GPL29893[RGSE] - GEO DataSets

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Items: 2

Select item 2002336601.

Adiponectin inhibits acquisition of the Lyme disease agent by ticks [Tick]

(Submitter supplied) Tick gut and salivary gland global gene expression change after feeding on adiponectin wildtype and knockout mice

Organism:: Ixodes scapularis

Type:: Expression profiling by high throughput sequencing

Platform:: GPL29893
4 Samples

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Accession:: GSE233660

ID:: 200233660

Select item 2001692932.

Tick Adiponectin Receptor-Mediated Phospholipid Metabolism Contributes to Borrelia burgdorferi Colonization

(Submitter supplied) Adiponectin-mediated pathways contribute to mammalian homeostasis; however, little is known about adiponectin and adiponectin receptor signaling in arthropods. In this study, we demonstrate that Ixodes scapularis ticks have an adiponectin receptor-like protein (ISARL) but lack adiponectin, suggesting activation by alternative pathways. ISARL expression is significantly upregulated in the tick gut after Borrelia burgdorferi infection, suggesting that ISARL signaling may be co-opted by the Lyme disease agent. more...