GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL1355 GPL341

45 Samples

Download data: CEL

(Submitter supplied) The aim of this study is to obtain the gene expression profiles of the intestine of young growing rats after mild restriction of food intake for one month.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

5 Samples

Download data: CEL

(Submitter supplied) The aim of this study is to obtain the gene expression profiles of the adipose tissue of young growing rats after mild restriction of food intake for one week or one month.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

20 Samples

Download data: CEL

(Submitter supplied) Ischemia-reperfusion injury (IRI) is a major cause of morbidity and mortality following conventional lung transplantation and warm ischemia may limit success of transplanting lungs from non-heart-beating donors. We sought to determine alterations in gene expression in rat lung tissue subjected to warm ischemia in vivo followed by reperfusion. Keywords: time course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

18 Samples

Download data: CEL, CHP

(Submitter supplied) The carcinogenic potential of chemicals is currently evaluated with rodent life-time bioassays, which are time consuming, and expensive with respect to cost, number of animals and amount of compound required. Since the results of these 2-year bioassays are not known until quite late during development of new chemical entities, and since the short-term test battery to test for genotoxicity, a characteristic of genotoxic carcinogens, is hampered by low specificity, the identification of early biomarkers for carcinogenicity would be a big step forward. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

421 Samples

Download data: CEL

(Submitter supplied) The rat pancreatic cell line AR42J is relatively undifferentiated under normal culture conditions. When the glucocorticoid dexamethasone is added to the medium the cells display a dramatic decrease in proliferative rate and are induced to a more exocrine phenotype that includes increased expression of exocrine pancreas products (digestive enzymes) and more developed regulated secretion. We used microarray to determine changes in gene expression comparing control (without dexamethasone) vs induced (plus dexamethasone).

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL342 GPL341

76 Samples

Download data: CEL

(Submitter supplied) The overlap of congenic regions in an earlier substitution mapping study suggested the location of two blood pressure quantitative trait loci (QTL)-containing regions in the q-terminus of rat chromosome 3, QTL1 and the more distal, QTL2. Male SS/jr rats and two congenic substrain rats S.R(D3Mco36-D3Mco46) and S.R(D3Mco36-D3Got166) were maintained on a low salt (0.4% NaCl Harlan Teklad diet TD7034) diet until 39-41 days of age. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL341 GPL342

52 Samples

Download data: CEL

(Submitter supplied) The overlap of congenic regions in an earlier substitution mapping study suggested the location of two blood pressure quantitative trait loci (QTL)-containing regions in the q-terminus of rat chromosome 3, QTL1 and the more distal, QTL2. Male SS/jr rats and two congenic substrain rats S.R(D3Mco36-D3Mco46) and S.R(D3Mco36-D3Got166) were maintained on a low salt (0.4% NaCl Harlan Teklad diet TD7034) diet until 39-41 days of age and then fed an intermediate (2% NaCl Harlan Teklad diet TD94217) salt diet for 28 days. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL341 GPL342

24 Samples

Download data: CEL

(Submitter supplied) Arterial smooth muscle cells (ASMCs) undergo phenotypic changes during development and pathological processes in vivo and during cell culture in vitro. Our previous studies demonstrated that retrovirally-mediated expression of the versican V3 splice variant (V3) that lacks glycosaminoglycan chains by ASMCs retards cell proliferation and migration in vitro and reduces neointimal thickening, macrophage and lipid accumulation in animal models of vascular injury and atherosclerosis. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Rattus norvegicus; synthetic construct; Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array; Methylation profiling by genome tiling array

14 related Platforms

2666 Samples

Download data: CEL, CSV, PAIR, TXT

(Submitter supplied) Two out-bred rat selection lines were separated to produce different hypersensitivity phenotypes following nerve injury. These lines were termed High Pain and Low Pain (HP or LP). Each sub-strain was either subject to a Sham surgery or a Spinal Nerve Ligation (SNL) surgery to the L4 and L5 spinal nerves. Three days following surgery L4/L5 Dorsal Root Ganglia (DRG) were dissected from these animals. For the rat line separation protocol see: Devor M, Raber P (1990) Heritability of symptoms in an experimental model of neuropathic pain. Pain 42:51-67.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by array; Non-coding RNA profiling by array; Protein profiling by protein array

Platforms:

GPL14889 GPL341 GPL17787

189 Samples

Download data: CEL, CSV, TXT

(Submitter supplied) In this study we performed microarray-based molecular profiling of liver samples from Wistar rats exposed to genotoxic carcinogens (GC), nongenotoxic carcinogens (NGC) or non-hepatocarcinogens (NC) for up to 14 days. In contrast to previous toxicogenomics studies aimed at the inference of molecular signatures for assessing the potential and mode of compound carcinogenicity, we considered multi-level omics data. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

63 Samples

Download data: CEL

(Submitter supplied) The aim of reprotoxicity testing is to reveal adverse effects of chemicals and drugs on reproduction and on pre and postnatal fetal development. There is very limited data available on gene expression profiling for elucidation of the teratogenic effects of nongenotoxic teratogens. Therefore, research was undertaken to obtain knowledge on the molecular effects of MSC1096199 (previously known as EMD 82571), a calcium sensitizer that was abandoned in the preclinical development phase due to its teratogenic effects in some foetuses. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

22 Samples

Download data: CEL, CHP

(Submitter supplied) Type 2 diabetes differs from type 1 diabetes in its pathogenesis. Type 1 diabetic diaphragm has altered gene expression which includes lipid and carbohydrate metabolism, ubiquitination and oxidoreductase activity. The objectives of the present study were to assess respiratory muscle gene expression changes in type 2 diabetes and to determine whether they are greater for the diaphragm than an upper airway muscle. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

22 Samples

Download data: CEL, CHP

(Submitter supplied) Effect of type 1 diabetes (induced by streptozotocin 60 mg/kg) on lung gene expression. Wistar rats, male. At age 8 weeks control rats got IP buffer, diabetic rats got streptozotocin. At age 12 weeks animals were anesthetized and lungs removed. RNA was extracted with Trizol, and gene expression array analysis was performed using Affymetrix RAE 230A microarrays according to the directions from the manufacturer. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS5255

Platform:

GPL341

12 Samples

Download data: CEL

Analysis of lungs of diabetic animals. Diabetes induced by streptozotocin treatment. Results provide insight into the impact of diabetes on the cellular and molecular processes in the lung.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL341

Series:

GSE15900

12 Samples

Download data: CEL

(Submitter supplied) A rat model of acute mitochondrial dysfunction in the cochlea is created by applying an irreversible mitochondrial complex II enzyme inhibitor, 3-NP, directly to the round window membrane. Treatment with 300 mM 3-NP results in temporary hearing loss (temporary threshold shift (TTS) model), whereas treatment with 500 mM 3-NP results in profound and permanent hearing loss (permanent threshold shift (PTS) model. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL341 GPL342

4 Samples

Download data: CEL, CHP

(Submitter supplied) Here, we investigated whether prenatal exposure to nicotine alters kidney glomerular mass and genome-wide gene expression profiles in two genetically distant strains of rats, namely spontaneously hypertensive rats (SHR) and Brown Norway (BN) rats. Nicotine or saline were administered to BN and SHR dams via osmotic pumps throughout gestation. Kidneys from 9-week-old male offspring were studied.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

4 Samples

Download data: CEL, CHP