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Items: 1 to 100 of 216

VariationLocationGene(s)Protein changeCondition(s)Clinical significance
(Last reviewed)
Review status
1.
GRCh37:
Chr22:42522148
GRCh38:
Chr22:42126146
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
2.
GRCh37:
Chr22:42522198
GRCh38:
Chr22:42126196
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
3.
GRCh37:
Chr22:42522213
GRCh38:
Chr22:42126211
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
4.
GRCh37:
Chr22:42522235
GRCh38:
Chr22:42126233
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
5.
GRCh37:
Chr22:42522244
GRCh38:
Chr22:42126242
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
6.
GRCh37:
Chr22:42522255
GRCh38:
Chr22:42126253
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
7.
GRCh37:
Chr22:42522312
GRCh38:
Chr22:42126310
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
8.
GRCh37:
Chr22:42522338
GRCh38:
Chr22:42126336
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
9.
GRCh37:
Chr22:42522392
GRCh38:
Chr22:42126390
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
10.
GRCh37:
Chr22:42522427
GRCh38:
Chr22:42126425
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
11.
GRCh37:
Chr22:42522464
GRCh38:
Chr22:42126462
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
12.
GRCh37:
Chr22:42522534
GRCh38:
Chr22:42126532
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
13.
GRCh37:
Chr22:42522538
GRCh38:
Chr22:42126536
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
14.
GRCh37:
Chr22:42522613
GRCh38:
Chr22:42126611
CYP2D6not specified, Tramadol responseLikely benign
(Mar 9, 2018)
criteria provided, single submitter
15.
GRCh37:
Chr22:42522613
GRCh38:
Chr22:42126611
CYP2D6S486T, S435Tnot specified, not providedBenign; other
(Aug 6, 2018)
criteria provided, multiple submitters, no conflicts
16.
GRCh37:
Chr22:42522629
GRCh38:
Chr22:42126627
CYP2D6F430L, F481LTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
17.
GRCh37:
Chr22:42522669
GRCh38:
Chr22:42126667
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
18.
GRCh37:
Chr22:42522749
GRCh38:
Chr22:42126747
CYP2D6R441C, R390Cnot provideddrug responseno assertion criteria provided
19.
GRCh37:
Chr22:42522751
GRCh38:
Chr22:42126749
CYP2D6R440H, R389Hnot provideddrug responseno assertion criteria provided
20.
GRCh37:
Chr22:42522755
GRCh38:
Chr22:42126753
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
21.
GRCh37:
Chr22:42522805
GRCh38:
Chr22:42126803
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
22.
GRCh37:
Chr22:42522815
GRCh38:
Chr22:42126813
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
23.
GRCh37:
Chr22:42522821
GRCh38:
Chr22:42126819
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
24.
GRCh37:
Chr22:42522867
GRCh38:
Chr22:42126865
CYP2D6L383Q, L434QTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
25.
GRCh37:
Chr22:42522883
GRCh38:
Chr22:42126881
CYP2D6K378E, K429ETramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
26.
GRCh37:
Chr22:42522933
GRCh38:
Chr22:42126931
CYP2D6P361L, P412LTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
27.
GRCh37:
Chr22:42522946
GRCh38:
Chr22:42126944
CYP2D6V408I, V357ITramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
28.
GRCh37:
Chr22:42523003
GRCh38:
Chr22:42127001
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
29.
GRCh37:
Chr22:42523029
GRCh38:
Chr22:42127027
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
30.
GRCh37:
Chr22:42523171
GRCh38:
Chr22:42127169
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
31.
GRCh37:
Chr22:42523182
GRCh38:
Chr22:42127180
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
32.
GRCh37:
Chr22:42523209
GRCh38:
Chr22:42127207
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
33.
GRCh37:
Chr22:42523211
GRCh38:
Chr22:42127209
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
34.
GRCh37:
Chr22:42523216
GRCh38:
Chr22:42127214
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
35.
GRCh37:
Chr22:42523223
GRCh38:
Chr22:42127221
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
36.
GRCh37:
Chr22:42523358
GRCh38:
Chr22:42127356
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
37.
GRCh37:
Chr22:42523377
GRCh38:
Chr22:42127375
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
38.
GRCh37:
Chr22:42523406
GRCh38:
Chr22:42127404
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
39.
GRCh37:
Chr22:42523409
GRCh38:
Chr22:42127407
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
40.
GRCh37:
Chr22:42523412
GRCh38:
Chr22:42127410
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
41.
GRCh37:
Chr22:42523464
GRCh38:
Chr22:42127462
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
42.
GRCh37:
Chr22:42523505
GRCh38:
Chr22:42127503
CYP2D6G373S, G322STramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
43.
GRCh37:
Chr22:42523528
GRCh38:
Chr22:42127526
CYP2D6R314H, R365HTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
44.
GRCh37:
Chr22:42523531
GRCh38:
Chr22:42127529
CYP2D6Q364R, Q313RTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
45.
GRCh37:
Chr22:42523532
GRCh38:
Chr22:42127530
CYP2D6Q313*, Q364*Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
46.
GRCh37:
Chr22:42523610
GRCh38:
Chr22:42127608
CYP2D6V338M, V287Mnot providedLikely benign; other
(Aug 6, 2018)
criteria provided, multiple submitters, no conflicts
47.
GRCh37:
Chr22:42523803
GRCh38:
Chr22:42127801
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
48.
GRCh37:
Chr22:42523805
GRCh38:
Chr22:42127803
CYP2D6not provided, Tramadol response, Tamoxifen response,
Deutetrabenazine response
Likely benign; drug response; other
(May 1, 2019)
criteria provided, multiple submitters, no conflicts
49.
GRCh37:
Chr22:42523826
GRCh38:
Chr22:42127824
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
50.
GRCh37:
Chr22:42523840
GRCh38:
Chr22:42127838
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
51.
GRCh37:
Chr22:42523848-42523866
GRCh38:
Chr22:42127846-42127864
CYP2D6M321fs, M270fsnot provideddrug responseno assertion criteria provided
52.
GRCh37:
Chr22:42523858
GRCh38:
Chr22:42127856
CYP2D6H324P, H273Pnot providedLikely benign; other
(Aug 6, 2018)
criteria provided, multiple submitters, no conflicts
53.
GRCh37:
Chr22:42523887
GRCh38:
Chr22:42127885
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
54.
GRCh37:
Chr22:42523888
GRCh38:
Chr22:42127886
CYP2D6L314P, L263PTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
55.
GRCh37:
Chr22:42523893
GRCh38:
Chr22:42127891
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
56.
GRCh37:
Chr22:42523923
GRCh38:
Chr22:42127921
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
57.
GRCh37:
Chr22:42523943
GRCh38:
Chr22:42127941
CYP2D6not providedother
(Aug 6, 2018)
criteria provided, single submitter
58.
GRCh37:
Chr22:42523943
GRCh38:
Chr22:42127941
CYP2D6not specified, Tramadol responseLikely benign
(Mar 9, 2018)
criteria provided, single submitter
59.
GRCh37:
Chr22:42523943
GRCh38:
Chr22:42127941
CYP2D6R296C, R245Cnot specifiedBenign
(Feb 27, 2018)
criteria provided, single submitter
60.
GRCh37:
Chr22:42523955
GRCh38:
Chr22:42127953
CYP2D6D241N, D292NTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
61.
GRCh37:
Chr22:42523956
GRCh38:
Chr22:42127954
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
62.
GRCh37:
Chr22:42523992
GRCh38:
Chr22:42127990
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
63.
GRCh37:
Chr22:42524003
GRCh38:
Chr22:42128001
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
64.
GRCh37:
Chr22:42524014
GRCh38:
Chr22:42128012
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
65.
GRCh37:
Chr22:42524088
GRCh38:
Chr22:42128086
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
66.
GRCh37:
Chr22:42524118
GRCh38:
Chr22:42128116
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
67.
GRCh37:
Chr22:42524130
GRCh38:
Chr22:42128128
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
68.
GRCh37:
Chr22:42524176-42524178
GRCh38:
Chr22:42128174-42128176
CYP2D6K281del, K230delnot provided, Tramadol responseLikely benign; other
(Aug 6, 2018)
criteria provided, multiple submitters, no conflicts
69.
GRCh37:
Chr22:42524183
GRCh38:
Chr22:42128181
CYP2D6M279K, M228KTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
70.
GRCh37:
Chr22:42524187
GRCh38:
Chr22:42128185
CYP2D6E227K, E278KTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
71.
GRCh37:
Chr22:42524207
GRCh38:
Chr22:42128205
CYP2D6L271P, L220PTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
72.
GRCh37:
Chr22:42524218
GRCh38:
Chr22:42128216
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
73.
GRCh37:
Chr22:42524225
GRCh38:
Chr22:42128223
CYP2D6A265V, A214VTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
74.
GRCh37:
Chr22:42524228
GRCh38:
Chr22:42128226
CYP2D6P264L, P213LTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
75.
GRCh37:
Chr22:42524244
GRCh38:
Chr22:42128242
CYP2D6R259fs, R208fsnot provided, Debrisoquine, poor metabolism ofLikely benign; other
(Aug 6, 2018)
criteria provided, multiple submitters, no conflicts
76.
GRCh37:
Chr22:42524251
GRCh38:
Chr22:42128249
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
77.
GRCh37:
Chr22:42524258
GRCh38:
Chr22:42128256
CYP2D6L254P, L203PTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
78.
GRCh37:
Chr22:42524264
GRCh38:
Chr22:42128262
CYP2D6D252G, D201GTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
79.
GRCh37:
Chr22:42524265
GRCh38:
Chr22:42128263
CYP2D6D252N, D201NTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
80.
GRCh37:
Chr22:42524310
GRCh38:
Chr22:42128308
CYP2D6A237S, A186Snot specified, Tramadol responseLikely benign
(Mar 9, 2018)
criteria provided, single submitter
81.
GRCh37:
Chr22:42524312
GRCh38:
Chr22:42128310
CYP2D6L185P, L236PTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
82.
GRCh37:
Chr22:42524323
GRCh38:
Chr22:42128321
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
83.
GRCh37:
Chr22:42524327
GRCh38:
Chr22:42128325
CYP2D6L180P, L231PTramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
84.
GRCh37:
Chr22:42524333
GRCh38:
Chr22:42128331
CYP2D6V178A, V229ATramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
85.
GRCh37:
Chr22:42524368
GRCh38:
Chr22:42128366
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
86.
GRCh37:
Chr22:42524476
GRCh38:
Chr22:42128474
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
87.
GRCh37:
Chr22:42524502
GRCh38:
Chr22:42128500
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
88.
GRCh37:
Chr22:42524531
GRCh38:
Chr22:42128529
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
89.
GRCh37:
Chr22:42524553
GRCh38:
Chr22:42128551
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
90.
GRCh37:
Chr22:42524554
GRCh38:
Chr22:42128552
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
91.
GRCh37:
Chr22:42524557
GRCh38:
Chr22:42128555
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
92.
GRCh37:
Chr22:42524560
GRCh38:
Chr22:42128558
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
93.
GRCh37:
Chr22:42524565
GRCh38:
Chr22:42128563
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
94.
GRCh37:
Chr22:42524572
GRCh38:
Chr22:42128570
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
95.
GRCh37:
Chr22:42524580
GRCh38:
Chr22:42128578
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
96.
GRCh37:
Chr22:42524621
GRCh38:
Chr22:42128619
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
97.
GRCh37:
Chr22:42524669
GRCh38:
Chr22:42128667
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
98.
GRCh37:
Chr22:42524679
GRCh38:
Chr22:42128677
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
99.
GRCh37:
Chr22:42524696
GRCh38:
Chr22:42128694
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
100.
GRCh37:
Chr22:42524707
GRCh38:
Chr22:42128705
CYP2D6Tramadol responsedrug response
(Apr 28, 2018)
no assertion criteria provided
Format
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