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Items: 1 to 20 of 77

1.

PRKCI promotes immune suppression in ovarian cancer through YAP1

(Submitter supplied) A key feature of high-grade serous ovarian carcinoma (HGSOC) is frequent amplification of the 3q26 locus harboring PRKC-iota (PRKCI). Here, we show that PRKCI is also expressed in early fallopian tube lesions, called Serous Tubal Intraepithelial Carcinoma. Transgenic mouse studies establish PRKCI as an ovarian cancer specific oncogene and system level and functional analyses identify YAP1 as a downstream effector in tumor progression. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16368
8 Samples
Download data: CEL
Series
Accession:
GSE82319
ID:
200082319
2.

Expression data from neuroblastoma of TH-MYCN/KI RetM919T mice

(Submitter supplied) The RET gene has been identified previously as a target of activated ALK at the mRNA level in both human neuroblastoma cell lines and primary tumors as well as in murine tumors driven by mutated Alk and MYCN. Moreover, it has been shown that tumor growth of murine TH-MYCN/KI Alkmut tumors was impaired upon Ret inhibition by the vandetanib inhibitor, suggesting RET as a therapeutic target in ALK mutated neuroblastoma. more...
Organism:
Mus musculus
Type:
Expression profiling by array; Third-party reanalysis
Platform:
GPL16368
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE72678
ID:
200072678
3.

Dorsal root ganglia (DRG) and Sciatic nerve (SCN) in female BTBR ob/ob mice - diabetic peripheral neuropathy

(Submitter supplied) Female mouse models of diabetic peripheral neuropathy (DPN) have not yet been identified. Our aim is firstly to demonstrate that female BTBR ob/ob mice display robust DPN and secondly, to perform relevant comparisons with non-diabetic and gender-matched controls. Lastly, microarray technology was employed to identify dysregulated genes and pathways in the SCN and DRG of female BTBR mice. Dorsal root ganglia (DRG) and sciatic nerve (SCN) were removed from female mice, RNA isolated and processed for gene expression profiling to identify differentially expressed genes using Affymetrix GeneChip Mouse Genome 430 2.0 Arrays.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16368
20 Samples
Download data: CEL
Series
Accession:
GSE70852
ID:
200070852
4.

Mouse Smarcb1-deficient models recapitulate subtypes of human rhabdoid tumors.

(Submitter supplied) Rhabdoid Tumors (RT) are highly aggressive tumors that are frequently localized in the central nervous system (CNS) where they are termed atypical teratoid and rhabdoid tumors (ATRT). We generated conditional Smarcb1-deficient mouse model leads to CNS Smarcb1-deficient tumors. We used microarrays to compared gene expression profilings of various human and mouse tumors. Our data demonstrate that the Smarcb1-deficient mouse model recapitulates the diversity of human RT.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by array
Platforms:
GPL16368 GPL17810
80 Samples
Download data: CEL
Series
Accession:
GSE64019
ID:
200064019
5.

Expression changes in MEL cells upon differentiation and Ldb1 knockdown

(Submitter supplied) Carbonic anhydrase 1 (Car1), an early specific marker of the erythroid differentiation, has been used to distinguish fetal and adult erythroid cells since its production closely follows the γ- to β-globin transition, but the molecular mechanism underlying transcriptional regulation of Car1 is unclear. Here, we show that Car1 mRNA decreases significantly when erythroid differentiation is induced in MEL cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL16368
10 Samples
Download data: CEL
Series
Accession:
GSE42839
ID:
200042839
6.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www.ncbi.nlm.nih.gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...
Organism:
Mus musculus
601 DataSets
4426 Series
40 Related Platforms
57683 Samples
Download data
Platform
Accession:
GPL1261
ID:
100001261
7.

[Mouse4302_Mm_ENTREZG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Brainarray Version 16]

(Submitter supplied) This is identical to GPL1261 but a custom CDF environment was used to extract data [Brainarray Version 16, Mouse4302_Mm_ENTREZG]. CDF and other files can be downloaded at: (see web link below).
Organism:
Mus musculus
5 Series
1 Related Platform
70 Samples
Download data: CDF, TXT
Platform
Accession:
GPL16368
ID:
100016368
8.

346 Tumor

Organism:
Mus musculus
Source name:
Tumor 346
Platform:
GPL16368
Series:
GSE82319
Download data: CEL
Sample
Accession:
GSM2188961
ID:
302188961
9.

367 Tumor

Organism:
Mus musculus
Source name:
Tumor 367
Platform:
GPL16368
Series:
GSE82319
Download data: CEL
Sample
Accession:
GSM2188960
ID:
302188960
10.

333 Tumor

Organism:
Mus musculus
Source name:
Tumor 333
Platform:
GPL16368
Series:
GSE82319
Download data: CEL
Sample
Accession:
GSM2188959
ID:
302188959
11.

316 Tumor

Organism:
Mus musculus
Source name:
Tumor 316
Platform:
GPL16368
Series:
GSE82319
Download data: CEL
Sample
Accession:
GSM2188958
ID:
302188958
12.

291 Tumor

Organism:
Mus musculus
Source name:
Tumor 291
Platform:
GPL16368
Series:
GSE82319
Download data: CEL
Sample
Accession:
GSM2188957
ID:
302188957
13.

FT3 Control

Organism:
Mus musculus
Source name:
FT3
Platform:
GPL16368
Series:
GSE82319
Download data: CEL
Sample
Accession:
GSM2188956
ID:
302188956
14.

FT2 Control

Organism:
Mus musculus
Source name:
FT2
Platform:
GPL16368
Series:
GSE82319
Download data: CEL
Sample
Accession:
GSM2188955
ID:
302188955
15.

FT1 Control

Organism:
Mus musculus
Source name:
FT1
Platform:
GPL16368
Series:
GSE82319
Download data: CEL
Sample
Accession:
GSM2188954
ID:
302188954
16.

Neuroblastoma MYCN/Ret M919T.Tum32297

Organism:
Mus musculus
Source name:
MYCN/Ret M919T tumor
Platform:
GPL16368
Series:
GSE72678
Download data: CEL
Sample
Accession:
GSM1868030
ID:
301868030
17.

Neuroblastoma MYCN/Ret M919T.Tum32288

Organism:
Mus musculus
Source name:
MYCN/Ret M919T tumor
Platform:
GPL16368
Series:
GSE72678
Download data: CEL
Sample
Accession:
GSM1868029
ID:
301868029
18.

Neuroblastoma MYCN/Ret M919T.Tum31577

Organism:
Mus musculus
Source name:
MYCN/Ret M919T tumor
Platform:
GPL16368
Series:
GSE72678
Download data: CEL
Sample
Accession:
GSM1868028
ID:
301868028
19.

Neuroblastoma MYCN/Ret M919T.Tum31105

Organism:
Mus musculus
Source name:
MYCN/Ret M919T tumor
Platform:
GPL16368
Series:
GSE72678
Download data: CEL
Sample
Accession:
GSM1868027
ID:
301868027
20.

Neuroblastoma MYCN/Ret M919T.Tum31003

Organism:
Mus musculus
Source name:
MYCN/Ret M919T tumor
Platform:
GPL16368
Series:
GSE72678
Download data: CEL
Sample
Accession:
GSM1868026
ID:
301868026
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