1NSI,1D1W,1LZX,1M8E,1M9M


Conserved Protein Domain Family
NOS_oxygenase_euk

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cd00795: NOS_oxygenase_euk 
Click on image for an interactive view with Cn3D
Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an intermediate. In mammals, there are three distinct NOS isozymes: neuronal (nNOS or NOS-1), cytokine-inducible (iNOS or NOS-2) and endothelial (eNOS or NOS-3) . Nitric oxide synthases are homodimers. In eukaryotes, each monomer has an N-terminal oxygenase domain, which binds to the substrate L-Arg, zinc, and to the cofactors heme and 5.6.7.8-(6R)-tetrahydrobiopterin (BH4) . Eukaryotic NOS's also have a C-terminal electron supplying reductase region, which is homologous to cytochrome P450 reductase and binds NADH, FAD and FMN.
Statistics
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PSSM-Id: 238410
Aligned: 40 rows
Threshold Bit Score: 729.102
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitedimer interface
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:the C-X(4)-C motif coordinates the zinc ion
  • Structure:1NSI_A, human iNOS bound to heme, L-Arg, tetrahydrobiopterin, and Zn2+
    View structure with Cn3D
  • Citation:PMID 9516116
  • Structure:1M8E_A, murine iNOS with inhibitor 7-Nitroindazole bound in place of L-Arg (displacing side chain of a glutamate residue), heme, and tetrahydrobiopterin
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
1NSI_A      11 HVRIKNWGSGMTFQDTLHHKAkg----iLTCRSKSCLGSIMtp---ksLTRGprdkptppDELLPQAIEFVNQYYgSFKE 83   human
O61608     112 PIKLKSIVTKAESYDTMHGKAsd----vMSCSREVCMGSVMtphvigtETRKp-------EIVQQHAKDFLDQYYsSIRR 180  Anopheles stephensi
Q26240      49 PIRLANVSTQAQSLDTLHYKCqq----eGPCMEQACLASVIya----gVNLKprv--rpkEELLAHAKDFLDQYFaSIRR 118  Rhodnius prolixus
AAK43730     2 LTNNQKYTIPETVAQRAHSQEtqv--atTDCRERFCTAARMdmd--yvITDItn-----pEIVLREANEWLAQFY-KEKK 71   slime mold
AAK83069   220 FAKVKNWVDEKTYVDTLHQKAis----nVPCNSDRCMGSLMs-----mQAHRppgaprttDELLIHAKDFIDQYFtSIKR 290  California sea hare
BAB85836    65 PIRLKNHVAHDENFDTLHSRInevthfnTKCSEKVCQTSIMd-----iPGRGdtp--rtaEEVFKDAQAFLTQYYaSIKR 137  domestic silkworm
AAK61379    34 YLRVNNWIEGTQMVDTLHQKAtn----pLHCTNGRCTGSIMypyggeiPEARpygiprpkDEVITHAQDFLEQLYsAKKL 109  Discosoma striata
Q27571     216 PMRLKNIEGRPEVYDTLHCKGre----iLSCSKATCTSSIMn------IGNAavea-rksDLILEHAKDFLEQYFtSIKR 284  fruit fly
AAQ02989   195 PVRLKNWLNERRIHDNLHAKAnd----vNPCSDGKCLGPLMrp----rPFTApgyf-rpkEEVLEQAEKFIFEYYaSLKR 265  Florida lancelet
AAK92211    10 PDRVKNWITGTEYDETLQSSAl-----pGRCTRDRCVGSIMgt----qPDRKqaap-ktkEEVLTQAKEFIDEYFaSFQP 79   California sea hare
Feature 1                                                 #                                    
1NSI_A      84 AKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTN 163  human
O61608     181 LKSPAHDSRWQQVQKEVEATGSYHLTETELIYGAKLAWRNSSRCIGRIQWSKLQVFDCRYVTTTSGMFEAICNHIKYATN 260  Anopheles stephensi
Q26240     119 LQSPAHEARWAQVEKEVAATGTYELTETELVYGAKLAWRNAPRCIGRIQWAKLQVFDCRQVTTTSGMFEALCNHIKYSTN 198  Rhodnius prolixus
AAK43730    72 LPEEKLAIRMKEVYDEVKKTGTYFQTYEELSYSCKVAWRNAPRCINRIQWSRMEVIDCRKVTTAEEVFEKCLEHLKFATN 151  slime mold
AAK83069   291 NNTPAHHKRWTEIQSSLEAQGNYELTTPELTYGAKLAWRNAPRCIGRIQWSKLQVFDARHILTARGMYEALCNHIKYGSN 370  California sea hare
BAB85836   138 ENSEAHKARLDEVKRELKERGTYQLKTSELVFGAKLAWRNATRCIGRIQWKKLQIFDCREVTTASGMFEALCNHIKYATN 217  domestic silkworm
AAK61379   110 SDSQEHLQRRTEVMKAVKETGTYHLTEDELIFASKTAWRNAARCIGRIQWNNLQLFDARHVKTAKEMFEAIKKHLVYATN 189  Discosoma striata
Q27571     285 TSSTAHETRWKQVRQSIETTGHYQLTETELIYGAKLAWRNSSRCIGRIQWSKLQVFDCRYVTTTSGMFEAICNHIKYATN 364  fruit fly
AAQ02989   266 SDVADRDRRWRDVQVQIEEKGVYHLTYGELTYAAKMSWRNSPRCIGRIQWSKLQLFDARDVTTARGMFEAICRHVKWCTN 345  Florida lancelet
AAK92211    80 PNKSAHQKRWSEISSATEAKGTYDLTTEELTFGAKLAWRNASRCIGRIQWSKLQLFDARDVNTAQGIFDAMCKHITYATN 159  California sea hare
Feature 1                                #                                                     
1NSI_A     164 NGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDP 243  human
O61608     261 KGNLRSAITIFPQRTDGKHDYRIWNNQIISYAGYKNADGKIIGDPANVEFTDFCVKLGWKSKRTEWDILPLVVSANGHDP 340  Anopheles stephensi
Q26240     199 KGNIRSAITIFPHRTDGKHDFRIWNKQLISYAGHKSKDGTVIGDPACVEFTEICIKLGWKGKGTMFDVLPLVLSANGEDP 278  Rhodnius prolixus
AAK43730   152 GGNIITTITVFAQQKAGEPAPRLWNSQLLRYAGYRQPDGSIIGDPSNVEMTEAAQKLGWVGQGTRFDVLPIVVQMPNEEP 231  slime mold
AAK83069   371 KGNLRSAITIFPQRKEGRGDFRVWNAQLIRYAGYKMEDGSIVGDPANVEFTEQCVKLGWKPKYGMFDVLPLVLSAAGSDP 450  California sea hare
BAB85836   218 KGNIRSAITIFPQRTDGKHDYRIWNPQLINYAGYQEPDGSITGDPARVEFTEICMKLGWKAPRTPWDILPLVLSADGKDP 297  domestic silkworm
AAK61379   190 EGNLRSAITVFPQRKESKKDFRVWNPQLIRYAGYKHLDGTVVGDPASVDFTELCQSLGWKGKGGRFDILPLVLQANGGPP 269  Discosoma striata
Q27571     365 KGNLRSAITIFPQRTDAKHDYRIWNNQLISYAGYKQADGKIIGDPMNVEFTEVCTKLGWKSKGSEWDILPLVVSANGHDP 444  fruit fly
AAQ02989   346 GGNIRSAITVFPPRTDGRHDYKVWNGQFLKYAAYQLPDGSILGDPINLEFTEVCQALGWKGEGTRFDLLPLVLSANGEDP 425  Florida lancelet
AAK92211   160 KGNLRSTITVFRPRQDGLPDHRIWNAQVIRYAGYKMDDGSIVGDPAGVEFTEVCMNLGWKPKYGRFDVLPLVISVAGADP 239  California sea hare
Feature 1                                    #                     ## ##   #   ##              
1NSI_A     244 ELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFpGCPFNGWYMGTEIGvRDFCDVQRYNILEEVG 323  human
O61608     341 DYFDYPPELILEVPLSHPQFKWFAELNLRWYAVPMVSSMLFDCGGIQFtATAFSGWYMSTEIGcRNLCDANRRNLLEPIA 420  Anopheles stephensi
Q26240     279 DYFDLPPELVFEVPLSHPKYKWFSELGLKWFALPAVSGMMFDCGGLQFtAAPFNGWYMNSEIGsRNLGDTNRYNMLEKIA 358  Rhodnius prolixus
AAK43730   232 KLFPIPKEYVLTVQFSHPKYPWFEEMKLEWFAVPFVSNIGLTSGGVQYtCTPFNGWFMGTELSrNIGDPQRYNLLPDIAT 311  slime mold
AAK83069   451 EWFEIPPELVLEVNMKHPKHPWFADLGLKWYALPAVSGMLFDCGGLEFpACPFNGWYMGTEIGaRDFCDANRYNMMETVA 530  California sea hare
BAB85836   298 EFFELPKEIVMEVQFEHPEYDWFKDMGWKWYALPAVSNMRLACGGLEFtANSFNGWYMGTEIGcRNLCDESRLNIVEAVA 377  domestic silkworm
AAK61379   270 ECFELPDELALQVKIKHPKYPWFEKLGLRWYALPAVSNMMLDAGGLEFtAAPFNGWYMVTEIGtRDLADQQRYNMLEPIA 349  Discosoma striata
Q27571     445 DYFDYPPELILEVPLTHPKFEWFSDLGLRWYALPAVSSMLFDVGGIQFtATTFSGWYMSTEIGsRNLCDTNRRNMLETVA 524  fruit fly
AAQ02989   426 EWFDIPRDIVMEVNITHPKYDWFEELGIKWYCVPAVSNMLFDCGGLEFtAAPFSGWYMGTEVG-RDLCDANRLNITEAVG 504  Florida lancelet
AAK92211   240 VMFDIPQDLVMEVDIAHPTNKKLAELDLKWFALPAIANMALDVGGIEFpASPFNGWYMGTEIGsRDFCDVARYNLLEPIA 319  California sea hare
Feature 1                                                                       ##             
1NSI_A     324 RRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVF 403  human
O61608     421 IKMGLDTRNPTSLWKDKALVEINIAVLHSYQSRNITIVDHHTASESFMKHFENETKLRNGCPADWIWIVPPMSASVTPVF 500  Anopheles stephensi
Q26240     359 QKMELDTRTPVTLWKDLAMVEANVAVLHSFQLHNVTIVDHHSAAESFMKHLENEQRLRGGCPADWVWIVPPISGSATPVF 438  Rhodnius prolixus
AAK43730   312 KLGVDPAGPPSSMWQEKANLELNAAILHSFQKSRVSIVDHHTAAAGFMNFWDAEHAAGRAVPGDWVWLVPPCAGSASPLF 391  slime mold
AAK83069   531 TKMGLDTRKSASLWKDRVLVEVNVAVLYSFQTSGVTITDHHAASESFIKHMENEHKLRGGCPGDWVWVVPPMSGSILEVF 610  California sea hare
BAB85836   378 KKMGLDTNSFVSLWKDKALVEVNIAVLHSFHRDNVSIVDHHSASEQFQKHLENENKSRGGCPADWIWIVPPMSSSLTTVF 457  domestic silkworm
AAK61379   350 KKMGPDTKSNASLWKDFALVELNYAVMYSFQEAGVTLADHHSTSESFMKHMEKEIKLRGGCPADWVWIVPPLSGGATPVF 429  Discosoma striata
Q27571     525 LKMQLDTRTPTSLWKDKAVVEMNIAVLHSYQSRNVTIVDHHTASESFMKHFENESKLRNGCPADWIWIVPPLSGSITPVF 604  fruit fly
AAQ02989   505 KRMGLDVARNSSLWKDAVFVEVNIAVLHSFQRNNVTIMDHHTASESFMKHLENEQRLRGGCPSDWVWIVPPMSASLTEVF 584  Florida lancelet
AAK92211   320 EKLGLDTMSNSSLWKDRALVEINVAVLHSFQSKGVTITDHHSASESFMTHLQKERKARGGCPGDWVWLVPPMSSSITEVF 399  California sea hare
Feature 1                    #     
1NSI_A     404 HQEMLNYVLSPFYYYQVEAW 423  human
O61608     501 HQEMAVYYLRPSFEYQESAM 520  Anopheles stephensi
Q26240     439 FQEMANYFLYPGYIYQEDAW 458  Rhodnius prolixus
AAK43730   392 HLEMANWLQKPAYFPMDFPG 411  slime mold
AAK83069   611 HQEMLLYKLKPSYEYQDEAW 630  California sea hare
BAB85836   458 HQEMALYYIRPSYDYQEPPW 477  domestic silkworm
AAK61379   430 HQEMLNYSLKPSYEYQPDPS 449  Discosoma striata
Q27571     605 HQEMALYYLKPSFEYQDPAW 624  fruit fly
AAQ02989   585 HQEMANYHVRPSFEYQEDAW 604  Florida lancelet
AAK92211   400 HQELLLYKLRPSYEYQTPAW 419  California sea hare

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