2VT4,2Y00


Conserved Protein Domain Family
7tmA_Beta1_AR

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cd15958: 7tmA_Beta1_AR 
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beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors
The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.
Statistics
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PSSM-Id: 320624
Aligned: 5 rows
Threshold Bit Score: 505.976
Created: 18-Sep-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 21 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2VT4: Meleagris gallopavo beta-1 adrenergic receptor binds cyanopindolol, contacts at 4A.
    View structure with Cn3D
  • Structure:2Y00: Meleagris gallopavo beta-1 adrenergic receptor binds partial agonist dobutamine, contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                   ##              #   #
2VT4_A        12 AGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLD 91  turkey
2Y00_A        12 AGMSLLMALVVLLIVAGNVLVIAAIGSTQRLQTLTNLFITSLACADLVVGLLVVPFGATLVVRGTWLWGSFLCELWTSLD 91  turkey
P08588        59 AGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVD 138 human
O42574        36 MGMTMFMAAIILLIVMGNIMVIVAIGRNQRLQTLTNVFITSLACADLIMGLFVVPLGATLVVSGRWLYGSIFCEFWTSVD 115 African clawed ...
XP_004080293  36 AGMSLVMALIVLSIVFGNILVILAIARTQRLQTLTNVFIVSLASADLIMGLLVVPFGAVLEVRGLWLYGSFFCEIWTSVD 115 Japanese medaka
Feature 1        #  #                                                                            
2VT4_A        92 VLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDedp-qalKCYQDPGCCD 170 turkey
2Y00_A        92 VLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMHWWRDedp-qalKCYQDPGCCD 170 turkey
P08588       139 VLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAesd-earRCYNDPKCCD 217 human
O42574       116 VLCVTASIETLCVISIDRYIAITSPFRYQSLLTKGRAKGIVCSVWGISALVSFLPIMMHWWRDtgdplamKCYEDPGCCD 195 African clawed ...
XP_004080293 116 VLCVTASIETLCVIAIDRYVAITSPFRYQSLLTKSRAKAVVCVVWAISALVSFLPILMHWSRDsm---dtDCYENPQCCD 192 Japanese medaka
Feature 1        # #   ##  ##  #                                                                 
2VT4_A       171 FVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRKIDraskr--------------------------------- 217 turkey
2Y00_A       171 FVTNRAYAIASSIISFYIPLLIMIFVALRVYREAKEQIRKIDraskrk-------------------------------- 218 turkey
P08588       218 FVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDscerrflggparppspspspvpapapppgpprpaaaaa 297 human
O42574       196 FVTNRAYAIASSIISFYFPLIIMIFVYIRVFKEAQKQMKKIDkcegrfshshvlsh------------------------ 251 African clawed ...
XP_004080293 193 FVTNRAYAISSSVISFYIPLVVMIFVYARVYREAKKQLKKIDkcegrfhntltgl------------------------- 247 Japanese medaka
Feature 1                                               #  ##  #               #  ##  #          
2VT4_A       218 --------------krvmlMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIY 283 turkey
2Y00_A       219 -------------tsrvmlMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDLVPDWLFVAFNWLGYANSAMNPIIY 285 turkey
P08588       298 taplangragkrrpsrlvaLREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIY 377 human
O42574       252 ------grssrrilskilvAKEQKALKTLGIIMGTFTLCWLPFFLANVVNVFYRNLIPDKLFLFLNWLGYANSAFNPIIY 325 African clawed ...
XP_004080293 248 ------tskckkrpskilaLREQKALKTLGIIMGTFTLCWLPFFIVNVVRVFCAELVDKNVFVFLNWLGYVNSAFNPIIY 321 Japanese medaka
Feature 1                  
2VT4_A       284 CRSPDFRKAF 293 turkey
2Y00_A       286 CRSPDFRKAF 295 turkey
P08588       378 CRSPDFRKAF 387 human
O42574       326 CRSPDFRKAF 335 African clawed frog
XP_004080293 322 CRSPDFRKAF 331 Japanese medaka

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