(txid10090[Organism]) AND gds_sra[filter] - GEO DataSets

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Select item 2002664851.

(Submitter supplied) Since its first description in 1906 by Dr. Alois Alzheimer, Alzheimer’s disease (AD) has been the most common type of dementia. Initially thought to be caused by age-associated accumulation of plaques, in recent years, research has increasingly associated AD with lysosomal storage and metabolic disorders, and the explanation of its pathogenesis has shifted from amyloid and tau accumulation to oxidative stress and impaired lipid and glucose metabolism aggravated by hypoxic conditions. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
12 Samples

Download data: XLS, XLSX

Series

Accession:: GSE266485

ID:: 200266485

Select item 2002664772.

Semaglutide interferes with postnatal growth in a diet-dependent manner

(Submitter supplied) Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been shown to impact glucose homeostasis and, more recently, the somatotropic axis. While the effects of GLP-1RAs have been extensively studied in the context of diet-induced obesity, their impact on physiology in other nutritional contexts have been less explored. We investigated the potential beneficial effects of the GLP-1RA semaglutide during juvenile protein malnutrition, a dietary challenge known to cause stunted growth and to disrupt metabolic homeostasis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
10 Samples

Download data: TSV

Series

Accession:: GSE266477

ID:: 200266477

Select item 2002664703.

Selective targeting and modulation of plaque associated microglia via systemic hydroxyl dendrimer administration in an Alzheimer’s disease mouse model.

(Submitter supplied) Background: In Alzheimer’s disease (AD), microglia surround extracellular plaques and mount a sustained inflammatory response, contributing to the pathogenesis of the disease. Identifying approaches to specifically target plaque-associated microglia (PAMs) without interfering in the homeostatic functions of non-plaque associated microglia would afford a powerful tool and potential therapeutic avenue. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
32 Samples

Download data: XLSX

Series

Accession:: GSE266470

ID:: 200266470

Select item 2002661854.

Tipifarnib Reduces Circulating Extracellular Vesicles and Protects Against Pressure Overload-mediated Cardiac Remodeling and Dysfunction

(Submitter supplied) BACKGROUND: Heart failure (HF) is one of the leading causes of mortality worldwide. Extracellular vesicles (EVs) including small EVs, or exosomes and their molecular cargo are known to modulate cell to cell communication during multiple cardiac diseases. However, the role of systemic EV biogenesis inhibition in the models of HF is not well documented and remains unclear. METHODS: We investigated the role of circulating exosomes during cardiac dysfunction and remodeling in a mouse transverse aortic constriction (TAC) model of HF. more...

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL24247
9 Samples

Download data: XLSX

Series

Accession:: GSE266185

ID:: 200266185

Select item 2002632235.

DAPK1 acts as a positive regulator of hypertension via induction of vasoconstriction

(Submitter supplied) The objective of this research is to compare the differentially expressed genes in the vascular tissues of DAPK1 wild-type (WT) and DAPK1 knockout (KO) mice after being induced with or without Ang II. WT (n=10) mice were randomly divided into two groups: WT+NS group and WT+Ang II group (n=5 for each group). KO (n=10) mice were also randomly divided into two groups: KO+NS group and KO+Ang II group (n=5 for each group). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
20 Samples

Download data: TXT

Series

Accession:: GSE263223

ID:: 200263223

Select item 2002666866.

Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity [ChIP-Seq]

(Submitter supplied) Isocitrate Dehydrogenase 1 (IDH1) is the most commonly mutated metabolic gene across human cancers. Mutant IDH1 (mIDH1) generates the oncometabolite (R)-2-hydroxyglutarate, disrupting enzymes involved in epigenetics and other processes. A hallmark of IDH1-mutant solid tumors is T cell exclusion, whereas mIDH1 inhibition in preclinical models restores anti-tumor immunity. Here, we define a cell-autonomous mechanism of mIDH1-driven immune evasion. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
32 Samples

Download data: BW

Series

Accession:: GSE266686

ID:: 200266686

Select item 2002666137.

Necroptosis enhances “Don’t eat me” signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis [scRNA-seq]

(Submitter supplied) We delved into the consequences of C57BL/6 orthotopic model injected with KPC cells with Vector/MLKL overexpression

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE266613

ID:: 200266613

Select item 2002662968.

The role of macrophage VCAM-1 in atherosclerosis and inflammation

(Submitter supplied) VCAM-1 is known to be expressed by endothelial cells. We showed that this is also expressed by atherosclerotic plaque macrophages. However, the merit of this adhesion molecule is now known in atherosclerosis. In this RNA sequencing experiment, we analyzed VCAM-1+ vs. - atherosclerotic plaque macrophages. Additionally, we sorted macrophages from atherosclerotic plaques of mice after mitochondrial biogenesis gene Cmpk2 silencing in macrophages in vivo.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
28 Samples

Download data: RDS, XLSX

Series

Accession:: GSE266296

ID:: 200266296

Select item 2002662719.

Mechanism of DNA break processing in mouse meiosis [SSDS]

(Submitter supplied) Nucleolytic resection of DNA ends is critical for homologous recombination, but its mechanism is not fully understood, particularly in mammalian meiosis. Here we examine roles of the conserved MRN complex (MRE11, RAD50, and NBS1) through genome-wide analysis of meiotic resection in mice with various MRN mutations, including several that cause chromosomal instability in humans. Meiotic DSBs form at elevated levels but remain unresected if Mre11 is conditionally deleted, thus MRN is required for both resection initiation and regulation of DSB numbers. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: BW

Series

Accession:: GSE266271

ID:: 200266271

Select item 20026625810.

Mechanism of DNA break processing in mouse meiosis [S1_Exo7T_ExoT]

Organism:: Mus musculus

Type:: Other

4 related Platforms
47 Samples

Download data: BW

Series

Accession:: GSE266258

ID:: 200266258

Select item 20026619211.

Single Cell Analysis of Lung Lymphatic Endothelial Cells and Lymphatic Responses during Influenza Infection

(Submitter supplied) Tissue lymphatic vessels network plays critical roles in immune surveillance and tissue homeostasis in response to pathogen invasion, but how lymphatic system per se is remolded during infection is less understood. Here, we observed that influenza infection induces a significant increase of lymphatic vessel numbers in the lung, accompanied with extensive proliferation of lymphatic endothelial cells (LECs). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: H5

Series

Accession:: GSE266192

ID:: 200266192

Select item 20026615112.

Mechanism of DNA break processing in mouse meiosis [ChIP-seq]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: BW

Series

Accession:: GSE266151

ID:: 200266151

Select item 20026604813.

Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma [scRNA-seq]

(Submitter supplied) In this study, we examine the effect of radiation on the transcriptional profile of medulloblastoma tumor cells and its microenvironment that could potentially be leading to metastatic dissemination.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: MTX, TSV

Series

Accession:: GSE266048

ID:: 200266048

Select item 20026604714.

Therapeutic radiation drives leptomeningeal dissemination of medulloblastoma [bulkRNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
54 Samples

Download data: TAB

Series

Accession:: GSE266047

ID:: 200266047

Select item 20026599115.

Pien Tze Huang enhances the killing effect of autologous T cells in colorectal cancer by inhibiting PD-L1, stem cell markers, and STAT3.

(Submitter supplied) Aim: The aim of this study is to explore the impact of Pien Tze Huang (PZH) on enhancing T cell cytotoxicity by modulating colorectal cancer stem cell (CRC-CSC) markers, programmed death protein ligand-1 (PD-L1), and the transcription factor signal transducer and activator of transcription 3 (STAT3) protein expression in vivo, ex vivo, and in vitro. Methods: HCT116, HCT15, and SW480 cell lines were subjected to treatment with PZH, followed by assessment of cell viability and stemness through CCK8 and spheroid formation assays. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: TXT

Series

Accession:: GSE265991

ID:: 200265991

Select item 20026425316.

IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering

(Submitter supplied) Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions are the leading cause of death in the world. The most common and effective means to reduce these major adverse cardiovascular events (MACE), including myocardial infarction (MI) and stroke, is aggressive lipid lowering via a combination of drugs and dietary modifications. However, little is known regarding the effects of reducing dietary lipids on the composition and stability of advanced atherosclerotic lesions, the mechanisms that regulate these processes, and what therapeutic approaches might augment the benefits of lipid lowering.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16417
8 Samples

Download data: TAR

Series

Accession:: GSE264253

ID:: 200264253

PubMed Similar studies

Select item 20026394117.

Conserved epigenetic hallmarks of T-cell aging during immunity and malignancy

(Submitter supplied) Chronological aging correlates with epigenetic modifications at specific loci, calibrated to species lifespan. Such ‘epigenetic clocks’ appear conserved among mammals, but whether they are cell-autonomous and restricted by maximal organismal lifespan remains unknown. We used a multi-lifetime murine model of repeat vaccination and memory T cell transplantation to test whether epigenetic aging tracks with cellular replication, and if such clocks continue ‘counting’ beyond species lifespan. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL24247
19 Samples

Download data: TXT

Series

Accession:: GSE263941

ID:: 200263941

Select item 20026184418.

Single-cell RNA sequencing of lung ILCs after combination airborne toxin exposure in mice

(Submitter supplied) Innate lymphoid cells (ILCs) are rapid responding lymphocytes to tissue damage/stress. In this study, we assed single cell transcriptomics of enriched lung ILCs after expsoure to fungal allergen Alternaria alternata together with environmental toxins.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE261844

ID:: 200261844

Select item 20026070119.

Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in brain tumors [RNA-seq]

(Submitter supplied) Macrophages are critical components of the immunosuppressive microenvironment that restrict anti-cancer immunity in glioblastoma (GBM). However, how GBM shapes the regulatory function of macrophages remains elusive. Here, we report that monocyte-derived macrophages (MDM), but not yolk-sac derived microglia (MG), exhibited potent immunosuppressive activity, which was mediated by a population of glycolytic GLUT1+MDM, in an IL10-dependent manner. more...