GEO DataSets

(Submitter supplied) Rosiglitazone-targeted transcriptional networks as gene expression signature of physiological and pathological mineralization – a top-down approach to identify novel targets for bone and vascular health Clinical studies have recently revealed detrimental skeletal and vascular effects of the insulin sensitizer rosiglitazone. At the cellular level, we have shown earlier that rosiglitazone accelerates osteoblast differentiation from human mesenchymal stem cells (hMSC) at the expense of increased oxidative stress and apoptosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

12 Samples

Download data: TXT

(Submitter supplied) We here present a novel subtype of fibroblasts isolated from sun-exposed skin of elderly donors and characterized by its prominent and stable myo-chondrocyte-type differentiation. As we depict a similar chondrocyte-type expression pattern at sites of solar elastosis in human skin, we propose that this fibroblasts phenotype develops in the course of massive and perseverative UV-dependent damage as part of the process terminating in the most severe appearance of photoaging - solar elastosis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL6947 GPL10558

24 Samples

Download data: IDAT, TXT

(Submitter supplied) We identified the molecular subtypes and conserved modules in gastric cancer by unsupervised clustering algorithm. We defined six molecular signatrues of gastric cancer associated with the biological heterogeneity of gastric cancer and clinical outcome of patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

50 Samples

Download data: IDAT, TXT

(Submitter supplied) Cancer patients often develop hemostasis disorders whose pathogenesis is poorly understood. Previous work in mouse models has shown that these disorders can be sustained by the MET oncogene by transcriptional upregulation of hemostasis genes. Here we investigated the correlation between the procoagulant state of colorectal cancer patients, and overexpression of MET and hemostasis genes in the tumor. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

46 Samples

Download data: TXT

(Submitter supplied) Differential transcriptome analysis in LUHMES cells overexpressing human wild-type alpha-synuclein or GFP

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

6 Samples

Download data: IDAT, TXT

(Submitter supplied) Genomic profiling can provide prognostic and predictive information to guide clinical care. Biomarkers that reliably predict patient response to chemotherapy and immune checkpoint inhibition in gastric cancer are lacking. In this retrospective analysis, we use our machine learning algorithm NTriPath [Park, Sunho et al. “An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer types.” Bioinformatics (2016): 1643-51. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

135 Samples

Download data: TXT

(Submitter supplied) To understand the mechanism by which TGFβ regulates tumor initiation in triple negative breast cancer (TNBC), we performed microarray analysis using Illumina Human HT-12 Gene Expression BeadChip. A TNBC cell line of SCP2 was treated or not with TGFβ for 24 hours. Differentially expressed genes were analyzed by comparing treated versus non-treated samples

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

4 Samples

Download data: TXT

(Submitter supplied) The C5/TRAF1 locus is a well validated genetic risk factor for RA. Upon further investigation of this region we recently discovered that the intergenic region between these two immune-related genes is activelly transcribed in a variety of tissues and is up-regulated in PBMCs, monocytes, B- and T-cells upon immune stimulation. The present study aimed to characterize the biological function of this newly identified C5/TRAF1 intergenic transcript, by analysing the effect of its knockdow on the gene expression profiles of Huh7 and THP1 cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

48 Samples

Download data: TXT

(Submitter supplied) Comprehensive understanding of the transcriptional foundations of human intestinal ischemia-reperfusion (IR) injury is imperative to find therapeutic targets and improve patient outcome. Here we analysed transcriptomes of the IR-injured human intestine, and showed that over 1,800 genes were significantly differentially expressed, predominantly during reperfusion. Intriguingly, protein processing in endoplasmic reticulum (ER) was one of the most perturbed pathways, which was supported by ontology analysis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

28 Samples

Download data: TXT

(Submitter supplied) Genome-wide methods for examining chromatin modification provide detailed information on regulatory regions of the genome.  Dynamic modifications of chromatin allow rapid access of the gene regulatory machinery to condensed genomic regions facilitating subsequent gene expression.  Inflammatory cytokine stimulation of cells can cause rapid gene expression changes through direct signalling pathway-mediated transcription factor activation and regulatory element binding.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

6 Samples

Download data: TXT

(Submitter supplied) As organ-specific models of breast cancer bone metastasis do not exist, we established a novel breast cancer line was established from the ER-/PR-/HER2- bone metastasis from a breast cancer patient. This cell line was characterized and compared to the primary tumour and/or normal mammary epithelial cells with regards to phenotypes (i.e. marker expression), gene expression and copy number variation.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

8 Samples

Download data: TXT

(Submitter supplied) To test the effect of Spag4 knockdown, we compared knockdown and control cells subjected to 48h 2uM camptothecin treatment or vehicle.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

12 Samples

Download data: TXT

(Submitter supplied) Alterations in intestinal microbiota and intestinal short chain fatty acids profiles have been associated with the pathophysiology of obesity and insulin resistance. Whether intestinal microbiota dysbiosis is a causative factor in humans remains to be clarified We examined the effect of fecal microbial infusion from lean donors on the intestinal microbiota composition, glucose metabolism and small intestinal gene expression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

46 Samples

Download data: TXT

(Submitter supplied) We identified molecular subtypes of 27 gastric cancer cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

108 Samples

Download data: IDAT, TXT

(Submitter supplied) The standardized uptake value (SUV), an indicator of the glucose uptake degree in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), has been used as a prognostic factor in malignant tumors. We aimed to identify a signature reflecting prognostic SUV characteristics in breast cancer (BRC). Transcriptome profiling was performed to identify a signature associated with the SUV in BRC patients who underwent preoperative FDG-PET. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

301 Samples

Download data: TXT

(Submitter supplied) We made use of the fact that patients with non-muscle invasive tumors show frequent local recurrences and multiple tumors to study re-initiation of tumor growth from the same urothelium. By extensive genomic analyses we show that tumors from the same patient are clonal. We show that gross genomic chromosomal aberrations may appear abruptly and disappear with no transitional stages being observed. By analysis of incompatible changes i.e., genomic alterations that cannot be reversed, we show that almost all tumors from a single patient show such changes, thus the tumors cannot have originated from each other. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL10558 GPL6947

47 Samples

Download data: TXT

(Submitter supplied) Analyis of the induction of myeloid derived suppressor cells using the LX2 model

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

6 Samples

Download data: TXT

(Submitter supplied) B cell depletion therapy is efficacious in RA patients failing on TNF blocking agents. However, approximately 40-50% of the rituximab-treated RA patients have a poor response. We investigated wheter baseline gene expression levels can discriminate between clinical nonresponders and responders to rituximab

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

14 Samples

Download data: TXT

(Submitter supplied) We examined the gene expression profiles resulting from the depletion of the non-canonical WNT receptor ROR2 in myeloma cells

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

10 Samples

Download data: TXT

(Submitter supplied) Proliferation and survival of CLL cells is highly dependent on the interaction of the tumor cells with different populations of accessory cells, incl. mesenchymal bone marrow stromal cells. In this project interactions between CLL cells and transformed bone-marrow derived fibroblast cell lines were studied. Gene expression was analyzed in CLL cells that were cocultured for different time periods with human (HS-5) or murine (M2-10B4) transformed fibroblasts, as compared to CLL cells from the same patient sample that were cultured in DMEM medium or conditioned medium in which HS-5 cells had been growing.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6947 GPL6884

44 Samples

Download data: TXT