nstd92 (Forsberg et al. 2014)
- Organism:
- Human
- Study Type:
- Control Set
- Submitter:
- Chiara Rasi
- Description:
- We describe age-related accumulation of copy number variation (CNVs) on periferal blood cells of elderly men from 2 Swedish cohorts of normally-aging subjects, ULSAM and PIVUS. DNA was tested on Illumina genotyping arrays and LogR Ratio and B-allele-frequency data were used to identify somatic copy number events on automosomes and sex chromosomes. Loss of chromosome Y was found in at least 8.2% and 20.5% of subjects respectively. Median survival time and all-cause mortality, as well as cancer mortality, were found to be significatively associated with loss of chromosome Y in the studied subjects. See Variant Summary counts for nstd92 in dbVar Variant Summary.
- Publication(s):
- Forsberg et al. 2014