKFKRVEMLIM 366 Pyrobaculum aer...
2YCB_A       377 ESTYGGHEDVQPSRNRAEKELVKTIYSTLRRGGKILIPVFAVGRAQELMIVLEEYIRTGIId-EVPVYIDGMIWEANAIH 455 Methanothermoba...
WP_010901037 380 ESTYGGRDDYSFTREEATQTLIDVINRTHDRGGSVLIPVFAVGRSQEVMIVLEDAMRNGRIp-QMDVYLDGMIMEAPAIH 458 Thermoplasma ac...
WP_011177488 379 ESTYAGRDDYTYTRSRAGEILTDVINRTFERGGSVLIPVFAVGRSQEVMLVIEDAVKRNIIp-RTNVYLEGMIMEATAIH 457 Picrophilus tor...
WP_011277529 373 ETTYGAHD--QENREESEAKLIDIINKTISKGGKVLIPVLSVGRGQEIMLVINDAMKNKKIp-EVPVYITGMVDEITAIH 449 Sulfolobus acid...
WP_011839227 385 ESTYGATR--QQSRREAEAELIRIVKKTIERKGIVLIPVFAVGRGQEIMLVLNDAISKGLIp-KVDVFIEGLVNEVTAIH 461 Staphylothermus...
WP_011822707 375 ESTYGDRD--QPRRDEAELELISVISKTIARRGKVLIPVMAVGRAQEILLVLVDALRKKLLppETKIYIDGSIKEVTAIH 452 Hyperthermus bu...
WP_011019595 393 EATYGDSR--HGSRRKEENRFRKIVRDTLKKGGKVLIPSFAVGRAQEVMLVLEDMHRKDEL--EGPVYLDGMIYEATAIH 468 Methanopyrus ka...
WP_010865809 394 EATYGSKE--TQPRAEAEEELINLVNKVYKRGGKLLIPVMAVGRGQEILVVLNEALRSGKIp-EIPIYVDGMVYEVTAVY 470 Aeropyrum pernix
WP_011751983 375 ESTYGSKSDVLPSEDDAKLELAKIVLETIERKGVVLIPVLAVGRAQEVLLALLDLMKKGAVp-RVPIFIEGMIDEVSAVH 453 Thermofilum pen...
WP_011007526 367 ESTYGGRDDVQPPRVEAENALAKHVSDAVTRGGKVLIPAFSTGRGQEILYILNKMMEGGLIp-RVPVYVDGMIVETLNVY 445 Pyrobaculum aer...
2YCB_A       456 TARPEYLSKDLRDQIFHMGHNPFISDIFHKVNGMDER--------REIVe-GEPSIILSTSGMLTGGNSLEYFKWLCEDP 526 Methanothermoba...
WP_010901037 459 AAYPEYLNKELREAIMVKKENPFLSPIFKKVETRDQR--------EEIAenPETTIVLATSGMMNGGPVMEYFKAWSADP 530 Thermoplasma ac...
WP_011177488 458 AAYPEYLNKDLREQIMVKRDNPFLSDIFKQVETKKQR--------EEIMdsSESKIILATAGMMNGGPVLDYFKSMAPLR 529 Picrophilus tor...
WP_011277529 450 TAYPEWLSRELREAILYRDENPFMSEFFKRIEGYK-----------EDIaqGEPSIIIATSGMLNGGPAVEFFKNMAHDT 518 Sulfolobus acid...
WP_011839227 462 TQYPEYLNRNIKEMIY-RGENPFTADYFHIIESGTAR--------PDIVe-TKPSIILATSGMLTGGPAVEYLKLIASDP 531 Staphylothermus...
WP_011822707 453 LTYPELLSAQVRARIL-RGENPFDHENIVRVEGRQMR--------EDIAksDEPGVILATAGMLTGGPSVEYLRLLAPDP 523 Hyperthermus bu...
WP_011019595 469 TAYPEYLNRRLQHRILHEDDDPFTSEVFEPVEGSDHR--------QAIMedDEPAVILSTSGMLEGGPILEYLRELSDDP 540 Methanopyrus ka...
WP_010865809 471 TNYPELLVKPIRDRILKQGENPFEGPTTVYVTDHYKR--------DEAMysDKPAIILSTSGMMNGGPIVEYFKYLADDP 542 Aeropyrum pernix
WP_011751983 454 MTFPEYLSATIREMIY-RDENPFTSENIHVIRGEA----------REDIteKKPSIILATSGMLTGGPVLDYLRILADDE 522 Thermofilum pen...
WP_011007526 446 LMYPHYLNPEVAEEIY-GGVNPFTTSGSVVIVDRAKRvedrinqvAKIAqsEEPAVIIAPHGMLNGGPVVDYFAQLAHDE 524 Pyrobaculum aer...
2YCB_A       527 DNSLVFVGYQAEGSLGRRIQKGWKEIPLKDeD-DKMRVYNVRMNIKTIEGFSGHSDRRQLMEYVKRISPK-PEKILLCHG 604 Methanothermoba...
WP_010901037 531 KHTLVFVGYQADGTLGKKIQSGAQEITLSG-E-GKNVTYPVKMDVETAEGFSGHSTKKQLLAYIATMQPK-PKKILVNHG 607 Thermoplasma ac...
WP_011177488 530 EHSLVFVGYQADGTLGRYIQSGAKNVTLTD-N-GKPVKIDINMSVETAEGFSGHSNKAQLLNYIATMQPK-PQRILVNHG 606 Picrophilus tor...
WP_011277529 519 RNSIVFVSYQAEGTLGRKVRDGAKDIQILDrD-GRVENIKVNMEIGVVEGFSGHSDRRQLLAFLRNLNVK-PKNLVLNHG 596 Sulfolobus acid...
WP_011839227 532 RNSLVFVGYQAEGTLGRRIKDGMRELQTVV-D-NKVEIIRINLEVYSIDGFSGHSDQSELLRYVRNISPK-PRNIILNHG 608 Staphylothermus...
WP_011822707 524 RNVLVFVSYQAKGTLGRRILDGEREITMVDeE-GKPQLVRIQMEVKSIDGFSGHSDRRQLLAFLANMKPK-PKNIILNHG 601 Hyperthermus bu...
WP_011019595 541 KNTLIFVGYQAEGTLGRQIQEGAKEVPLPT-PtGKTETLRIELRVETVSGFSGHGDKIELTKYVRSIRPSpPSKVFTNHG 619 Methanopyrus ka...
WP_010865809 543 RNALAFVSYQAPGTLGRRLQSGEREIELEM-D-GGIRRIKVNMEIVSIEGFTGHSTRGELLSFLRRLNPK-PRNIVLNHG 619 Aeropyrum pernix
WP_011751983 523 NSSLVFVSYQVEGTLGRKILQGLRKLSFTD-PsGKVINKDLKMRVYRVEGFSGHSDRRQLEAFIRRMEPS-PRTVILNHG 600 Thermofilum pen...
WP_011007526 525 RNKLIFVSYQAEGTLGRRILNGEREFVIKS-LvGGESKINMRMEVVSIPGFSGHSDRRELMKYVEHMEPK-PKKIVLIHG 602 Pyrobaculum aer...
2YCB_A       605 DNYKTLDLASSIYR-------T-------YRIET--K--TPLNLETVRIQ 636 Methanothermobacter thermautotrophicus str. D...
WP_010901037 608 DNGKTAEFARLVRQ-------R-------FNIEA--Y--ALKNLETIRLL 639 Thermoplasma acidophilum
WP_011177488 607 DGDKCYEFSRLIRS-------K-------FGIDA--I--SLKNLETVRVY 638 Picrophilus torridus
WP_011277529 597 EPSAISSFKRLVESgk----iK-------GIDNV--Y--APKILESIRTI 631 Sulfolobus acidocaldarius
WP_011839227 609 EPSAIMTLARLVSKiirnpstG-------YGANTmvY--TPHLLDSIHLT 649 Staphylothermus marinus
WP_011822707 602 EPQSIHALAETIRR-------RarhlglpEDIRV--Y--TPTILDTLHIa 640 Hyperthermus butylicus
WP_011019595 620 EPRACKYFSNHLRR-------Tv------RKVFS--M--APENLECFRLT 652 Methanopyrus kandleri
WP_010865809 620 EPSAIAALAHTVKTgws--klG-------FESPP--IieAPENLEGVRLY 658 Aeropyrum pernix
WP_011751983 601 EAGKIEEFRRYLSSewfkkktG-------LNLDV--L--TPKNAESIRIV 639 Thermofilum pendens
WP_011007526 603 EPSKIISLATSIEL-------K-------YKITT--I--IPKVGERIRAL 634 Pyrobaculum aerophilum
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap