5TUY,5JHN,3K5K,4NVQ,5VSE,5VSC,2O8J,5JJ0


Conserved Protein Domain Family
SET_EHMT2
?
cd10533: SET_EHMT2 
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.
Links
?
Statistics
?
PSSM-Id: 380931
Aligned: 13 rows
Threshold Bit Score: 498.003
Created: 13-May-2010
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:5JHN; Homo sapiens EHMT2 binds histone H3k9ala mutant peptide and S-adenosylmethionine, contacts at 4A.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
5TUY_A         28 EDYKYIsENCETStmnidrnitHLQHCTCvdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACSCwrNC 107  human
5JHN_A         33 EDYKYIsENCETStmnidrnitHLQHCTCvdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACSCwrNC 112  human
3K5K_A         38 EDYKYIsENCETStmnidrnitHLQHCTCvdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACSCwrNC 117  human
4NVQ_A         40 EDYKYIsENCETStmnidrnitHLQHCTCvdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACSCwrNC 119  human
5VSE_A         33 EDYKYIsENCETStmnidrnitHLQHCTCvdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACSCwrNC 112  human
5VSC_A         33 EDYKYIsENCETStmnidrnitHLQHCTCvdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACSCwrNC 112  human
2O8J_A         36 EDYKYIsENCETStmnidrnitHLQHCTCvdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACSCwrNC 115  human
NP_001107087  913 SDYKYIaENCETSamnidrnitHLQHCSCtdDCsssNCLCGQLsirCWYDKDhrllqefnkiepPLIFECNMACSChkTC 992  zebrafish
Q96KQ7        948 EDYKYIsENCETStmnidrnitHLQHCTCvdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACSCwrNC 1027 human
PIO25282      729 EDYKYVsENCETSamsidrnitHLQNCSCqdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACACwqTC 808  bullfrog
XP_014350755  783 EDYKYIsENCETStmnidrnitHLQHCSCldDCsssNCLCGQLsirCWYDKDrrllqefnkiepPLIFECNQACTCwrTC 862  coelacanth
KYO48936      669 SDYKYIaENCETSamsidrnitHLQHCTCqdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACACwrTC 748  American alli...
5JJ0_A         33 EDYKYIsENCETStmnidrnitHLQHCTCvdDCsssNCLCGQLsirCWYDKDgrllqefnkiepPLIFECNQACSCwrNC 112  human

Feature 1                             ###                       #  ## #  ######  #                
5TUY_A        108 KNRvvQSGIKVRLQLYRTaKMGWGVRALQtIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 187  human
5JHN_A        113 KNRvvQSGIKVRLQLYRTaKMGWGVRALQtIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 192  human
3K5K_A        118 KNRvvQSGIKVRLQLYRTaKMGWGVRALQtIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 197  human
4NVQ_A        120 KNRvvQSGIKVRLQLYRTaKMGWGVRALQtIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 199  human
5VSE_A        113 KNRvvQSGIKVRLQLYRTaKMGWGVRALQtIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 192  human
5VSC_A        113 KNRvvQSGIKVRLQLYRTaKMGWGVRALQtIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 192  human
2O8J_A        116 KNRvvQSGIKVRLQLYRTaKMGWGVRALQtIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 195  human
NP_001107087  993 KNRvvQAGIKVRLQLYRTeKMGWGVRALQdIPQGSFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 1072 zebrafish
Q96KQ7       1028 KNRvvQSGIKVRLQLYRTaKMGWGVRALQtIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 1107 human
PIO25282      809 KNRvvQSGIKVRLQLYRTaKMGWGVRALQdIPPGSFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNV 888  bullfrog
XP_014350755  863 KNRvvQEGIKVRLQLYRTaKMGWGVRALQdIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 942  coelacanth
KYO48936      749 KNRvvQSGIRVRLQLYRTaKMGWGVRALQaIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNV 828  American alli...
5JJ0_A        113 KNRvvQSGIKVRLQLYRTaKMGWGVRALQtIPQGTFICEYVGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNI 192  human

Feature 1          #####       # #                             ##  ##  ##   ####                 
5TUY_A        188 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIRtGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 266  human
5JHN_A        193 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIRtGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 271  human
3K5K_A        198 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIRtGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 276  human
4NVQ_A        200 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIRtGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 278  human
5VSE_A        193 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIRtGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 271  human
5VSC_A        193 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIRtGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 271  human
2O8J_A        196 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIRtGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 274  human
NP_001107087 1073 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIFtGQELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 1151 zebrafish
Q96KQ7       1108 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIRtGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 1186 human
PIO25282      889 SRFINHLCEPNLIPVRVFMsHQDLRFPRIAFFSGKDIKaGEELGFDYGDRFWDIKSKYFTCQCGSERCKHSAEAIALEQ 967  bullfrog
XP_014350755  943 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIKsGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIAQEQ 1021 coelacanth
KYO48936      829 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRHIRaGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEALALEQ 907  American allig...
5JJ0_A        193 SRFINHLCDPNIIPVRVFMlHQDLRFPRIAFFSSRDIRtGEELGFDYGDRFWDIKSKYFTCQCGSEKCKHSAEAIALEQ 271  human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap