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Items: 1 to 20 of 997038

1.

Single Cell RNA Sequencing of MIC WT and B1KO early invasive breast carcinoma

(Submitter supplied) The goal of this study is the compare the tumour compositions between B1 integrin-proficient and -deficient dormant lesions based on single cell transcripts. Tumours were dissociated and pooled into single cell suspension, passed multi-stage quality checks, and sequenced by Génome Québec Innovation Tumour. Clustering visualization by UMAP and differential gene expression analyses show that B1 integrin-deficient dormant lesions have significantly more cancer-associated fibroblasts by depleted of antitumourigenic immune cells, altogether promoting dormnacy exit and recurrence.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
2 Samples
Download data: H5
Series
Accession:
GSE186118
ID:
200186118
2.

Inpolin maintains hepatic lipid homeostasis through suppression of de novo lipogenesis

(Submitter supplied) Hepatic lipid homeostasis is tightly regulated by nutritional and hormonal signals. Here we show that Orosomucoid 2 (Orm2), a hepatocyte-derived cytokine with previously unknown biological function, as an inhibitor of lipogenesis (Inpolin). Hepatic and plasma Orm2/Inpolin levels were markedly decreased in obese murine models and patients with nonalcoholic fatty liver disease (NAFLD). Through multiple loss- and gain-of functions experiments, we demonstrate that Orm2/Inpolin maintains hepatic and systemic lipid homeostasis by downregulation of sterol regulatory element binding protein 1c (SREBP-1c)-mediated lipogenic gene program. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
8 Samples
Download data: XLSX
Series
Accession:
GSE186024
ID:
200186024
3.

Pancreatic Tumor Microenvironment Maintains Tumor Growth through Nucleosides Secretion

(Submitter supplied) Cancer-associated fibroblasts (CAFs) are one of the most prominent and active components in the pancreatic tumor microenvironment. Our data show that CAFs are critical for PDAC survival upon glutamine deprivation. Specifically, we uncovered a role for nucleosides, which are secreted by CAFs through autophagy in an NUFIP1-depenent manner, increased glucose utilization and promoted growth of PDAC. Moreover, we demonstrate that CAF-derived nucleosides induced glucose consumption under glutamine-deprived conditions and displayed a dependence on MYC. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
2 Samples
Download data: TXT
Series
Accession:
GSE185750
ID:
200185750
4.

Transcriptional analysis of noncanonical and canonical Tregs from ITK deficient mice (ITK KO)

(Submitter supplied) Regulatory T cells (Tregs) play a critical role in controlling autoimmunity and limiting tissue destruction and inflammation. IL2-inducible T cell kinase (Itk) belongs to the Tec family of tyrosine kinases and is an important component of TCR-mediated signaling. Here we showed that either genetic ablation of Itk signaling, or inhibition of Itk signaling pathways resulted in increased frequency of “noncanonical” CD4+CD25−FoxP3+ Tregs (ncTregs), as well as of “canonical” CD4+CD25+FoxP3+ Tregs (canTregs). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
9 Samples
Download data: TSV
Series
Accession:
GSE185327
ID:
200185327
5.

Efficient stimulation of retinal regeneration from Muller glia in adult mice using combinations of proneural bHLH transcription factors.

(Submitter supplied) Regenerative neuroscience aims to stimulate endogenous repair mechanisms in the nervous system to replace neurons that have been lost from degenerative diseases or trauma. In the retina, many non-mammalian vertebrate species spontaneously regenerate retinal neurons from glial cells, through an injury-induced reprogramming of the cells to a retinal progenitor state. Recently, we have reported that engineering mouse Muller glia to express a retinal progenitor gene, the proneural transcription factor, Ascl1, is sufficient to stimulate neurogenesis in the glia to generate functional neurons. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
4 Samples
Download data: TAR
Series
Accession:
GSE184286
ID:
200184286
6.

Cilia locally synthesize proteins to sustain their ultrastructure and functions

(Submitter supplied) Cilia are microtubule-based hair-like organelles propelling locomotion and extracellular liquid flow or sensing environmental stimuli. As cilia are diffusion barrier-gated subcellular compartments, their protein components are thought to come from the cell body through intraflagellar transport or diffusion. Here we show that cilia locally synthesize proteins to maintain their ultrastructure and functions. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21273
4 Samples
Download data
Series
Accession:
GSE179935
ID:
200179935
7.

Sequencing of Mus musculus skin of two different age groups

(Submitter supplied) Comparison of gene expression profiles from Mus musculus skin of two age groups. The RNA-seq data comprise 2 groups at ages: 2 and 9 months. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
10 Samples
Download data: XLS
Series
Accession:
GSE120570
ID:
200120570
8.

RNA-seq of NIH 3T3 and HepG2 cells after arsenite treatment

(Submitter supplied) Expression profiling of HepG2 human liver carcinoma cells and NIH 3T3 mouse fibroblasts after arsite treatment for 24h. RNA-seq data comprise 4 groups: NIH 3T3 mouse fibroblasts control and arsite treatment, and HepG2 human liver carcinoma cells control and arsenite treatment. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL11002 GPL10999
8 Samples
Download data: XLS
Series
Accession:
GSE117815
ID:
200117815
9.

Sequencing of Mus musculus skin of five different age groups (smallRNA)

(Submitter supplied) Comparison of temporal small RNA gene expression from Mus musculus skin. The RNA-seq data comprise 5 groups at ages: 2, 9, 15, 24 and 30 months. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
25 Samples
Download data: TXT
Series
Accession:
GSE111282
ID:
200111282
10.

Sequencing of Mus musculus brain (hemispheres) of five different age groups (smallRNA)

(Submitter supplied) Comparison of temporal small RNA gene expression from Mus musculus right hemisphere. The RNA-seq data comprise 5 groups at ages: 2, 9, 15, 24 and 30 months. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
25 Samples
Download data: TXT
Series
Accession:
GSE111279
ID:
200111279
11.

Sequencing of Mus musculus brain (hemisphere) after enriched environment

(Submitter supplied) Comparison of gene expression profiles from Mus musculus brain (hemisphere) of animals kept in standard environment and enriched environment. The RNA-seq data comprise 4 groups: 2 age groups, each w/ and w/o enriched environment. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
24 Samples
Download data: TXT
Series
Accession:
GSE111273
ID:
200111273
12.

Sequencing of Mus musculus brain (hippocampus) after enriched environment

(Submitter supplied) Comparison of gene expression profiles from Mus musculus brain (hippocampus) of animals kept in standard environment and enriched environment. The RNA-seq data comprise 4 groups: 2 age groups, each w/ and w/o enriched environment. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
20 Samples
Download data: TXT
Series
Accession:
GSE111271
ID:
200111271
13.

Sequencing of Mus musculus brain (hippocampus) after enriched environment 3

(Submitter supplied) Comparison of gene expression profiles from Mus musculus brain (hippocampus) of animals kept in standard environment and enriched environment. The RNA-seq data comprise 4 groups: 2 age groups, each w/ and w/o enriched environment. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
39 Samples
Download data: TXT
Series
Accession:
GSE111270
ID:
200111270
14.

Sequencing of Mus musculus brain (hippocampus) after enriched environment 2

(Submitter supplied) Comparison of gene expression profiles from Mus musculus brain of animals kept in standard environment and enriched environment. The RNA-seq data comprise 4 groups: 2 age groups, each w/ and w/o enriched environment. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
20 Samples
Download data: TXT
Series
Accession:
GSE111215
ID:
200111215
15.

Sequencing of Mus musculus hemisphere after physical exercise at two different ages

(Submitter supplied) Comparison of gene expression profiles from Mus musculus cerebral hemisphere after physical exercise (treadmill; endurance training over 4 weeks). The RNA-seq data comprise4 groups: 2 age groups, each w/ and w/o physical exercise. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
20 Samples
Download data: TXT
Series
Accession:
GSE111214
ID:
200111214
16.

Sequencing of Mus musculus hippocampus after physical exercise at two different ages

(Submitter supplied) Comparison of gene expression profiles from Mus musculus hippocampus after physical exercise (treadmill; endurance training over 4 weeks). The RNA-seq data comprise 4 groups: 2 age groups, each w/ and w/o physical exercise. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
20 Samples
Download data: TXT
Series
Accession:
GSE111212
ID:
200111212
17.

Sequencing of Mus musculus brain (hemisphere) of 5 months old animals

(Submitter supplied) Comparison of gene expression profiles from Mus musculus brain (hemisphere) at age 5 months following enriched environment. The RNA-seq data comprise 1 groups. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11002
5 Samples
Download data: TXT
Series
Accession:
GSE111209
ID:
200111209
18.

Sequencing of Mus musculus brain (hemispheres) of five different age groups

(Submitter supplied) Comparison of gene expression profiles from Mus musculus brain (hemispheres) of different age groups. The RNA-seq data comprise 5 groups at ages: 2, 9, 15, 24 and 30 months. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
25 Samples
Download data: TXT
Series
Accession:
GSE111202
ID:
200111202
19.

Sequencing of Mus musculus blood of five different age groups (smallRNA)

(Submitter supplied) Comparison of temporal small RNA gene expression from Mus musculus blood. The RNA-seq data comprise 5 groups at ages: 2, 9, 15, 24 and 30 months. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL17021
25 Samples
Download data: TXT
Series
Accession:
GSE111186
ID:
200111186
20.

Sequencing of Mus musculus blood of five different age groups 2

(Submitter supplied) Comparison of gene expression profiles from Mus musculus blood of different age groups. The RNA-seq data comprise 5 groups at ages: 2, 9, 15, 24 and 30 months. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
28 Samples
Download data: XLS
Series
Accession:
GSE111164
ID:
200111164
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