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Items: 1 to 20 of 31

1.
Full record GDS5822

Anti-CTLA-4 immunotherapy effect on αSMA+ myofibroblast late-depleted pancreatic ductal adenocarcinoma model

Analysis of pancreatic ductal adenocarcinoma (PDAC) tumors from PKT; αSMA-tk+ transgenics injected daily with ganciclovir at 6 weeks of age for 10 days or less to deplete αSMA+ myofibroblasts and treated with anti-CTLA4. Results provide insight into molecular basis of anti-CTLA4 therapy in PDAC.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 protocol sets
Platform:
GPL6887
Series:
GSE52812
9 Samples
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2.
Full record GDS5821

αSMA+ myofibroblast late depletion effect on pancreatic ductal adenocarcinoma model

Analysis of pancreatic ductal adenocarcinoma (PDAC) tumors from PKT; αSMA-tk+ transgenics injected daily with ganciclovir at 6 weeks of age for 10 days or less to selectively deplete αSMA+ myofibroblasts. Results provide insight into the role of αSMA+ myofibroblasts in late-stage PDAC.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6887
Series:
GSE52812
6 Samples
Download data
3.
Full record GDS5820

αSMA+ myofibroblast early depletion effect on pancreatic ductal adenocarcinoma model

Analysis of pancreatic ductal adenocarcinoma (PDAC) tumors from PKT; αSMA-tk+ transgenics injected daily with ganciclovir at 4 to 4.5 weeks of age for 14 days or less to selectively deplete αSMA+ myofibroblasts. Results provide insight into the role of αSMA+ myofibroblasts in early-stage PDAC.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6887
Series:
GSE52812
6 Samples
Download data
4.
Full record GDS5807

Snail transcription factor/ERα ligand-binding region chimeric protein effect on embryonic stem cells: time course

Analysis of ESC line E14 expressing 4-hydroxytamoxifen (4-OHT)-inducible Snai1-ER at various time points of induction with 4-OHT. Snai1 (Snail homolog 1) is a member of the Snail family of zinc finger transcription factors. Results provide insight into the role of Snai1 in ESC differentiation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 6 time sets
Platform:
GPL6887
Series:
GSE57854
6 Samples
Download data
5.
Full record GDS6000

High-fat diet effect on brown adipose tissue development

Analysis of interscapular brown adipose tissues from mice fed a high fat diet for up to 24 weeks. Results compared to those from epididymal white adipose tissues (GDS6247) in order to provide insight into the effect of high-fat diets on the development of brown and white adipose tissues.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 6 time sets
Platform:
GPL6887
Series:
GSE64718
33 Samples
Download data
DataSet
Accession:
GDS6000
ID:
6000
6.
Full record GDS5436

Metformin effect on Mycobacterium tuberculosis-infected lung

Analysis of lung from M. tuberculosis (MT)-infected C57BL/6 mice treated with metformin (MET). The antidiabetic drug MET is an activating agent of adenosine monophosphate-activated protein kinase (AMPK). Results provide insight into the potential use of MET as adjunct antituberculosis therapy.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 infection sets
Platform:
GPL6887
Series:
GSE57275
14 Samples
Download data
DataSet
Accession:
GDS5436
ID:
5436
7.
Full record GDS5425

Monoacylglycerol acyltransferase 1 deficiency effect on high-fat diet fed mice: liver

Analysis of liver from diet-induced obese males depleted for monoacylglycerol acyltransferase 1 (Mogat1) via intraperitoneal injections of antisense oligonucleotide directed against Mogat1. Results provide insight into the role of Mogat1 in the development of nonalcoholic steatohepatitis (NASH).
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6887
Series:
GSE60349
8 Samples
Download data
8.
Full record GDS5336

Anterior stomach vagotomy effect on INS-GAS gastric cancer model stomach: time course

Analysis of anterior and posterior stomach regions following vagotomy of anterior stomach of 6 month old INS-GAS animals at 2, 4, and 6 months post-surgery. Results provide insight into molecular mechanisms underlying denervation-mediated suppression of gastric tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 time, 2 tissue sets
Platform:
GPL6887
Series:
GSE30295
32 Samples
Download data
9.
Full record GDS5157

Auditory fear conditioning effect on amygdala: time course

Analysis of bilateral amygdala up to 2 hrs after auditory fear conditioning. Neurons within the centromedial amygdala are proposed to modulate fear memories. Results provide insight into molecular pathways mediating fear memory in the amygdala.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol, 3 time sets
Platform:
GPL6887
Series:
GSE57465
12 Samples
Download data
10.
Full record GDS5325

TRPM7 deficiency effect on embryonic stem cells

Analysis of embryonic stem cells from mutants lacking TRPM7. TRPM7 is a kinase and an ion channel. Results provide insight into the function of TRPM7 in cell differentiation and embryonic development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6887
Series:
GSE55578
6 Samples
Download data
11.
Full record GDS5295

Kelch-like family member 40 deficiency effect on the skeletal muscle

Analysis of quadriceps muscles of mutants lacking kelch-like family member 40 (KLHL40). KLHL40 mutations occur in severe nemaline myopathies (NMs). NMs are congenital myopathies that can result in lethal muscle dysfunction. Results provide insight into the role of KLHL40 in the pathogenesis of NM.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6887
Series:
GSE56570
6 Samples
Download data
12.
Full record GDS5648

Chronic high-calorie diet effect on Kras-driven lung tumors

Analysis of lung tumors isolated from mice that develop KRAS-driven lung tumors. The KrasG12D mice were fed a high-calorie diet (HCD) starting 12 wk before tumor induction; tumors were collected 11 wk after tumor induction. Results provide insight into HCD effects on KRAS-driven lung tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 growth protocol sets
Platform:
GPL6887
Series:
GSE56260
11 Samples
Download data
13.
Full record GDS5651

DNA methyltransferase inhibitor 5-Aza-2’deoxycytidine effect on partially-ligated left carotid artery

Analysis of arteries from C57BL/6 males pretreated with DNMT inhibitor 5Aza for 2 wk, then subjected to partial carotid ligation (PCL) and continued 5Aza treatment for 1 wk after ligation. PCL induces disturbed blood flow. Results provide insight into molecular basis of atherosclerosis development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 protocol, 2 tissue sets
Platform:
GPL6887
Series:
GSE56143
12 Samples
Download data
14.
Full record GDS6248

Diet-induced obesity model: liver

Analysis of livers of C57BL/6J mice fed a high fat diet for up to 24 weeks. Significant body weight gain was observed after 4 weeks. Results provide insight into the effect of high fat diets on metabolism in the liver.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 protocol, 9 time sets
Platform:
GPL6887
Series:
GSE39549
51 Samples
Download data
15.
Full record GDS6247

Diet-induced obesity model: white adipose tissue

Analysis of epididymal and mesenteric white adipose tissues (WAT) of mice fed a high fat diet for up to 24 weeks. Excessive fat accumulation was evident in visceral WAT depots after 4 weeks. Results provide insight into the molecular events that occur during the development of diet-induced obesity.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 5 time, 2 tissue sets
Platform:
GPL6887
Series:
GSE39549
40 Samples
Download data
16.
Full record GDS5360

Casein kinase 1 α deficiency effect on leukemia stem cells

Analysis of leukemia stem cells (LSC) knocked down for casein kinase 1 α (Csnk1a1). Csnk1a1, a serine-threonine kinase, is critical for acute myeloid leukemia (AML) cell survival in vivo. Results provide insight into the role of Csnk1a1 in AML.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol sets
Platform:
GPL6887
Series:
GSE52928
9 Samples
Download data
17.
Full record GDS5342

Maternal western diet effect on post-weaning low-fat diet fed offspring liver

Analysis of liver of C57BL/6J male offspring exposed prenatally to a western-style diet (rich in energy, fat, cholesterol) or a low-fat diet and then a post-weaning low-fat diet. Results provide insight into the role of maternal western diet in the development of liver disease in offspring.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6887
Series:
GSE44901
11 Samples
Download data
DataSet
Accession:
GDS5342
ID:
5342
18.
Full record GDS5293

Maternal western diet effect on post-weaning western diet fed offspring liver

Analysis of liver of C57BL/6J male offspring exposed prenatally to a western-style diet (rich in energy, fat, cholesterol) or a low-fat diet and then a post-weaning western diet. Results provide insight into the role of maternal western diet in the development of liver disease in offspring.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6887
Series:
GSE44901
11 Samples
Download data
DataSet
Accession:
GDS5293
ID:
5293
19.
Full record GDS5311

Lipopolysaccharide effect on fatty acid-loaded peritoneal macrophages in vitro

Analysis of fatty acid (FA)-loaded macrophages stimulated with bacterial lipopolysaccharide (LPS). LPS is a Toll-like receptor 4 (TLR4) agonist. Results provide insight into the molecular mechanisms that promote triglyceride retention in LPS-exposed macrophages.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 4 other, 4 protocol sets
Platform:
GPL6887
Series:
GSE42190
15 Samples
Download data
20.
Full record GDS4834

Colistin effect on the kidney

Analysis of kidneys from C57BL/6J males following treatment with colistin. Colistin is an antibiotic prescribed for multidrug resistant gram negative bacterial infections. It is associated with nephrotoxicity. Results provide insight into the molecular basis of colistin nephrotoxicity.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL6887
Series:
GSE46410
12 Samples
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