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Items: 2

1.

Transcriptomic characterization of a mixed population of pluripotent stem cell derived cerebellar neuron-like progenitors

(Submitter supplied) We set out to ascertain whether it was possible to use PSCs (pluripotent stem cells) to generate a mix of neuronal cell types resembling those in the cerebellum, most notably Purkinje and granule cells. Several groups have previously demonstrated generation of cerebellar-like neuronal cells from murine ESCs (embryonic stem cells), and more recently the Erceg group achieved similar success using human PSCs. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TXT
Series
Accession:
GSE65423
ID:
200065423
2.

Molecular signatures of neural connectivity in the olfactory cortex

(Submitter supplied) Purpose:This work aimed to identify the genetic profiles of piriform projection neurons and characterize their spatial organization within the piriform cortex. Methods: We microdissected the three layers of pirifrom cortex by laser capture (LMD) and performed RNA deep sequencing in order to identify layer-specific molecular markers, we then validated these data by using RNA in situ hybridization and immunohistochemistry.We next performed anterograde neural tracing experiments to identify piriform target regions, and retrograde neural tracing experiments to analyze how piriform projection neurons are organized within piriform cortex.We then combined the analysis of patterns of gene expression with retrograde tracing experiments to identify molecular signatures of the different subclasses of piriform projecting neurons. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
9 Samples
Download data: TSV
Series
Accession:
GSE70800
ID:
200070800

Supplemental Content

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