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Items: 1 to 20 of 581

1.
Full record GDS5455

Ribosomal S6 kinase 2 deficiency effect on TNF-α transgenic model of inflammatory arthritis: fibroblast-like synoviocytes

Analysis of primary fibroblast-like synoviocytes from human tumor necrosis factor-α transgenics (hTNFtg) knocked out for ribosomal S6 kinase (Rsk2). Rsk2 belongs to the p90(RSK) family of serine/threonine kinases. Results provide insight into the role of Rsk2 in TNF-induced synovial hyperplasia.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE52992
6 Samples
Download data: CEL, CHP
2.
Full record GDS5451

Pregnancy effect on liver of cytochrome P450 2D6 hepatic metabolism model: time course

Analysis of livers of Cytochrome P450 2D6 (CYP2D6)-humanized mice at various gestational stages: pre-pregnancy, 21 days of pregnancy, and 7 days postpartum. Results provide insight into molecular mechanisms underlying increased CYP2D6-mediated drug metabolism during pregnancy.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 development stage sets
Platform:
GPL1261
Series:
GSE50166
6 Samples
Download data: CEL
3.
Full record GDS5460

Survival motor neuron deficiency effect on axonal compartment of cultured motoneurons

Analysis of the axonal compartment of cultured motoneurons depleted for survival motor neuron (Smn). Smn is the protein deficient in spinal muscular atrophy (SMA). Results provide insight into the axonal mRNA content of degenerating motoneurons in vitro.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL1261
Series:
GSE59506
9 Samples
Download data: CEL
4.
Full record GDS5459

Survival motor neuron deficiency effect on somatodendritic compartment of cultured motoneurons

Analysis of the somatodendritic compartment of cultured motoneurons depleted for survival motor neuron (Smn). Smn is the protein deficient in spinal muscular atrophy (SMA). Results provide insight into the somatodendritic mRNA content of degenerating motoneurons in vitro.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL1261
Series:
GSE59506
9 Samples
Download data: CEL
5.
Full record GDS5458

Onecut1 deficiency effect on embryonic E14.5 retina

Analysis of embryonic retinas from onecut1 (OC1) knockouts at E14.5 and from wild type littermates. OC1 is a member of the Onecut family of transcription factors characterized by a cut domain and an atypical homeodomain. Results provide insight into the role of OC1 in the retina.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE57917
6 Samples
Download data: CEL, CHP
6.
Full record GDS5457

Onecut2 deficiency effect on adult retina

Analysis of adult retinas from onecut2 (OC2) knockouts and wild type littermates. OC2 is a member of the Onecut family of transcription factors characterized by a cut domain and an atypical homeodomain. Results provide insight into the role of OC2 in the retina.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE57918
6 Samples
Download data: CEL, CHP
7.
Full record GDS5437

Metastatic breast cancer model: premetastatic lung

Analysis of premetastatic lung from BALB/c mice without any tumors (naïve) and from mice bearing nonmetastatic (67NR) or metastatic (4T1) breast carcinomas. Results provide insight into metastatic tumor-induced molecular changes in premetastatic lungs before the arrival of metastatic tumor cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 disease state sets
Platform:
GPL1261
Series:
GSE62817
14 Samples
Download data: CEL
8.
Full record GDS5433

Articular cartilage zones: 1-week old normal proximal tibia

Analysis of superficial (SZ), intermediate/deep (IDZ), and resting (RZ) zones microdissected from articular cartilage of the proximal tibiae of 1-week old mice. Results provide insight into the spatial regulation of gene expression in articular cartilage.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 tissue sets
Platform:
GPL1261
Series:
GSE51994
14 Samples
Download data: CEL, CHP
9.
Full record GDS5274

Alopecia areata model: skin

Analysis of alopecic skin from C3H/HeJ animals. The C3H/HeJ strain develops spontaneous alopecia areata (AA) with high similarity to human AA. AA is an autoimmune disease resulting from damage of hair follicle by T cells. Results provide insight into molecular mechanisms underlying AA pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL1261
Series:
GSE45513
6 Samples
Download data: CEL
10.
Full record GDS5273

Topical protein tyrosine kinase inhibitor effect on graft model of alopecia areata: time course

Analysis of skin from C3H/HeJ grafted recipients with established alopecia areata (AA) following alopecic graft transplantation that were treated with topical Janus kinase (JAK) inhibitor ruxolitinib or tofacitinib for up to 24 wks. Results provide insight into molecular basis of AA pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 agent, 4 time sets
Platform:
GPL1261
Series:
GSE45514
31 Samples
Download data: CEL
11.
Full record GDS5374

Histone/protein acetyltransferase (HAT) deficiency effect on Foxp3+ T-regulatory cells

Analysis of CD4+CD25+ T regulatory (Treg) cells from C57Bl/6 mice deficient in p300 or CBP (a p300 paralog). p300 and CBP are histone/protein acetyltransferases (HATs). Results provide insight into mechanisms by which HATs affect Treg biology.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL1261
Series:
GSE60318
9 Samples
Download data: CEL
12.
Full record GDS5297

Fezf2 overexpresson effect on cortical neural progenitors in vivo: time course

Analysis of cortical neural progenitor cells overexpressing forebrain expressed zinc finger 2 (Fezf2) for 24 and 48 hours. Fezf2 expression vectors delivered to cells in utero. Results provide insight into the role of Fezf2 in the differentiation of corticospinal motor neurons from progenitors.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 2 time sets
Platform:
GPL1261
Series:
GSE56451
14 Samples
Download data: CEL
13.
Full record GDS5250

Striatal-enriched protein tyrosine phosphatase (STEP) knockout effect on striatum

Analysis of striatum from striatal-enriched protein tyrosine phosphatase (STEP)+/- and -/- littermates. Brain-specific tyrosine phosphatase STEP is associated with de-phosphorylation of several key neuronal signaling proteins. Results provide insight into role of STEP in synaptic plasticity.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 genotype/variation sets
Platform:
GPL1261
Series:
GSE51678
13 Samples
Download data: CEL
DataSet
Accession:
GDS5250
ID:
5250
14.
Full record GDS5020

Nonobese diabetic NOD spleen CD4 T-cells: 4-week old females

Analysis of CD4 T-cells from 4-week old NOD females in the preinsulitis stage of Type 1 diabetes. Control strains NOR (~88% similarity to NOD genome) and C57BL/6 (genetically distant) are both insulitis- and diabetes-free. Results provide insight into molecular basis of CD4 T-cell diabetogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 disease state, 3 strain sets
Platform:
GPL1261
Series:
GSE46600
15 Samples
Download data: CEL
15.
Full record GDS5019

Nonobese diabetic NOD spleen CD4 T-cells: 3-week old females

Analysis of CD4 T-cells from 3-week old NOD females in the preinsulitis stage of Type 1 diabetes. Control strains NOR (~88% similarity to NOD genome) and C57BL/6 (genetically distant) are both insulitis- and diabetes-free. Results provide insight into molecular basis of CD4 T-cell diabetogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 disease state, 3 strain sets
Platform:
GPL1261
Series:
GSE46600
15 Samples
Download data: CEL
16.
Full record GDS5018

Nonobese diabetic NOD spleen CD4 T-cells: 2-week old females

Analysis of CD4 T-cells from 2-week old NOD females in the preinsulitis stage of Type 1 diabetes. Control strains NOR (~88% similarity to NOD genome) and C57BL/6 (genetically distant) are both insulitis- and diabetes-free. Results provide insight into molecular basis of CD4 T-cell diabetogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 disease state, 3 strain sets
Platform:
GPL1261
Series:
GSE46600
14 Samples
Download data: CEL
17.
Full record GDS5396

TGF-beta receptor type 1 gene Alk5 deficiency effect on embryonic tongue bud

Analysis of tongue bud collected from E13.5 embryos with conditional inactivation of Alk5 in cranial neural crest cells (CNCCs). The Alk5 gene encodes TGF-β type 1 receptor. Results provide insight into the role of Alk5-mediated TGF-β signaling in CNCCs on early tongue myogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE52358
8 Samples
Download data: CEL
18.
Full record GDS5315

Linezolid and vancomycin effect on whole blood of methicillin-resistant Staphylococcus aureus (MRSA) sepsis model: time course

Analysis of blood from A/J males injected with S. aureus USA300 then treated intravenously with linezolid (L) or vancomycin (V) for up to 24hr. L and V represent two different classes of antibiotics. Results provide insight into the molecular effects of each antibiotic on the host in MRSA sepsis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 agent, 2 infection, 3 time sets
Platform:
GPL1261
Series:
GSE38531
35 Samples
Download data: CEL
19.
Full record GDS5285

Early B-cell factor 1 depletion effect on mature adipocyte cell line

Analysis of mature 3T3-L1 adipocyte cells depleted for early B-cell factor 1 (EBF1). EBF1 is required in adipogenesis. Results provide insight into the role of EBF1 in mature adipocytes.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 agent, 2 protocol sets
Platform:
GPL1261
Series:
GSE58193
9 Samples
Download data: CEL
20.
Full record GDS5385

Lipopolysaccharide effect on tumor progression locus 2 kinase-deficient macrophages

Analysis of tumor progression locus 2 (Tpl2)-deficient bone marrow derived macrophages (BMDMs) stimulated with lipopolysaccharide (LPS) for 4 hrs. Tpl2 (Map3k8) is a serine/threonine kinase critical in innate immunity. Results provide insight into the role of Tpl2 in BMDMs during acute inflammation.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL1261
Series:
GSE48338
8 Samples
Download data: CEL
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