GEO DataSets

(Submitter supplied) This was a prospective clinical trial testing the ability of gene expression models of drug sensitivity that were developed in human and canine cell lines and applied to outcomes in dogs treated with adjuvant carboplatin and/or doxorubicin. Tumor samples were collected prospectively, and gene expression analysis was conducted using Affymetrix Canine Genome 2.0 Arrays.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

109 Samples

Download data: CEL

(Submitter supplied) We have previously established two sibling glioma subclones, J3T-1 and J3T-2, showing distinct invasive and angiogenic phenotypes. J3T-1, expressing high annexin A2, demonstrates robust angiogenesis and tumor invasion around neovasculature. J3T-2, expressing low annexin A2, demonstrates diffuse invasion along white matter tracts. Knockdown of annexin A2 in J3T-1 (J3T-1shA) resulted in diffuse invasion pattern, and overexpression of annexin A2 in J3T-2 (J3T-2A) showed prominent angiogenesis. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

4 Samples

Download data: CEL

(Submitter supplied) Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) commonly used for the treatment of arthritis and chronic pain associated with musculoskeletal injuries. However, its use is associated with a variety of adverse drug reaction, including rare but severe hepato- and nephrotoxicity. The molecular mechanism leading to diclofenac induced immunoallergic hepatitis is unknown. The objective of this study is to identify the molecular mechanisms involving immune mediated inflammatory reactions and its link to DILI through whole genome gene expression profiling.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

18 Samples

Download data: CEL, CHP

(Submitter supplied) Heart failure (HF) is a leading cause of mortality and is associated with cardiac remodeling. Vulnerability to atrial fibrillation (AF) has been shown to be greater in the early stages of HF, whereas ventricular tachycardia/fibrillation develop during late stages. Here, we explore changes in gene expression that underlie the differential development of fibrosis and structural alterations that predispose to atrial and ventricular arrhythmias.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

18 Samples

Download data: CEL

(Submitter supplied) No one pathway was identified in up- and downregulated genes profile in HIF2A KD Madin-Darby canine kidney epithelial cells (MDCKII) in normoxic condition. We used microarray to study the differential expression of genes in HIF2A knockdown versus WT Madin-Darby canine kidney epithelial cells (MDCKII)

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

4 Samples

Download data: CEL

(Submitter supplied) The Epstein-Barr virus (EBV)-encoded LMP1 oncogene can induce profound effects on epithelial growth and differentiation including many of the features of the epithelial-to-mesenchymal transition (EMT). To better characterise these effects, we used the well-defined MDCK cell model and found that LMP1 expression in these cells induces EMT as defined by characteristic morphological changes accompanied by loss of E-cadherin, desmosomal cadherin and tight junction protein expression. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

15 Samples

Download data: CEL

(Submitter supplied) We established two novel glioma subclones those showed different invasive and angiogenic phenotypes. J3T-1 demonstrates robust angiogenesis and perivascular invasion. J3T-2 demonstrates diffuse invasion along white matter tracts. We used microarrays to show the difference of gene expression that contribute to the difference of phenotype.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

2 Samples

Download data: CEL

(Submitter supplied) 11 Arctic fox samples were analyzed to see if blood cells contained polychlorinated biphenyls (PCBs) and/or mercury.

Organism:

Canis lupus familiaris; Vulpes lagopus

Type:

Expression profiling by array

Platform:

GPL3738

12 Samples

Download data: CEL

(Submitter supplied) The expression of TGFbeta pathway genes were downregulated in HIF1A KD Madin-Darby canine kidney epithelial cells (MDCKII) in hypoxic condition. We used microarray to study the differential expression of genes in HIF1A knockdown versus WT Madin-Darby canine kidney epithelial cells (MDCKII)

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

4 Samples

Download data: CEL

(Submitter supplied) It has been demonstrated that parvovirus infection causing cytotoxicity and immune activation effect in many virus-induced cell lines, however, the underlying mechanisms are not fully understood. To investigate the gene expression signature of host cell after CPV-2 infection, we performed transcriptome profiling of MDCK after persistent infection of CPV-2a using microarray analysis. Uninfected MDCK cells act as negative control. more...

Organism:

Canis lupus; Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

2 Samples

Download data: CEL

(Submitter supplied) Molecular characterization of tumour cell lines is increasingly regarded as a prerequisite for defining their validity as models of in vivo neoplasia. We present the first comprehensive catalogue of genomic and transcriptional characteristics of five widely used canine lymphoid tumour cell lines. High-resolution microarray-based comparative genomic hybridization defined their unique profiles of genomic DNA copy number imbalance. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

5 Samples

Download data: CEL, CHP

(Submitter supplied) Background Leukemia/lymphoma cell lines have been critical in the investigation of the pathogenesis and therapy of hematological malignancies. While human LL cell lines have generally been found to recapitulate the primary tumors from which they were derived, appropriate characterization including cytogenetic and transcriptional assessment is crucial for assessing their clinical predictive value. Results In the following study, five canine LL cell lines, CLBL-1, Ema, TL-1 (Nody-1), UL-1, and 3132, were characterized using extensive immunophenotyping, karyotypic analysis, oligonucleotide array comparative genomic hybridization (oaCGH), and gene expression profiling. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

5 Samples

Download data: CEL, CHP

(Submitter supplied) In 2013, Richards, et al. reported in Cancer Research that canine b-cell lymphomas could be subclassificed by gene expression profiling as ABC-like or GCB-like, similar to their human diffuse large B-cell lymphomas. This study, therefore, sought to classify the cell line CLBL1 as either GCB or ABC.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array; Third-party reanalysis

Platform:

GPL3738

1 Sample

Download data: CEL, CHP, TXT

(Submitter supplied) Hereditary hyperplastic gingivitis (HHG) is a progressive growth of gingival tissues in foxes resulting in dental encapsulation. It is an autosomal recessive condition displaying a sex-biased penetrance, with an association with superior fur quality. The goal of this study was to explore potential molecular or cellular mechanisms underlying HHG by analysis of global gene expression patterns from Affymetrix Canine 2.0 microarrays cross-referenced.

Organism:

Vulpes vulpes; Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

8 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

62 Samples

Download data: CEL

(Submitter supplied) The recently developed COXEN method (PMID: 17666531) has been used to successfully extrapolate gene signatures of drug sensitivity across different tumor histotypes. We wanted to explore the utility of COXEN to predict chemosensitivity in canine cancer, specifically if we could extrapolate gene signatures identified in human datasets over to canine osteosarcoma tumors. This dataset of canine osteosarcoma tumor samples has available clinical outcome data after patients had infected limbs amputated and were treated with doxorubicin and/or carboplatin. more...

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

33 Samples

Download data: CEL

(Submitter supplied) Cancer cell line panels that incorporate genomic and pharmacologic screening data have become powerful tools for investigating the relationship between gene expression and drug response in human cancer research. Similar cell line panels of such a scale as the NCI60, CCLE, or GDSC do not currently exist in canine cancer research. Here we have assembled a canine cancer cell line panel of 29 cell lines representing multiple tumor types that have undergone gene expression profiling and have begun to be used for pharmacologic screening.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

29 Samples

Download data: CEL

(Submitter supplied) To characterize the inflammatory events occuring during early experimental acute AD lesions, skin biopsies were collected 6, 24, and 48 h after epicutaneous application of Dermatophagoides farinae house dust mites (HDM) to sensitized atopic dogs.

Organism:

Canis lupus familiaris

Type:

Expression profiling by array

Platform:

GPL3738

32 Samples

Download data: CEL, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Canis lupus familiaris; Mustela putorius furo

Type:

Expression profiling by array

Platform:

GPL3738

18 Samples

Download data: CEL

(Submitter supplied) Influenza virus transmission between mothers and nursing-infants has not been investigated although mothers and infants often develop severe disease. Ferrets are considered the most appropriate model for influenza studies. We investigated influenza transmission in infant and nursing-mother ferrets. Influenza infected infants transmitted virus to mother mammary glands leading to live virus excretion in milk and influenza virus positive mammary gland epithelial cells. more...

Organism:

Canis lupus familiaris; Mustela putorius furo

Type:

Expression profiling by array

Platform:

GPL3738

9 Samples

Download data: CEL