GEO DataSets

(Submitter supplied) Long-term peritoneal dialysis is associated with progressive fibrosis of the peritoneum. Epithelial-mesenchymal transition (EMT) of mesothelial cells is an important mechanism involved in peritoneal fibrosis, and TGF-b1 is considered central in this process. We conducted network-based integrated analysis of transcriptomic data to systemically characterize the molecular signature of TGF-b1-stimulated human peritoneal mesothelial cells (HPMCs).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

4 Samples

Download data: TXT

(Submitter supplied) The objective of this study was to profile the gene-regulatory heterogeneities of breast epithelial cells grown in an ECM-rich environment. The approach was to use stochastic profiling (Janes et al., Nat Methods 7(4):311-7 [2010]) to collect 10-cell pools of ECM-attached cells obtained by laser-capture microdissection and measure fluctuations in the 10-cell-averaged measurements to infer heterogeneous regulatory states.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

32 Samples

Download data: TXT

(Submitter supplied) Basal-like carcinoma is a subtype of breast cancer that is characterized by poor prognosis and high intratumor heterogeneity. Using a basal-like breast epithelial line, we have identified two anti-correlated gene-expression programs that arise among single extracellular matrix (ECM)-attached cells during organotypic 3D culture. The first program contains TGFBR3, a high-affinity receptor for transforming growth factor β (TGFβ) and other related ligands. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL6255 GPL6947 GPL10558

141 Samples

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(Submitter supplied) Immune impairment and high circulating level of pro-inflammatory cytokines are landmarks of human aging. However, the molecular basis of immune dysregulation and the source of inflammatory markers remain unclear. Here we demonstrate that in the absence of overt cell stimulation, gene expression mediated by the transcription factor NF-κB is higher in purified and rested human CD4+ T lymphocytes from older compared to younger individuals. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

31 Samples

Download data: TXT

(Submitter supplied) Analysis of PBMC from 10 week old infants vaccinated with BCG at birth. During follow-up 26 infants developed tuberculosis (TB) (non-protected by BCG) and 20 infants did not develop TB despite documented exposure (protected by BCG). PBMC were stimulated with media only or reconstituted BCG for 4 and 12 hours. Results provide insight into the mechanisms behind the failure of BCG to protect against disease.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

182 Samples

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(Submitter supplied) The majority of gastric cancer cases are believed to be caused by chronic infection with the bacterium Helicobacter pylori, and atrophic corpus gastritis is a predisposing condition to gastric cancer development. We aimed to increase understanding of the molecular details of atrophy by performing a global transcriptome analysis of stomach tissue. Biopsies from patients with different stages of H. pylori infection were taken from both the antrum and corpus mucosa and analyzed on microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS5338 GDS5411

Platform:

GPL6255

18 Samples

Download data: TXT

Analysis of stomach biopsies at different stages of Helicobacter pylori (HB) infection. Many gastric cancers believed caused by chronic HB infection and atrophic corpus gastritis predisposes to gastric cancer development. Results provide insight into mechanisms underlying atrophic HB infection.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 9 individual sets

Platform:

GPL6255

Series:

GSE27411

9 Samples

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Analysis of stomach biopsies of different stages of Helicobacter pylori (HB) infection. Many gastric cancers believed caused by chronic HB infection and atrophic corpus gastritis predisposes to gastric cancer development. Results provide insight into mechanisms underlying atrophic HB infection.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 disease state, 9 individual sets

Platform:

GPL6255

Series:

GSE27411

9 Samples

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(Submitter supplied) We performed a broad-spectrum microarray analysis using mRNA from 3 NL and 5 DS astrocyte cultures. The microarray output was validated for several genes To explore the relation between gene expression and potential oxidative stress in DS samples, we also evaluated the transcription profile in NL astrocytes subjected to mild oxidative stress (50µM H2O2 for 24 hr).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

16 Samples

Download data: TXT

(Submitter supplied) Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1 These studies detail transcriptional changes induced in cancer cells by the complex of saporin (b-SO6) and the antibody fusion protein ch128.1Av. Delivery of saporin into cancer cells by ch128.1Av, induces a transcriptional response consistent with oxidative stress and DNA damage, a response that is not observed with ch128.1Av alone.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

17 Samples

Download data: TXT

(Submitter supplied) Investigation of the gene expression changes associated with TLR2 adjuvant (lipoteichoic acid; LTA) inhibition of allergic TH2 responses in peripheral blood mononuclear cell cultures (derived from house dust mite allergic individuals) stimulated with house dust mite extract.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

4 Samples

Download data: TXT

(Submitter supplied) Androgen receptor (AR) orchestrates an intricate transcriptional regulatory network that governs prostate cancer initiation, development and progression. To understand this network in detail, we generated genome-wide maps of AR occupancy by ChIP-seq in LNCaP cells. We found NKX3-1, an androgen-dependent homeobox protein well-characterized for its role in prostate development and differentiation, being recruited to AR binding sites (ARBS) in response to androgen signaling. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

8 Samples

Download data: TXT

(Submitter supplied) PRKAR1A inactivating mutations are responsible for primary pigmented nodular adrenocortical disease (PPNAD) whereas somatic GNAS activating mutations cause macronodular disease in the context of McCune-Albright syndrome (MAS), ACTH-independent hyperplasia (AIMAH) and, rarely, cortisol-producing adenomas (CPA). The whole-genome expression profile (WGEP) of normal (pooled) adrenals, PRKAR1A- (3) and GNAS-mutant (3) was studied.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

9 Samples

Download data: TXT

(Submitter supplied) Gene expression studies in peripheral tissues from patients with neurodegenerative disorders can provide insights into disease pathogenesis, and identify potential biomarkers, an important goal of translational research in neurodegeneration. Friedreich’s Ataxia (FRDA) is a chronic neurodegenerative disease caused by reduced transcription of frataxin, a ubiquitously expressed protein. We studied in vitro lymphocytes from FRDA patients and carriers, in order to identify a peripheral gene expression phenotype. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

108 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL6883 GPL6255

48 Samples

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(Submitter supplied) Results of blocking HER-2 kinase activity in MCF-10A cells by treatment with CP724,714 and measuring gene expression as a function of time provides information as to what genes are regulated by HER-2 in these nontransformed breast epithelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

16 Samples

Download data: TXT

(Submitter supplied) Results of blocking the kinase function of the activated HER-2 oncogene in MCF-10HER-2 cells by treatment with CP724,714 and measuring gene expression as a function of time provides information as to what genes are regulated by HER-2 in these breast epithelial cells that express transformed phenotypes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

16 Samples

Download data: TXT

(Submitter supplied) Neurodegenerative diseases of the central nervous system are characterised by pathogenetic cellular and molecular changes in specific areas of the brain that lead to the dysfunction and/or loss of explicit neuronal populations. Despite exhibiting different clinical profiles and selective neuronal loss, common features such as abnormal protein deposition, dysfunctional cellular transport, mitochondrial deficits, glutamate excitotoxicity and inflammation are observed in most, if not all, neurodegenerative disorders, suggesting converging pathways of neurodegeneration. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6255

118 Samples

Download data: TXT

(Submitter supplied) Multiple breast cancer cell lines with different metastatic capabilities The goal of this study is to identify metastasis related genes in breast cancer We obtained RNA from each cell line using regular Trizol and RNA purification kit. Keywords: Expression profiling by array

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6255 GPL6103

6 Samples

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