GEO DataSets

(Submitter supplied) Analysis of Immediate Early Response 2 (Ier2)-inducible NIH 3T3 cells after Ier2 induction with RheoSwitch ligand RSL-1. Results provide insight into the function of Ier2 in NIH 3T3 mouse embryonal fibroblasts. Immediate early genes, including Ier2, are rapidly induced in quiescent cells by proliferation and migration-inducing stimuli. Microarray gene expression profiling was performed to identify differentially expressed genes following overexpression of Ier2 in NIH 3T3-Ier2 inducible cells after 24 hour induction of Ier2.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

12 Samples

Download data: CEL

(Submitter supplied) mRNA poly(A) tail plays a key role in post-transcriptional regulation of gene expression, including mRNA decay and translation. Deadenylation is a rate-limiting step in mRNA decay, which is catalyzed by the CCR4-NOT complex. To identify mRNAs associated with the CCR4-NOT complex, we have done RIP-CHIP (RNA-immunoprecipitation followed by DNA microarray) using primary hepatocytes from CNOT6L wild-type and knockout mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

12 Samples

Download data: CEL, CHP

(Submitter supplied) Diabetes is associated with altered metabolism, but how altered metabolism contributes to the development of complications such as diabetic kidney disease is unknown. We used a systems approach with transcriptomics and mass spectrometry (MS)-based metabolomics to determine alterations in carbohydrate and lipid metabolism in kidney cortex tissue from 24-week-old BKS db/db diabetic mice and db/+ controls. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

10 Samples

Download data: CEL

(Submitter supplied) Autosomal trisomies and monosomies bring serious threats to embryonic development through transcriptional disarray primarily caused by the dosage effect of the aneuploid part of the genome. The present study compared the effect of a mouse viable 30 Mb segmental trisomy on the genome-wide transcriptional profile of somatic (liver) cells and male germ cells. While the 1.6-fold change in expression of triplicated genes reflected the gene dosage in liver cells, the extra copy was almost fully compensated in early pachytene spermatocytes, showing 1.18-fold increase. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

22 Samples

Download data: CEL

(Submitter supplied) The CEL files of this study are additional to the GSE32583 and GSE44691; they are microarrays of lupus nephritis NZBW mouse model at 30 wks old, or treated with CTX+CTLAIg+anti-CD154 (early and late after remission) or Ad-TACI-Ig+CTLA4Ig (late after remission) and NZM2410 treated with Ad-BAFF-R-Ig.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

32 Samples

Download data: CEL

(Submitter supplied) We defined the shared and unique features of systemic lupus erythematosus (SLE) nephritis in 2 mouse models of proliferative renal disease. We identified shared inflammatory mechanisms of SLE nephritis that can be therapeutically targeted. Some common mechanisms are shared with non-immune-mediated renal diseases, suggesting that new strategies to prevent tissue hypoxia and remodeling may be useful in SLE nephritis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

11 Samples

Download data: CEL, TXT

(Submitter supplied) We investigated the influence of extension of autosomal asynapsis on expression profiles during spermatogenesis. We used the mouse autosomal translocation T(16;17)43H (abbreviated T43H) and t12 haplotype, a natural variant of Chr 17 encompassing four adjacent non-overlapping inversions proximal to the T43H translocation breakpoint, as a model. The presence of t12 haplotype in trans to the T43H translocation resulted in stringent spermatogenic block and in more complete silencing of genes surrounding the T43H translocation break. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

18 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

100 Samples

Download data: CEL

(Submitter supplied) Regulatory T cells expressing the transcription factor Foxp3 play indispensable roles for the induction and maintenance of immunological self-tolerance and immune homeostasis. Genome-wide mRNA expression-studies have defined canonical signatures of T-cell subsets. Changes in steady-state mRNA levels do, however, often not reflect those of corresponding proteins due to post-transcriptional mechanisms including mRNA translation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

16 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL14663 GPL7546

150 Samples

Download data: CEL

(Submitter supplied) Nephritis (LN) is a serious manifestation of SLE. Therapeutic studies in mouse LN models do not always predict outcomes of human therapeutic trials, raising concerns about the human relevance of these models. In this study we used an unbiased transcriptional network approach to define similarities and differences between three lupus models and human LN. Affymetrix-based expression profiles were analyzed using Genomatix Bibliosphere software and transcriptional networks were compared using the Tool for Approximate LargE graph matching (TALE). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

57 Samples

Download data: CEL, TXT

(Submitter supplied) Renal infiltration with mononuclear cells is associated with poor prognosis in SLE. A renal macrophage/dendritic cell signature is associated with onset of nephritis in NZB/W mice and immune modulating therapies can reverse this signature and the associated renal damage despite ongoing immune complex deposition. Our findings suggest that mononuclear phagocytes with an aberrant activation profile contribute to tissue damage in lupus nephritis by mediating both local inflammation and excessive tissue remodeling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4194

Platform:

GPL7546

17 Samples

Download data: CEL

Analysis of F4/80hi renal macrophages isolated at an early stage of lupus, during lupus nephritis, and after induction of remission. The infiltrating F4/80hi cells are associated with renal damage. Results provide insight into mechanisms by which F4/80hi macrophages contribute to lupus nephritis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 tissue sets

Platform:

GPL7546

Series:

GSE27045

17 Samples

Download data: CEL

(Submitter supplied) The platelet-derived growth factor (PDGF) signaling system contributes to tumor angiogenesis and vascular remodeling. Here, we show PDGF-BB markedly induces erythropoietin (EPO) mRNA and protein expression by targeting the PDGFR-beta+ stromal and perivascular compartments. In mouse tumor models, PDGF-BB-induced EPO promotes tumor growth via two mechanisms: 1) paracrine stimulation of tumor angiogenesis by directly inducing endothelial cell proliferation, migration, sprouting and tube formation; and 2) endocrine stimulation of extramedullary hematopoiesis leading to increased oxygen perfusion and protection against tumor-associated anemia. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

6 Samples

Download data: CEL

(Submitter supplied) Introduction: The mouse skeletal muscle is composed of four distinct fiber types that differ in contractile function, number of mitochondria and metabolism. Every muscle group has a specific composition and distribution of the four fiber types. Until now, three genes (CnA, PGC1α and PPARδ) are identified that are involved in the generation of more oxidative muscle types. In the present study we searched for novel genes that are involved in specifying different muscle types. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

40 Samples

Download data: CEL

(Submitter supplied) An 8-week high fat palm oil diet causes obesity and insulin resistance in C57BL/6J mice, but induces only small changes in the muscle transcriptome. Introduction: The metabolic syndrome (MS) is a cluster of metabolic abnormalities linked to an increased risk of type 2 diabetes and cardiovascular diseases. Two major characteristics of the MS are obesity and insulin resistance. In the present study we investigated the effect of obesity and insulin resistance on the mouse muscle transcriptome. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4015

Platform:

GPL7546

30 Samples

Download data: CEL

Analysis of skeletal muscle of C57BL/6J males fed a high fat diet (HFD) for 8 weeks to induce obesity and insulin resistance. Results provide insight into the molecular mechanisms underlying the development of diet-induced obesity and insulin resistance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 growth protocol, 2 time sets

Platform:

GPL7546

Series:

GSE17576

30 Samples

Download data: CEL

(Submitter supplied) The HGF/c-Met system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been demonstrated in acute liver regeneration its cell specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determined yet. In order to better characterize the role of c-Met in hepatocytes we generated a hepatocyte-specific c-Met knockout mouse (c-Met∆hepa) using the Cre-loxP system and studied its relevance after bile-duct ligation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

12 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4538 Series

40 Related Platforms

58877 Samples

Download data

(Submitter supplied) CDF file was created by Microarray Lab at the Molecular and Behavioral Neuroscience Institute at the University of Michigan. Oligonucleotide probes on GeneChips were reorganized based on the latest genome and transcriptome information. In this particular case the Entrez Gene database (build: Jun 28, 2007) was used as source. For the CDF file based on Entrez Gene: A probe must hit only one genomic location; Probes that can be mapped to the same target sequence in the correct direction are grouped together in the same probe set; Each probe set must contain at least three oligonucleotide probes and probes in a set are ordered according to their location in the corresponding exon. more...

Organism:

Mus musculus

2 DataSets

16 Series

1 Related Platform

295 Samples

Download data: TAR