GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL342 GPL341

76 Samples

Download data: CEL

(Submitter supplied) The overlap of congenic regions in an earlier substitution mapping study suggested the location of two blood pressure quantitative trait loci (QTL)-containing regions in the q-terminus of rat chromosome 3, QTL1 and the more distal, QTL2. Male SS/jr rats and two congenic substrain rats S.R(D3Mco36-D3Mco46) and S.R(D3Mco36-D3Got166) were maintained on a low salt (0.4% NaCl Harlan Teklad diet TD7034) diet until 39-41 days of age. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL341 GPL342

52 Samples

Download data: CEL

(Submitter supplied) The overlap of congenic regions in an earlier substitution mapping study suggested the location of two blood pressure quantitative trait loci (QTL)-containing regions in the q-terminus of rat chromosome 3, QTL1 and the more distal, QTL2. Male SS/jr rats and two congenic substrain rats S.R(D3Mco36-D3Mco46) and S.R(D3Mco36-D3Got166) were maintained on a low salt (0.4% NaCl Harlan Teklad diet TD7034) diet until 39-41 days of age and then fed an intermediate (2% NaCl Harlan Teklad diet TD94217) salt diet for 28 days. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL342 GPL341

24 Samples

Download data: CEL

(Submitter supplied) A rat model of acute mitochondrial dysfunction in the cochlea is created by applying an irreversible mitochondrial complex II enzyme inhibitor, 3-NP, directly to the round window membrane. Treatment with 300 mM 3-NP results in temporary hearing loss (temporary threshold shift (TTS) model), whereas treatment with 500 mM 3-NP results in profound and permanent hearing loss (permanent threshold shift (PTS) model. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL341 GPL342

4 Samples

Download data: CEL, CHP

(Submitter supplied) CNS autoimmunity is induced by autoreactive T cells reactive against CNS antigen. However how these T cells become able to transgress the blood brain barrier is not CNS autoimmunity is induced by autoreactive T cells reactive against CNS antigen. Here a gene expression profile of the pathogenic T cells in different functional states was performed. These studies were performed in a classical model of multiple sclerosis, experimental autoimmune encephalomyelitis in Lewis rats induced by transfer of CD4+myelin basic protein specific T cells. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL341 GPL342

22 Samples

Download data: CEL

(Submitter supplied) Background. Vaginal atrophy (VA) is the thinning of the vaginal epithelial lining, typically the result of lowered estrogen levels during menopause. Some of the consequences of VA include increased susceptibility to bacterial infection, pain during sexual intercourse, and vaginal burning or itching. Although estrogen treatment is highly effective, alternative therapies are also desired for women who are not candidates for hormone replacement therapy (HRT). more...

Organism:

Rattus norvegicus; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL570 GPL341 GPL342

98 Samples

Download data: CEL

(Submitter supplied) Oligodendrocytes are cells from the central nervous system that can be grouped into precursors, myelin-forming, and non-myelinating perineuronal. The function of perineuronal oligodendrocytes is unknown; it was suggested that they can ensheath denuded axons. We tested this hypothesis. Using cell-specific tags, microarray technology and bioinformatics tools to identify gene expression differences between these subpopulations allowed us to capture the genetic signature of perineuronal oligodendrocytes. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL341 GPL342

8 Samples

Download data: CEL

(Submitter supplied) Oligodendrocytes undergo extensive changes as they differentiate from progenitors into myelinating cells. To better understand the molecular mechanisms underlying this transformation, we performed a comparative analysis using gene expression profiling of A2B5+ oligodendrocyte progenitors and O4+ oligodendrocytes. Cells were sort-purified ex vivo from postnatal rat brain using flow cytometry. Using Affymetrix microarrays, 1707 transcripts were identified with a more than twofold increase in expression inO4+oligodendrocytes. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS2379 GDS2380

Platforms:

GPL341 GPL342

18 Samples

Download data

(Submitter supplied) Expression data from rats exposed to cigarette smoke (CS) at three concentrations (sham, 300µgTPM/l and 600µgTPM/l) for 13 weeks (5d/week; 2hrs/day) after three different recovery times (2hrs, 6hrs and 20hrs after last treatment); lung tissue Keywords: recovery time course and dose dependency

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS2194 GDS2195

Platforms:

GPL341 GPL342

18 Samples

Download data

(Submitter supplied) Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates. We used microarray analysis to identify genes whose expression in rat liver was significantly altered by pregnenolone 16alpha-carbonitrile (PCN) treatment. Keywords: a single ip injection of PCN (100 mg/kg), 8 h treatment

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS2093 GDS2094

Platforms:

GPL341 GPL342

19 Samples

Download data

(Submitter supplied) Specific Aims To identify novel transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated rat aortic rings. Our studies take advantage of the capacity of rat aortic rings to generate new vessels in collagen gels. Rat aortic rings embedded in collagen gel immediately after excision from the animal produce a self-limited angiogenic response under serum-free conditions and in the absence of exogenous stimuli. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS1922 GDS1923

Platforms:

GPL341 GPL342

18 Samples

Download data

(Submitter supplied) Single cell-derived colonies were obtained by sorting 21 days fetal Rat calvaria cells into microtitre wells using flow cytometry. Colonies were categorized according to a limited gene expression profiling for a specific bone (osteocalcin) and a specific adipocyte (adipsin) marker by real-time PCR. Colonies expressing neither, one or both bone and adipocyte markers are in the sample set. Microarray analysis will address the global gene expression profiles of CFU-O (bone marker only), CFU-F (neither bone nor adipocyte marker) and CFU-bipotential (both markers) derived from single cells. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL341 GPL342

18 Samples

Download data: CEL, EXP

(Submitter supplied) 12-week-old rats, iron-replete or iron-deficient. Three groups of each condition. 230A and 230B chips used with cRNA derived from jejunal scrapes. Keywords: ordered

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS2073 GDS2074

Platforms:

GPL341 GPL342

12 Samples

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(Submitter supplied) The effect of iron-deficiency on duodenal gene expression was investigated in rats at different developmental stages. Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS1054 GDS1055

Platforms:

GPL341 GPL342

60 Samples

Download data

(Submitter supplied) PC12 cells (passage 22) were cultured at 5% CO2 in a 37 C incubator. The growth medium was DMEM (high glucose, Invitrogen) supplemented with 25mM HEPES, 10% FCS, 5% FBS and 1x Pen/Strep (Invitrogen). 1x106 cells were starved overnight in DMEM+25 mM HEPES and treated with 10 uM 1,9 dideoxy forskolin or forskolin for 60 min. The final DMSO concentration was 0.05%. Total RNA was purified using Trizol (Invitrogen) according to the manufacturers protocol. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS1038 GDS1039

Platforms:

GPL342 GPL341

8 Samples

Download data

(Submitter supplied) Rat germ cells Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS698 GDS699

Platforms:

GPL341 GPL342

18 Samples

Download data: CEL