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Items: 1 to 20 of 149

1.

Mild food restriction and gene expression profile

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL341 GPL1355
45 Samples
Download data: CEL
Series
Accession:
GSE176300
ID:
200176300
2.

Mild food restriction and gene expression profile (intestine)

(Submitter supplied) The aim of this study is to obtain the gene expression profiles of the intestine of young growing rats after mild restriction of food intake for one month.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
5 Samples
Download data: CEL
Series
Accession:
GSE176298
ID:
200176298
3.

Mild food restriction and gene expression profile (adipose)

(Submitter supplied) The aim of this study is to obtain the gene expression profiles of the adipose tissue of young growing rats after mild restriction of food intake for one week or one month.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
20 Samples
Download data: CEL
Series
Accession:
GSE176295
ID:
200176295
4.

Gene Expression Changes due to Rat Lung Ischemia-Reperfusion Injury

(Submitter supplied) Ischemia-reperfusion injury (IRI) is a major cause of morbidity and mortality following conventional lung transplantation and warm ischemia may limit success of transplanting lungs from non-heart-beating donors. We sought to determine alterations in gene expression in rat lung tissue subjected to warm ischemia in vivo followed by reperfusion. Keywords: time course
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
18 Samples
Download data: CEL, CHP
Series
Accession:
GSE9634
ID:
200009634
5.

Trancriptional profiling of rat liver after short-term (up tp 14 days) administration of carcinogenic and non-carcinogenic chemicals

(Submitter supplied) The carcinogenic potential of chemicals is currently evaluated with rodent life-time bioassays, which are time consuming, and expensive with respect to cost, number of animals and amount of compound required. Since the results of these 2-year bioassays are not known until quite late during development of new chemical entities, and since the short-term test battery to test for genotoxicity, a characteristic of genotoxic carcinogens, is hampered by low specificity, the identification of early biomarkers for carcinogenicity would be a big step forward. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
421 Samples
Download data: CEL
Series
Accession:
GSE68110
ID:
200068110
6.

Effects of dexamethasone on gene expression in rat pancreatic AR42J cell line

(Submitter supplied) The rat pancreatic cell line AR42J is relatively undifferentiated under normal culture conditions. When the glucocorticoid dexamethasone is added to the medium the cells display a dramatic decrease in proliferative rate and are induced to a more exocrine phenotype that includes increased expression of exocrine pancreas products (digestive enzymes) and more developed regulated secretion. We used microarray to determine changes in gene expression comparing control (without dexamethasone) vs induced (plus dexamethasone).
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
6 Samples
Download data: CEL
Series
Accession:
GSE72907
ID:
200072907
7.

Dietary Salt effects on Renal Expression of Dahl SS/Jr (S) and Congenic Rats

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL342 GPL341
76 Samples
Download data: CEL
Series
Accession:
GSE29078
ID:
200029078
8.

Renal Expression of Dahl SS/Jr (S) and Congenic Rats after 24 hours of Dietary Salt Loading

(Submitter supplied) The overlap of congenic regions in an earlier substitution mapping study suggested the location of two blood pressure quantitative trait loci (QTL)-containing regions in the q-terminus of rat chromosome 3, QTL1 and the more distal, QTL2. Male SS/jr rats and two congenic substrain rats S.R(D3Mco36-D3Mco46) and S.R(D3Mco36-D3Got166) were maintained on a low salt (0.4% NaCl Harlan Teklad diet TD7034) diet until 39-41 days of age. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL341 GPL342
52 Samples
Download data: CEL
Series
Accession:
GSE12424
ID:
200012424
9.

Renal Expression of Dahl SS/Jr (S) and Congenic Rats after 28 days of dietary salt elevation

(Submitter supplied) The overlap of congenic regions in an earlier substitution mapping study suggested the location of two blood pressure quantitative trait loci (QTL)-containing regions in the q-terminus of rat chromosome 3, QTL1 and the more distal, QTL2. Male SS/jr rats and two congenic substrain rats S.R(D3Mco36-D3Mco46) and S.R(D3Mco36-D3Got166) were maintained on a low salt (0.4% NaCl Harlan Teklad diet TD7034) diet until 39-41 days of age and then fed an intermediate (2% NaCl Harlan Teklad diet TD94217) salt diet for 28 days. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL342 GPL341
24 Samples
Download data: CEL
Series
Accession:
GSE12423
ID:
200012423
10.

Expression of V3 Versican by Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes

(Submitter supplied) Arterial smooth muscle cells (ASMCs) undergo phenotypic changes during development and pathological processes in vivo and during cell culture in vitro. Our previous studies demonstrated that retrovirally-mediated expression of the versican V3 splice variant (V3) that lacks glycosaminoglycan chains by ASMCs retards cell proliferation and migration in vitro and reduces neointimal thickening, macrophage and lipid accumulation in animal models of vascular injury and atherosclerosis. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
12 Samples
Download data: CEL
Series
Accession:
GSE66624
ID:
200066624
11.

IMI MARCAR Project: towards novel biomarkers for cancer risk assessment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Rattus norvegicus; synthetic construct; Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array; Methylation profiling by genome tiling array
14 related Platforms
2666 Samples
Download data: CEL, CSV, PAIR, TXT
Series
Accession:
GSE68387
ID:
200068387
12.

A novel functional role for the serine protease inhibitor SerpinA3N and its substrate leukocyte elastase in neuropathic pain

(Submitter supplied) Two out-bred rat selection lines were separated to produce different hypersensitivity phenotypes following nerve injury. These lines were termed High Pain and Low Pain (HP or LP). Each sub-strain was either subject to a Sham surgery or a Spinal Nerve Ligation (SNL) surgery to the L4 and L5 spinal nerves. Three days following surgery L4/L5 Dorsal Root Ganglia (DRG) were dissected from these animals. For the rat line separation protocol see: Devor M, Raber P (1990) Heritability of symptoms in an experimental model of neuropathic pain. Pain 42:51-67.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
12 Samples
Download data: CEL
Series
Accession:
GSE63442
ID:
200063442
13.

Cross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Rattus norvegicus
Type:
Expression profiling by array; Non-coding RNA profiling by array; Protein profiling by protein array
Platforms:
GPL14889 GPL17787 GPL341
189 Samples
Download data: CEL, CSV, TXT
Series
Accession:
GSE53085
ID:
200053085
14.

Cross-platform toxicogenomics for the prediction of nongenotoxic hepatocarcinogenesis in rat (mRNA)

(Submitter supplied) In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular signatures for assessing the potential and mode of compound carcinogenicity, we considered multi-level omics data. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
63 Samples
Download data: CEL
Series
Accession:
GSE53082
ID:
200053082
15.

A rat toxicogenomics study with Calcium Sensitizer EMD 82571 reveals a pleiotropic cause and adverse outcome pathway of teratogenicity

(Submitter supplied) The aim of reprotoxicity testing is to reveal adverse effects of chemicals and drugs on reproduction and on pre and postnatal fetal development. There is very limited data available on gene expression profiling for elucidation of the teratogenic effects of nongenotoxic teratogens. Therefore, research was undertaken to obtain knowledge on the molecular effects of MSC1096199 (previously known as EMD 82571), a calcium sensitizer that was abandoned in the preclinical development phase due to its teratogenic effects in some foetuses. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
22 Samples
Download data: CEL, CHP
Series
Accession:
GSE58225
ID:
200058225
16.

Zucker Diabetic Fatty (ZDF) Rat Study - Diaphragm vs. Sternohyoid

(Submitter supplied) Type 2 diabetes differs from type 1 diabetes in its pathogenesis. Type 1 diabetic diaphragm has altered gene expression which includes lipid and carbohydrate metabolism, ubiquitination and oxidoreductase activity. The objectives of the present study were to assess respiratory muscle gene expression changes in type 2 diabetes and to determine whether they are greater for the diaphragm than an upper airway muscle. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
22 Samples
Download data: CEL, CHP
Series
Accession:
GSE21791
ID:
200021791
17.

Diabetic lung

(Submitter supplied) Effect of type 1 diabetes (induced by streptozotocin 60 mg/kg) on lung gene expression. Wistar rats, male. At age 8 weeks control rats got IP buffer, diabetic rats got streptozotocin. At age 12 weeks animals were anesthetized and lungs removed. RNA was extracted with Trizol, and gene expression array analysis was performed using Affymetrix RAE 230A microarrays according to the directions from the manufacturer. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS5255
Platform:
GPL341
12 Samples
Download data: CEL
Series
Accession:
GSE15900
ID:
200015900
18.

Gene expression data from rat cochlear lateral wall after 3NP damage

(Submitter supplied) A rat model of acute mitochondrial dysfunction in the cochlea is created by applying an irreversible mitochondrial complex II enzyme inhibitor, 3-NP, directly to the round window membrane. Treatment with 300 mM 3-NP results in temporary hearing loss (temporary threshold shift (TTS) model), whereas treatment with 500 mM 3-NP results in profound and permanent hearing loss (permanent threshold shift (PTS) model. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL341 GPL342
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE52500
ID:
200052500
19.

Effect of prenatal exposure to nicotine on kidney structure and gene expression in rats

(Submitter supplied) Here, we investigated whether prenatal exposure to nicotine alters kidney glomerular mass and genome-wide gene expression profiles in two genetically distant strains of rats, namely spontaneously hypertensive rats (SHR) and Brown Norway (BN) rats. Nicotine or saline were administered to BN and SHR dams via osmotic pumps throughout gestation. Kidneys from 9-week-old male offspring were studied.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL341
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE29677
ID:
200029677
20.

Gene expression profiling of CD4+myelin basic protein specific T cells

(Submitter supplied) CNS autoimmunity is induced by autoreactive T cells reactive against CNS antigen. However how these T cells become able to transgress the blood brain barrier is not CNS autoimmunity is induced by autoreactive T cells reactive against CNS antigen. Here a gene expression profile of the pathogenic T cells in different functional states was performed. These studies were performed in a classical model of multiple sclerosis, experimental autoimmune encephalomyelitis in Lewis rats induced by transfer of CD4+myelin basic protein specific T cells. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platforms:
GPL341 GPL342
22 Samples
Download data: CEL
Series
Accession:
GSE38645
ID:
200038645
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