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Items: 1 to 100 of 2495

VariationLocationGene(s)Protein changeCondition(s)Clinical significance
(Last reviewed)
Review statusAccession
1.
GRCh37:
Chr10:86194737-90910559
GRCh38:
Chr10:84434981-89150802
See casesPathogenic
(Aug 12, 2011)
criteria provided, single submitterVCV000059703
2.
GRCh37:
Chr10:88514773-89725239
GRCh38:
Chr10:86755016-87965482
Generalized juvenile polyposis/juvenile polyposis coliPathogenic
(Mar 6, 2019)
criteria provided, single submitterVCV000661198
3.
GRCh37:
Chr10:88598623-89725239
GRCh38:
Chr10:86838866-87965482
Generalized juvenile polyposis/juvenile polyposis coliPathogenic
(Nov 1, 2018)
criteria provided, single submitterVCV000646972
4.
GRCh37:
Chr10:88635625-89653886
GRCh38:
Chr10:86875868-87894129
PTEN hamartoma tumor syndromePathogenic
(Sep 17, 2018)
criteria provided, single submitterVCV000660158
5.
GRCh37:
Chr10:89590587-90376982
GRCh38:
Chr10:87830830-88617225
ATAD1, KLLN, LIPJ, LOC121815954, LOC124416863, LOC124416864, PTEN, RNLSPoly (ADP-Ribose) polymerase inhibitor responsedrug response
(Nov 27, 2017)
no assertion criteria providedVCV000523155
6.
GRCh37:
Chr10:89621727
GRCh38:
Chr10:87861970
KLLN, PTENK173Rnot specifiedUncertain significance
(Jul 23, 2019)
criteria provided, single submitterVCV001337289
7.
GRCh37:
Chr10:89621800
GRCh38:
Chr10:87862043
KLLN, PTENW149Rnot specifiedBenign
(Aug 25, 2020)
criteria provided, single submitterVCV001337818
8.
GRCh37:
Chr10:89621853
GRCh38:
Chr10:87862096
KLLN, PTENN131Snot specifiedBenign
(Aug 25, 2020)
criteria provided, single submitterVCV001337856
9.
GRCh37:
Chr10:89621861
GRCh38:
Chr10:87862104
KLLN, PTENnot specifiedUncertain significance
(Mar 3, 2020)
criteria provided, single submitterVCV001337567
10.
GRCh37:
Chr10:89621863
GRCh38:
Chr10:87862106
KLLN, PTENR128Gnot provided, not specifiedBenign
(Aug 25, 2020)
criteria provided, single submitterVCV001174734
11.
GRCh37:
Chr10:89621902-89621903
GRCh38:
Chr10:87862145-87862146
KLLN, PTENA115fsnot specifiedUncertain significance
(Apr 20, 2020)
criteria provided, single submitterVCV001336143
12.
GRCh37:
Chr10:89621905-89621906
GRCh38:
Chr10:87862148-87862149
KLLN, PTENA115fsnot specified, not providedConflicting interpretations of pathogenicity
(Apr 20, 2020)
criteria provided, conflicting interpretationsVCV000717443
13.
GRCh37:
Chr10:89622010
GRCh38:
Chr10:87862253
KLLN, PTENP79Tnot specifiedUncertain significance
(Apr 20, 2020)
criteria provided, single submitterVCV001336732
14.
GRCh37:
Chr10:89622011
GRCh38:
Chr10:87862254
KLLN, PTENnot specifiedUncertain significance
(Apr 20, 2020)
criteria provided, single submitterVCV001336731
15.
GRCh37:
Chr10:89622041
GRCh38:
Chr10:87862284
KLLN, PTENnot specifiedUncertain significance
(Nov 30, 2021)
criteria provided, single submitterVCV001338182
16.
GRCh37:
Chr10:89622114
GRCh38:
Chr10:87862357
KLLN, PTENG44Anot specifiedUncertain significance
(Dec 18, 2020)
criteria provided, single submitterVCV001338012
17.
GRCh37:
Chr10:89622115
GRCh38:
Chr10:87862358
KLLN, PTENG44Rnot specifiedUncertain significance
(Dec 18, 2020)
criteria provided, single submitterVCV001337958
18.
GRCh37:
Chr10:89622179
GRCh38:
Chr10:87862422
KLLN, PTENnot specifiedUncertain significance
(Nov 15, 2019)
criteria provided, single submitterVCV001337428
19.
GRCh37:
Chr10:89622180
GRCh38:
Chr10:87862423
KLLN, PTENV22Dnot specifiedUncertain significance
(Nov 15, 2019)
criteria provided, single submitterVCV001337427
20.
GRCh37:
Chr10:89622187
GRCh38:
Chr10:87862430
KLLN, PTENY20Hnot specifiedLikely benign
(Apr 2, 2019)
criteria provided, single submitterVCV001337087
21.
GRCh37:
Chr10:89622188
GRCh38:
Chr10:87862431
KLLN, PTENnot specifiedLikely benign
(Apr 2, 2019)
criteria provided, single submitterVCV001337086
22.
GRCh37:
Chr10:89622228
GRCh38:
Chr10:87862471
KLLN, PTENP6Lnot specifiedUncertain significance
(Jan 4, 2021)
criteria provided, single submitterVCV001337796
23.
GRCh37:
Chr10:89622885
GRCh38:
Chr10:87863128
KLLN, PTENnot providedUncertain significance
(Jul 9, 2014)
criteria provided, single submitterVCV000189461
24.
GRCh37:
Chr10:89622888
GRCh38:
Chr10:87863131
KLLN, PTENnot providedUncertain significance
(Aug 30, 2019)
criteria provided, multiple submitters, no conflictsVCV000488770
25.
GRCh37:
Chr10:89622891
GRCh38:
Chr10:87863134
KLLN, PTENnot providedUncertain significance
(Dec 1, 2015)
criteria provided, single submitterVCV000488849
26.
GRCh37:
Chr10:89622896
GRCh38:
Chr10:87863139
KLLN, PTENnot specifiedUncertain significance
(Mar 30, 2015)
criteria provided, single submitterVCV000503507
27.
GRCh37:
Chr10:89622902
GRCh38:
Chr10:87863145
KLLN, PTENnot providedUncertain significance
(Dec 31, 2014)
criteria provided, single submitterVCV000503638
28.
GRCh37:
Chr10:89622905
GRCh38:
Chr10:87863148
KLLN, PTENnot providedUncertain significance
(Jun 21, 2017)
criteria provided, single submitterVCV000488905
29.
GRCh37:
Chr10:89622915
GRCh38:
Chr10:87863158
KLLN, PTENPTEN hamartoma tumor syndrome, not providedBenign
(Jun 2, 2017)
reviewed by expert panel
FDA Recognized Database
VCV000127667
30.
GRCh37:
Chr10:89622916
GRCh38:
Chr10:87863159
KLLN, PTENnot providedUncertain significance
(May 12, 2015)
criteria provided, single submitterVCV000488761
31.
GRCh37:
Chr10:89622918-89624325
GRCh38:
Chr10:87863161-87864568
KLLN, PTENPTEN hamartoma tumor syndromeUncertain significance
(Feb 27, 2018)
criteria provided, single submitterVCV000583889
32.
GRCh37:
Chr10:89622919
GRCh38:
Chr10:87863162
KLLN, PTENnot providedUncertain significance
(Aug 16, 2016)
criteria provided, single submitterVCV000488860
33.
GRCh37:
Chr10:89622921
GRCh38:
Chr10:87863164
KLLN, PTENnot specifiedUncertain significance
(Apr 28, 2017)
criteria provided, single submitterVCV000439287
34.
GRCh37:
Chr10:89622925
GRCh38:
Chr10:87863168
KLLN, PTENnot providedUncertain significance
(Mar 26, 2016)
criteria provided, single submitterVCV000488886
35.
GRCh37:
Chr10:89622928-89624315
GRCh38:
Chr10:87863171-87864558
KLLN, PTENPTEN hamartoma tumor syndromePathogenic
(Sep 9, 2021)
criteria provided, single submitterVCV000584299
36.
GRCh37:
Chr10:89622928
GRCh38:
Chr10:87863171
KLLN, PTENnot providedUncertain significance
(Oct 11, 2017)
criteria provided, single submitterVCV000488783
37.
GRCh37:
Chr10:89622931
GRCh38:
Chr10:87863174
KLLN, PTENnot providedUncertain significance
(Oct 9, 2017)
criteria provided, single submitterVCV000488754
38.
GRCh37:
Chr10:89622933
GRCh38:
Chr10:87863176
KLLN, PTENnot providedUncertain significance
(Sep 26, 2016)
criteria provided, single submitterVCV000488713
39.
GRCh37:
Chr10:89622936
GRCh38:
Chr10:87863179
KLLN, PTENnot specifiedUncertain significance
(Oct 13, 2016)
criteria provided, single submitterVCV000234639
40.
GRCh37:
Chr10:89622938-89622939
GRCh38:
Chr10:87863181-87863182
KLLN, PTENnot providedUncertain significance
(Feb 22, 2019)
criteria provided, single submitterVCV000801274
41.
GRCh37:
Chr10:89622939
GRCh38:
Chr10:87863182
KLLN, PTENHereditary cancer-predisposing syndrome, not providedUncertain significance
(Mar 17, 2018)
criteria provided, multiple submitters, no conflictsVCV000488910
42.
GRCh37:
Chr10:89622939
GRCh38:
Chr10:87863182
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Sep 7, 2017)
criteria provided, single submitterVCV000141821
43.
GRCh37:
Chr10:89622941
GRCh38:
Chr10:87863184
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(May 9, 2018)
criteria provided, single submitterVCV000818802
44.
GRCh37:
Chr10:89622942
GRCh38:
Chr10:87863185
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Jun 7, 2018)
criteria provided, single submitterVCV000818794
45.
GRCh37:
Chr10:89622945
GRCh38:
Chr10:87863188
KLLN, PTENnot providedUncertain significance
(May 2, 2016)
criteria provided, single submitterVCV000488901
46.
GRCh37:
Chr10:89622951
GRCh38:
Chr10:87863194
KLLN, PTENHereditary cancer-predisposing syndrome, not providedUncertain significance
(May 2, 2018)
criteria provided, multiple submitters, no conflictsVCV000488934
47.
GRCh37:
Chr10:89622960
GRCh38:
Chr10:87863203
KLLN, PTENnot providedUncertain significance
(Jan 26, 2015)
criteria provided, single submitterVCV000503639
48.
GRCh37:
Chr10:89622964
GRCh38:
Chr10:87863207
KLLN, PTENnot specifiedUncertain significanceno assertion criteria providedVCV000492717
49.
GRCh37:
Chr10:89622965
GRCh38:
Chr10:87863208
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Oct 16, 2019)
criteria provided, single submitterVCV000818721
50.
GRCh37:
Chr10:89622970
GRCh38:
Chr10:87863213
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Oct 24, 2019)
criteria provided, single submitterVCV000141062
51.
GRCh37:
Chr10:89622976-89622977
GRCh38:
Chr10:87863219-87863220
KLLN, PTENHereditary cancer-predisposing syndrome, not specifiedUncertain significance
(Sep 27, 2018)
criteria provided, multiple submitters, no conflictsVCV000189445
52.
GRCh37:
Chr10:89622980
GRCh38:
Chr10:87863223
KLLN, PTENnot provided, Cowden syndrome 1, Malignant tumor of prostate,
PTEN hamartoma tumor syndrome, Macrocephaly-autism syndrome, Familial meningioma,
VACTERL with hydrocephalus, Glioma susceptibility 2
Uncertain significance
(Oct 31, 2018)
criteria provided, multiple submitters, no conflictsVCV000488964
53.
GRCh37:
Chr10:89622982
GRCh38:
Chr10:87863225
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Feb 23, 2018)
criteria provided, single submitterVCV000818681
54.
GRCh37:
Chr10:89622983
GRCh38:
Chr10:87863226
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Jul 5, 2018)
criteria provided, single submitterVCV000127666
55.
GRCh37:
Chr10:89622984
GRCh38:
Chr10:87863227
KLLN, PTENnot provided, PTEN hamartoma tumor syndromeUncertain significance
(May 28, 2019)
criteria provided, multiple submitters, no conflictsVCV000189522
56.
GRCh37:
Chr10:89622986
GRCh38:
Chr10:87863229
KLLN, PTENnot providedUncertain significance
(Jul 28, 2015)
criteria provided, single submitterVCV000488776
57.
GRCh37:
Chr10:89622989
GRCh38:
Chr10:87863232
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Jan 25, 2019)
criteria provided, single submitterVCV000818672
58.
GRCh37:
Chr10:89622989
GRCh38:
Chr10:87863232
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Dec 26, 2017)
criteria provided, single submitterVCV000818671
59.
GRCh37:
Chr10:89622991
GRCh38:
Chr10:87863234
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Apr 23, 2018)
criteria provided, single submitterVCV000186644
60.
GRCh37:
Chr10:89622991
GRCh38:
Chr10:87863234
KLLN, PTENnot provided, Hereditary cancer-predisposing syndromeUncertain significance
(Feb 25, 2019)
criteria provided, multiple submitters, no conflictsVCV000127665
61.
GRCh37:
Chr10:89622992
GRCh38:
Chr10:87863235
KLLN, PTENCowden syndrome 4, not specifiedUncertain significance
(Dec 9, 2020)
criteria provided, multiple submitters, no conflictsVCV000234894
62.
GRCh37:
Chr10:89622992
GRCh38:
Chr10:87863235
KLLN, PTENnot providedUncertain significance
(Jan 3, 2014)
criteria provided, single submitterVCV000189526
63.
GRCh37:
Chr10:89623000
GRCh38:
Chr10:87863243
KLLN, PTENnot providedUncertain significance
(Sep 29, 2016)
criteria provided, single submitterVCV000488867
64.
GRCh37:
Chr10:89623002
GRCh38:
Chr10:87863245
KLLN, PTENnot providedUncertain significance
(Oct 17, 2017)
criteria provided, single submitterVCV000488868
65.
GRCh37:
Chr10:89623004
GRCh38:
Chr10:87863247
KLLN, PTENnot providedUncertain significance
(Apr 4, 2018)
criteria provided, single submitterVCV000488935
66.
GRCh37:
Chr10:89623005
GRCh38:
Chr10:87863248
KLLN, PTENnot providedUncertain significance
(Nov 9, 2016)
criteria provided, single submitterVCV000488954
67.
GRCh37:
Chr10:89623005
GRCh38:
Chr10:87863248
KLLN, PTENnot providedUncertain significance
(May 25, 2020)
criteria provided, multiple submitters, no conflictsVCV000488773
68.
GRCh37:
Chr10:89623010
GRCh38:
Chr10:87863253
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Oct 30, 2014)
criteria provided, single submitterVCV000186991
69.
GRCh37:
Chr10:89623012
GRCh38:
Chr10:87863255
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Apr 2, 2014)
criteria provided, single submitterVCV000142999
70.
GRCh37:
Chr10:89623014
GRCh38:
Chr10:87863257
KLLN, PTENnot providedUncertain significance
(Oct 27, 2017)
criteria provided, multiple submitters, no conflictsVCV000488850
71.
GRCh37:
Chr10:89623016
GRCh38:
Chr10:87863259
KLLN, PTENnot providedUncertain significance
(Aug 11, 2017)
criteria provided, single submitterVCV000189521
72.
GRCh37:
Chr10:89623018
GRCh38:
Chr10:87863261
KLLN, PTENnot providedUncertain significance
(Apr 21, 2014)
criteria provided, single submitterVCV000189469
73.
GRCh37:
Chr10:89623019
GRCh38:
Chr10:87863262
KLLN, PTENnot providedUncertain significance
(Apr 8, 2020)
criteria provided, multiple submitters, no conflictsVCV000234396
74.
GRCh37:
Chr10:89623020
GRCh38:
Chr10:87863263
KLLN, PTENnot providedUncertain significance
(May 11, 2015)
criteria provided, single submitterVCV000488714
75.
GRCh37:
Chr10:89623021
GRCh38:
Chr10:87863264
KLLN, PTENnot providedUncertain significance
(Jul 10, 2017)
criteria provided, single submitterVCV000488715
76.
GRCh37:
Chr10:89623024
GRCh38:
Chr10:87863267
KLLN, PTENnot providedUncertain significance
(Nov 29, 2017)
criteria provided, single submitterVCV000234473
77.
GRCh37:
Chr10:89623027-89623038
GRCh38:
Chr10:87863270-87863281
KLLN, PTENHereditary cancer-predisposing syndrome, PTEN hamartoma tumor syndrome, not provided
Likely benign
(Mar 5, 2019)
reviewed by expert panel
FDA Recognized Database
VCV000189433
78.
GRCh37:
Chr10:89623034
GRCh38:
Chr10:87863277
KLLN, PTENHereditary cancer-predisposing syndrome, not providedUncertain significance
(Nov 30, 2019)
criteria provided, multiple submitters, no conflictsVCV000488900
79.
GRCh37:
Chr10:89623036-89623038
GRCh38:
Chr10:87863279-87863281
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Apr 26, 2014)
criteria provided, single submitterVCV000142982
80.
GRCh37:
Chr10:89623036
GRCh38:
Chr10:87863279
KLLN, PTENnot provided, PTEN hamartoma tumor syndrome, Hereditary cancer-predisposing syndrome,
Macrocephaly-autism syndrome, Malignant tumor of prostate, Cowden syndrome 1,
PTEN hamartoma tumor syndrome, Familial meningioma, VACTERL with hydrocephalus,
Glioma susceptibility 2
Uncertain significance
(Mar 23, 2020)
reviewed by expert panel
FDA Recognized Database
VCV000127663
81.
GRCh37:
Chr10:89623045
GRCh38:
Chr10:87863288
KLLN, PTENnot specifiedUncertain significance
(Aug 2, 2021)
criteria provided, single submitterVCV001192233
82.
GRCh37:
Chr10:89623045-89623061
GRCh38:
Chr10:87863288-87863304
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Apr 8, 2019)
criteria provided, single submitterVCV000818504
83.
GRCh37:
Chr10:89623045
GRCh38:
Chr10:87863288
KLLN, PTENnot providedUncertain significance
(Dec 23, 2017)
criteria provided, multiple submitters, no conflictsVCV000488716
84.
GRCh37:
Chr10:89623047-89623048
GRCh38:
Chr10:87863290-87863291
KLLN, PTENnot providedUncertain significance
(Aug 29, 2016)
criteria provided, single submitterVCV000503748
85.
GRCh37:
Chr10:89623047
GRCh38:
Chr10:87863290
KLLN, PTENnot specified, not provided, Hereditary cancer-predisposing syndrome
Uncertain significance
(Jul 19, 2021)
criteria provided, multiple submitters, no conflictsVCV000142652
86.
GRCh37:
Chr10:89623050
GRCh38:
Chr10:87863293
KLLN, PTENCowden syndrome 1, Hereditary cancer-predisposing syndrome, not provided
Uncertain significance
(Feb 13, 2018)
criteria provided, multiple submitters, no conflictsVCV000142844
87.
GRCh37:
Chr10:89623052
GRCh38:
Chr10:87863295
KLLN, PTENnot specifiedUncertain significance
(Jan 7, 2020)
criteria provided, single submitterVCV001337509
88.
GRCh37:
Chr10:89623052
GRCh38:
Chr10:87863295
KLLN, PTENnot providedUncertain significance
(Sep 19, 2016)
criteria provided, single submitterVCV000488939
89.
GRCh37:
Chr10:89623053
GRCh38:
Chr10:87863296
KLLN, PTENnot providedUncertain significance
(Mar 7, 2016)
criteria provided, single submitterVCV000488866
90.
GRCh37:
Chr10:89623054
GRCh38:
Chr10:87863297
KLLN, PTENnot providedUncertain significance
(Jan 3, 2017)
criteria provided, single submitterVCV000488786
91.
GRCh37:
Chr10:89623054
GRCh38:
Chr10:87863297
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(May 17, 2018)
criteria provided, single submitterVCV000141170
92.
GRCh37:
Chr10:89623056
GRCh38:
Chr10:87863299
KLLN, PTENnot provided, Hereditary cancer-predisposing syndrome, Cowden syndrome 1
Uncertain significance
(Sep 12, 2019)
criteria provided, multiple submitters, no conflictsVCV000140783
93.
GRCh37:
Chr10:89623056
GRCh38:
Chr10:87863299
KLLN, PTENHereditary cancer-predisposing syndrome, Cowden syndrome 1, not provided,
PTEN hamartoma tumor syndrome
Likely benign
(Mar 23, 2020)
reviewed by expert panel
FDA Recognized Database
VCV000127662
94.
GRCh37:
Chr10:89623058
GRCh38:
Chr10:87863301
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Aug 14, 2018)
criteria provided, single submitterVCV000818474
95.
GRCh37:
Chr10:89623061
GRCh38:
Chr10:87863304
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Dec 6, 2018)
criteria provided, single submitterVCV000822264
96.
GRCh37:
Chr10:89623065-89623066
GRCh38:
Chr10:87863308-87863309
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Jan 2, 2019)
criteria provided, single submitterVCV000818444
97.
GRCh37:
Chr10:89623072
GRCh38:
Chr10:87863315
KLLN, PTENnot provided, Hereditary cancer-predisposing syndrome, Glioma susceptibility 2,
PTEN hamartoma tumor syndrome, Macrocephaly-autism syndrome, Malignant tumor of prostate,
VACTERL with hydrocephalus, Cowden syndrome 1, Familial meningioma
Uncertain significance
(Aug 12, 2019)
criteria provided, multiple submitters, no conflictsVCV000187362
98.
GRCh37:
Chr10:89623073
GRCh38:
Chr10:87863316
KLLN, PTENnot providedUncertain significance
(Feb 17, 2017)
criteria provided, single submitterVCV000488717
99.
GRCh37:
Chr10:89623074
GRCh38:
Chr10:87863317
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Jun 10, 2019)
criteria provided, single submitterVCV000818430
100.
GRCh37:
Chr10:89623075
GRCh38:
Chr10:87863318
KLLN, PTENHereditary cancer-predisposing syndromeUncertain significance
(Jul 18, 2018)
criteria provided, single submitterVCV000818427
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