2KS9


Conserved Protein Domain Family
7tmA_NK1R

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cd16002: 7tmA_NK1R 
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neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.
Statistics
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PSSM-Id: 320668
Aligned: 5 rows
Threshold Bit Score: 482.057
Created: 10-Dec-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 41 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
2KS9_A        33 VLWAAAYTVIVVTSVVGNVVVMWIILAHKRmrtvTNYFLVNLAFAEASMAAFNTVVNFTYAvhneWYYGlfyCKFHNFFP 112 human
NP_990199     37 ALWAVAYTLIVVVSVVGNVVVMWIILAHKRmrtvTNYFLVNLAFAEASMSAFNTVVNFTYAihneWYYGllyCKFHNFFP 116 chicken
AFN07676      39 VLWAVAYSTIVVVSVVGNITVIWIILAHKRmrtvTNYFLVNLAFAEASMSAFNTVINFVYSvhneWYFGlyyCRFHNFFP 118 zebrafish
Q98982        34 ALWSVAYSIIVIVSLVGNIIVMWIIIAHKRmrtvTNYFLVNLAFAEASMSAFNTVINFTYAihnhWYYGliyCKFHNFFP 113 bullfrog
XP_006008551  45 ALWAIAYSVIVIIAVVGNIIVMWVILAHKRmrtvTNYFLVNLAFAEASMAAFNTVINFTYAshneWYYGheyCMFHNFFP 124 coelacanth
Feature 1        #  #                                          # #####                           
2KS9_A       113 IAAVFASIYSMTAVAFDRYMAIIHPlqpRLSATATKVVICVIWVLALLLAFPQGYYsttetmpsrvVCMIEWPEhpn-ki 191 human
NP_990199    117 IAAVFASIYSMTAIALDRYMAIIHPlqpRLSATATKVVICVIWLLAFLLAFPQGYYsvteelpgrlVCLVAWPEhst-dv 195 chicken
AFN07676     119 IAAVFASIYSMTAIALDRYMAIIHPlqqRMSATQTKVVIGVIWILALLLAFPQYYYsdtdqlpgrvVCYIDWPEytl-ld 197 zebrafish
Q98982       114 ISAVFTSIYSMTAIALDRYMAIIHPlkpRLSATATKIVICVIWSFSFCMAFPLGYYadvypmeggdICYLNWPDseenrk 193 bullfrog
XP_006008551 125 ITAVFASIYSMTAIALDRYMAIIHPlkpRLPATATKIIICVIWVLASSLAFPLFYFskteeifgrfVCYVEWPE------ 198 coelacanth
Feature 1         #  ### ### ##                                                                  
2KS9_A       192 YEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGdssd------------ryheQVSAKRKVVKMMIVVVCTFAI 259 human
NP_990199    196 YGKTYHFCMTVLIYFLPLLVIGCAYTVVSITLWASEIPGdssd------------ryheQVSAKRKVVKMMIIVVCTFAL 263 chicken
AFN07676     198 FKTMYFVCVAVLIYFLPLLVMGCAYLVVGLTLWASEIPGdssd------------ryqeQLTAKRKVVKMMIVVVCTFAV 265 zebrafish
Q98982       194 YEQVYQVLVFCLIYILPLLVIGCAYTFIGMTLWASEIPGdssd------------ryheQVVAKRKVVKMMIVVVCTFAI 261 bullfrog
XP_006008551 199 QDTGFRESIEAGLYFGAVLTTVNVQCFVNIKQGPREIPQeeqrlqlqvgpdsaikrsgvSYLQRLHVVKMMIVVVCTFAI 278 coelacanth
Feature 1         #  ## ##  #           ## ###  #  ##                     
2KS9_A       260 CWLPFHIFFLLPyinpdlylkkFIQQVYLAIMWLAMSSTMYNPIIYCCLNdRFRLGF 316 human
NP_990199    264 CWLPYHIYFTLQyfnpewylqkFIQQVYLAVMWLAMSSTMYNPIIYCCLNdRFRVGF 320 chicken
AFN07676     266 CWLPYHVYFLIHqfyphlfehtFIQQVYLTIMWLAMSSTMYNPIIYCCLNdRFRAGF 322 zebrafish
Q98982       262 CWLPFHIFFLLQtlhe--mtqkFYQQFYLAIMWLAMSSTMYNPIIYCCLNdRFRIGF 316 bullfrog
XP_006008551 279 CWLPYHVYFLLQhfhpelyeqkFIQQVYLAIMWLAMSSTMYNPIIYCCLNdRFRVGF 335 coelacanth

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