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Items: 1 to 20 of 67

1.

Sequential rather than coincident molecular mechanisms govern the combinatorial control logic underlying pathogen-responsive gene expression programs

(Submitter supplied) Combinatorial control of gene expression is presumed to be mediated by molecular interactions between coincident transcription factors (TFs). While information on the genome-wide locations of TFs is available, the genes they regulate and whether they function combinatorially often remain open questions. Here, we developed a mechanistic, rather than statistical, modeling approach to elucidate TF control logic from gene expression data. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
40 Samples
Download data: TXT
Series
Accession:
GSE35521
ID:
200035521
2.

In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes

(Submitter supplied) Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with the effects of caloric restriction, the most effective rejuvenating treatment known so far. Analysis of the transcriptomic profiles of SAMP8 astrocytes cultured in control conditions and treated with caloric restriction serum was performed using mRNA microarrays. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
12 Samples
Download data: TXT
Series
Accession:
GSE60388
ID:
200060388
3.

Global murine pulmonary response to highly and less virulent influenza A (H3N2) virus infections at 12, 48 and 96 h post-infection

(Submitter supplied) Array analysis of total lung RNAs from female BALB/c mice collected at 12, 48 and 96 h post-infection with highly and less virulent influenza A (H3N2) viruses. Viruses (designated as LVI and HVI) were derived from influenza strain virus A/Aichi/2/68 (Aichi68). LVI is Aichi68 propagated in eggs, and HVI is mouse adapted Aichi68.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5159
Platform:
GPL6103
18 Samples
Download data: TXT
Series
Accession:
GSE55994
ID:
200055994
4.

Global transcriptomic profiling of oxygen-glucose deprivation (OGD)-mediated neuronal injury

(Submitter supplied) Oxygen-glucose deprivation (OGD) is a cellular phenomenon consistently observed upon occurrence of ischemic stroke which eventually results in neuronal death. Neuronal cell death after ischemia takes place via two distinct processes, necrosis and apoptosis. Apoptosis, programmed cell death, is denoted by chromatin condensation, nuclear blebbing, cellular shrinkage, and DNA fragmentation. Unlike apoptosis, cellular swelling and lysis is suggestive of necrosis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
20 Samples
Download data: TXT
Series
Accession:
GSE23158
ID:
200023158
5.

Comparative global transcriptomic profiling of low and high concentration of lactacystin-mediated neuronal death

(Submitter supplied) Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. Pharmacological proteasomal inhibitors such as lactacystin can induce apoptosis in cultured mouse cortical neurons through the activation of caspase-3. However, Meiners et al., 2003 suggested that low dose of lactacystin induces a concerted expression of proteasome genes and de novo formation of proteasomes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
24 Samples
Download data: TXT
Series
Accession:
GSE23155
ID:
200023155
6.

Global gene profiling of rotenone-induced neuronal death

(Submitter supplied) Rotenone is a naturally occurring toxic substance from the Leguminosa plant and belongs to the group of compounds known as rotenoids (Bové et al., 2005). It is commercially used as a pesticide and is epidemiologically linked to PD. Being lipophilic, rotenone can diffuse across biological membranes in the body and gain entry to all the organs and cells (Bové et al., 2005). Rotenone can bind to complex I of the electron transport chain (ETC) and inhibit the enzymatic activity of the NADH-ubiquinone reductase (Schuler and Casida, 2001). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5341
Platform:
GPL6103
13 Samples
Download data: TXT
Series
Accession:
GSE22997
ID:
200022997
7.

Global gene profiling of (-)-Epigallocatechin-3-gallate (EGCG)-induced neuronal death

(Submitter supplied) Alzheimer’s disease (AD) is the most common form of adult-onset dementia with severe intellectual deterioration and is characterised by the accumulation of the amyloid-β (Aβ) peptides and the presence of hyperphosphorylated microtubule- associated protein, tau. (-)-Epigallocatechin-3-gallate (EGCG) – a polyphenolic catechin found in green tea leaves, not only acts as a proteasome inhibitor, it is also involved in neuroprotection.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
7 Samples
Download data: TXT
Series
Accession:
GSE22996
ID:
200022996
8.

Global gene profiling of kainate-induced neuronal death

(Submitter supplied) It has long been established that in neurological disease models, KA is a potent excitotoxin, mediating acute limbic seizures and long-term morphologic changes in the hippocampus, which are hallmark characteristics seen in temporal lobe epilepsy (i.e. mossy-fiber sprouting, neuronal loss, and reactive gliosis; Ben-Ari and Cossart, 2000). Persuasive clinical evidence employing KA receptor agonists further substantiate the detrimental effects of kainate. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
15 Samples
Download data: TXT
Series
Accession:
GSE22994
ID:
200022994
9.

Global gene profiling of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced neuronal death

(Submitter supplied) AMPA receptors are involved not only in neuronal plasticity but also in excitotoxicity, mediated largely by the influx of Ca2+ (Choi et al., 1988). Their implication has been highlighted in animal models of ischemia and epilepsy. Studies of ischemic rodent models featured that prior to cell death, hippocampal CA1 pyramidal cells exhibit an increased AMPA receptor-mediated Ca2+ influx and decreased GluR2 and GluR3 mRNA and protein levels (Gorter et al., 1997; Heuerteaux et al., 1995).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
15 Samples
Download data: TXT
Series
Accession:
GSE22993
ID:
200022993
10.

Global gene profiling of glutamate-induced neuronal death

(Submitter supplied) Glutamate, a major neurotransmitter in the mammalian nervous sytem, has been involved in the mediation of excitotoxicity commonly observed in the pathogenesis of stroke. Current study focused on gaining an insight into the molecular mechanisms of glutamate-induced neuronal death
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
15 Samples
Download data: TXT
Series
Accession:
GSE19936
ID:
200019936
11.

Genome-wide analysis of gene expression in mouse spleen stroma

(Submitter supplied) Comparison between gene expression profiles of splenic stroma from wild type and lymphotoxin beta receptor knockout mice. The goal was to identify a set of genes which expression in splenic stroma is under lymphotoxin control and which can potentially be important for proper stroma development and function in secondary lymphoid organs.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
8 Samples
Download data: IDAT, JPG, SDF, TIFF, TXT, XML
Series
Accession:
GSE52294
ID:
200052294
12.

Characterization of cholesterol loading effect on the gene expression of bone marrow derived macrophages of AKR and DBA/2 ApoE-deficient mice

(Submitter supplied) Strain effects on the response to cholesterol loading in bone marrow derived macrophages (BMM) are not well studied. The atherosclerosis susceptible strain, DBA/2 on the ApoE deficient background and the atherosclerosis resistant AKR strains show differences in cholesterol handling when loaded with AcLDL. To understand the molecular basis for these differences, BMM from both strains were loaded with acetylated low desnisty lipoprotein (AcLDL) and gene expression quantified. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6103 GPL6885
32 Samples
Download data
Series
Accession:
GSE38736
ID:
200038736
13.

Genes induced by Oxi-beta overexpression in dopaminergic neuronal cell SN4741

(Submitter supplied) To identify genes regulated by Oxi-beta, differential gene chip analysis was perfomed. And the greatest upregulation (about 25-fold) of FBXW5 mRNA was observed in response to Oxi-beta overexpression in SN4741 dopaminergic neuronal cells
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
2 Samples
Download data: TXT
Series
Accession:
GSE47634
ID:
200047634
14.

Sox7 and Sox17

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL6103 GPL6885
15 Samples
Download data
Series
Accession:
GSE43234
ID:
200043234
15.

Gene expression analysis of F9 cells double knock-down for Sox7 and Sox17

(Submitter supplied) Analysis of the expression of F9 cells after knockdown of Sox7 and Sox17 during their primitive endoderm differnetiation induction with retinoic acid. Results provide information on the endodermal gene expression program regulated by Sox7 and Sox17.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
5 Samples
Download data: TXT
Series
Accession:
GSE43232
ID:
200043232
16.

Gene expression profile of G93A-SOD1 mouse spinal cord, blood and muscle

(Submitter supplied) To investigate the usefulness of gene expression as diagnostic biomarkers, we compared whole genome expression profiles of lumbar spinal cord with profiles of peripheral blood and tibialis anterior muscle in 16 mutant G93A-SOD1 mice and 15 wild type littermates.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
92 Samples
Download data: TXT
Series
Accession:
GSE27933
ID:
200027933
17.

Transcriptome of MEFs with BMP2 and DNA damage reagents

(Submitter supplied) The tightly controlled BMP-Smad1 pathway is essential for embryonic development and postnatal tissue homeostasis. Dysfunction of BMP-Smad1 signaling also leads to tumor development such as juvenile polyposis and Cowden syndromes and various tumors in mouse models, with unknown pathological mechanisms. Here we establish a link between the BMP-Smad pathway and the prominent tumor suppressor Atm-p53 pathway. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
16 Samples
Download data: TXT
Series
Accession:
GSE36843
ID:
200036843
18.

Zbtb16 Has a Role in Brown Adipocyte Bioenergetics

(Submitter supplied) Study designed to identify genes that are induced in both BAT and skeletal muscle during acute adaptive thermogenesis in mouse using gene expression microarray. Animal studies were performed under approved UCLA animal research protocols and according to guidelines established in the Guide for Care and Use of Laboratory Animals. C57BL/6J mice were maintained in 12-h light/dark conditions and fed a regular chow diet (Purina 50010, Lab Diet, USA). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4849 GDS4850
Platform:
GPL6103
8 Samples
Download data: TXT
Series
Accession:
GSE40486
ID:
200040486
19.

Stromal factors SDF1alpha, sFRP1 and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells

(Submitter supplied) The identified stromal factors SDF1alpha, sFRP1 and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells. Human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons are potentially useful for treating Parkinson’s disease (PD) through cell replacement therapy. Generation of DA neurons from hESCs has been achieved by co-culture with the stromal cell line PA6, a source of stromal cell-derived inducing activity (SDIA). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
4 Samples
Download data: TXT
Series
Accession:
GSE20503
ID:
200020503
20.

Differences in gene expression patterns in mouse embryonic fibroblast Flp-In-3T3 cell lines stably expressing Pax6 or Pax6(5a).

(Submitter supplied) Novel target genes for the two transcription factor isoforms Pax6 and Pax6(5a) were identified by generating mouse embryonic fibroblast cell lines stably expressing either Pax6 or Pax6(5a), and comparing their gene expression pattern with the original mouse embryonic fibroblast cell line.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
8 Samples
Download data: TXT
Series
Accession:
GSE31402
ID:
200031402
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