GEO DataSets

(Submitter supplied) We examined early and late gene expression changes using the IT LPS model of Acute Lung Injury (ALI). In this model, injury peaks at day 4 and is almost completely resolved by day 10 in wild type (WT) C57BL/6 mice. In contrast to the pattern in WT mice, lymphocyte-deficient Rag-1 -/- mice exhibit strikingly delayed resolution despite similar initial injury.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3749

Platform:

GPL4865

24 Samples

Download data: TXT

Temporal analysis of lungs from recombinase-activating gene-1-deficient (Rag-1 -/-), lymphocyte-deficient animals following acute lung injury. Resolution of acute lung injury is impaired in Rag-1 null mutants. Results provide insight into molecular mechanisms underlying resolution of lung injury.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation, 4 time sets

Platform:

GPL4865

Series:

GSE17355

24 Samples

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(Submitter supplied) A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our method through the characterization of transgenic and knockout mouse models of candidate genes that were predicted to be causal for abdominal obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL3562 GPL3677 GPL4865

96 Samples

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(Submitter supplied) A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our method through the characterization of transgenic and knockout mouse models of candidate genes that were predicted to be causal for abdominal obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4865

16 Samples

Download data: TXT

(Submitter supplied) A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our method through the characterization of transgenic and knockout mouse models of candidate genes that were predicted to be causal for abdominal obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4865

10 Samples

Download data: TXT

(Submitter supplied) A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our method through the characterization of transgenic and knockout mouse models of candidate genes that were predicted to be causal for abdominal obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4865

8 Samples

Download data: TXT

(Submitter supplied) A major task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. We previously developed a method to infer causal relationships among genes through the integration of DNA variation, gene transcription, and phenotypic information. Here we validated our method through the characterization of transgenic and knockout mouse models of candidate genes that were predicted to be causal for abdominal obesity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4865

14 Samples

Download data: TXT

(Submitter supplied) We compared 12 different cell populations, including embryonic stem cells before and during differentiation into embryoid bodies as well as various types of normal and tumor cells to determine if pluripotent vs. differentiated cell types use different mechanisms to establish their transcriptome. We first identified genes that were not expressed in the 12 different cell populations and then determined which of them were regulated by histone methylation, DNA methylation, at the step of productive elongation, or by the inability to establish a pre-initiation complex. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by genome tiling array; Methylation profiling by array

9 related Platforms

47 Samples

Download data: CSV, IDAT, JPG, PAIR, TIFF, TXT, XML

(Submitter supplied) The Ets2 transcription factor is essential for the development of the mouse placenta and for generating signals for embryonic mesoderm and axis formation. Using a conditional targeted Ets2 allele, we show that Ets2 is essential for trophoblast stem (TS) cells self renewal. Inactivation of Ets2 results in slower growth, increased expression of a subset of differentiation associated genes and decreased expression of several genes implicated in TS self renewal. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL4865 GPL4234

24 Samples

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(Submitter supplied) KRAS mutations are present at a high frequency in human cancers. The development of therapies targeting mutated KRAS requires cellular and animal preclinical models. We exploited adeno-associated virus-mediated homologous recombination to insert the KRAS G12D allele in the genome of mouse somatic cells. Heterozygous mutant cells displayed a constitutively active Kras protein, marked morphologic changes, increased proliferation and motility but were not transformed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3455 GDS3456

Platforms:

GPL4865 GPL8321

12 Samples

Download data: CEL

Analysis of MLP-29 liver cells bearing the heterozygous Kras G12D mutation. KRAS mutations are present at a high frequency in human cancers. Results identify a gene expression signature for the presence of the mutated Kras.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL4865

Series:

GSE8711

4 Samples

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(Submitter supplied) We created mice, which are deficient for Myc specifically in cardiac myocytes by crossing crossed Myc-floxed mice (Mycfl/fl) and MLC-2VCre/+ mice. Serial analysis of earlier stages of gestation revealed that Myc-deficient mice died prematurely at E13.5-14.5. Morphological analyses of E13.5 Myc-null embryos showed normal ventricular size and structure; however, decreased cardiac myocyte proliferation and increased apoptosis was observed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3031

Platform:

GPL4865

7 Samples

Download data: TXT

Analysis of Myc-deficient hearts from embryonic day 13.5 transgenics. The E13.5 Myc-null embryos show normal ventricular size and structure, but decreased cardiac myocyte proliferation. Results provide insight into the molecular mechanisms underlying Myc-induced cellular proliferation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL4865

Series:

GSE7162

7 Samples

Download data: TXT

(Submitter supplied) Mouse embryonic fibroblasts stimulated with 40 ng/ml of FGF2 in conventional hES cell medium were analysed on whole-genome expression chips to reveal altered expression of genes encoding secreted proteins. Keywords: Growth factor stimulation experiment

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4865

2 Samples

Download data: TXT

(Submitter supplied) Mouse embryonic fibroblasts stimulated with 40 ng/ml of FGF2 in conventional hES cell medium were analysed on whole-genome expression chips to reveal altered expression of genes encoding secreted proteins. Keywords: Growth factor stimulation experiment

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4865

2 Samples

Download data: TXT

(Submitter supplied) Expression profile of miRNAs during retinoic acid (RA) induced differentiation of mose embryonic stem cells Expression profile of mRNAs during retinoic acid (RA) amd miR-134 induced differentiation of mouse embryonic stem cells. Keywords: affymetrix custom array and illumina MouseRef-8

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL3576 GPL4865

30 Samples

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(Submitter supplied) The Sentrix MouseRef-8 BeadChip can be used to study expression of approximately 24,000 well-annotated transcripts from the NCBI RefSeq database. Researchers can generate whole-genome expression profiles for 8 samples in parallel on a single BeadChip. The array is composed of 3 micron features with average feature redundancy of 30-fold. All features are quality controlled by sequential hybridizations process called array decoding. more...

Organism:

Mus musculus

3 DataSets

13 Series

128 Samples

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