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Items: 1 to 20 of 5232

1.

PRMT7 knocdown in Jurkat-Cas9 T-ALL cell line

(Submitter supplied) T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with only few established prognostic biomarkers.In this study, we examined the expression of protein arginine methyltransferases across hematological malignancies and discovered high levels of PRMT7 mRNA in T-ALL, particularly in the mature subtypes of T-ALL. High PRMT7 was associated with decreased event-free and overall survival in two independent patient cohorts. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
6 Samples
Download data: TXT
Series
Accession:
GSE186238
ID:
200186238
2.

Characterization of nucleocapsid-RNA interactions in Rift Valley fever virus infected cells

(Submitter supplied) Crosslinking immunoprecipitation and sequencing was used to characterize nucleocapsid-RNA interactions in Rift Valley fever virus infection. This data set includes illumina HiSeq paired-end reads of Rift Valley fever virus infected HEK293 cells. The sequencing libraries were generated from nucleocapsid-bound RNAs.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
9 Samples
Download data: TXT
Series
Accession:
GSE186067
ID:
200186067
3.

The Nuclear Transcription factor TAF7 is a Cytoplasmic RNA Chaperone

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL16791 GPL20301 GPL18573
13 Samples
Download data: TSV
Series
Accession:
GSE161671
ID:
200161671
4.

Transcriptome profiling of HeLa TAF7 (WT) cytoplasmic extracts

(Submitter supplied) We perform RNA-Seq to analyze gene expression profiles in HeLa TAF7 (WT) cytoplasmic extracts, which are the inputs of RIP-Seq and PAR-CLIP.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL16791 GPL20301
5 Samples
Download data: TSV
Series
Accession:
GSE161668
ID:
200161668
5.

FLAG RIP-Seq identifies RNA species bound by cytoplasmic TAF7 in HeLa TAF7 (WT) cells

(Submitter supplied) We perform FLAG RIP-Seq to generate a transcriptome-view of RNA targets bound by TAF7
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL16791 GPL20301
6 Samples
Download data: TSV
Series
Accession:
GSE161667
ID:
200161667
6.

Single cell RNA-sequencing of long-term human control and C9ORF72 ALS/FTD patient-specific iPSC-derived cortical organoid slice cultures

(Submitter supplied) Single cell RNA sequencing data was collected from 150 day old human cortical organoid slice cultures grown at the air-liquid interface (ALI-COs) from control and ALS/FTD patient-specific induced pluripotent stem cell (iPSC) lines harbouring the C9ORF72 hexanucleotide repeat expansion mutation. Data collection included ALI-COs derived from the following iPSC lines: WTSli042-B (WTS42b) and A18945 (EpiC) for healthy controls, CS30iALS-C9nxx (CS30) and CS29iALS-C9nxx (CS29) for ALS/FTD, and CS29iALS-C9n1.ISOxx (ISO29), a mutation-corrected isogenic line. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
10 Samples
Download data: CSV
Series
Accession:
GSE180122
ID:
200180122
7.

Muscle biopsy RNA-seq from 5 week bedrest study volunteers

(Submitter supplied) Sedentary lifestyle, chronic disease or microgravity can cause muscle deconditioning that then has an impact on other physiological systems. An example is the nervous system, which is adversely affected by decreased physical activity resulting in increased incidence of neurological problems such as chronic pain. We sought to better understand how this might occur by conducting RNA sequencing experiments on muscle biopsies from human volunteers in a 5-week bed-rest study with an exercise intervention arm. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
26 Samples
Download data: XLSX
Series
Accession:
GSE186045
ID:
200186045
8.

BulkRNAseq - Neurotransmitters regulate distinct phases of multimodal human interneuron migration

(Submitter supplied) We use cerebral organoid fusions and a novel migration tracking platform to understand the functional impact of neurotransmitter signaling on migrating human interneurons.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
52 Samples
Download data: TXT
Series
Accession:
GSE182614
ID:
200182614
9.

Human amniotic epithelial stem cell-derived retinal pigment epithelium cells repair retinal degeneration

(Submitter supplied) Age-related macular degeneration (AMD), featured with dysfunction and loss of retinal pigment epithelium (RPE), is lacking efficient therapeutic approaches. According to our previous studies, human amniotic epithelial stem cells (hAESCs) may serve as a potential seed cell source of RPE cells for therapy because they have no ethical concerns, no tumorigenicity, and little immunogenicity. Herein, trichostatin A and nicotinamide can direct hAESCs differentiation into RPE like cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
6 Samples
Download data: TXT
Series
Accession:
GSE180616
ID:
200180616
10.

Dysregulated lncRNA and mRNA may promote the progression of ischemic stroke via immune and inflammatory pathways: results from RNA sequencing and bioinformatics analysis

(Submitter supplied) Long non-coding RNAs (lncRNAs) are widely involved in gene transcription regulation and which act as epigenetic modifiers. To determine whether lncRNAs are involved in ischemic stroke (IS), we analyzed the expression profile of lncRNAs and mRNAs in IS. RNA sequencing was performed on the blood of three pairs of IS patients and heathy controls. Differential expression analysis was used to identify differentially expressed lncRNAs (DElncRNAs) and mRNAs (DEmRNAs). more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL20301
6 Samples
Download data: TXT
Series
Accession:
GSE180470
ID:
200180470
11.

RNA-seq analysis of HeLa cells following MYC inhibition with ASO

(Submitter supplied) We performed RNA-seq on HeLa cells treated with MYCASO-3, a non-targeting ASO (NT-ASO), Lipofectamine alone, and untreated cells
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
21 Samples
Download data: CSV
Series
Accession:
GSE183535
ID:
200183535
12.

Determine the chromatin association change of H3K27me3 and PRC2 in response to CTR9 inducible loss as well as genome-wide mapping of Flag-CTR9 binding sites in MCF7 cells

(Submitter supplied) CTR9 is the scaffold subunit in PAFc (Polymerase associated factor complex), a multifunctional complex employed in multiple steps of RNA Pol II-mediated transcription. CTR9/PAFc is well known as an evolutionarily conserved elongation factor regulating gene activation via coupling with histone modifications enzymes. However, little is known about its function to restrain repressive histone markers. Using inducible and stable CTR9 knockdown breast cancer cell lines, we discovered that the amount of H3K27me3 is strictly controlled by CTR9. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL20301 GPL18573
28 Samples
Download data: BW
Series
Accession:
GSE173176
ID:
200173176
13.

The FASTK family proteins are master regulators in mitochondrial RNA processing

(Submitter supplied) Investigation of roles of the FASTK protein family in non-canonical mitochondrial RNA processing
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20301
6 Samples
Download data: XLSX
Series
Accession:
GSE156556
ID:
200156556
14.

RNA-seq of mimic miR-34a transfected H1299 and DDX21 KO cell lines.

(Submitter supplied) In order to investigate the role of DDX21 in RNA activation by miR-34a, next-generation sequencing analysis of RNA extracted from miR-34a transfected H1299 and DDX21 knock-out cell line was performed.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
4 Samples
Download data: XLSX
Series
Accession:
GSE185946
ID:
200185946
15.

the mechanism of lncRNA HOXC-AS3 in regulating brest cancer progression.

(Submitter supplied) Here we show that lncRNA HOXC-AS3, a key factor in promoting brest cancer progression through metabolic reprogramming pathways.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
2 Samples
Download data: XLSX
Series
Accession:
GSE185898
ID:
200185898
16.

lncRNA HOXC-AS3 regulates brest cancer glycolysis through binding with SIRT6 (RIP-seq)

(Submitter supplied) Here we show that lncRNA HOXC-AS3, a key factor in controling metabolic reprogramming through binding with SIRT6, thereby promoting the metastases of brest cancer.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20301
6 Samples
Download data: TXT
Series
Accession:
GSE185897
ID:
200185897
17.

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

(Submitter supplied) FOXA pioneer transcription factors (TFs) associate with primed enhancers in endodermal organ precursors. Using a human stem cell model of pancreas differentiation, we here discover that only a subset of pancreatic enhancers is FOXA-primed, whereas the majority is unprimed and engages FOXA upon lineage induction. Primed enhancers are enriched for signal-dependent TF motifs and harbor abundant and strong FOXA motifs. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL24676 GPL20301
107 Samples
Download data: BIGWIG, MTX, TSV
Series
Accession:
GSE148368
ID:
200148368
18.

Impact of AZA on myeloid leukemia cells

(Submitter supplied) To understand the transcriptional changes of myeloid leukemia cells when exposed to Aza we used different AML cell lines and exposed them to AZA for multiple time periods.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
24 Samples
Download data: TXT
Series
Accession:
GSE184891
ID:
200184891
19.

Human lung tissue resident memory T cells are re-programmed but not eradicated with systemic glucocorticoids after acute cellular rejection

(Submitter supplied) Acute cellular rejection is common after lung transplantation and is associated with an increased risk of early chronic rejection. We present combined single cell RNA and T cell receptor sequencing on recipient derived T cells obtained from the bronchoalveolar lavage of three lung transplant recipients with acute cellular rejection and compare them with T cells obtained from the same three patients after clinical treatment of rejection with high-dose, systemic glucocorticoids. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
14 Samples
Download data: CSV, H5
Series
Accession:
GSE185659
ID:
200185659
20.

scPower accelerates and optimizes the design of multi-sample single cell transcriptomic studies

(Submitter supplied) Single cell RNA-seq has revolutionized transcriptomics by providing cell type resolution for differential gene expression and expression quantitative trait loci (eQTL) analyses. However, efficient power analysis methods for single cell data and inter-individual comparisons are lacking. Here, we present scPower; a statistical framework for the design and power analysis of multi-sample single cell transcriptomic experiments. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
6 Samples
Download data: MTX, TSV
Series
Accession:
GSE185714
ID:
200185714
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