GPL19026[RGSE] - GEO DataSets

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Items: 2

Select item 2000601221.

Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Candida albicans; Candida albicans SC5314

Type:: Expression profiling by array; Genome variation profiling by array

Platforms:: GPL19026 GPL19049
19 Samples

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Series

Accession:: GSE60122

ID:: 200060122

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000601202.

Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans [CGH]

(Submitter supplied) The fungal pathogen Candida albicans and other pathogens of the CTG clade reassigned the leucine CUG codon to serine and tolerate highly variable levels of both serine and leucine at CUG positions in response to environmental cues. Previous studies found that increased leucine misincorporation levels enhance resistance to drugs but the underlying mechanisms are not known. To clarify the biological role of this tuneable codon ambiguity, we evolved C. more...