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Items: 1 to 20 of 195

1.

Expression data from ethanol extract of Aurantiochytrium Sp. (EEA)-treated human amnion epithelial cells (hAECs)

(Submitter supplied) Gene expression profiling reveals a potential role of EEA in neural induction and neuronal differentiation of hAECs. hAECs were isolated from discarded term placenta and were treated with EEA at the concentration of 20 µg/ml for seven days. Microarray gene expression profiling was conducted for three biological replicates of EEA-treated and untreated control cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
6 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE188411
ID:
200188411
2.

Transcriptomic Analysis of Wound Healing and Skin Rejuvenation Following Ablative Fractional Laser Treatment of Human Skin

(Submitter supplied) Ablative fractional laser treatment is considered the gold standard for skin rejuvenation. In order to understand how fractional laser works to rejuvenate skin, we performed microarray profiling on skin biopsies to identify temporal and dose-response changes in gene expression following fractional laser treatment.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
140 Samples
Download data: CEL
Series
Accession:
GSE168760
ID:
200168760
3.

Expression data from Luteolin-treated human Neural Stem Cells (hNSCs)

(Submitter supplied) Gene expression profiling reveals a potential role of Luteolin in human neuronal stem cells (hNSCs) differentiation . hNSCs purchased from Gibco were treated with 1 μM verbenalin for 24 hours. Microarray gene expression profiling was conducted for biological replicates of hNSCs cultured in differentiation cell culture medium supplemented with Luteolin for 24 hours and untreated control cells cultured in differentiation cell cultured medium .
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE148160
ID:
200148160
4.

Expression data from glioma stem cells (GSC), comparing the WT cells to those after ALDH1A3-KO

(Submitter supplied) Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many solid tumors as ALDHs potentially regulate cell proliferation and chemoresistance of cancer stem cells (CSCs). ALDH1A3 is the dominant isomer of the ALDH gene family in Mesenchymal subtype of GSC cells and is highly upregulated compared to other subtype of GSCs. ALDH1A3 is an important enzyme in the synthesis of Retinoic Acid, which regulates various downstream pathways and the transcription of numerous genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
9 Samples
Download data: CEL
Series
Accession:
GSE185463
ID:
200185463
5.

Newborn infant skin gene expression: Remarkable differences versus adults

(Submitter supplied) At birth, human infants are poised to survive in harsh, hostile conditions. An understanding of the state of newborn skin development and maturation is key to the maintenance of health, optimum response to injury, healing and disease. The observational study collected full-thickness newborn skin samples from 27 infants at surgery and compared them to skin samples from 43 adult sites protected from ultraviolet radiation exposure, as the standard for stable, mature skin. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
70 Samples
Download data: CEL, CHP
Series
Accession:
GSE181022
ID:
200181022
6.

Molecular characterization of chronic liver disease dynamics: from liver fibrosis to acute-on-chronic liver failure

(Submitter supplied) BACKGROUND: The molecular mechanisms driving the progression from early chronic liver disease (eCLD) to cirrhosis and, finally, acute-on-chronic liver failure (ACLF) are largely unknown. Thus, the aim of this work is to develop a network-based approach to investigate molecular pathways driving progression from eCLD to ACLF. We created 9 liver-specific biological networks capturing key pathophysiological processes potentially related to CLD. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
39 Samples
Download data: CEL
Series
Accession:
GSE139602
ID:
200139602
7.

Transcriptomic comparison of the vitamin A ester retinyl propionate and retinol in human keratinocytes

(Submitter supplied) Retinoids are potent skin care actives used to treat a number of common clinical and cosmetic skin conditions, including skin aging. Here, we compare the effects of retinyl proprionate and retinol on gene expression in immortalized human keratinocytes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
12 Samples
Download data: CEL
Series
Accession:
GSE155789
ID:
200155789
8.

Expression data from JVM13 cells with cyclin D1 exogenous overexpression

(Submitter supplied) Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm characterized by the t(11;14)(q13;q32) translocation leading to cyclin D1 overexpression. Cyclin D1 is a major cell cycle regulator and also has a role in transcription, but the effect of the latter in tumorigenesis remains largely unknown. Here, we investigated the transcriptional role of cyclin D1 in MCL and its impact on the pathogenesis of this neoplasm. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
8 Samples
Download data: CEL
Series
Accession:
GSE144095
ID:
200144095
9.

Microarray analysis of NS-SV-AC cells treated with TNF-a

(Submitter supplied) TNF-a markedly induced the expression of IP-10 in NS-SV-AC cells. We identified TNF-a-induced genes in NS-SV-AC cells using Affymetrix GeneAtlasTM System.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
8 Samples
Download data: CEL
Series
Accession:
GSE69050
ID:
200069050
10.

Molecular characterization of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis

(Submitter supplied) Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We aimed to identify unique molecular traits characterizing NASH-HCC compared to other HCC aetiologies. We collected 80 NASH-HCC and 125 NASH samples from 5 institutions. Expression array (n=53 NASH-HCC; n=74 NASH) and whole exome sequencing (n=50 NASH-HCC) data were compared to HCCs of other aetiologies (n=184). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
170 Samples
Download data: CEL, XLSX
Series
Accession:
GSE164760
ID:
200164760
11.

Expression data from Minoxidil- and TCQA-3D treated HFDPCs

(Submitter supplied) Gene expression profiling reveals a potential higher effect of minoxdil and TCQA in stimulating hair growth in 3D cultered dermal papilla cells. HFDPCs were human primary cells line, treated with 0,1 µM minoxidil and 10 µM TCQA for 48 h. Microarray gene expression profiling was conducted for three biological replicates
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
5 Samples
Download data: CEL, TXT
Series
Accession:
GSE178637
ID:
200178637
12.

Expression data from Minoxidil- and TCQA-2D treated HFDPCs

(Submitter supplied) Gene expression profiling reveals a potential effect of minoxdil and TCQA in stimulating hair growth in 2D cultered dermal papilla cells. HFDPCs were human primary cells line, treated with 0,1 µM minoxidil and 10 µM TCQA for 48 h. Microarray gene expression profiling was conducted for three biological replicates
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
4 Samples
Download data: CEL, TXT
Series
Accession:
GSE178510
ID:
200178510
13.

Gene expression profiling of granulocytes from primary and secondary myelofibrosis

(Submitter supplied) Primary myelofibrosis (PMF) together with polycythemia vera (PV) and essential thrombocythemia (ET) belongs to the classic Philadelphia-negative myeloproliferative neoplasms (MPNs). PV and ET can evolve to secondary myelofibrosis (SMF) giving rise to post-PV (PPV) and post-ET (PET) myelofibrosis (MF). PMF and SMF patients are currently managed in the same way and prediction of survival is based on the same prognostic models, even if it has been demonstrated that they can’t accurately distinguish different risk categories in SMF. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
114 Samples
Download data: CEL
Series
Accession:
GSE159514
ID:
200159514
14.

Bacterial effect on gene expression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL13667 GPL11180
48 Samples
Download data: CEL
Series
Accession:
GSE162253
ID:
200162253
15.

Expression data profile of A498 cells infected with E. coli 536 or PAI I delation mutant

(Submitter supplied) MYC has been named the quintessential oncogene and is deregulated in the majority of human cancers. Still, finding c-MYC inhibitors for therapeutic use has been problematic and MYC itself has long been viewed as “undruggable”. Here we present a novel strategy for achieving c-MYC inhibition, involving specific bacterial effector molecules. We made the surprising observation that uropathogenic E. coli activate c-MYC degradation and attenuate MYC expression in host cells and tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
3 Samples
Download data: CEL
Series
Accession:
GSE162250
ID:
200162250
16.

Healthy, adjacent normal and tumor colon cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Methylation profiling by genome tiling array
Platforms:
GPL13667 GPL13534
486 Samples
Download data: CEL, IDAT
Series
Accession:
GSE166427
ID:
200166427
17.

Macrophage contribution to follicular lymphoma pathogenesis: CSF-1R as a novel prognostic factor and therapeutic target

(Submitter supplied) Follicular lymphoma (FL) patient samples from lymph node biopsies were in co-culture or not with M2 macrophages (generated from healthy donors) for 48h We used microarrays to uncover the mechanisms underlying FL and macrophages crosstalk
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
10 Samples
Download data: CEL
Series
Accession:
GSE147211
ID:
200147211
18.

Expression data from APC 50% or 80% -treated HFDPCs

(Submitter supplied) Gene expression profiling reveals a potential role of APC 50% or APC 80% in stimulating hair growth in dermal papilla cells. HFDPCs were human primary cells line, treated with 5 μg/ml APC 50% for 48 h. Microarray gene expression profiling was conducted for three biological replicates HFDPCs were human primary cells line, treated with 5 μg/ml APC 80% for 48 h. Microarray gene expression profiling was conducted for three biological replicates
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
9 Samples
Download data: CEL, CHP, TXT
Series
Accession:
GSE163091
ID:
200163091
19.

Expression data profile of A498 cells infected with E. coli 83972, mutants or stimualted with rNlpD

(Submitter supplied) Unlike pathogens, which attack the host, commensal bacteria create a state of friendly coexistence. Here, we identify a new mechanism of bacterial adaptation to the host niche, where they reside. Asymptomatic carrier strains are shown to inhibit RNA Polymerase II (Pol II) in host cells by targeting Ser2 phosphorylation; a step required for productive mRNA elongation. Assisted by a rare, spontaneous loss-of-function mutant from a human carrier, the bacterial NlpD protein is identified as a Pol II inhibitor. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
16 Samples
Download data: CEL
Series
Accession:
GSE162190
ID:
200162190
20.

Disrupted mitochondrial function in aged human dermal fibroblasts

(Submitter supplied) Skin undergoes changes in structure and function with age, including a shift in metabolic programs. This is particularly evident relative to mitochondrial function in skin cells. Dermal fibroblasts have been known to accumulate damage caused by both external and internal stressors, leading to altered bioenergetics that limits efficient synthesis of ATP and NAD+. To better understand the changes in mitochondrial function with age, metabolic profiles and transcriptomic profiles of primary dermal fibroblasts from varying aged donors were analysed.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
10 Samples
Download data: CEL
Series
Accession:
GSE131938
ID:
200131938
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