GPL18223[RGSE] - GEO DataSets

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Items: 3

Select item 2000544171.

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

(Submitter supplied) The mechanistic target of rapamycin mTORC1 is a key regulator of cell metabolism and autophagy. Despite widespread clinical use of mTOR inhibitors, the role of mTORC1 in renal tubular function and kidney homeostasis remains elusive. By utilizing constitutive and inducible deletion of conditional Raptor alleles in renal tubular epithelial cells, we discovered that mTORC1 deficiency caused a marked concentrating defect, loss of tubular cells and slowly progressive renal fibrosis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL18223
10 Samples

Download data: CEL

Series

Accession:: GSE54417

ID:: 200054417

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000547172.

Basonuclin-1 modulates epithelial plasticity and TGF-β1-induced loss of epithelial cell integrity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL18223 GPL18243
21 Samples

Download data: CEL

Series

Accession:: GSE54717

ID:: 200054717

Select item 2000547163.

Basonuclin-1 modulates epithelial plasticity and TGF-β1-induced loss of epithelial cell integrity [NIAC-NTR]

(Submitter supplied) TGF-b1-stimulation induces an epithelial dedifferentiation-process, throughout which epithelial cell sheets disintegrate and gradually switch into fibroblastic-appearing cells (EMT-like transition). The purpose of these profiles was to identify differentially expressed genes that are regulated transcriptionally. Standard microarry-based gene expression profiles measure steady-state RNA but do not provide insight into underlying regulatory principles. more...