GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

16 Samples

Download data: CEL

(Submitter supplied) In the animal study, both a decrease of serum alanine aminotransferase level and whole blood gene expression changes were observed in rats fed a MLP-containing high-fat diet compared with rats fed a high-fat diet.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

8 Samples

Download data: CEL

(Submitter supplied) In the animal study, both a decrease of serum alanine aminotransferase level and whole blood gene expression changes were observed in rats fed a MLP-containing high-fat diet compared with rats fed a high-fat diet.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

8 Samples

Download data: CEL

(Submitter supplied) Malignant mesothelioma is an aggressive cancer that often originates in the pleural and peritoneal mesothelium. Exposure to asbestos is a frequent cause. But studies in rodents showed that certain multiwalled carbon nanotubes (MWCNTs) can induce malignant mesotheliomas. This study aimed to understand molecular pathways leading to the development of malignant mesotheliomas induced by MWCNTs and amosite asbestos in Wistar rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

14 Samples

Download data: CEL, CHP

(Submitter supplied) Oxidative stress (OS), inflammation, and endoplasmic reticulum (ER) stress sequentially occur in the rat model of hyperoxia (HOX) induced bronchopulmonary dysplasia (BPD), and they all increase DNA damage. Tumor suppressors increase after DNA damage, followed by apoptosis or cellular senescence when the damage becomes irreparable. Although cellular senescence contributes to wound healing, its persistence will inhibit growth potential. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

11 Samples

Download data: CEL

(Submitter supplied) Compromised maternal health and specifically, the occurrence of maternal seizures can have adverse effects on the healthy development of offspring possibly via hypoxia-ischemia, disrupted programmed cell death, or GABA signaling. The current study examined cortical tissue from F2b postnatal day 4 offspring of female Harlan SD rats following a two-generation reproductive and continuous breeding (RACB) study design with daily oral exposure to the seizure genic compound 4-Methylimidazole (0, 750, or 2500 ppm 4-MeI). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

9 Samples

Download data: CEL

(Submitter supplied) Early in fetal development, maternal nutritional environments are expected to induce changes in epigenetic regulation in offspring.In the present study, we integrated methylome and transcriptome data to identify potential salt-sensitive hypertension genes using the kidneys of pups exposed to a low-protein diet throughout their fetal life. We aimed to uncover how specific candidate marker genes are modified over time and under different nutritional interventions at an early age. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

30 Samples

Download data: CEL, XLS

(Submitter supplied) Using DNA microarray analysis, vasopressin, cocaine-amphetamine regulated transcript prepropeptide, corticotropin releasing hormone, and thyrotropin releasing hormone, all of which are involved in the sympathetic activation of heart rate, were found to be down-regulated in the chow diet group. Our results provided the molecular and physiological bases for understanding the autonomic nervous regulation of cardiovascular function by the mastication stimuli.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

10 Samples

Download data: CEL

(Submitter supplied) Recent studies have shown that the sensitized and excited nerves innervating the tumor establish intimate communications with cancer cells by releasing various tumor-stimulating factors for tumor progression. To understand the mechanism by which interactions of cancer cells and SNs regulate tumor growth in bone, we aimed to identify molecules released from DRGs in communication with cancer cells.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

2 Samples

Download data: CEL, CHP

(Submitter supplied) In the present study, we designed a 7-week rat model, consuming high-fat diet or heat-misture-treated high fat diet. The liver was used for microarray analyses. Transcriptome profiling reveal that high-fat diet with or with out heat-moisture treatment induced different transcriptome changes, mainly on lipid metabolism and inflammation.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, DOCX, XLSX

(Submitter supplied) In the present study, we designed a 1-month protein restriction model using post-weaning rats, followed by a 2-month rebound feeding, to investigate how early life protein restriction affects overall body growth and muscle development, and whether these influences could be corrected by the following rebound feeding. Transcriptome profiling reveal that myogenic differentiation functions are upregulated while protein catabolism are downregulated as compensatory toward protein restriction, while endo-plasmic reticulum stress are enhanced, inducing undesired apoptosis.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

15 Samples

Download data: CEL

(Submitter supplied) Type 1 diabetes (T1D) is an autoimmune disease characterized by destruction of the pancreatic β-cells. T1D pathogenesis has a strong genetic basis. However, in recent decades, the prevalence of high-risk HLA haplotypes among new diagnoses has declined, the age of onset has decreased, and T1D incidence has increased. These changes are consistent with increased environmental pressure and coincide with introduction of the Western diet, widespread antibiotic use and reduced breast feeding. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

15 Samples

Download data: CEL

(Submitter supplied) The mastication stimuli during the weaning period can enhance the learning ability of rats by increasing the dendrite branches of hippocampal CA1 neurons and by regulating genes related to dendrite growth. Using DNA microarray analysis, differentially expressed genes were enriched in functional terms related to dendrite growth and included the Igf2, RhoA, and Rho GEF genes, most of which were upregulated in the chow diet group.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

10 Samples

Download data: CEL

(Submitter supplied) Myeloperoxidase (MPO), oxidative stress (OS), and endoplasmic reticulum (ER) stress are all increased in the lungs of neonatal rat pups raised in hyperoxia (HOX, >90% O2), an established model of bronchopulmonary dysplasia (BPD). However, the relationship between OS, MPO, and ER stress has not been examined in HOX rat pups. To determine the relationship between OS, MPO, and ER stress in BPD we treated Sprague-Dawley neonatal rat pups with Tunicamycin (Tun) or with HOX. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL

(Submitter supplied) Tricresyl Phosphate (TCP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for TCP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

20 Samples

Download data: CEL

(Submitter supplied) Isopropylated Phenol Phosphate (IPP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for IPP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

17 Samples

Download data: CEL

(Submitter supplied) Isodecyl Diphenyl Phosphate (IDDP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for IDDP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

20 Samples

Download data: CEL

(Submitter supplied) 2-Ethylhexyl Diphenyl Phosphate (EHDP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for EHDP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

21 Samples

Download data: CEL

(Submitter supplied) tert-Butylphenyl Diphenyl Phosphate (BPDP) is an organophosphate flame retardant currently on the market and used as a replacement for phased-out polybrominated diphenyl ethers. Toxicity information on this class of chemicals is inadequate. Herein, the NTP use short-term, in vivo transcriptomic studies to inform potential points of departure for BPDP.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

21 Samples

Download data: CEL

(Submitter supplied) 2-Hydroxy-4-methoxybenzophenone (HMB) is an approved Food and Drug Administration (FDA) over-the-counter Category I product considered to be a deterrent to ultraviolet (UV) radiation-induced skin cancer. HMB is used in pharmaceuticals, plastic products, fabric coatings, finishes, and cosmetics. Exposure to HMB occurs through both occupational and consumer routes. HMB is used in skin moisturizing products and sunscreen lotions. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

10 Samples

Download data: CEL