GEO DataSets

(Submitter supplied) RNA-seq analysis was performed to identify key signaling responding to RUNX2 knockdown in MDA-MB-231

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23525

6 Samples

Download data: TXT

(Submitter supplied) To understand the changes in the expression of genes in U87MG cells due to LMO2, we analyzed the transcriptome of U87MG cells overexpressing LMO2. As a result, we identify differentially expressed genes patterns so that the signaling mechanism regulated by LMO2 in GBM and changes in cells were observed. These RNA sequencing analysis results enable an understanding of the signaling mechanism by LMO2 in GBM.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23525

6 Samples

Download data: TXT

(Submitter supplied) RNA-seq analysis was performed to identify key signaling responding to PCI-24781 in MDA-MB-231

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23525

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL24676 GPL23525 GPL20795

16 Samples

Download data: BED, BW

(Submitter supplied) Common fragile sites (CFSs) are genomic loci prone to the formation of breaks or gaps on metaphase chromosomes. Here, we seek to map human CFSs with high resolution on a genome-wide scale by sequencing the sites of mitotic DNA synthesis (MiDASeq) that are specific for CFSs. We generated a nucleotide-resolution atlas of MiDAS sites (MDSs) that covered most of know CFSs, and comprehensively analyzed their sequence characteristics and genomic features.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23525

2 Samples

Download data: CSV

(Submitter supplied) mRNA profiles of HAP1 wild type (WT) and MPG-/- cells were generated by deep sequencing using Complete Genomics

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23525

2 Samples

Download data: TXT

(Submitter supplied) This study investigated the biological function of ABCB7 in U87MG glioblastoma cell line. Many ABC transporters are known contributions to drug resistance and various biological process. However, mitochondrial ABC transporters aren’t known mechanism to control biological process. We identified the potential roles of ATP-binding cassette (ABC) transporter subfamily member 7 (ABCB7), one of the mitochondrial ABC transporters. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23525

6 Samples

Download data: TXT

(Submitter supplied) This study demonstrates the role of TP53 gain-of-function (GOF) mutation on glioblastoma progression. However, little is known about the transcriptional alteration upon TP53 GOF mutation. In this study, we found that TP53 GOF mutation (R248L mutation) promotes the enrichment of multiple gene signatures related to inflammation and chemotaxis. Particularly, through in vitro and in vivo approaches, we verified that TP53 GOF mutation enhances NFKB signaling which in turn up-regulates CCL2 and TNFA. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23525

2 Samples

Download data: TXT

(Submitter supplied) This study investigated the biological function of CD133 by ectopic expression of CD133 in U87MG cell line. Although CD133 is widely used as a cancer stem cell marker, there are a few studies that examined its own biological functions. While a number of loss-of-function studies about CD133 have shown that CD133 have effects on cancer progression, there are few gain-of-function studies about functions of CD133. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23525

2 Samples

Download data: TXT

(Submitter supplied) Although clinically associated with severe intellectual disability, West syndrome, Dandy-Walker malformation, and syndactyly, the biological function of FOXK2 remains poorly explored. Here we report that FOXK2 acts as a transcription repressor. Strikingly, FOXK2 interacts with multiple transcription corepressor complexes including NCoR/SMRT, SIN3A, NuRD, and REST/CoREST. FOXK2 assembles these transcription programs to repress a cohort of genes including HIF1 and EZH2 and to regulate several signaling pathways including the hypoxic response that is critically implicated in tumor development and progression. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL16791 GPL23525

4 Samples

Download data: BED, BW