GEO DataSets

(Submitter supplied) Rationale: A critical step in heart development is the coordinated formation of nodal myocardium and cushion tissue from the atrioventricular canal (AVC). After its specification, the myocardium of the AVC aligns the chambers, forms the AV node, and induces the formation of the mesenchymal AV cushions, primordia of valves and septa, while it resists working myocardial differentiation. Objective: To assess what roles Tbx2 and Tbx3, two closely related T-box transcription factors expressed in the AVC, play in these processes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

12 Samples

Download data

(Submitter supplied) Transcript abundance in adipose and liver tissues was used to map expression quantitative trait loci (eQTL) underlying fat accretion, weight gain and liver weight. Gonadal fat and liver tissues were used from 48 individuals F2 selected from a cohort (1,200 mice) originated from a cross between M16i and MB2 mice. A complex polygenic architecture within the MB2 locus was observed which was comprised of several locally regulated eQTL (cis-eQTL) with significant correlations to obesity traits.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

96 Samples

Download data: TXT

(Submitter supplied) Dendritic cell activation through ligation of pattern recognition receptors leading to full functional maturation causes induction of CD8 T cell immunity instead of tolerance through increased delivery of co-stimulatory signals. Here we investigate whether a prototypic organ-resident antigen-presenting cells, i.e. liver sinusoidal endothelial cells (LSEC), also switch from tolerogenic to immunogenic CD8 T cell activation upon such activation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

18 Samples

Download data: TXT

(Submitter supplied) Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation in the time course and severity of RGC loss. Indeed, this process appears to be influenced by a wide variety of genetic and environmental factors. In this study we explored the genetic basis for differences in ganglion cell death in two inbred strains of mice. We found that RGCs are more susceptible to death following optic nerve crush in C57BL/6J mice (54% survival) than in DBA2/J mice (62% survival). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

18 Samples

Download data: TXT

(Submitter supplied) Pituitaries of basal and stressed Crhr1-wildtype (wt) and -knockout (ko) mice (Timpl et al., 1998) As the Crh-system and the HPA-axis are known to be crucially invovled in the onset, development and maintainance of psychiatric disorders like anxiety and depression and regulate the behavioural and endocrine stress responses the further analysis of Crhr1-dependent signaling cascades is essential to understand the molecular mechanisms behind these psychiatric diseases. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

12 Samples

Download data: TXT

(Submitter supplied) Measuring global gene expression using cDNA or oligonucleotide microarrays is an effective approach to understanding the complex mechanisms of the effects of radiation. However, few studies have been carried out that investigate gene expression in vivo after prolonged exposure to low-dose-rate radiation. In this study, C57BL/6J mice were continuously irradiated with γ-rays for 485 days at dose-rates of 0.032 – 13 μGy/min. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

24 Samples

Download data: CSV

(Submitter supplied) Cancer-induced tolerance mostly involves myeloid suppressor cells, regulatory T cells and immunosuppressive cytokines, which all subvert adaptive immune responses against tumor cells. Here, we show that a subset of innate effectors, c-kit expressing NK cells (Kit+ NK), can participate in tumor-induced tolerance by compromising the NK cell arm of tumor immunosurveillance. IL-18 produced by tumor cells can convert Kit- into Kit+ NK cells that overexpress B7-H1/PD-L1 molecules. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

6 Samples

Download data: TXT

(Submitter supplied) RNA was prepared from papilomas of 2-3 mice (2 for WT and 3 for Knockout) and this was pooled to perform the array. Each pooled sample was run in triplicates. The mice were treated once with DMBA, followed by TPA application for 30 wks. These mice are mixed background of FVB and C57bl6 and the age when they got the papillomas was about 9 months. Keywords: Genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3334

Platform:

GPL4234

6 Samples

Download data: TXT

Analysis of papillomas initiated by DMBA/TPA treatment of epidermal keratinocytes deficient for activating transcriptional factor 2 (ATF2). ATF2 mutant animals show increased susceptibility to papillomas relative to the WT counterparts. Results provide insight into the role of ATF2 in skin cancer.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL4234

Series:

GSE9328

6 Samples

Download data: TXT

(Submitter supplied) The aim of the present study was to compare, on a statistical basis, the performance of different microarray platforms to detect differences in gene expression in a realistic and challenging biological setting. Gene expression profiles in the hippocampus of five wild-type and five transgenic δC-doublecortin-like kinase mice were evaluated with five microarray platforms: Applied Biosystems, Affymetrix, Agilent, Illumina and home-spotted oligonucleotide arrays. more...

Organism:

Mus musculus

Type:

Expression profiling by array

5 related Platforms

50 Samples

Download data: CEL, CSV, GPR, TXT

(Submitter supplied) Parkinson disease (PD) is a major neurodegenerative condition with several rare Mendelian forms. Oxidative stress and mitochondrial function have been implicated in the pathogenesis of PD but the molecular mechanism(s) involved in the degeneration of specific neuronal groups remains unclear. DJ-1 mutations are one cause of recessive parkinsonism, but this gene is also involved in cancer by promoting Ras signaling and suppressing PTEN-induced apoptosis. more...

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2507 GPL4234

4 Samples

Download data: TXT

(Submitter supplied) Gene expressions of wild-type, IKKa-/- and IKKa+/+ reconstituted MEFs were compared Keywords: Gene Knockout and reconstituted

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

6 Samples

Download data: TXT

(Submitter supplied) Recently, it was shown that the Bmp antagonist Noggin could strongly induce cardiomyocyte differentiation by transient treatment of undifferentiated ES cells. In order to determine how Noggin may induce cardiac differentiation, we compared differentially expressed genes during Noggin treatment of ES cells using microarray analysis and found that matrix metalloproteinase (Mmp)-3 is the only gene whose expression is increased by Noggin treatment. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

6 Samples

Download data: TXT

(Submitter supplied) Hereditary Hemochromatosis (HH) is an autosomal recessive disorder characterized by an abnormally low expression or functional derangement of the iron regulatory hormone hepcidin. The absorption of dietary iron is disproportionate in these patients, leading to iron deposition in several tissues and consequent damage of organs including liver, heart, and pancreas. Late complications in absence of diagnosis and treatment include cirrhosis, hepatocellular carcinoma, cardiomyopathy and diabetes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3086

Platform:

GPL4234

12 Samples

Download data: TXT

Analysis of cardiac and skeletal muscles of animals fed a high-iron diet to induce iron overload. The cardiac muscle is a tissue affected by iron overload. Result provides insight into the molecular mechanisms underlying the pathological effect of iron overload on muscle cells.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 2 tissue sets

Platform:

GPL4234

Series:

GSE9726

12 Samples

Download data: TXT

(Submitter supplied) The Ets2 transcription factor is essential for the development of the mouse placenta and for generating signals for embryonic mesoderm and axis formation. Using a conditional targeted Ets2 allele, we show that Ets2 is essential for trophoblast stem (TS) cells self renewal. Inactivation of Ets2 results in slower growth, increased expression of a subset of differentiation associated genes and decreased expression of several genes implicated in TS self renewal. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL4865 GPL4234

24 Samples

Download data

(Submitter supplied) Global gene expression effects of silencing Jmjd1a and Jmjd2c genes We used microarrays to detail the global programme of gene expression after silencing Jmjd1a gene and Jmjd2c gene separately Keywords: dose response

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3037

Platform:

GPL4234

12 Samples

Download data: JPG, XML

Analysis of embryonic stem (ES) cells following depletion of the histone H3 Lys 9 demethylase genes, Jmjd1a and Jmjd2c. Pluripotent ES cells possess the ability to self-renew indefinitely. Results provide insight into the role of Jmjd1a and Jmjd2c in the maintenance of self-renewal in ES cells.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol sets

Platform:

GPL4234

Series:

GSE8937

12 Samples

Download data: JPG, XML

(Submitter supplied) Some individuals are more vulnerable than others to chronic psychiatric illnesses, such as drug addiction or depression, but the neural and molecular mechanisms responsible for this are poorly understood. Although addiction and depression are known to have a strong genetic component, recent evidence has suggested that epigenetic mechanisms, such as histone acetylation, may also contribute. However, the mechanisms which integrate drugs of abuse or stress with changes in chromatin structure remain unclear. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2993

Platform:

GPL4234

30 Samples

Download data: TXT

Analysis of nuclei accumbens (NAc) from histone deacetylase 5 (HDAC5) mutants treated with cocaine for 7 days. The NAc is a major brain reward region; loss of HDAC5 causes hypersensitive responses to chronic cocaine. Results provide insight into the role of histone deacetylation in drug addiction.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL4234

Series:

GSE9134

30 Samples

Download data: TXT