GEO DataSets

(Submitter supplied) The TAL1/SCL and LMO1 oncogenic transcription factors establish a pre-leukemic state by reprogramming thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Pre-TCR signaling accelerates the progression to T-cell acute lymphoblastic leukemia (T-ALL). To directly address the importance of pre-TCR signaling in driving progression to T-ALL, we leverage on Cd3-deficient mice in which pre-TCR signaling and progression through β-selection is abrogated. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

12 Samples

Download data: CEL, XLSX

(Submitter supplied) Shiga toxin type 2 (Stx2) from Escherichia coli is thought to be a main factor to casue renal dysfunction in Enterohemorrhagic E. coli (EHEC) infection. The renal dysfunction caused by the proximal tubular defects can be detected in the earlier EHEC infection. However, the precise information of gene expression from proximal tubular epithelial cells has yet to be clarified. We performed microarray experiments using Stx2-injected mouse kidney and Stx2-treated human renal proximal tubular epithelial cells (RPTEC), and extracted common genes that were differentially expressed.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

30 Samples

Download data: CEL

(Submitter supplied) Background: Ozone (O3) is the predominant oxidant air pollutant associated with respiratory inflammation, lung dysfunction, and worsening preexisting airway diseases. We determined that TNFR signlaing pathway plays a key role in lung injury and inflammation caused by O3 in mice. However, downstream molecular mechanisms underlying TNFR pathway have not been investigated. Methods: To investigate the role of TNFR pathway in gene expression changes, Tnfr1/2-deficient (Tnfr-/-) and wild-type (Tnfr+/+, C57BL/6J) mice were exposed to air or 0.3-ppm O3. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

24 Samples

Download data: CEL, CHP

(Submitter supplied) Folic acid is a nutrient essential for embryonic development. Folate deficiency can cause embryolethality or neural tube defects and orofacial anomalies. Folate receptor 1 (Folr1), is a folate binding protein that facilitates the cellular uptake of dietary folate. Animal studies highlighted critical roles of folate in embryogenesis including orofacial development. Orofacial clefts were observed in the offspring of experimental animals on folic acid-deficient diets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

5 Samples

Download data: CEL, CHP

(Submitter supplied) Analysis of whole small intestine tissue of 10-week old C57BL/6J mice, C57BL/6J mice with the disruption of either Fabp2 gene or Fabp6 gene, and C57BL/6J mice with the simultaneous disruption of Fabp2 and Fabp6 genes. Fabp2 and Fabp6 are two types of fatty acid binding proteins expressed primarily in the small intestine.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL340 GPL339

32 Samples

Download data: CEL, CSV

(Submitter supplied) Garlic is a popular flavor enhancer in modern cuisines. Although anti-atherosclerotic, anti-proliferative, hypolipidemic and chemopreventative effects of garlic are known for a long time, the mechanisms of garlic as a dietary supplement ramain largely unknown. We used microarrays to analyze the global programme of gene expression in control (cellulose) and garlic-fed C57BL/6J mice serendipitously infected with Pasteurella multocida and identified acute phase response genes, particularly Lcn2 and Orm2, as the major players in the innate response. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

12 Samples

Download data: CEL

(Submitter supplied) We have previously shown that human fibulin-1 (FBLN1) is a binding partner of fibroblast growth factor 8 (FGF8) and affects its expression and signaling. Herein, we investigate the mechanisms by which FBLN1 affects FGF8 signaling. Fibulin-1 (Fbln1) -deficiency in mouse embryo fibroblasts (MEF) caused downregulation of Fgf8 as well as fibroblast growth factor receptors (Fgfr) 1 and 3 and several downstream genes in the Fgf8 pathway, including Six1, Eya1 and Barx1. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

10 Samples

Download data: CEL

(Submitter supplied) Akt is a serine/threonine protein kinase that is activated by a variety of growth factors or cytokines in a PI3-kinase dependent manner. Using a conditional transgenic system in which Akt signaling can be turned on or off in the adult heart, we have recently demonstrated that short-term Akt activation induces a ‘physiological’ form of cardiac hypertrophy with enhanced coronary angiogenesis and maintained contractility. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL340 GPL339

18 Samples

Download data

(Submitter supplied) Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric oxide synthase 2 (NOS2) is required, but not sufficient, for the effect of endotoxin on HPV. The aim of the current study was to identify additional factors that might contribute to the impairment of HPV during endotoxemia. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

17 Samples

Download data: CEL

(Submitter supplied) Skeletal (striated) muscle is one of the four basic tissue types, together with the epithelium, connective and nervous tissues. Lungs, on the other hand, develop from the foregut and among various cell types contain smooth, but not skeletal muscle. Therefore, during earlier stages of development, it is unlikely that skeletal muscle and lung depend on each other. However, during the later stages of development, respiratory muscle, primarily the diaphragm and the intercostal muscles, execute so called fetal breathing-like movements (FBMs), that are essential for lung growth and cell differentiation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL339 GPL340

4 Samples

Download data: CEL, CHP

(Submitter supplied) To understand the developing striatum, key genes during development were identified using microarray analsyis tha could be considered as marker of medium spiny neurons. The ages studied is at peak striatal neurogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

9 Samples

Download data: CEL

(Submitter supplied) Under steady-state conditions, eosinophils are abundantly found in the small intestinal lamina propria, but their physiological function is largely unexplored. We performed a global gene expression analysis to examine which genes are highly expressed by small intestinal eosinophils (CD11b+CD11c(int)MHCII-SiglecF+) compared with dendritic cells (CD11c+MHCII+).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

2 Samples

Download data: CEL, CHP

(Submitter supplied) The SCL and LMO1 oncogenic transcription factors reprogram thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Here we report that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Apis mellifera

Type:

Expression profiling by array

Platforms:

GPL339 GPL20903

66 Samples

Download data: CEL, GPR

(Submitter supplied) The objective of the study was to assess the technical error due to blending of individual samples into pools in experimental data. The blending error variance component corresponds to random effects for inaccuracies, which were modeled on the logarithmic scale of normalized gene expression. It's estimation based on a linear mixed model, fitted for each transcript.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

44 Samples

Download data: CEL

(Submitter supplied) Unr (upstream of N-ras) is a cytoplasmic RNA-binding protein with cold shock domains, involved in regulation of messenger RNA stability and translation. To address the biological role of Unr, we inactivated the unr gene by homologous recombination in mice and embryonic stem (ES) cells. Embryos deficient for Unr die at mid-gestation, and the main phenotypic defects observed, growth deficiency and absence of neural tube closure, suggest a role of Unr in the balance proliferation/differentiation during early development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

16 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) We used microarrays to investigate gene expression changes in the pancreas of RasGrf1 KO mice. These animals have a reduction in the number and size of the pancreatic islets which lead to lower levels of insulin and glucagon in their blood.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

6 Samples

Download data: CEL

(Submitter supplied) Myostatin (Mstn) knockout mice exhibit large increases in skeletal muscle mass. However, relatively few of the genes that mediate or modify MSTN effects are known. In this study, we performed co-expression network analysis using whole transcriptome microarray data from Mstn-null and wild-type mice to identify genes involved in important biological processes and pathways related to skeletal muscle and adipose development.Genes differentially expressed between wild-type and Mstn-null mice were identified at 13.5 d.p.c. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL340 GPL339

60 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus; Mesocricetus auratus

Type:

Expression profiling by array

Platforms:

GPL96 GPL339

12 Samples

Download data: CEL

(Submitter supplied) Current knowledge of the molecular regulation of the blastocyst implantation event has been largely derived from studies in the mouse that requires ovarian estrogen for initiation of the implantation event. However, there are species such as the hamster, guinea pig, pig, horse, rhesus monkey and perhaps the human where the blastocyst implantation event initiates only in the progesterone-primed uterus. more...

Organism:

Mesocricetus auratus; Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

6 Samples

Download data: CEL