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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 37716	NM_000059.3(BRCA2):c.-39-20T>C	BRCA2	Single nucleotide variant	Hereditary breast ovarian cancer syndrome	GLikely benign
Select item 37715	NM_000059.4(BRCA2):c.-39-12_-39-10del	BRCA2	Microsatellite (intron variant)	Breast and/or ovarian cancer +5 more	GConflicting classifications of pathogenicity
Select item 91743	NM_000059.3(BRCA2):c.-39-14C>T	BRCA2	Single nucleotide variant	Hereditary breast ovarian cancer syndrome	GLikely benign
Select item 125965	NM_000059.4(BRCA2):c.-26G>A	BRCA2	Single nucleotide variant (5 prime UTR variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 252811	NM_000059.3(BRCA2):c.-24A>G	BRCA2	Single nucleotide variant	Hereditary breast ovarian cancer syndrome	GLikely benign
Select item 37714	NM_000059.4(BRCA2):c.-15A>C	BRCA2	Single nucleotide variant (5 prime UTR variant)	not provided +3 more	GBenign/Likely benign
Select item 37717	NM_000059.4(BRCA2):c.-9T>C	BRCA2	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 96758	NM_000059.4(BRCA2):c.-3A>G	BRCA2	Single nucleotide variant (5 prime UTR variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 51579	NM_000059.4(BRCA2):c.3G>A (p.Met1Ile)	BRCA2 (M1I)	Single nucleotide variant (missense variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37872	NM_000059.4(BRCA2):c.3del (p.Met1fs)	BRCA2	Deletion (frameshift variant +1 more)	Familial cancer of breast +3 more	GPathogenic
Select item 37871	NM_000059.4(BRCA2):c.3G>T (p.Met1Ile)	BRCA2 (M1I)	Single nucleotide variant (missense variant +1 more)	Hereditary breast ovarian cancer syndrome	GPathogenic
Select item 51198	NM_000059.4(BRCA2):c.17_18del (p.Lys6fs)	BRCA2	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 51267	NM_000059.4(BRCA2):c.22_23del (p.Arg8fs)	BRCA2 (R8fs)	Microsatellite (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 51330	NM_000059.4(BRCA2):c.26del (p.Pro9fs)	BRCA2 (P9fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 51509	NM_000059.4(BRCA2):c.36dup (p.Glu13Ter)	BRCA2 (E13*)	Duplication (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 51477	NM_000059.4(BRCA2):c.34T>G (p.Phe12Val)	BRCA2 (F12V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 91828	NM_000059.3(BRCA2):c.48_50delGACins10 (p.?)	BRCA2	Indel	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 51855	NM_000059.4(BRCA2):c.53G>A (p.Arg18His)	BRCA2 (R18H)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 91433	NM_000059.4(BRCA2):c.59A>G (p.Asn20Ser)	BRCA2 (N20S)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 38033	NM_000059.4(BRCA2):c.62A>G (p.Lys21Arg)	BRCA2 (K21R)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2 +4 more	GConflicting classifications of pathogenicity
Select item 52161	NM_000059.4(BRCA2):c.67+1G>T	BRCA2	Single nucleotide variant (splice donor variant +1 more)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 52160	NM_000059.4(BRCA2):c.67+1G>A	BRCA2	Single nucleotide variant (splice donor variant +1 more)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic
Select item 38061	NM_000059.4(BRCA2):c.67+4T>C	BRCA2	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 38065	NM_000059.4(BRCA2):c.68-7dup	BRCA2	Duplication (intron variant)	Hereditary cancer-predisposing syndrome +13 more	GBenign/Likely benign
Select item 52187	NM_000059.4(BRCA2):c.68-7T>A	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 52467	NM_000059.4(BRCA2):c.79A>G (p.Ile27Val)	BRCA2 (I27V)	Single nucleotide variant (missense variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 91748	NM_000059.4(BRCA2):c.116C>T (p.Ala39Val)	BRCA2 (A39V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 37734	NM_000059.4(BRCA2):c.125A>G (p.Tyr42Cys)	BRCA2 (Y42C)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 126008	NM_000059.3(BRCA2):c.132_133ins8	BRCA2	Insertion	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 51129	NM_000059.4(BRCA2):c.145G>T (p.Glu49Ter)	BRCA2 (E49*)	Single nucleotide variant (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 96765	NM_000059.4(BRCA2):c.146A>T (p.Glu49Val)	BRCA2 (E49V)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome	GUncertain significance
Select item 96767	NM_000059.4(BRCA2):c.162CAA[1] (p.Asn56del)	BRCA2 (N56del)	Microsatellite (inframe_deletion)	Hereditary breast ovarian cancer syndrome +5 more	GConflicting classifications of pathogenicity
Select item 37751	NM_000059.4(BRCA2):c.167A>C (p.Asn56Thr)	BRCA2 (N56T)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 91755	NM_000059.4(BRCA2):c.172G>A (p.Glu58Lys)	BRCA2 (E58K)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 51185	NM_000059.4(BRCA2):c.175C>G (p.Pro59Ala)	BRCA2 (P59A)	Single nucleotide variant (missense variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 37758	NM_000059.4(BRCA2):c.179A>G (p.Asn60Ser)	BRCA2 (N60S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +6 more	GConflicting classifications of pathogenicity
Select item 91761	NM_000059.4(BRCA2):c.186del (p.Phe62fs)	BRCA2 (F62fs)	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 91770	NM_000059.4(BRCA2):c.217C>T (p.Gln73Ter)	BRCA2 (Q73*)	Single nucleotide variant (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 51258	NM_000059.4(BRCA2):c.223G>C (p.Ala75Pro)	BRCA2 (A75P)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 37780	NM_000059.4(BRCA2):c.229A>G (p.Thr77Ala)	BRCA2 (T77A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +5 more	GUncertain significance
Select item 91774	NM_000059.4(BRCA2):c.232C>T (p.Pro78Ser)	BRCA2 (P78S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GConflicting classifications of pathogenicity
Select item 37783	NM_000059.4(BRCA2):c.235A>G (p.Ile79Val)	BRCA2 (I79V)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2 +3 more	GConflicting classifications of pathogenicity
Select item 37785	NM_000059.4(BRCA2):c.241T>A (p.Phe81Ile)	BRCA2 (F81I)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 51298	NM_000059.4(BRCA2):c.250C>T (p.Gln84Ter)	BRCA2 (Q84*)	Single nucleotide variant (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37799	NM_000059.4(BRCA2):c.274C>T (p.Gln92Ter)	BRCA2 (Q92*)	Single nucleotide variant (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37803	NM_000059.4(BRCA2):c.280C>T (p.Pro94Ser)	BRCA2 (P94S)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2 +5 more	GConflicting classifications of pathogenicity
Select item 51371	NM_000059.4(BRCA2):c.291_296del (p.Glu97_Leu98del)	BRCA2	Deletion (inframe_deletion)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 51368	NM_000059.4(BRCA2):c.289G>T (p.Glu97Ter)	BRCA2 (E97*)	Single nucleotide variant (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37816	NM_000059.4(BRCA2):c.303C>A (p.Phe101Leu)	BRCA2 (F101L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 51406	NM_000059.4(BRCA2):c.314T>G (p.Leu105Ter)	BRCA2 (L105*)	Single nucleotide variant (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37823	NM_000059.4(BRCA2):c.316+1G>C	BRCA2	Single nucleotide variant (splice donor variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37822	NM_000059.4(BRCA2):c.316+1G>A	BRCA2	Single nucleotide variant (splice donor variant)	Breast-ovarian cancer, familial, susceptibility to, 2 +2 more	GPathogenic/Likely pathogenic
Select item 51409	NM_000059.4(BRCA2):c.316+5G>A	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37821	NM_000059.3(BRCA2):c.316+10G>A	BRCA2	Single nucleotide variant	Hereditary breast ovarian cancer syndrome	GLikely benign
Select item 37825	NM_000059.4(BRCA2):c.317-10A>G	BRCA2	Single nucleotide variant (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2 +4 more	GLikely benign
Select item 51430	NM_000059.4(BRCA2):c.323A>G (p.Asn108Ser)	BRCA2 (N108S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +6 more	GConflicting classifications of pathogenicity
Select item 37843	NM_000059.4(BRCA2):c.348T>G (p.Ser116Arg)	BRCA2	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 91803	NM_000059.4(BRCA2):c.352C>T (p.Arg118Cys)	BRCA2 (R118C)	Single nucleotide variant (missense variant)	not specified +6 more	GConflicting classifications of pathogenicity
Select item 37845	NM_000059.4(BRCA2):c.353G>A (p.Arg118His)	BRCA2 (R118H)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 37854	NM_000059.4(BRCA2):c.370A>C (p.Met124Leu)	BRCA2 (M124L)	Single nucleotide variant (missense variant)	Hereditary breast ovarian cancer syndrome	GUncertain significance
Select item 51526	NM_000059.4(BRCA2):c.379G>T (p.Ala127Ser)	BRCA2 (A127S)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 254474	NM_000059.4(BRCA2):c.391del (p.Ser131fs)	BRCA2	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37869	NM_000059.4(BRCA2):c.396T>A (p.Cys132Ter)	BRCA2 (C132*)	Single nucleotide variant (nonsense)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37876	NM_000059.4(BRCA2):c.407del (p.Asn136fs)	BRCA2	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 91813	NM_000059.3(BRCA2):c.410_411ins8	BRCA2	Insertion	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37882	NM_000059.4(BRCA2):c.413G>T (p.Cys138Phe)	BRCA2 (C138F)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2 +5 more	GUncertain significance
Select item 91816	NM_000059.4(BRCA2):c.426-12_426-9del	BRCA2	Deletion (intron variant)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 91817	NM_000059.4(BRCA2):c.426-2A>G	BRCA2	Single nucleotide variant (splice acceptor variant)	Hereditary cancer-predisposing syndrome +4 more	GPathogenic/Likely pathogenic
Select item 37895	NM_000059.4(BRCA2):c.430GTT[1] (p.Val145del)	BRCA2 (V145del)	Microsatellite (inframe_deletion)	Hereditary breast ovarian cancer syndrome +3 more	GConflicting classifications of pathogenicity
Select item 51644	NM_000059.4(BRCA2):c.440A>G (p.Gln147Arg)	BRCA2 (Q147R)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GBenign
Select item 37900	NM_000059.4(BRCA2):c.440A>T (p.Gln147Leu)	BRCA2 (Q147L)	Single nucleotide variant (missense variant)	Familial cancer of breast +5 more	GUncertain significance
Select item 51645	NM_000059.4(BRCA2):c.441A>G (p.Gln147=)	BRCA2	Single nucleotide variant (synonymous variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GLikely benign
Select item 51647	NM_000059.4(BRCA2):c.442T>C (p.Cys148Arg)	BRCA2 (C148R)	Single nucleotide variant (missense variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 37908	NM_000059.4(BRCA2):c.451G>A (p.Val151Ile)	BRCA2 (V151I)	Single nucleotide variant (missense variant)	not provided +3 more	GUncertain significance
Select item 51674	NM_000059.4(BRCA2):c.455C>A (p.Thr152Lys)	BRCA2 (T152K)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 51684	NM_000059.4(BRCA2):c.462_463del (p.Arg155_Asp156insTer)	BRCA2	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37916	NM_000059.4(BRCA2):c.464G>C (p.Arg155Thr)	BRCA2 (R155T)	Single nucleotide variant (missense variant)	not provided +11 more	GConflicting classifications of pathogenicity
Select item 51694	NM_000059.4(BRCA2):c.467A>G (p.Asp156Gly)	BRCA2 (D156G)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2 +4 more	GConflicting classifications of pathogenicity
Select item 51701	NM_000059.4(BRCA2):c.470_474del (p.Lys157fs)	BRCA2	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 51698	NM_000059.4(BRCA2):c.469_470del (p.Lys157fs)	BRCA2	Deletion (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 51706	NM_000059.4(BRCA2):c.473C>T (p.Ser158Leu)	BRCA2 (S158L)	Single nucleotide variant (missense variant)	Familial cancer of breast +2 more	GConflicting classifications of pathogenicity
Select item 37921	NM_000059.4(BRCA2):c.475+4del	BRCA2	Deletion (intron variant)	Breast-ovarian cancer, familial, susceptibility to, 2 +3 more	GPathogenic/Likely pathogenic
Select item 91825	NM_000059.3(BRCA2):c.476-4C>T	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 37925	NM_000059.4(BRCA2):c.476-3C>T	BRCA2	Single nucleotide variant (intron variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 37924	NM_000059.4(BRCA2):c.476-3C>A	BRCA2	Single nucleotide variant (intron variant)	Familial cancer of breast +2 more	GUncertain significance
Select item 37923	NM_000059.4(BRCA2):c.476-2A>G	BRCA2	Single nucleotide variant (splice acceptor variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37922	NM_000059.4(BRCA2):c.476-1G>A	BRCA2	Single nucleotide variant (splice acceptor variant)	Breast-ovarian cancer, familial, susceptibility to, 2 +2 more	GPathogenic/Likely pathogenic
Select item 91827	NM_000059.4(BRCA2):c.489T>G (p.Ser163Arg)	BRCA2 (S163R)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 230063	NM_000059.4(BRCA2):c.497A>T (p.His166Leu)	BRCA2 (H166L)	Single nucleotide variant (missense variant)	Breast-ovarian cancer, familial, susceptibility to, 2 +3 more	GConflicting classifications of pathogenicity
Select item 37941	NM_000059.4(BRCA2):c.506A>G (p.Lys169Arg)	BRCA2 (K169R)	Single nucleotide variant (missense variant)	not provided +7 more	GConflicting classifications of pathogenicity
Select item 91834	NM_000059.4(BRCA2):c.512dup (p.Lys172fs)	BRCA2 (K172fs)	Duplication (frameshift variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 96816	NM_000059.4(BRCA2):c.515A>G (p.Lys172Arg)	BRCA2 (K172R)	Single nucleotide variant (missense variant)	Hereditary breast ovarian cancer syndrome +1 more	GUncertain significance
Select item 91837	NM_000059.4(BRCA2):c.517-12C>A	BRCA2	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +2 more	GLikely benign
Select item 51797	NM_000059.4(BRCA2):c.517-11T>C	BRCA2	Single nucleotide variant (intron variant)	Hereditary cancer-predisposing syndrome +4 more	GConflicting classifications of pathogenicity
Select item 51802	NM_000059.4(BRCA2):c.517-4C>G	BRCA2	Single nucleotide variant (intron variant)	not specified +5 more	GConflicting classifications of pathogenicity
Select item 156169	NM_000059.3(BRCA2):c.517-2A>C	BRCA2	Single nucleotide variant	Breast-ovarian cancer, familial, susceptibility to, 2	GUncertain significance
Select item 51801	NM_000059.4(BRCA2):c.517-2A>G	BRCA2	Single nucleotide variant (splice acceptor variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 37949	NM_000059.4(BRCA2):c.518del (p.Gly173Valfs)	BRCA2	Deletion (splice acceptor variant)	Breast-ovarian cancer, familial, susceptibility to, 2	GPathogenic
Select item 51805	NM_000059.4(BRCA2):c.517G>T (p.Gly173Cys)	BRCA2 (G173C)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 51818	NM_000059.4(BRCA2):c.520C>T (p.Arg174Cys)	BRCA2 (R174C)	Single nucleotide variant (missense variant)	not specified +5 more	GUncertain significance

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