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Items: 1 to 20 of 4505

1.

mRNA expression data from livers of wild-type (WT) mice, mice that lack ribosomal protein S6 (Rps6) (DS6), mice that overexpress c-Myc (Myc) and livers that lack Rps6 and also overexpress c-Myc (DS6 Myc)

(Submitter supplied) Targeted depletion of ribosomal protein S6 (Rps6) from hepatoblasts of the developing liver results in neonatal sub-lethal hepatic failure due to inhibition of bile duct development and widespread induction of hepatocyte death triggering regeneration. Overexpression of c-Myc is hepatoprotective in the context of Rps6-deficiency and eliminates the need for DS6 livers to regenerate by preventing hepatocyte death. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE212363
ID:
200212363
2.

Expression data for mouse skin-in atopy DNCB model

(Submitter supplied) Atopic dermatitis (AD) is the most common chronic inflammatory skin disorder, characterized by intense itch and recurrent eczematous lesions. Due to lack of proper therapy, the strategies of T cell modulators in combination with targeting keratinocytes and/or myeloid cells might hold promise for achieving disease control in AD patients better than T cell modulators alone. we used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during HY209 treatment in mouse skin
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE195596
ID:
200195596
3.

Alterations in MAPK Signaling in Alveolar Bronchiolar Carcinomas From B6C3F1/N Mice Exposed to Antimony Trioxide by Inhalation for 2 Years

(Submitter supplied) To identify transcripts differentially expressed between control samples and spontaneous tumors, or control samples and antimony treated lung tumors, we collected RNA from male and female B6C3F1 mice from a 2-year inhalation NTP bioassay exposed to 0 to 30 mg/m3 antimony trioxide. These samples were interrogated with the Affymetrix Mouse Genome 430 2.0 GeneChip Array. A total of 9941 gene transcripts were differentially expressed between control samples and spontaneous tumors, and 12441 gene transcripts were differentially expressed between control samples and treated antimony tumors (false discovery rate (FDR) < 0.05).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
18 Samples
Download data: CEL
Series
Accession:
GSE152629
ID:
200152629
4.

Expression data from nDKO and nTKO Tumor cells

(Submitter supplied) To investigate how Pygo2 regulate the downstream moleculars in vivo to affct the progression of prostate tumor using prostate specific GEMM model We used microarrays to find out the differetial expression gene between nDKO and nTKO to study the molecular mechanism of Pygo2 in prostate cancer progression
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
5 Samples
Download data: CEL
Series
Accession:
GSE195948
ID:
200195948
5.

Comprehensive expression analysis with cell-type-specific transcriptome in ALS-linked mutant SOD1 mice

(Submitter supplied) Non-cell autonomous mechanisms are involved in the pathogenesis of amyotrophic lateral sclerosis (ALS), an adult neurodegenerative disease characterized by selective motor neuron loss. While the emerging role of glial cells in ALS has been noted, the detailed cell-type-specific role of glial cells has not been clarified. Here, we examined mRNA expression changes using microarrays of the spinal cords of three distinct lines of mutant superoxide dismutase (SOD) 1 transgenic mice, an established ALS model. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, XLSX
Series
Accession:
GSE220705
ID:
200220705
6.

Expression data from mouse heart three days after myocardial infarction

(Submitter supplied) Identification of the genes whose expresion levels are changed by the operation of myocardial infarction in C57BL/6J mice
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
2 Samples
Download data: CEL
Series
Accession:
GSE158157
ID:
200158157
7.

Expression data from Tead1 beta cell KO

(Submitter supplied) Tead1 is a transcription factor downstream of the hippo pathway. Gene expression is compared between whole islets from beta cell specific tead1 KO (using Rip-Cre) and Floxed control islets
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE139228
ID:
200139228
8.

Gene expression microarray analysis on the dentate gyrus of forebrain-specific calcineurin knockout mice and control mice

(Submitter supplied) The gene expression patterns in the dentate gyrus of forebrain-specific calcineurin knockout mice and control mice were examined using Affymetrix GeneChip arrays.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE175896
ID:
200175896
9.

Single cell expression data from ICM cells of mouse blastocysts

(Submitter supplied) Transcriptional reactivation of the paternal X chromosome occurs in specific cells of the mouse blastocyst between E(mbryonic day)3.5 and E4.5 during pre- to peri-implantation development. While the trophectoderm (TE) and the primitive endoderm (PE) maintain Xist RNA expression and thereby imprinted silencing of genes on the Xp, the epiblast (EPI) cells within the inner cell mass (ICM) gradually downregulate Xist and undergo XCR. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
14 Samples
Download data: CEL, XLSX
Series
Accession:
GSE208430
ID:
200208430
10.

Integrated Expression Profiling of MicroRNAs and Messenger RNAs in the Developing Neural Tube

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
synthetic construct; Mus musculus
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL1261 GPL14613
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE140777
ID:
200140777
11.

Expression data (messenger RNA) from developing Neural Tubes of mouse embryos

(Submitter supplied) Morphogenesis of the mammalian neural tube (NT) is reliant on precise, spatio-temporal expression of numerous genes and coordinated interaction of signal transduction and gene regulatory networks, disruption of which may contribute to the etiology of neural tube defects (NTDs). MicroRNAs (miRNAs) as well as their downstream messenger RNA (mRNA) targets are key modulators of cell and tissue differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE140775
ID:
200140775
12.

Expression data from subcutaneous PDAC xenograft tumor tissue of lactation mice and ctrl mice.

(Submitter supplied) Progestin secretion increases remarkably during pregnancy and lactation. To explore how prolactin affect tumor growth, we used microarray to detailed the different expressed genes between lactation mice and ctrl mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE217408
ID:
200217408
13.

Expression data from mouse bone marrow derived macrophages

(Submitter supplied) To understand the effect of LPS on macrophages, macrophages were stimulated with LPS and the gene expressions were analyzed by microarray.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
2 Samples
Download data: CEL, CHP
Series
Accession:
GSE167853
ID:
200167853
14.

The Nup98::Nsd1 fusion gene induces CD123 expression in 32D cells

(Submitter supplied) The NUP98::NSD1 fusion gene is associated with extremely poor prognosis in patients with acute myeloid leukemia (AML). NUP98::NSD1 induces self-renewal and blocks differentiation of hematopoietic stem cells, leading to leukemia development. Despite its association with poor prognosis, targeted therapy for NUP98::NSD1-positive AML is lacking, as the details of NUP98::NSD1 function are unknown. Here, we generated 32D cells (a murine interleukin-3 (IL-3)-dependent myeloid progenitor cell line) expressing mouse Nup98::Nsd1 to explore the function of NUP98::NSD1 in AML, including by comprehensive gene expression analysis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE216409
ID:
200216409
15.

Expression data from intestinal epithelial cells of hindlimb unloading (HU) and control mice

(Submitter supplied) Commensal bacteria can manipulate the proliferation, differentiation, and survival of intestinal epithelial cells. Hindlimb unloading alters the composition and structure of the microbial community. To further characterize the epithelial changes, we performed a genome-wide microarray analysis of colon epithelium isolated from HU and control mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE89277
ID:
200089277
16.

Transcriptome analysis of Tregs (CD4+Foxp3+) and Tcons (CD4+Foxp3-) from spleen and CNS of naïve mice and at the peak of EAE

(Submitter supplied) Tregs and Tcons were isolated by flow cytometry from the spleen of naïve mice and from the spleen and central nervous system (brain + spinal cord) (CNS) of mice at the peak of experimental autoimmune encephalomyelitis (EAE) induced by immunization with MOG(35-55). Samples at EAE peak were collected at day 16-18 after immunization. Purity was >99.5%. Foxp3.eGFP mice (provided by A. Rudensky) were used to identify Tregs. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
20 Samples
Download data: CEL
Series
Accession:
GSE164460
ID:
200164460
17.

Sexually Dimorphic Estrogen Sensing in Skeletal Stem Cells Controls Skeletal Regeneration

(Submitter supplied) Sexually dimorphic tissues are formed by cells that are regulated by sex hormones. While a number of systemic hormones and transcription factors are known to regulate proliferation and differentiation of osteoblasts and osteoclasts, the mechanisms that determine sexually dimorphic differences in bone regeneration are unclear. To explore how sex hormones regulate bone regeneration, we compared bone fracture repair between adult male and female mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
17 Samples
Download data: CEL
Series
Accession:
GSE213574
ID:
200213574
18.

Transcriptome of EpoR-/- CFU-E cells

(Submitter supplied) During erythropoiesis, erythroid progenitor cells proliferate in response to erythropoietin (Epo) and progressively differentiate, which encompasses an increasing accumulation of iron-bound hemoglobin. The impact of Epo on these dynamic processes remained to be resolved. By combining the development of a time-collapsed super SILAC method with transcriptome analysis we examined Epo-induced alterations in the proteome of erythroid progenitor cells at the colony-forming unit erythroid stage (CFU E). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
2 Samples
Download data: CEL
Series
Accession:
GSE108696
ID:
200108696
19.

Expression data from PD-1+/- Th cells

(Submitter supplied) PD-1+/- Th cells were sorted by flow cytometry C57BL/6 mice were infected with P. yoelii. The differentially expressed genes of PD-1+/- Th cells from the spleen of the infected mice were acquired by microarray
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
2 Samples
Download data: CEL
Series
Accession:
GSE199687
ID:
200199687
20.

Endothelial Rbpj is essential for the education of tumor-associated macrophages

(Submitter supplied) Epithelial ovarian cancer (EOC) is one of the most lethal gynecological cancers worldwide. EOC cells educate tumor-associated macrophages (TAMs) through CD44-mediated cholesterol depletion to generate an immunosuppressive tumor microenvironment (TME). In addition, tumor cells frequently activate Notch1 receptors on endothelial cells (ECs) to facilitate metastasis. However, little is known whether the endothelium would also influence the education of recruited monocytes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
16 Samples
Download data: CEL
Series
Accession:
GSE213371
ID:
200213371
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