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Items: 1 to 20 of 102

1.

Expression data from RAW-264.7 cells transfected with empty vector and mouse FoxQ1 expression construct

(Submitter supplied) Transcription factor FoxQ1 belongs to family of Fox transcription factors containing forkhead box (winged helix) domain. This family of proteins plays an important role in cell growth, proliferation, and differentiation. Expression of FoxQ1 was found in cancer cells and was associated with increased migration and invasion. Recently, elevated FoxQ1 expression was found in IL4 stimulated macrophages. We used microarrays to clarify the role of FoxQ1 in macrophages
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
9 Samples
Download data: CEL
Series
Accession:
GSE79521
ID:
200079521
2.

Expression data from Amacr knock-out mouse liver and intestine

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
32 Samples
Download data: CEL
Series
Accession:
GSE40125
ID:
200040125
3.

Expression data from Amacr knock-out mouse intestine

(Submitter supplied) Bile acids play multiple roles in vertebrate metabolism by facilitating lipid absorption in the intestine and acting as a signaling molecule in lipid and carbohydrate metabolism. Bile acids are also the main route to excrete excess cholesterol out of the body. Alpha-methyl-Coa racemase (Amacr) is one of the enzymes needed to produce bile acids from cholesterol. The mouse model lacking Amacr can produce only minor (less than 10%) amounts of bile acids, but still they are symptomless in normal laboratory conditions.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
24 Samples
Download data: CEL
Series
Accession:
GSE40124
ID:
200040124
4.

Expression data from Amacr knock-out mouse liver

(Submitter supplied) Bile acids play multiple roles in vertebrate metabolism by facilitating lipid absorption in the intestine and acting as a signaling molecule in lipid and carbohydrate metabolism. Bile acids are also the main route to excrete excess cholesterol out of the body. Alpha-methyl-Coa racemase (Amacr) is one of the enzymes needed to produce bile acids from cholesterol. The mouse model lacking Amacr can produce only minor (less than 10%) amounts of bile acids, but still they are symptomless in normal laboratory conditions.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
8 Samples
Download data: CEL
Series
Accession:
GSE40085
ID:
200040085
5.

Fip1 regulates mRNA alternative polyadenylation to promote embryonic stem cell self-renewal and somatic cell reprogramming.

(Submitter supplied) Expression profiling of mESCs after Fip1 depletion, 4 days post-transfection with siRNAs
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
6 Samples
Download data: CEL
Series
Accession:
GSE47907
ID:
200047907
6.

Expression profiles of wildtype and SHOX transgenic embryonic mouse limbs

(Submitter supplied) Deficiency of the human short stature homeobox-containing gene (SHOX) has been identified in several disorders characterized by reduced height and skeletal anomalies such as Turner, Leri-Weill and Langer syndrome as well as idiopathic short stature. Although highly conserved in vertebrates, rodents lack a SHOX orthologue. Here, we compared gene expression profiles of wildtype and SHOX transgenic mouse limbs using microarray experiments to identify SHOX target genes in the developing limb.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
4 Samples
Download data: CEL
Series
Accession:
GSE47902
ID:
200047902
7.

Transcriptional co-factor TBLR1 controls lipid mobilization in white adipose tissue

(Submitter supplied) Lipid mobilization (lipolysis) in white adipose tissue (WAT) critically controls lipid turnover and adiposity in humans. While the acute regulation of lipolysis has been studied in detail, the transcriptional determinants of WAT lipolytic activity remain still largely unexplored. Here we show that the genetic inactivation of transcriptional co-factor transducin beta-like-related (TBLR) 1 blunts the lipolytic response of white adipocytes through the impairment of cAMP-dependent signal transduction. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
12 Samples
Download data: CEL
Series
Accession:
GSE43658
ID:
200043658
8.

Drug-induced hepatotoxicity screening in primary mouse hepatocytes, an Omics approach.

(Submitter supplied) Drug-induced hepatotoxicity is a leading cause of attrition of candidate drugs in drug development. Therefore new screening methods are necessary which predict these hazards more accurate and earlier in the drug development process. Of all in vitro hepatotoxicity models, primary human hepatocytes are considered as 'the gold standard'. However, the use of these hepatocytes is hindered by their scarcity and major inter-individual variation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
6 Samples
Download data: CEL
Series
Accession:
GSE33742
ID:
200033742
9.

In vivo and in vitro investigations of heterozygous nebulin knock-out mice reveal similarities with mild human form of nemaline myopathy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
synthetic construct; Mus musculus
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platforms:
GPL8786 GPL14661
12 Samples
Download data: CEL
Series
Accession:
GSE36745
ID:
200036745
10.

In vivo and in vitro investigations of heterozygous nebulin knock-out mice reveal similarities with mild human form of nemaline myopathy [mRNA]

(Submitter supplied) In the present study, we used a multimodal approach including protein and gene expression analysis and combined in vivo and in vitro measurements of force production. Overall, we aimed at investigating the functional impact of the expression of a single nebulin allele.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
6 Samples
Download data: CEL
Series
Accession:
GSE36743
ID:
200036743
11.

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity [expression profiling]

(Submitter supplied) The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which they further oxidize into 5-formylcytosine and 5-carboxylcytosine. Tet1 is robustly expressed in mouse embryonic stem cells (mESCs) and has been implicated in mESC maintenance. Here we demonstrate that, unlike genetic deletion, RNAi-mediated depletion of Tet1 in mESCs led to a significant reduction in 5hmC and loss of mESC identity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
8 Samples
Download data: CEL
Series
Accession:
GSE34886
ID:
200034886
12.

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Methylation profiling by high throughput sequencing
Platforms:
GPL14661 GPL9250
12 Samples
Download data: BED, CEL, WIG
Series
Accession:
GSE34267
ID:
200034267
13.

Sarcolipin is a potential biomarker for dystrophy and is involved in inflammatory processes in skeletal muscles

(Submitter supplied) Myopathies and muscular dystrophies are devastating diseases sharing characteristic symp-toms. Little is known about common aetiopathology and biomarkers are rare. We studied skeletal muscle gene expression in mouse models of myopathies. As dystrophic processes in muscles are characterised by inflammatory processes, we expanded our analy-sis on a rat model of sepsis. We find 25 commonly dysregulated genes. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL14661
4 Samples
Download data: CEL
Series
Accession:
GSE33157
ID:
200033157
14.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4423 Series
40 Related Platforms
57646 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
15.

[Mouse430_2_Mm_EntrezG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 13]

(Submitter supplied) This is identical to GPL1261 but a custom CDF environment was used to extract data [Brainarray Version 13, Mouse4302_Mm_ENTREZG]. CDF and other files can be downloaded at: (see web link below).
Organism:
Mus musculus
13 Series
1 Related Platform
87 Samples
Download data
Platform
Accession:
GPL14661
ID:
100014661
16.

RAW-264.7 FoxQ1, clone 7.5

Organism:
Mus musculus
Source name:
RAW-264.7 macrophage/monocyte cell line
Platform:
GPL14661
Series:
GSE79521
Download data: CEL
Sample
Accession:
GSM2096890
ID:
302096890
17.

RAW-264.7 FoxQ1, clone 7.4

Organism:
Mus musculus
Source name:
RAW-264.7 macrophage/monocyte cell line
Platform:
GPL14661
Series:
GSE79521
Download data: CEL
Sample
Accession:
GSM2096889
ID:
302096889
18.

RAW-264.7 FoxQ1, clone 7.3

Organism:
Mus musculus
Source name:
RAW-264.7 macrophage/monocyte cell line
Platform:
GPL14661
Series:
GSE79521
Download data: CEL
Sample
Accession:
GSM2096888
ID:
302096888
19.

RAW-264.7 FoxQ1, clone 7.2

Organism:
Mus musculus
Source name:
RAW-264.7 macrophage/monocyte cell line
Platform:
GPL14661
Series:
GSE79521
Download data: CEL
Sample
Accession:
GSM2096887
ID:
302096887
20.

RAW-264.7 FoxQ1, clone 7.1

Organism:
Mus musculus
Source name:
RAW-264.7 macrophage/monocyte cell line
Platform:
GPL14661
Series:
GSE79521
Download data: CEL
Sample
Accession:
GSM2096886
ID:
302096886
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