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Items: 1 to 20 of 94

1.

Sexually dimorphic characteristics of the small intestinal transcriptome of Fabp-gene ablated mice

(Submitter supplied) Analysis of whole small intestine tissue of 10-week old C57BL/6J mice, C57BL/6J mice with the disruption of either Fabp2 gene or Fabp6 gene, and C57BL/6J mice with the simultaneous disruption of Fabp2 and Fabp6 genes. Fabp2 and Fabp6 are two types of fatty acid binding proteins expressed primarily in the small intestine.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL340
32 Samples
Download data: CEL, CSV
Series
Accession:
GSE128862
ID:
200128862
2.

Short-term Akt activation in cardiac muscle cells improves contractile dysfunction in failing hearts.

(Submitter supplied) Akt is a serine/threonine protein kinase that is activated by a variety of growth factors or cytokines in a PI3-kinase dependent manner. Using a conditional transgenic system in which Akt signaling can be turned on or off in the adult heart, we have recently demonstrated that short-term Akt activation induces a ‘physiological’ form of cardiac hypertrophy with enhanced coronary angiogenesis and maintained contractility. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL340
18 Samples
Download data
Series
Accession:
GSE4728
ID:
200004728
3.

Role of skeletal muscle in lung development.

(Submitter supplied) Skeletal (striated) muscle is one of the four basic tissue types, together with the epithelium, connective and nervous tissues. Lungs, on the other hand, develop from the foregut and among various cell types contain smooth, but not skeletal muscle. Therefore, during earlier stages of development, it is unlikely that skeletal muscle and lung depend on each other. However, during the later stages of development, respiratory muscle, primarily the diaphragm and the intercostal muscles, execute so called fetal breathing-like movements (FBMs), that are essential for lung growth and cell differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL340
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE109783
ID:
200109783
4.

Gene co-expression network analysis of myostatin regulation at three different mouse developmental timepoints

(Submitter supplied) Myostatin (Mstn) knockout mice exhibit large increases in skeletal muscle mass. However, relatively few of the genes that mediate or modify MSTN effects are known. In this study, we performed co-expression network analysis using whole transcriptome microarray data from Mstn-null and wild-type mice to identify genes involved in important biological processes and pathways related to skeletal muscle and adipose development.Genes differentially expressed between wild-type and Mstn-null mice were identified at 13.5 d.p.c. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL340 GPL339
60 Samples
Download data: CEL
Series
Accession:
GSE63154
ID:
200063154
5.

Expression data from cultured mouse BALB 3T3 cells containing bacterial plasmid gene mucAB

(Submitter supplied) The gene mucAB has an error-prone activity in bacteria. We introduced mucAB into mouse 3T3 cells with an expression vector and found drastic increase of spontaneous transformation, accompanied by increase of expression of eight oncogenes, i. e., Gpnmb, Foxml, Maff, Myc, Aurka, Aukb, Fosl1, and Anxa8 and decrease of expression in two oncogenes, i. e., Lrig1 and RhoX in order of the magnitude of change, as compared with those in non-treated 3T3 cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL340
20 Samples
Download data: CEL, CHP
Series
Accession:
GSE42927
ID:
200042927
6.

Molecular Phenotyping of Immune Cells from Young NOD Mice

(Submitter supplied) Islet leukocytic infiltration (insulitis) is first obvious at around 4 weeks of age in the NOD mouse – a model for human type 1 diabetes (T1DM). The molecular events leading to insulitis are poorly understood. Since TIDM is caused by numerous genes, we hypothesized that multiple molecular pathways are altered and interact to initiate this disease. Analysis of the global gene expression profiles using microarrays followed by hierarchical clustering revealed that the majority (~90%) of the differentially expressed genes in NOD mice relative to control mice were repressed. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL340
60 Samples
Download data: CEL
Series
Accession:
GSE37450
ID:
200037450
7.

Gene Expression Levels in PiZ mice Compared to Wild-type (Wt)C57Bl/6

(Submitter supplied) Individuals expressing alpha-1-antitrypsin mutant Z protein accumulate misfolded, mutant protein in the liver and are at risk for liver diseases including cirrhosis and hepatocellular carcinoma. Transgenic PiZ mice, a model for this liver disease, display similar pathologies to humans, including inflammation, increases in proliferation, autophagy and apoptosis, accumulation of globules and develop fibrosis and hepatocellular carcinoma with age. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL340 GPL339
8 Samples
Download data: CEL
Series
Accession:
GSE36478
ID:
200036478
8.

Cerebellar Granule Neuron Temporal-NFI Microarray Data

(Submitter supplied) Dendrite and synapse development are critical for establishing appropriate neuronal circuits, and disrupted timing of these events can alter connectivity leading to disordered neural function. In early postnatal development of cerebellar granule neurons (CGNs), the expression of many genes is temporally regulated. Further, NFI (Nuclear Factor I) proteins have been shown to play important roles in the regulation of gene expression in developing CGNs. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL1261 GPL339 GPL340
20 Samples
Download data: CEL, XLSX
Series
Accession:
GSE42018
ID:
200042018
9.

Long-term proteasomal inhibition in transgenic mice by UBB+1 expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients

(Submitter supplied) Aging and neurodegeneration are often accompanied by a functionally impaired ubiquitin-proteasome system (UPS). In tauopathies and polyglutamine diseases a mutant form of Ubiquitin B, UBB+1, accumulates in disease-specific aggregates. UBB+1 mRNA is generated at low levels in vivo during transcription from the Ubiquitin B locus by molecular misreading. The resulting mutant protein has been shown to inhibit proteasome function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL340 GPL339
23 Samples
Download data: CEL
Series
Accession:
GSE13691
ID:
200013691
10.

Brain BRCA1 conditional knockout

(Submitter supplied) BRCA1 nestin CRE conditional knockout cortrices of P7 animals were compared to wildtype littermates to characterize the mutant phenotype. Keywords: expression
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL340 GPL8321 GPL1261
18 Samples
Download data: CEL
Series
Accession:
GSE6310
ID:
200006310
11.

Gene expression of polyoma middle T antigen induced mammary tumors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
5 related Platforms
210 Samples
Download data: CEL, TXT
Series
Accession:
GSE30866
ID:
200030866
12.

Gene expression of polyoma middle T antigen induced mammary tumors [AKXD x PyMT]

(Submitter supplied) Mouse genetic crosses were established between the PyMT model of metastatic breast cancer and AKXD strain. Tumors were harvested from the animals for gene expression analysis to identify genes and network modules associated with progression to distant metastatic disease.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL340 GPL339
112 Samples
Download data: CEL
Series
Accession:
GSE30864
ID:
200030864
13.

Expression data from Pou4f3-Rb1 cKO and control inner ear

(Submitter supplied) Retinoblastoma gene (Rb1) is required for proper cell cycle exit in the developing mouse inner ear and its deletion in the embryo leads to proliferation of sensory progenitor cells that differentiate into hair cells and supporting cells. In the Pou4f3-Cre:Rb1 flox/flox (Rb1 cKO) inner ear, utricular hair cells differentiate and survive into adulthood whereas differentiation and survival of cochlear hair cells are impaired. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL340
24 Samples
Download data: CEL
Series
Accession:
GSE25732
ID:
200025732
14.

Gene expression data from undifferentiated mouse embryonal carcinoma cell strains (MOE430A and MOE430B)

(Submitter supplied) Gene expression profiles of undifferentiated mouse embryonal carcinoma cell strains (P19, P19CL6, and 4 P19CL6 sublines) were obtained, using Affymetrix GeneChip Mouse Genome 430A and 430B. Heart diseases such as cardiac infarction damage cardiomyocytes and consequently lead to significant loss of the contractile capacity of the heart. To repair functions of the injured heart, a great deal of research has attempted to develop regenerative medicine using pluripotent stem cell-based cardiomyocytes as cell therapy products. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL340 GPL339
60 Samples
Download data
Series
Accession:
GSE26875
ID:
200026875
15.

Identification and functional analysis of novel genes expressed in the Anterior Visceral Endoderm

(Submitter supplied) During early development, the correct establishment of the body axes is a critical step. The anterior pole of the mouse embryo is established when Distal Visceral Endoderm (DVE) cells migrate to form the Anterior Visceral Endoderm (AVE). Asymmetrical expression of Lefty1, Cerl and Dkk determines the direction of DVE migration and the future anterior side. Besides being implicated in the establishment of Anterior-Posterior axis the AVE has also been correlated with anterior neural specification. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL340
10 Samples
Download data: CEL
Series
Accession:
GSE25675
ID:
200025675
16.

Hepatic gene expression in transgenic mice with conditional liver-specific expression of the SV40 17kT/LT oncoproteins

(Submitter supplied) The SV40 large (LT) and small (st) antigens are produced from a single alternatively spliced pre-mRNA, that when co-expressed, transform a variety of cells in vitro and in vivo. However, 17kT, a relatively uncharacterized third protein that is co-linear with LT for the first 131 amino acids, is also produced from the early viral pre-mRNA by removal of an additional intron from the LT transcript. Here we report a line of transgenic mice expressing a liver-specific dox-inducible viral transcript that fails to yield any detectable LT protein, yet produces abundant 17kT. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL340
6 Samples
Download data: CEL, CHP, DAT, EXP, RPT
Series
Accession:
GSE5242
ID:
200005242
17.

Screening of genes involved in chromosome segregation in meiosis I

(Submitter supplied) Prophase I of male meiosis involves dynamic chromosome segregation processes during early spermatogenesis, including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility in humans, we performed expression profiling of mouse spermatogenic cells undergoing meiotic prophase I.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL340 GPL339
10 Samples
Download data: CEL, CHP
Series
Accession:
GSE19532
ID:
200019532
18.

Synergistic Action of LIF and Glucocorticoids on pituitary corticotrophs cell line (AtT-20)

(Submitter supplied) While the hypothalamo-pituitary-adrenal axis (HPA) activates a general stress response by increasing glucocorticoid (Gc) synthesis, biological stress resulting from infections triggers the inflammatory response through production of cytokines. The pituitary gland integrates some of these signals by responding to the pro-inflammatory cytokines IL6 and LIF and to a negative Gc feedback loop. The present work used whole-genome approaches to define the LIF/STAT3 regulatory network and to delineate cross-talk between this pathway and Gc action. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL1261 GPL340
24 Samples
Download data: CEL
Series
Accession:
GSE19042
ID:
200019042
19.

Transcriptional and post-transcriptional impact of toxic RNA in myotonic dystrophy

(Submitter supplied) Myotonic dystrophy type 1 (DM1) is an RNA dominant disease in which mutant transcripts containing an expanded CUG repeat (CUGexp) cause muscle dysfunction by interfering with biogenesis of other mRNAs. The toxic effects of mutant RNA are mediated partly through sequestration of splicing regulator Muscleblind-like 1 (Mbnl1), a protein that binds to CUGexp RNA. A gene that is prominently affected encodes chloride channel 1 (Clcn1), resulting in hyperexcitability of muscle (myotonia). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL340 GPL339 GPL1261
58 Samples
Download data: CEL
Series
Accession:
GSE14691
ID:
200014691
20.

The effects of dietary curcumin on colonic gene expression in TNBS-induced colitis

(Submitter supplied) Curcumin is a potent anti-inflammatory compound capable of preventing chemically induced colitis in mice. We used microarray analysis to detail the global programme of colonic gene expression in BALB/c mice fed standard or 2% curcumin-supplemented diet and treated with control or TNBS (trnitrobenzene-sulfonic acid, 2 mg/mouse) enema. Keywords: Diet and disease effect.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL339 GPL340
24 Samples
Download data: CEL
Series
Accession:
GSE13705
ID:
200013705
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