GEO DataSets

(Submitter supplied) Host cell infection by the intracellular pathogen, Trypanosoma cruzi, involves activation of signaling pathways, cytoskeletal reorganization, and targeted recruitment of host cell lysosomes. To determine the consequences of T. cruzi invasion on host cell gene expression, high density microarrays consisting of approximately 27,000 human cDNAs were hybridized with fluorescent probes generated from T. cruzi-infected human fibroblasts (HFF) at early time points following infection (2-24 h). Surprisingly, no genes were induced > or =2-fold in HFF between 2 and 6 h post-infection (hpi) in repeated experiments while immediate repression of six host cell transcripts was observed. A significant increase in transcript abundance for 106 host cell genes was observed at 24 hpi. Among the most highly induced is a set of interferon-stimulated genes, indicative of a type I interferon (IFN) response to T. cruzi. In support of this, T. cruzi-infected fibroblasts begin to secrete IFNbeta at 18 hpi following the induction of IFNbeta transcripts. As compared with global transcriptional responses evoked by other intracellular pathogens, T. cruzi is a stealth parasite that elicits few changes in host cell transcription during the initiation of infection. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Keywords: Logical Set

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

22 Samples

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(Submitter supplied) Identification of host pathways affected by the Salmonella virulence transcription factor phoP Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS77 GDS78 GDS80

5 related Platforms

53 Samples

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Identification of host pathways affected by the Salmonella virulence transcription factor phoP. phoP found to play a role in Salmonella-induced human macrophage cell death.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 2 infection, 4 time sets

Platform:

GPL181

Series:

GSE503

10 Samples

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(Submitter supplied) A microarray with 24192 spot features. Tip Configuration: Standard 32-tip Columns per Sector: 28 Rows per Sector: 27 Column Spacing: 200 Row Spacing: 200

Organism:

Homo sapiens

1 DataSet

2 Series

17 Samples

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