GEO DataSets

(Submitter supplied) Only a minuscule fraction of long non-coding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but comparative analyses have been precluded by our ignorance of lncRNAs in non-model organisms. Here, we use RNA sequencing to identify lncRNAs in eleven tetrapod species and we present the first large-scale evolutionary study of lncRNA repertoires and expression patterns. more...

Organism:

Gallus gallus; Ornithorhynchus anatinus; Monodelphis domestica; Xenopus tropicalis; Macaca mulatta; Gorilla gorilla; Homo sapiens; Mus musculus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

15 related Platforms

55 Samples

Download data: BEDGRAPH, TXT

(Submitter supplied) MicroRNAs (miRNAs) are major post-transcriptional regulators of gene expression, yet their origins and functional evolution in mammals remain little understood due to the lack of appropriate comparative data. Using RNA sequencing, we have generated extensive and comparable miRNA data for five organs in six species that represent all main mammalian lineages and birds (the evolutionary outgroup), with the aim to unravel the evolution of mammalian miRNAs. more...

Organism:

Macaca mulatta; Homo sapiens; Monodelphis domestica; Gallus gallus; Ornithorhynchus anatinus; Didelphis virginiana; Mus musculus

Type:

Non-coding RNA profiling by high throughput sequencing

7 related Platforms

38 Samples

Download data: TXT

(Submitter supplied) As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore dosage balance between the X and autosomes, and that the resulting X overexpression in females then drove the evolution of X inactivation (XCI). However, this model has never been directly tested and patterns and mechanisms of dosage compensation across different mammals and birds generally remain little understood. more...

Organism:

Ornithorhynchus anatinus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13798

3 Samples

Download data: TXT

(Submitter supplied) Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. more...

Organism:

Gallus gallus; Ornithorhynchus anatinus; Macaca mulatta; Pan paniscus; Pan troglodytes; Pongo pygmaeus; Monodelphis domestica; Gorilla gorilla; Homo sapiens; Mus musculus

Type:

Expression profiling by high throughput sequencing

10 related Platforms

131 Samples

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