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Items: 1 to 20 of 51

1.
Full record GDS6063

Influenza A effect on plasmacytoid dendritic cells

Analysis of primary plasmacytoid dendritic cells (pDC) exposed to influenza A for 8 hours ex vivo. pDCs are vital to antiviral defense, directing immune responses via secretion of interferon-alpha. Results provide insight into the regulation of the response of pDC to viral pathogens.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 5 individual, 2 infection sets
Platform:
GPL10558
Series:
GSE68849
10 Samples
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2.
Full record GDS5662

Histone demethylase KDM3A-deficiency effect on estrogen-stimulated breast cancer cells in vitro

Analysis of estrogen receptor (ER)-positive breast cancer cell line MCF-7 depleted for KDM3A (histone lysine demethylase 3A) then treated with estrogen. Histone lysine methylation is an important regulator of transcription. Results provide insight into role of KDM3A in ER signaling in breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL10558
Series:
GSE68918
11 Samples
Download data
3.
Full record GDS6100

MicroRNA-135b overexpression effect on prostate cancer cell line: time course

Analysis of LNCaP prostate cancer (PCa) cells overexpressing miRNA-135b for up to 36 hours. LNCaP cells express the androgen receptor (AR). MiRNA-135b overexpression in AR+ PCa cells results in slower growth compared to AR knockdown. Results provide insight into the basis of this slower growth.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol, 3 time sets
Platform:
GPL10558
Series:
GSE57820
12 Samples
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4.
Full record GDS5626

pH1N1 influenza virus infection of interferon regulatory factor 7-deficient peripheral blood mononuclear cells: time course

Analysis of PBMCs isolated from an IRF7-deficient patient and infected with influenza A/CA/4/2009 for up to 16 hrs. Transcription factor IRF7 amplifies type I and III interferon response to viruses. Results provide insight into the role of IRF7 in antiviral immunity.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 6 individual, 2 infection, 3 time sets
Platform:
GPL10558
Series:
GSE66486
18 Samples
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5.
Full record GDS6082

Sendai virus infection effect on monocytic cell line: dose response

Analysis of U937 monocytic cells infected at multiplicities of infection of 0.0002 and 0.02 with the Sendai virus. Results provide insight into the differences between the innate immune response of cells infected with a low and high concentration of virus.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 dose, 2 infection sets
Platform:
GPL10558
Series:
GSE67198
11 Samples
Download data
6.
Full record GDS5622

Myelodysplastic syndrome disorder: bone marrow mesenchymal stromal cells

Analysis of bone marrow (BM) mesenchymal stromal cells from adult patients representing MDS subtypes RCMD (refractory cytopenia with multilineage dysplasia) and RAEB (refractory anemia with excess blasts). Results provide insight into molecular changes in the BM microenvironment contributing to MDS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 disease state sets
Platform:
GPL10558
Series:
GSE61853
14 Samples
Download data
7.
Full record GDS5615

Oral histone deacetylase inhibitor ST7612AA1 effect on diffuse large B-cell lymphoma in vitro models

Analysis of lymphoma cell lines DOHH2 (derived from GCB-DLBCL) and TMD8 (derived from ABC-DLBCL) exposed to ST7612AA1 (300nM) for 8 hrs. ST7612AA1 is an oral thiol-based histone deacetylase inhibitor (HDACi). Results provide insight into the molecular mechanisms underlying ST7612AA1 action in DLBCL.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 cell line sets
Platform:
GPL10558
Series:
GSE62460
12 Samples
Download data
8.
Full record GDS5621

Estradiol effect on MCF7 breast cancer cells expressing progesterone receptor-B

Analysis of estradiol-treated, progesterone receptor (PR)-low/estrogen receptor (ER)+ MCF7 breast cancer cells stably-expressing PR-B. Progesterone and estrogen are major drivers of breast cancer. Results provide insight into the molecular cross-talk between ER and PR-B in breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL10558
Series:
GSE45643
12 Samples
Download data
9.
Full record GDS5801

Protein kinase C δ deficiency effect on breast cancer cells

Analysis of basal-like breast cancer (BC) cell lines MDA-MB-468 and BT-549 treated with protein kinase C δ (PKCδ) siRNA to induce apoptosis. Results provide insight into candidate apoptosis regulators in BC cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 cell line, 2 protocol sets
Platform:
GPL10558
Series:
GSE55503
12 Samples
Download data
10.
Full record GDS5627

Dasatinib-resistant and dasatinib-sensitive pancreatic cancer cell lines

Analysis of dasatinib-resistant and dasatinib-sensitive PC cell lines. Dasatinib, a small-molecule kinase inhibitor, is FDA-approved for PC, but certain PC cells can have intrinsic or acquired resistance to dasatinib. Results provide insight into molecular basis of dasatinib-resistance in PC cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 6 cell line, 2 cell type sets
Platform:
GPL10558
Series:
GSE59357
18 Samples
Download data
11.
Full record GDS5620

H3K79 histone methyl transferase DOT1L inhibitor Compound 55 effect on breast cancer cells: dose response

Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor Compound 55 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent, 4 dose sets
Platform:
GPL10558
Series:
GSE56630
8 Samples
Download data
12.
Full record GDS5619

H3K79 histone methyl transferase DOT1L inhibitor EPZ004777 effect on breast cancer cells: dose response

Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor EPZ004777 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent, 4 dose sets
Platform:
GPL10558
Series:
GSE56630
8 Samples
Download data
13.
Full record GDS5819

Metastatic breast cancer and sepsis: monocytes

Analysis of the total population of monocytes from patients with metastatic breast cancer (MBC), sepsis, or tuberculosis. Results provide insight into molecular similarities between monocytes from MBC patients and reprogrammed immunosuppressive monocytes from sepsis patients.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 disease state sets
Platform:
GPL10558
Series:
GSE65517
13 Samples
Download data
14.
Full record GDS5816

Methyltransferase EZH2 inhibition effect on ARID1A mutated ovarian clear cell cancer cell line

Analysis of ARID1A-mutated OVISE ovarian clear cell carcinoma (OCCC) cells restored with wild-type ARID1A or treated with GSK126, an inhibitor of epigenetic regulator EZH2. Epigenetic modifier ARID1A is often mutated in OCCC. Results provide insight into the role of epigenetic mechanisms in OCCC.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 genotype/variation sets
Platform:
GPL10558
Series:
GSE54979
9 Samples
Download data
15.
Full record GDS5800

Interstitial fluid flow effect on noninvasive and invasive ERBB2-positive breast cancer cells

Analysis of non-invasive NeuN cells and invasive NeuT cells (i.e., MCF10A cells overexpressing wild-type ERBB2 or a constitutively active mutant of ERBB2, respectively) treated with IFF. Results provide insight into the molecular pathways activated by IFF in ERBB2-positive breast cancer cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 cell line, 2 protocol sets
Platform:
GPL10558
Series:
GSE64670
12 Samples
Download data
DataSet
Accession:
GDS5800
ID:
5800
16.
Full record GDS5473

Short-term fasting effect on skeletal muscle: time course

Analysis of skeletal muscle biopsies collected at 1.5, 4, 10, and 24hr post-meal time from healthy young men subjected to a 24hr fast. Results provide insight into the molecular mechanisms underlying metabolic adaptation to fasting in healthy humans.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 12 individual, 4 time sets
Platform:
GPL10558
Series:
GSE55924
48 Samples
Download data
DataSet
Accession:
GDS5473
ID:
5473
17.
Full record GDS5439

Mutant HLA-F-adjacent transcript 10 overexpression effect on HCT116 colon cancer cell line

Analysis of HCT116 cells expressing wildtype HLA-F-adjacent transcript 10 (FAT10) or FAT10 mutants with mutations at mitotic arrest-deficient 2 (MAD2)-binding region 1 (M1), region 2 (M2), or at both regions (M12). Results assess the molecular effects of abrogating the FAT10-MAD2 interaction.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 genotype/variation sets
Platform:
GPL10558
Series:
GSE54167
10 Samples
Download data
18.
Full record GDS5375

DEK oncogene deficiency effect in U937 leukemic monocyte lymphoma cells

Analysis of U937 cells following DEK oncogene knockdown by two different shRNAs (shDEK14, shDEK17). The DEK gene is highly expressed in many types of cancer cells and involved in chromosomal translocation in acute myelogenous leukemia. Results provide insight into the role of DEK in gene regulation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 protocol sets
Platform:
GPL10558
Series:
GSE60732
9 Samples
Download data
19.
Full record GDS5367

miR-542-3p overexpression effect on TP53 wild-type osteosarcoma cell line

Analysis of U2OS osteosarcoma cells overexpressing miR-542-3p. U2OS contains wild-type p53 tumor suppressor TP53. Results provide insight into the function of miR-542-3p and its role in regulating the expression and function of p53.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol sets
Platform:
GPL10558
Series:
GSE47363
6 Samples
Download data
20.
Full record GDS5263

Enforced Grainyhead-like 1 expression effect on BE(2)-C neuroblastoma cell line: time course

Analysis of BE(2)-C cells up to 72 hrs after transient transfection with construct pTRex-GRHL1. The three mammalian GRHL genes (GRHL1, -2, and -3) represent a highly conserved family of β-scaffold transcription factors. Results provide insight into the role of GRHL1 in neuroblastoma biology.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol, 3 time sets
Platform:
GPL10558
Series:
GSE47407
12 Samples
Download data
DataSet
Accession:
GDS5263
ID:
5263
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db=gds|term=4089%204539%204540%204786%204808%204826%204828%204829%204957%205064%205077%205099%205167%205189%205221%205222%205227%205260%205263%205269%205310%205352%205364%205365%205367%205375%205393%205397%205409%205431%205439%205473%205615%205619%205620%205621%205622%205626%205627%205638%205646%205649%205662%205674%205800%205801%205816%205819%206063%206082%206100[uid]|query=1|qty=2|blobid=MCID_61e7729cb1ef894ff76cd0b0|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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