GEO DataSets

(Submitter supplied) Transcriptome analysis of NesCre:Atg7 conditional knockout mice. Autophagy plays an important role in regulating protein metabolism and tissue homeostasis. Recent studies have reported that neural stem cell-specific Atg7 knockout mice (NesCre:Atg7f/f cKO mice) exhibit neonatal lethal due to severe neurodegeneration. However, the precise mechanisms of how neuronal fate is regulated by the autophagic pathway have not been elucidated. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

6 Samples

Download data: CEL, CHP, XLSX

(Submitter supplied) To identify differentially expressed genes in the developmental mouse dorsal spinal cord, we characterized the global gene expression profiling of mouse embryonic dorsal spinal cord commissural neurons at E10.5, E11.5 and E12.5. We used the Affymetrix Mouse Exon 1.0 ST Array platform to analyze the gene expression profiling. We included the gene expression data obtained from dorsal spinal cord commissural neuron at different embryonic stage. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

6 Samples

Download data: CEL

(Submitter supplied) p53 is a known tumor suppressor. We have found that stromal p53 regulates breast cancer development, the immune landscape, and survival in an oncogene specific manner when comparing the epithelial oncogenes ErbB2 and KrasG12D In this dataset, we have evaluated mammary epithelia from mice with and without epithelial KrasG12D and with and without stromal p53 deletion. We have also evaluated mammary fibroblasts from mice with and without epithelial KrasG12D and with and without stromal p53 deletion.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

32 Samples

Download data: CEL, XLSX

(Submitter supplied) Skeletal muscle aging is characterized by a progressive decline in muscle mass and function, which is referred to as sarcopenia. However, the molecular mechanisms implicated in sarcopenia remain unclear. In this dataset, we include the expression data obtained from gastrocnemius muscle of young, mature adult and old C57BL6 male mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

18 Samples

Download data: CEL

(Submitter supplied) Laser captured regions surrounding the perifornical area (PeFA) in adult male mice that attacked pups; a control outside region (unk); a c-fos positive region (c-fos); an oxytocin positive region (oxt) In this dataset, we include the expression data obtained from dissected mouse forelimbs using a variety of gain- and loss-of-function hedgehog pathway mutants, as well as limbs dissected into responsive (posterior 2/3ds) and non-responsive (anterior 1/3d) Hh tissues. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

9 Samples

Download data: CEL

(Submitter supplied) To understand the transcriptional effect of fasting and feeding a ketogenic diet on mouse CNS astrocytes, we performed translating ribosomal affinity purification (TRAP) of mRNAs immunoprecipitated from hippocampus. TRAP mice express a ribosomal epitope tag upon Cre-induced recombination that can be immunoprecipitated following activation. We measured the abundance of actively translating mRNAs from a ribosomal pull-down that came from adult astrocyte (Aldh1l1-Cre)-specific TRAP mice that were subjected to one of three dietary conditions: four weeks of normal chow diet, four weeks of ketogenic diet (high-fat, low-carbohydrate)43, or an 18-hour fast. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

11 Samples

Download data: CEL

(Submitter supplied) Transcriptome analysis of RNA samples from islets To gain grater insight into the role and mechanisms behind the inhibitory G-Protein, Gaz we used global gene expression profiling. In mice, transgenic loss of B-cell Gaz is protective against high fat diets. through increased insulin secretion. This mechansism is poorly understood and here, using global transcriptomics we attempt to understand the genetic impact of Gaz knockout on control and HFD diets in male mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6096 GPL6193

36 Samples

Download data: CEL, CHP

(Submitter supplied) Although intensively studied, the gene networks regulating limb development is still incomplete. Indeed, efforts to decipher the genetic and transcriptional control of limb formation rely mainly on transcriptome approaches obtained from embryos collected 0.5 or 1 day apart from E9.5 to E13.5. This approach identified gene networks tightly regulated during limb morphogenesis as well as novel genes possibly involved in these networks. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

21 Samples

Download data: CEL, CHP

(Submitter supplied) Transcriptome analysis of usp15 deficient mice RNA metabolism plays an important for regulating protein diversity. USP15, which is a deubiquitinating enzyme, is known to be a responsible gene for developmental disorders and neurodegenerative disorders. Although USP15 is implicated in RNA processing, the downstream targets regulated by USP15 have not been elucidated. Here, we performed exon array screening to identify the target of USP15 using Usp15 deficient mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6096 GPL6193

24 Samples

Download data: CEL, CHP

(Submitter supplied) The RNA from NMJ and non-NMJs samples were examined using microarray analysis with of identifying novel regulatory genes that are preferentially expressed in the synaptic regions of the isolated muscle fibers.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

6 Samples

Download data: CEL, CHP

(Submitter supplied) Astroglia are the most abundant cell type in the central nervous system. They play essential roles in the homeostasis of the CNS. Astroglia are extremely diverse. In Amyotrophic Lateral Sclerosis (ALS) astroglia in spinal cord undergo dramatic transcriptomic dysregulation. However there is little to no data on the effects that cortical astroglia undergo during ALS pathogenesis. In this study we isolated pure cortical astroglia in end stage ALS mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6096 GPL6193

14 Samples

Download data: CEL

(Submitter supplied) We demonstrate that the cell-surface molecule LRRC33 associates with proTGF-β1 and provides a milieu for a restricted subset of TGF-β-dependent functions. We deposit microglia transcriptional profiles from three Lrrc33+/+ mice and three Lrrc33-/- mice. In this dataset, we include the expression data obtained from microglia that were isolated from 3 Lrrc33+/+ mice and 3 Lrrc33-/- mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6096 GPL6193

12 Samples

Download data: CEL

(Submitter supplied) We used microarrays to decipher the global programme of gene expression in normal colon tissue versus colorectal tumor tissue explants from 6 months old cav1-/+ apcmin/+ mice and identified distinct classes of differentially regulated genes.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

2 Samples

Download data: CEL

(Submitter supplied) The medial nucleus of the trapezoid body (MNTB) contains a nearly homogeneous population of neurons, which are innervated by large glutamatergic nerve terminals called calyces of Held (CH). Key steps in maturation of CHs and MNTB neurons, including CH growth and competition, occur very quickly for most cells between postnatal days (P)2 and P6. Therefore, we characterized genome-wide changes in this system, with dense temporal sampling during the first postnatal week. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

33 Samples

Download data: CEL

(Submitter supplied) Epigenetic factors (EFs) regulate multiple aspects of cerebral cortex development, including proliferation, neuronal differentiation, laminar fate, and regional identity. The same neurodevelopmental processes are also regulated by transcription factors (TFs), notably the Pax6→Tbr2→Tbr1 cascade expressed sequentially in radial glial progenitors, intermediate progenitors, and postmitotic projection neurons, respectively. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

12 Samples

Download data: CEL

(Submitter supplied) The tumor suppressor gene p53 is frequently mutated in human breast cancer and is a marker for poor prognosis and resistance to chemotherapy. Transplantation of p53-null mouse mammary epithelium into syngeneic wild-type mice leads to normal mammary gland development followed by spontaneous mammary tumors that recapitulate many of the phenotypic, molecular, and genetic features of human breast cancer. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

4 related Platforms

24 Samples

Download data: BEDGRAPH, CEL, TXT

(Submitter supplied) Eavluation of temporal expression kinetics during mouse osteoclast differentiation evaluated by microarray. We overlayed gene expression data with correspoding DNA binding data from MITF and PU.1 ChIP-seq to evaluate gene regulatory networks in osteoclasts.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

9 Samples

Download data: CEL

(Submitter supplied) Transcriptome analysis of cardiac progenitor cells and cardiomyocytes The identification of cell surface proteins on stem cells or stem cell derivatives is a key strategy for the functional characterization, isolation, and understanding of stem cell population dynamics. Here, using an integrated mass spectrometry and microarray based approach, we analyzed the surface proteome and transcriptome of cardiac progenitor cells (CPCs) generated from the stage-specific differentiation of mouse and human pluripotent stem cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

9 Samples

Download data: CEL, CHP

(Submitter supplied) Development of the human gut microbiota commences at birth, with bifidobacteria being among the first colonizers of the newborn gastrointestinal tract. To date, the genetic basis of Bifidobacterium colonization, persistence and dialogue with the host remains poorly understood. We previously identified tight adherence (Tad) pili from Bifidobacterium breve UCC2003 as an essential colonisation factor using murine models.We have identified the protein that mediates the proliferation response, and demonstrate that bifidobacteria contribute to the maturation of the naïve gut in early life through the production of specific extracellular protein structures under in vivo conditions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

16 Samples

Download data: CEL, XLSX