GPL18850[RGSE] - GEO DataSets

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Items: 2

Select item 2000588871.

Drug screening and genomic analyses of HER2 positive breast cancer cell lines reveal predictors for treatment response

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL9128 GPL18850
17 Samples

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Series

Accession:: GSE58887

ID:: 200058887

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Select item 2000587002.

Drug screening and genomic analyses of HER2 positive breast cancer cell lines reveal predictors for treatment response [Expression profiling]

(Submitter supplied) Thirteen HER2 positive breast cancer cell lines were screened with 22 commercially available compounds, mainly targeting proteins in the ErbB2 signaling pathway, and the molecular mechanisms related to treatment response were sought. To search for response predictors, genomic and transcriptomic profiling, PIK3CA mutations and PTEN status were associated to the drug responses and several genes involved in the response of the compounds were identified.