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Items: 1 to 20 of 2836

1.

Danger signal initiates differentiation of monocytes into osteopontin‑producing macrophages II

(Submitter supplied) Analysis of gene expression of monocytes differentiating into different macrophages and dendritic cells. All cells were activated with lipopolysaccharide after differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
16 Samples
Download data: CSV, TXT
Series
Accession:
GSE180111
ID:
200180111
2.

Danger signal initiates differentiation of monocytes into osteopontin‑producing macrophages

(Submitter supplied) Analysis of gene expression of monocytes differentiating into macrophages in the presence of a danger signal. Kinetic analysis (1 day, 2 days, 4 days, 7 days) and analysis of lipopolysaccharide stimulated 7 day macrophages in comparison to unstimulated 7 day macrophages.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
24 Samples
Download data: TSV, TXT
Series
Accession:
GSE180027
ID:
200180027
3.

Modular transcriptional repertoire analyses identify neutrophil signature as candidate biomarker for lupus nephritis

(Submitter supplied) Gene expression profiling (compared to healthy controls) to identify a biomarker for lupus nephritis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
238 Samples
Download data: TXT
Series
Accession:
GSE72326
ID:
200072326
4.

Novel non-integrating DNA Nano-S/MAR vectors restore gene function in patient-derived pancreatic tumour models II

(Submitter supplied) Non-integrating minimally sized Nano-S/MAR DNA vectors can be used to genetically modify dividing cells in place of integrating vectors such as lentivirus and sleeping beauty. They represent a unique genetic tool, which avoids vector-mediated genetic damage cells and the activation of innate immune responses. Previous work has shown that DNA vectors comprising the mammalian scaffold/matrix attachment region (S/MAR) element can provide persistent mitotic stability over hundreds of cell divisions, resisting epigenetic silencing and thereby allowing sustained transgene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
9 Samples
Download data: TXT
Series
Accession:
GSE142117
ID:
200142117
5.

Novel non-integrating DNA Nano-S/MAR vectors restore gene function in patient-derived pancreatic tumour models I

(Submitter supplied) Non-integrating minimally sized Nano-S/MAR DNA vectors can be used to genetically modify dividing cells in place of integrating vectors such as lentivirus and sleeping beauty. They represent a unique genetic tool, which avoids vector-mediated genetic damage cells and the activation of innate immune responses. Previous work has shown that DNA vectors comprising the mammalian scaffold/matrix attachment region (S/MAR) element can provide persistent mitotic stability over hundreds of cell divisions, resisting epigenetic silencing and thereby allowing sustained transgene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE142115
ID:
200142115
6.

Genome-wide analysis of blood gene expression profile at diagnosis and post treatment in latent TB and active TB subjects

(Submitter supplied) Changes in the blood transcriptome upon treatment were studied in a cohort of 42 latent tuberculosis (TB) subjects and 8 active TB subiects. Samples were collected at diagnosis (prior the start of treatment) and post treatment and gene expression studied with Illumina microarrays. We hypothesize that individuals with latent TB at risk of developing active disease are immunologically closer to those with active TB and will thus display a blood transcriptomic signature similar to active TB subjects upon treatment. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
147 Samples
Download data: IDAT
Series
Accession:
GSE152532
ID:
200152532
7.

Late eating decreases energy expenditure, increases hunger and appetite, and modifies metabolic pathways in adipose tissue

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL20301 GPL10558
24 Samples
Download data: IDAT
Series
Accession:
GSE190168
ID:
200190168
8.

Late eating decreases energy expenditure, increases hunger and appetite, and modifies metabolic pathways in adipose tissue [array]

(Submitter supplied) Late eating has been linked to obesity risk. It is not clear whether this is caused by changes in hunger and appetite, energy expenditure or both, nor what molecular pathways in adipose tissues are involved. We conducted a randomized crossover trial to determine the effects of late vs. early meal schedule on the above measures while rigorously controlling for nutrient intake, fasting duration, light exposure, physical activity and sleep opportunity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: IDAT, TXT
Series
Accession:
GSE190166
ID:
200190166
9.

Transcriptome profiling of HepG2 cells in Cdc20 overexpressed and downregulated condition

(Submitter supplied) Cdc20 acts as a regulatory protein interacting with many other proteins at multiple points in the cell cycle. Here we tried to explore the novel transcription regulatory function of Cdc20 by means of altering Cdc20 level in HepG2 cells. We transiently over expressed Flag tagged Cdc20 (F) and siRNA mediated knocked down Cdc20(S) in HepG2 cell line and performed whole genome microarray analysis using illumina BeadChip Array. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
6 Samples
Download data: TXT
Series
Accession:
GSE99756
ID:
200099756
10.

Analysis of gene expression of hESCs upon genetic modification with EBNA and S/MAR episomal vectors

(Submitter supplied) Analysis of the episomal backbone's influence on gene expression. The first hypothesis tested in the present study is that the episomal EBNA vectors, which rely on the EBNA-1 oncoprotein for episomal maintenance, have a greater influence on the cells' expression profiles than S/MAR vectors. The second hypothesis tested was that when bacterial sequences are removed from the episomal vector backbone, the gene disturbance is minimal.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE142299
ID:
200142299
11.

Nicotinamide promotes human pluripotent stem cells differentiation into cardiomyocytes [2]

(Submitter supplied) Nicotinamide, the amide form of vitamin B3, is essential to maintain the human fetal development. It benefits the ectoderm and endoderm development, but its influence in mesoderm differentiation is elusive. In this study, we reported that nicotinamide regulated the gene expression of cardiovascular system, and it induced functional cardiomyocytes which was independent of canonical WNT signaling. Through a kinase screening, we found that nicotinamide inhibited the activity of P38δ to promote cardiomyocyte differentiation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
4 Samples
Download data: TXT
Series
Accession:
GSE154454
ID:
200154454
12.

Nicotinamide promotes human pluripotent stem cells differentiation into cardiomyocytes [1]

(Submitter supplied) Nicotinamide, the amide form of vitamin B3, is essential to maintain the human fetal development. It benefits the ectoderm and endoderm development, but its influence in mesoderm differentiation is elusive. In this study, we reported that nicotinamide regulated the gene expression of cardiovascular system, and it induced functional cardiomyocytes which was independent of canonical WNT signaling. Through a kinase screening, we found that nicotinamide inhibited the activity of P38δ to promote cardiomyocyte differentiation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
2 Samples
Download data: TXT
Series
Accession:
GSE154453
ID:
200154453
13.

Mitochondrial Plasticity Promotes Resistance to Sorafenib and Vulnerability to STAT3 Inhibition in Human Hepatocellular Carcinoma

(Submitter supplied) Enhanced expression of mitochondrial ribosomal proteins and marked reprogramming of the mitochondrial network are associated with sorafenib resistance in human cell lines and hepatocarcinoma patients, providing novel actionable targets for increasing therapeutic efficacy.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
6 Samples
Download data: TXT
Series
Accession:
GSE189711
ID:
200189711
14.

Transcriptome analysis of naive CD4T cells from Granulomatosis with Polyangiitis(GPA) patients and healthy control (HC)

(Submitter supplied) Analysis of transcriptional profile of GPA and HC naive CD4 T cells to understand intrinsic molecular differences after early TCR activation that may explain different effector T cell genereation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
20 Samples
Download data: TXT
Series
Accession:
GSE184898
ID:
200184898
15.

Nicotinamide promotes human pluripotent stem cells differentiation into cardiomyocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
6 Samples
Download data
Series
Accession:
GSE154455
ID:
200154455
16.

SMAD4 is dispensable for execution of epithelial-mesenchymal transition downstream of SNAIL1 in colorectal cancer cells

(Submitter supplied) Transforming growth factor beta (TGFβ) superfamily signaling is a prime inducer of epithelial-mesenchymal transitions (EMT) that foster cancer cell invasion and metastasis, a major cause of cancer-related deaths. Yet, TGFβ signaling is frequently inactivated in human tumor entities including colorectal cancer (CRC) and pancreatic adenocarcinoma (PAAD) with a high proportion of mutations incapacitating SMAD4, which codes for a transcription factor (TF) central to canonical TGFβ and bone morphogenetic protein (BMP) signaling. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
24 Samples
Download data: IDAT
Series
Accession:
GSE169735
ID:
200169735
17.

Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies unique proteotypes associated with patient outcomes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL10558 GPL14951
110 Samples
Download data
Series
Accession:
GSE166999
ID:
200166999
18.

Integrative analysis of non-small cell lung cancer patient-derived xenografts identifies unique proteotypes associated with patient outcomes [HT12v4]

(Submitter supplied) Non-small cell lung cancer (NSCLC) death rates exceed the next 3 prevalent cancers combined; however, most NSCLC tumors lack actionable mutations. Recent studies of NSCLC and other cancers revealed profound proteome remodelling with prognostic impact that is not fully predicted by DNA or RNA analyses. These revelations portend proteome-based cancer classification and treatment. This will require model systems that recapitulate tumor proteomes and phenotypes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
10 Samples
Download data: TXT
Series
Accession:
GSE166997
ID:
200166997
19.

Genome-wide analysis of human bone marrow-derived MSC cells in comparision with MSC with EGR1 knockdown or EGR1 overexpressing cells

(Submitter supplied) Analyze and compare the gene expression profile of human bone marrow derived-MSC in comparison with EGR1 knockdown or EGR1 overexpressing cells. The hypothesis was some genes were differentially expressed in these cell populations. Results provided important information regarding the gene expression difference by EGR1.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
20 Samples
Download data: TXT
Series
Accession:
GSE122831
ID:
200122831
20.

Transcriptional impacts of lipids on hESC

(Submitter supplied) Pluripotent stem cells can be maintained in a continuum of cellular states with distinct features. Exogenous lipid supplements are commonly utilized to shift the balance of global metabolism relieving the dependence on de novo lipogenesis. However, it is largely unexplored how specific lipid components regulate metabolism and pluripotency state. In this study, we investigate the impact of lipid supplements on human embryonic stem cells (hESCs), and report that signaling lipid lysophosphatidic acid (LPA) is the key component to shift the metabolic landscape in lipid supplement AlbuMAX. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
7 Samples
Download data: TXT
Series
Accession:
GSE165892
ID:
200165892
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