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Items: 1 to 20 of 142

1.
Full record GDS4925

Age-related hearing loss model: cochlea

Analysis of cochlea from old CBA females and males with mild or severe age-related hearing loss (presbycusis). The CBA strain it loses its hearing progressively over its lifetime. Results provide insight into the molecular mechanisms underlying presbycusis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 age, 4 disease state, 2 gender sets
Platform:
GPL339
Series:
GSE49543
41 Samples
Download data: CEL, CHP
2.
Full record GDS4510

rd1 model of retinal degeneration: time course

Analysis of rd1 retinas starting at P2 (prior to obvious biochemical/morphological differences) and ending at P8 (early degenerative changes present, but prior to onset of rod photoreceptor cell death). Results provide insight into molecular mechanisms underlying photoreceptor development.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 4 age, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE41821
32 Samples
Download data: CEL
3.
Full record GDS4585

Ozone effect on Toll-like receptor 4-deficient C3H/HeJ lung: time course

Analysis of lung from Toll-like receptor 4 (Tlr4)-deficient, C3H/HeJ males exposed to 0.3 ppm ozone (O3) for up to 48hr. Tlr4 is involved in O3-induced pulmonary hyperpermeability and inflammation. Results provide insight into the molecular basis of Tlr4 modulation of O3-induced pulmonary responses.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 genotype/variation, 2 strain, 4 time sets
Platform:
GPL339
Series:
GSE20715
24 Samples
Download data: CEL
4.
Full record GDS4493

Transcription factor Trps1 GATA-domain deletion effect on embryonic whisker pads

Analysis of whisker pads from E12.5 embryos in which the GATA domain of Trps1 has been deleted. Trps1∆gt/∆gt mutants have fewer pelage follicles and lack vibrissae follicles postnatally. Results provide insight into molecular mechanisms underlying vibrissa follicle morphogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE33766
6 Samples
Download data: CEL
5.
Full record GDS4204

Growth factor independence 1 knockout effect on LSK hematopoietic stem bone marrow cells

Analysis of Lin-Sca1+ckit+Flt3- (LSKFlt3-) hematopoietic stem cells (HSC) depleted of growth factor independence 1 (Gfi1). Transcriptional repressor Gfi1 restricts HSC proliferation and is essential to self-renewal. Results provide insight into molecular mechanisms underlying Gfi1 effects in HSCs.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE20282
6 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS4204
ID:
4204
6.
Full record GDS3768

Fat-Specific protein 27 knockout effect on white adipose tissue

Analysis of gonadal white adipose tissue (WAT) from Fat-Specific protein 27 (FSP27)-null males. FSP27-null WATs have reduced lipid storage, smaller lipid droplets, and increased mitochondrial activity. Results provide insight into molecular mechanisms by which FSP27 controls lipid storage in WAT.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE22693
4 Samples
Download data: CEL, CHP
7.
Full record GDS3803

Embryonic pharyngeal arch and embryonic heart

Analysis of second heart field (SHF)-containing pharyngeal arch from E10.5 embryos and heart from E12.5 embryos. These results, together with results from P19CL6 cells induced to differentiate into a cardiac lineage, provide insight into Nkx2.5 target genes relevant specifically to the SHF.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 tissue sets
Platform:
GPL339
Series:
GSE17936
10 Samples
Download data: CEL, CHP
8.
Full record GDS3958

Preimplantation embryonic development (MOE430A)

Analysis of embryos at different stages of preimplantation embryonic development (PED): one-cell, two-cell, four-cell, eight-cell, morula, and blastocyst. The progression of PED is highly conserved among mammals. Results provide insight into molecular mechanisms underlying PED.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 6 development stage sets
Platform:
GPL339
Series:
GSE18290
18 Samples
Download data: CEL
9.
Full record GDS3575

Aryl hydrocarbon receptor deficiency effect on Langerhan cells

Analysis of Langerhan cells (LCs) lacking the aryl hydrocarbon receptor (AhR). LCs are Ag-presenting cells of the epidermis. AhR is a ligand-activated transcription factor involved in low molecular mass chemical metabolism and cell differentiation. Results provide insight into the role of AhR in LC.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE13130
4 Samples
Download data: CEL
DataSet
Accession:
GDS3575
ID:
3575
10.
Full record GDS4028

Maternal diabetes effect on developing embryo

Analysis of diabetes-exposed, E10.5 whole embryos. Diabetes was induced in FVB females (aged 7-9 wks) by streptozotocin. Maternal diabetes is a well-known risk factor for birth defects, such as neural tube defects. Results provide insight into the causative molecular mechanisms in developing embryo.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 disease state, 2 stress sets
Platform:
GPL339
Series:
GSE9675
7 Samples
Download data: CEL, CHP
11.
Full record GDS3504

Dendritic cell response to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced aryl hydrocarbon receptor activation

Analysis of MACS-sorted splenic dendritic cells (DC) from aryl hydrocarbon receptor (AHR) +/+, C57BL6 females after 24hr in vivo treatment with TCDD. The TCDD ligand is an AHR agonist and a potent immunotoxicant. Results provide insight into the consequences of TCDD-induced AHR activation in DCs.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL339
Series:
GSE13719
4 Samples
Download data: CEL
DataSet
Accession:
GDS3504
ID:
3504
12.
Full record GDS3473

Aiolos/OBF-1 double null mutation effect on bone marrow pre-BII cells

Analysis of bone marrow pre-BII cells from Aiolos/OBF-1 double null mutants. Aiolos is a chromatin regulator, OBF-1 a transcriptional activator. Small pre-BII to immature B cell transition is impaired in the double mutants. Results provide insight into the role of Aiolos and OBF-1 in pre-BII cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 genotype/variation sets
Platform:
GPL339
Series:
GSE12356
8 Samples
Download data: CEL, EXP
13.
Full record GDS3368

Ovaries from a high-fertility line

Analysis of ovaries from high-fertility FL1 animals. FL1 animals exhibit an increase in ovulation number. Results provide insight into the molecular basis of this increase in ovulation number.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 strain sets
Platform:
GPL339
Series:
GSE11113
24 Samples
Download data: CEL
14.
Full record GDS3316

Leptin deficiency effect on lungs

Analysis of lungs from leptin-deficient (ob/ob) mutants treated with saline or leptin. Leptin deficiency results in low lung volumes and an attenuated chemical control of breathing. Results provide insight into molecular mechanisms by which leptin alters respiratory system structure and function.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL339
Series:
GSE10915
6 Samples
Download data: CEL
15.
Full record GDS3398

Utrophin overexpression effect on dystrophin-deficient mdx skeletal muscles

Analysis of skeletal muscles from dystrophin-deficient mdx trangenics engineered to overexpress utrophin, a dystrophin-related protein. Dystrophin mutations result in Duchenne muscular dystrophy. mdx trangenics overexpressing utrophin display improved muscle function.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 strain sets
Platform:
GPL339
Series:
GSE7187
17 Samples
Download data: CEL
DataSet
Accession:
GDS3398
ID:
3398
16.
Full record GDS3408

Amyotrophic lateral sclerosis model

Analysis of motor neurons of 60, 90, and 120 day old SOD1 G93A transgenics, a model for familial amyotrophic lateral sclerosis (ALS). ALS is an adult-onset neurodegenerative disease characterized by degeneration of upper and lower motor neurons. Results provide insight into the pathogenesis of ALS.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 age, 2 strain sets
Platform:
GPL339
Series:
GSE10953
18 Samples
Download data: CEL
17.
Full record GDS3392

Newborn intestinal tissues response to Shigella flexineri infection

Analysis of intestinal tissues from 4- or 7-day-old animals infected with Shigella flexineri strains for 2 or 4 hr. Animals >1 wk old are no longer susceptible to infection by Shigella. Results provide insight into the molecular basis of the switch from disease susceptibility to resistance.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 3 infection, 3 time sets
Platform:
GPL339
Series:
GSE9785
36 Samples
Download data: CEL, CHP
DataSet
Accession:
GDS3392
ID:
3392
18.
Full record GDS3544

Spinocerebellar ataxia type 1 knock-in model: cerebellum

Analysis of cerebella from spinocerebellar ataxia type 1 (SCA1) knockin animals at an early symptomatic disease stage. SCA1 is a neurodegenerative disorder caused by expansion of a glutamine tract in ataxin-1. Results provide insight into the molecular basis of cerebellar pathogenesis in SCA1.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 age, 2 genotype/variation sets
Platform:
GPL339
Series:
GSE9914
12 Samples
Download data: CEL
19.
Full record GDS3103

Liver response to a high cholesterol diet and phenobarbital

Analysis of livers from animals treated with phenobarbital or fed a high cholesterol diet for 7 days. Results provide insight into the molecular mechanisms underlying the effects of these exogenous sources on cholesterol homeostasis and drug metabolism.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 agent sets
Platform:
GPL339
Series:
GSE6721
12 Samples
Download data: CEL, EXP
20.
Full record GDS3176

pRb p107 double deficient skin

Analysis of skin grafts lacking pRb, p107, or both genes. pRb and p107 belong to the retinoblastoma family important in cell cycle regulation. Results provide insight into the role of p107 in epidermal tumor development when pRb is absent.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 4 genotype/variation sets
Platform:
GPL339
Series:
GSE9567
8 Samples
Download data: CEL
DataSet
Accession:
GDS3176
ID:
3176
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