GEO DataSets

(Submitter supplied) Natural killer T (NKT) cells are a distinct lymphocyte lineage thought to operate primarily at the interface between the innate and adaptive immune response. Yet, their unique role in the immune system remains elusive. Whilst NKT cells show high similarities to other cells of the innate and adaptive immune system, they express unique functional features such as rapid, concomitant production of Th1 and Th2 cytokines upon TCR ligation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1868

16 Samples

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(Submitter supplied) Peumonia is the most common cause of death due to infectious diseases in the western hemisphere. The molecular events associated with pulmonary infections caused by Streptococcus pneumoniae and Influenza A virus are incompletely understood. Pathophysiological and protective processes are initiated by immune receptors specifically recognizing pathogenic structures serving to elicit a qualitatively and quantitatively adequate immune response. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2165

Platform:

GPL1868

7 Samples

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Analysis of female C57BL/6 lungs at various time points after influenza A virus or Streptococcus pneumoniae infection. Secondary bacterial infection during or after influenza recovery is common cause of pneumonia (PN). Results provide insight into molecular pathogenesis of severe infectious PN.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 2 infection, 5 time sets

Platform:

GPL1868

Series:

GSE5289

7 Samples

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(Submitter supplied) IL-15 has critical impact on the homeostasis and activation of NK, NKT, gdT and CD8+T cells, and contributes to antimicrobial defenses particularly at mucosal sites. The respiratory tract also comprises a large mucosal surface and harbors significant amounts of lymphocytes, but the expression pattern of IL-15 in the lung and its role in local immune responses are largely unknown. We therefore analyzed the differential expression of IL-15 and the IL-15 receptor (IL-15R) complex in the lungs of mice, and demonstrated substantial constitutive expression in bronchial and alveolar epithelial cells, alveolar macrophages, and vascular smooth muscle cells, implicating contribution to pulmonary immune cell homeostasis already under normal conditions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1868

3 Samples

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(Submitter supplied) A potent Th1 immune response is critical to the control of tuberculosis. The impact of an additive Th2 response on the course of disease has so far been insufficiently characterized, despite increased morbidity after coinfection with Mycobacterium tuberculosis and Th2 eliciting helminths and possible involvement of Th2 polarization in reactivation of latent tuberculosis. Here, we describe the gene expression profile of murine bone marrow derived macrophages alternatively activated by IL-4 to infection with M. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1868

5 Samples

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(Submitter supplied) Following the initial demonstration of Helicobacter pylori’s pathogenic potential, evidence has been accumulated that H. pylori is the leading cause of gastric ulcers, carcinoma and lymphoma3. Cholesterol is a physiological constituent of membranes critical for their biophysical properties, but is stigmatised as mediating detrimental effects in obesity and cardiovascular disease. Since H. pylori is auxotrophic for cholesterol, we explored the assimilation of cholesterol by H. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1868

8 Samples

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(Submitter supplied) new and stripped microarrays Keywords: reuse of Agilent custom 8.4 in situ microarrays

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1868

10 Samples

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(Submitter supplied) color swap ratio profiles (dye-reversal) wildtype CD4+ alpha beta T cells vs. LATY136F CD4+ alpha beta T cells: GSM42565 and GSM42566 Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1868

2 Samples

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(Submitter supplied) ratio experiment by combining dye-reversal ratio profiles CD4+ alpha beta T cells were positively sorted from LatY136F or from wild-type spleen using a MACS and anti-CD4 beads. Gamma delta T cells were sorted from the spleen of Lat3YF and of Eb-/- mice using MACS and anti-CD5 beads. In vitro differentiated Th1 and Th2 cells were generated by culturing naive wild-type CD4+ T cells for 4 days in complete RPMI in the presence of anti-CD3 (1 µg/ml) plus anti-CD28 (1 µg/ml) with the addition of IL-12 (10ng/ml) and of anti-IL-4 (5µg/ml) for Th1-polarizing conditions, and of IL-4 (20ng/ml) plus anti-IFN-gamma (10µg/ml) for Th2-polarizing conditions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1868

2 Samples

Download data: TIFF

(Submitter supplied) ratio experiment by combining dye-reversal ratio profiles CD4+ alpha beta T cells were positively sorted from LatY136F or from wild-type spleen using a MACS and anti-CD4 beads. Gamma delta T cells were sorted from the spleen of Lat3YF and of Eb-/- mice using MACS and anti-CD5 beads. In vitro differentiated Th1 and Th2 cells were generated by culturing naive wild-type CD4+ T cells for 4 days in complete RPMI in the presence of anti-CD3 (1 µg/ml) plus anti-CD28 (1 µg/ml) with the addition of IL-12 (10ng/ml) and of anti-IL-4 (5µg/ml) for Th1-polarizing conditions, and of IL-4 (20ng/ml) plus anti-IFN-gamma (10µg/ml) for Th2-polarizing conditions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1868

2 Samples

Download data: TIFF

(Submitter supplied) custom tailored 'SurePrint' 60-mer oligonucleotide microarray with 8015 features derived from Unigene clusters (Unigene Build#148) with major focus on immunologically relevant genes

Organism:

Mus musculus

1 DataSet

9 Series

50 Samples

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