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Items: 1 to 20 of 1185

1.

Lmo2 is dispensable for maintenance of most Lmo2-induced murine T-cell leukemias

(Submitter supplied) Lmo2 is an oncogenic transcription factor that is a frequent target of chromosomal abnormalities in this T-cell acute lymphoblastic leukemia (T-ALL). In transgenic mouse models, overexpression of Lmo2 causes thymocyte self-renewal leading to T-cell leukemia with long latency. However, the requirement of Lmo2 for maintenance of overt leukemia is poorly understood. We found that Lyl1, a critical cofactor for Lmo2-induced leukemia, is frequently lost in cell lines derived from Lmo2-transgenic mice, raising the possibility that Lmo2 function is dispensable at this stage. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
9 Samples
Download data: TXT
Series
Accession:
GSE125674
ID:
200125674
2.

Transcriptomic profiles of splenic Gr-1+ cells from IDO-KO hosts and WT hosts after bone marrow transplantation

(Submitter supplied) Tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1) has also immunological function to suppress T cell activation in inflammatory circumstances, including graft-versus-host disease (GVHD), a fatal complication after allogeneic bone marrow transplantation (allo-BMT). Although the mononuclear cell expression of IDO1 has been associated with improved outcomes in GVHD, the underlying mechanisms remain unclear. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
9 Samples
Download data: IDAT, TXT
Series
Accession:
GSE163730
ID:
200163730
3.

Analysis of differentiating 3T3L1 mouse pre-adipocytes with knock-down of Tmem120a and Tmem120b

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL13112 GPL6887
19 Samples
Download data: BW, XLS
Series
Accession:
GSE150507
ID:
200150507
4.

Transcriptome analysis of differentiating 3T3L1 mouse pre-adipocytes with knock-down of Tmem120a and Tmem120b

(Submitter supplied) The nuclear envelope transmembrane proteins (NETs) NET29a/Tmem120a and NET29b/Tmem120b are expressed or localise preferentially to the nuclear envelope in adipocytes. We knocked these proteins down using specific shRNAs and studied their effect in the diffentiation of the mouse 3T3L1 preadipocyte cell line.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
11 Samples
Download data: TXT
Series
Accession:
GSE150022
ID:
200150022
5.

An Antagonist of Toll-like Receptor 7 and 9 lowers cholesterol and reduces atherosclerosis in hyperlipidemic mice

(Submitter supplied) The impact of a dual TLR7 and TLR9 antagonist on hypercholesteremia and atherosclerosis was evaluated in hyperlipidemic mice. Treatment with antagonist induced a dose dependent reduction of total cholesterol (TC) and LDL-cholesterol. Changes in Adiponectin, Leptin and free fatty acids levels were observed. Plaque formation was inhibited in ApoE-/- and LDL-R-/- mice fed high fat diet and treated with the antagonist. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
20 Samples
Download data: TXT
Series
Accession:
GSE28125
ID:
200028125
6.

Molecular Pathways are influenced by Progranulin in a neuronal cell model

(Submitter supplied) Gene expression microarrays were used to identify how the mRNA phenotype of NSC-34 cells responds to PGRN expression levels. PGRN expression correlated well with molecular phenotypes that included mRNA pathways associated with the regulation of the cytoskeleton Gene expression profile was determined using Illumina Mouse Whole-Genome Expression BeadChips (MouseWG-6 v2.0
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
12 Samples
Download data: TXT
Series
Accession:
GSE185877
ID:
200185877
7.

Identification of Jmjd2a KO regulated genes in the mouse hearts

(Submitter supplied) Cardiac hypertrophy and failure are accompanied by a reprogramming of gene expression that involves transcription factors and chromatin remodeling enzymes. Little is known about the role of histone methylation and demethylation in this process. To understand the role of JMJD2A, a trimethyl demethylase for histone 3 lysine 9 and 36, in cardiac hypertrophy, we generated heart specific JMJD2A deletion (JMJD2A hKO) and overexpression (JMJD2A-Tg) mouse lines. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: IDAT, TXT
Series
Accession:
GSE169645
ID:
200169645
8.

Role of TGFb1 and Wnt6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
40 Samples
Download data
Series
Accession:
GSE164631
ID:
200164631
9.

Role of TGFb1 and Wnt6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells [3h]

(Submitter supplied) In this work we investigated the molecular mechanisms that sustain the endothelial differentiation of murine embryonic stem cells (ES). When ES cells are co-cultured with the stromal PA6 cells in serum-free medium they differentiate mainly into neurons, thanks to the neural inducing activity exerted by the stroma. The addition of exogenous FGF2 allows also the differentiation of endothelial cells whereas, in presence of exogenous BMP4, ES cells differentiate exclusively into endothelium. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: TXT
Series
Accession:
GSE164630
ID:
200164630
10.

Role of TGFb1 and Wnt6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells [7d]

(Submitter supplied) In this work we investigated the molecular mechanisms that sustain the endothelial differentiation of murine embryonic stem cells (ES). When ES cells are co-cultured with the stromal PA6 cells in serum-free medium they differentiate mainly into neurons, thanks to the neural inducing activity exerted by the stroma. The addition of exogenous FGF2 allows also the differentiation of endothelial cells whereas, in presence of exogenous BMP4, ES cells differentiate exclusively into endothelium. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
16 Samples
Download data: TXT
Series
Accession:
GSE164629
ID:
200164629
11.

Role of TGFb1 and Wnt6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells [3d]

(Submitter supplied) In this work we investigated the molecular mechanisms that sustain the endothelial differentiation of murine embryonic stem cells (ES). When ES cells are co-cultured with the stromal PA6 cells in serum-free medium they differentiate mainly into neurons, thanks to the neural inducing activity exerted by the stroma. The addition of exogenous FGF2 allows also the differentiation of endothelial cells whereas, in presence of exogenous BMP4, ES cells differentiate exclusively into endothelium. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
18 Samples
Download data: TXT
Series
Accession:
GSE164625
ID:
200164625
12.

Gene expression in the F1 and F2 mouse hippocampus with intrauterine hyperglycemia exposure

(Submitter supplied) Studies on human and animals suggest associations between gestational diabetes mellitus (GDM) with impaired cognitive performance in offspring. Using a mouse model of diabetes during pregnancy, we found that intrauterine hyperglycemia exposure resulted in memory impairment in both the first filial (F1) males and the second filial (F2) males from the F1 male offspring. The effects of intrauterine hyperglycemia exposure on F1 and F2 hippocampus gene expression were also examined.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
15 Samples
Download data: IDAT, TXT
Series
Accession:
GSE147039
ID:
200147039
13.

Gene expression in the mouse embryo following early pregnancy exposure to ethanol or nicotine

(Submitter supplied) The in utero environment is a critical determinant of the immediate and future health of the developing fetus. Two of the most commonly used drugs during pregnancy are alcohol and nicotine. While prolonged gestational exposure to alcohol or nicotine has been associated with a range of adverse outcomes in the offspring, the consequences of exposure during early gestation only are less well understood. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
36 Samples
Download data: TXT
Series
Accession:
GSE94347
ID:
200094347
14.

Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of IL-22

(Submitter supplied) We wanted to identify effector molecules which confer rotavirus resistance in microbiota-depleted mice We used microarrays to analyze the global programme of gene expression in response to IL22 treatment in the ileum of antibiotic-treated Ifnlr1-/- mice
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
10 Samples
Download data: TXT
Series
Accession:
GSE166400
ID:
200166400
15.

Gene expression profiles of radiation-induced hepatocellular carcinoma (HCC) in C3H mice

(Submitter supplied) Analysis of whole transcriptome gene expression in 6 groups of liver samples in mice: HCC induced by high-LET radiation, HCC induced by low-LET radiation, spontaneous HCC, non-tumor liver irradiated with high-LET radiation, non-tumor liver irradiated with low-LET radiation, normal liver without radiation.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
34 Samples
Download data: TXT
Series
Accession:
GSE166653
ID:
200166653
16.

Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL19057 GPL6887
12 Samples
Download data
Series
Accession:
GSE178449
ID:
200178449
17.

Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon [Array]

(Submitter supplied) The strength of the T cell receptor interaction with self-ligands affects antigen-specific immune responses. However, the precise role, functional relationship, and underlying mechanisms have not been elucidated completely. Here, we demonstrate that naive CD8+ T cells with relatively high self-reactivity are phenotypically heterogeneous owing to varied responses to type I interferon (T1IFN), resulting in three distinct subsets, CD5loLy6C–, CD5hiLy6C–, and CD5hiLy6C+ cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: TXT
Series
Accession:
GSE178445
ID:
200178445
18.

Gene expression profiling during RANKL-mediated osteoclast differentiation

(Submitter supplied) The hexosamine biosynthetic pathway (HBP) is a pathway that requires glucose using approximately 3% ~ 5% of total glucose coming into cells. HBP synthesizes UDP-GlcNAc using not only glucose but also various metabolic products such as those amino acid, fatty acid and nucleotide. O-GlcNAcylation by Ogt is considered the act as a nutrient sensor because the amount of UDP-GlcNAc is influenced by various metabolites. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
24 Samples
Download data: TXT
Series
Accession:
GSE176265
ID:
200176265
19.

Whole gene expression profiling after overexpression of Evl or miR-342 in murine hematopoietic LSK cells

(Submitter supplied) Analyzing the influence of the protein-coding gene Evl or it's intronic miR-342 on hematopoietic stem and progenitor cells on gene expression level. Evl drives lymphopoiesis, whereas miR-342 deregulates myeloid signaling pathways.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: IDAT, TXT
Series
Accession:
GSE109600
ID:
200109600
20.

Genomic profiling of spermatogonial stem cells and embryonic stem cells

(Submitter supplied) Through comparing the global expression profiles of SSCs and ESCs using DNA microarrays, the differences between the SSC and ESCs have been revealed , especially these pluripotency-related genes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: TXT
Series
Accession:
GSE38776
ID:
200038776
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