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Items: 1 to 20 of 4430

1.

Hepatocyte-specific YAP is crucial for CAR-driven hepatocyte proliferation, but not for induction of drug metabolism genes in mice

(Submitter supplied) Constitutive androstane receptor (CAR) agonists, such as TCPOBOP, are known to cause robust hepatocyte proliferation and hepatomegaly in mice along with induction of drug metabolism genes, without any associated liver injury. Yes-associated protein (YAP) is a key transcription regulator that tightly controls organ size including that of liver. Ours and other previous studies suggested increased nuclear localization and activation of YAP after TCPOBOP treatment in mice and potential role of YAP in CAR-driven proliferative response. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE148607
ID:
200148607
2.

Cobalt Induced Oxidative Stress Contributes to Alveolar/Bronchiolar Carcinogenesis in B6C3F1/N Mice

(Submitter supplied) To identify differentially expressed transcripts between control samples and spontaneous tumors, or control samples and cobalt treated tumors, we collected RNA from male and female B6C3F1 mice from a 2-year inhalation NTP bioassay exposed to 0 or 5 mg/m3 cobalt metal dust. These samples were interrogated with the Affymetrix Mouse Genome 430 2.0 GeneChip Array. A total of 11557 gene transcripts were differentially expressed between control samples and spontaneous tumors, and 12420 gene transcripts were differentially expressed between control samples and treated cobalt tumors (false discovery rate (FDR) < 0.05).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
18 Samples
Download data: CEL
Series
Accession:
GSE152630
ID:
200152630
3.

Expression data from distal colorectal tissues of Pdgfc+/+ and Pdgfc-/- mice with or without irradiation

(Submitter supplied) Radiation therapy for malignancies in the pelvic region leads to a crucial complication called radiation proctopathy(RP) with acute changes in bowel habits or long-term morbidity. We used microarrays to detail the genome-wide profiles of mice with different genotypes (Pdgfc+/+ and Pdgfc-/- ) under irradiation treatment or not.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
10 Samples
Download data: CEL
Series
Accession:
GSE145131
ID:
200145131
4.

Analysis of mouse central bone marrow versus endosteal transcriptome to define the hematopoietic stem cell niche at the endosteum

(Submitter supplied) Stem cell function is regulated by specialized microenvironments called stem cell niches. These niches maintain stem cells in a dormant state and promote self-renewal. The most potent hematopoietic stem cells (HSC) with high self-renewal potential are reportedly enriched in the endosteal compared to the central region of the bone marrow. Therefore we analyzed the global transcriptome of the endosteal region and directly compared it to that of the central bone marrow (BM). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE25078
ID:
200025078
5.

mRNA expression data of a mouse T-lymphoma cell line WR19L

(Submitter supplied) Impacts of a point mutation identified in a patient exhibiting developmental and neurological disorders on a phospholipid flippase, ATP11A. We used microarrays to comprehensively investigate gene expressions which was affected by the mutant ATP11A found in the patient.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE181171
ID:
200181171
6.

Metabolic modulation by PD-1 signaling promotes long-lived quiescent CD8 T cell memory in mice

(Submitter supplied) Inhibitory signaling in dysfunctional CD8 T cells through the programmed cell death 1 (PD-1) axis is well established in chronic viral infections and cancers. PD-1 is also transiently induced to high concentrations during priming of acute infections and immunizations, yet its impact on the development of long-lived antigen-independent T cell memory remains unclear. In addition to its expected role in restraining clonal effector expansion, here we show that PD-1 expression on antigen-specific CD8 T cells is required for the development of a durable CD8 T cell memory pool after antigen clearance. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE181068
ID:
200181068
7.

Gene expression data from murine cutaneous squamous cell carcinoma genomes induced by Sleeping Beauty transposon mutagenesis

(Submitter supplied) Transcriptome analysis of mRNA samples from a cohort of mice with histopathologically diagnosed cutaneous squamous cell carcinoma.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
21 Samples
Download data: CEL
Series
Accession:
GSE141167
ID:
200141167
8.

Expression data from mouse endothelial cell in human ovarian cancer

(Submitter supplied) To examine potential mechanisms underlying resistance to anti-VEGF antibody (AVA) therapy, we used mouse models to identify tumors that demonstrated growth subsequent to a period of initial response. Specifically, we established orthotopic mouse models of ovarian cancer designed to develop adaptive resistance after treatment with an AVA. To examine potential mechanisms underlying resistance to anti-VEGF antibody (AVA) therapy, we used mouse models to identify tumors that demonstrated growth subsequent to a period of initial response. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
13 Samples
Download data: CEL
Series
Accession:
GSE180687
ID:
200180687
9.

Identification of the likely pathways downstream of Pdia4 in cancer stromal cells

(Submitter supplied) 14151 genes whose signal intensity > 200 1554 genes whose expression ratio (WT/Pdia4-/-) was over 2.4 or below 0.4
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL, TXT, XLS
Series
Accession:
GSE179339
ID:
200179339
10.

Gene expression in the colon tumor of AOM/DSS-treated RBJ-/- mice

(Submitter supplied) The purpose of this study was to determine which genes are differentially regulated by the Ras-related small GTPase RBJ after induction by AOM/DSS treatment in the colon of C57BL/6 mice compared to RBJ+/+ mice. The results demonstrate decreased induction of cell proliferation-associated genes in RBJ-/- mice than in RBJ+/+ mice on day 80 after AOM/DSS treatment. The majority of differentially expressed genes are regulated by MEK/ERK signaling pathway. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, TXT
Series
Accession:
GSE55126
ID:
200055126
11.

Expression data of the livers of male C57Bl6/N mice after partial (two-third) hepatectomy

(Submitter supplied) After surgical removal of approximately two-thirds of liver tissue the liver mass restors within ~2 weeks.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
52 Samples
Download data: CEL
Series
Accession:
GSE167034
ID:
200167034
12.

Expression data of the livers of male C57Bl6/N mice after i.p. injection of CCl4

(Submitter supplied) Intoxication with CCl4 is a frequently used technique to induce liver damage in mice. The compound induces cell death of hepatocytes in the pericentral region of the liver lobule.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
46 Samples
Download data: CEL
Series
Accession:
GSE167033
ID:
200167033
13.

Expression data of the livers of male C57Bl6/N mice after i.p. injection of paracetamol (APAP)

(Submitter supplied) Male C57BL6/N mice were obtained from Janvier Labs (France). Mice were starved overnight before APAP administration and were fed ad libitum afterward. A single dose of 300 mg APAP/kg b.w. was intraperitoneally injected in warm phosphate-buffered saline (PBS; Table 3). The used APAP was obtained from Sigma-Aldrich (A7085-500G, Germany). The mice were sacrificed at 1, 6, and 12 hours, and on days 1, 2, 4, 6, and 8 after APAP administration. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
49 Samples
Download data: CEL
Series
Accession:
GSE167032
ID:
200167032
14.

Mouse models of acute and chronic liver damage

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL17021 GPL1261 GPL16570
220 Samples
Download data: CEL
Series
Accession:
GSE166868
ID:
200166868
15.

Expression data of the livers of male C57Bl6/N mice after i.p. injection of lipopolysaccharide (LPS)

(Submitter supplied) Lipopolysaccharides (LPS) are found in the outer membrane of Gram-negative bacteria. The intraperitoneal (i.p.) application of LPS into mice represents a frequently applied experimental model to induce hepatic and systemic inflammation.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE166488
ID:
200166488
16.

Enzymatically-hydrolysed eggshell membrane (eESM) in Human keratinocyte - Eggshell membrane powder (pESM)-supplemented IL-10 KO mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL1261 GPL23159
5 Samples
Download data: CEL
Series
Accession:
GSE178597
ID:
200178597
17.

Expression data from eggshell membrane powder (pESM)-supplemented IL-10 KO mice

(Submitter supplied) Skin aging is one of the hallmarks of the aging process that causes physiological and morpho-logical changes. Recently, several nutritional studies were conducted to delay or suppress the aging process. This study investigated whether nutritional supplementation of the eggshell membrane (ESM) has a beneficial effect on maintaining skin health and improving the skin aging process in interleukin-10 knockout (IL-10 KO) mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
3 Samples
Download data: CEL
Series
Accession:
GSE178595
ID:
200178595
18.

Expression data from freshly isolated murine muscle satellite cells

(Submitter supplied) Calcitonin receptor (CalcR) signaling is essential pathway for maintaining quiescence in muscle stem cells (Stem Cells. 2007 Oct;25(10):2448-59, Cell Rep. 2015 Oct 13;13(2):302-14). Collagen V functions as a surrogate ligand for CalcR, and Protein kinase A (PKA)-mediated Yap1 suppression serve as the downstream of CalcR in quiescent muscle stem cells (Nature. 2018 May;557(7707):714-718, Cell Rep. 2019 Nov 19;29(8):2154-2163.e5.). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE154082
ID:
200154082
19.

Opposing tumor promoting and suppressive functions of Rictor/mTORC2 signaling in adult glioma and pediatric SHH medulloblastoma

(Submitter supplied) Most human cancers arise from stem/progenitor cells by sequential accumulation of genetic/epigenetic alterations, while cancer modeling typically requires simultaneous multiple oncogenic events. Here we show that a single p53 mutation, despite causing no defect in mouse brain, promoted neural stem/progenitor cells to spontaneously accumulate oncogenic alterations, including loss of multiple chromosomal (chr) regions syntenic to human chr10 containing Pten, forming malignant gliomas/glioblastomas with PI3K/Akt activation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
52 Samples
Download data: CEL
Series
Accession:
GSE115840
ID:
200115840
20.

Gene expression data from memory Rictor-/- and WT Tfh and Th1 cells in LCMV acute infection

(Submitter supplied) Microarray experiments were performed to demonstrate the transcriptome changes due to Rictor deficiency in memory follicular T helper (Tfh) and Type 1 T helper (Th1) cells. These data revealed that the immunological memory formation and persistance associated genes are changed in Rictor-null memory Tfh and Th1 cells, indicating that Rictor is essential for memory CD4 T cell pool.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE151800
ID:
200151800
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