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Items: 1 to 20 of 58

1.

Snail-dependent epithelial splicing regulatory protein 1 (ESRP1) silencing drives malignant transformation of human pulmonary epithelial cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Human polyomavirus 1; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Mus musculus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Rattus norvegicus; Murid gammaherpesvirus 4
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL570 GPL7723
8 Samples
Download data: CEL
Series
Accession:
GSE108137
ID:
200108137
2.

Snail-dependent epithelial splicing regulatory protein 1 (ESRP1) silencing drives malignant transformation of human pulmonary epithelial cells [miRNA]

(Submitter supplied) The significance of epithelial-to-mesenchymal transition (EMT)-inducing transcription factors in the onset of non-small cell lung cancer has not been resolved. Here, we report increased Snail expression in pulmonary premalignant lesions relative to histologically normal-appearing pulmonary epithelium. Utilizing immortalized human pulmonary epithelial cells and isogenic derivatives, we document Snail-dependent anchorage-independent growth of the epithelial cells in vitro, as well as transformation, primary tumor growth, and metastatic behavior in vivo. more...
Organism:
Human polyomavirus 1; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Murid gammaherpesvirus 4
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
4 Samples
Download data: TXT
Series
Accession:
GSE108136
ID:
200108136
3.

microRNA profiling of different adipose tissues and muscles

(Submitter supplied) Purpose: The goals of this study are to compare microRNA profiling in different adipose tissues and muscles using microRNA arrays. Methods: Tissue microRNA profiles of 2-3-month old mice were generated by using miRCURY™ LNA microRNA Array. The samples were hybridized on a hybridization station following the scheme you outlined in the sample submission. Scanning is performed with the Axon GenePix 4000B microarray scanner. more...
Organism:
Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Human gammaherpesvirus 4; Murid gammaherpesvirus 4; Human polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
5 Samples
Download data: XLS
Series
Accession:
GSE81976
ID:
200081976
4.

Identification of microRNA profiling of human ovary in PCOS with insulin resistance (pilot study)

(Submitter supplied) Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. It has become increasingly evident that insulin resistance plays a significant role both as a cause and result of the syndrome. In an effort to investigate further the observed insulin resistance in the ovarian tissue of women with PCOS, we conducted array-based, global miRNA profiling.
Organism:
Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Murid gammaherpesvirus 4; Human polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
1 Sample
Download data: GPR
Series
Accession:
GSE28832
ID:
200028832
5.

Divergent influence of microRNA-21 deletion on murine colitis phenotypes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Homo sapiens; Murid gammaherpesvirus 4; Human polyomavirus 1; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human gammaherpesvirus 4; Human immunodeficiency virus 1
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL6885 GPL7723
26 Samples
Download data
Series
Accession:
GSE59651
ID:
200059651
6.

Divergent influence of microRNA-21 deletion on murine colitis phenotypes [TNBS]

(Submitter supplied) Background: MicroRNAs (miRNAs) acting as negative regulators of gene expression are differentially expressed in intestinal tissues of patients with inflammatory bowel disease (IBD). Assessing the functional role of miRNAs in murine models of colitis facilitates elucidating the role of specific miRNAs in human IBD. The aim of this study was to determine the miRNA signature of murine models of colitis and to assess the influence of miR-21 on intestinal inflammation. more...
Organism:
JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Rattus norvegicus; Homo sapiens; Murid gammaherpesvirus 4; Human polyomavirus 1; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
8 Samples
Download data: TXT
Series
Accession:
GSE59650
ID:
200059650
7.

Divergent influence of microRNA-21 deletion on murine colitis phenotypes [DSS]

(Submitter supplied) Background: MicroRNAs (miRNAs) acting as negative regulators of gene expression are differentially expressed in intestinal tissues of patients with inflammatory bowel disease (IBD). Assessing the functional role of miRNAs in murine models of colitis facilitates elucidating the role of specific miRNAs in human IBD. The aim of this study was to determine the miRNA signature of murine models of colitis and to assess the influence of miR-21 on intestinal inflammation. more...
Organism:
JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Murid gammaherpesvirus 4; Human polyomavirus 1; Rattus norvegicus; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
12 Samples
Download data: TXT
Series
Accession:
GSE59649
ID:
200059649
8.

miRNA expression profiling in hereditary breast tumors

(Submitter supplied) The objective of the study was to characterize hereditary breast tumors based on their miRNA expression profiles. To this end, we performed global miRNA expression analysis of more than 800 human miRNA genes in a large series of 80 FFPE breast tissue samples. The series included 66 hereditary breast primary tumors from 13 BRCA1 mutation carriers, 10 BRCA2 mutation carriers and 43 non-BRCA12 tumors denominated hereafter as BRCAX tumors. more...
Organism:
Human alphaherpesvirus 1; Macaca mulatta polyomavirus 1; Homo sapiens; Mus musculus; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
80 Samples
Download data: TXT
Series
Accession:
GSE44899
ID:
200044899
9.

Comparison between hereditary breast tumors and normal breast tissue samples.

(Submitter supplied) Tumor associated miRNAs in hereditary breast cancer. In this study we investigated the role of miRNAs in hereditary breast tumors comparing with normal breast tissue. Global miRNA expression profiling was performed on 22 hereditary breast tumors and 15 non-tumoral breast tissues. We identified 19 miRNAs differentially expressed, most of them down-regulated in tumors. An important proportion of deregulated miRNAs in hereditary tumors were previously identified commonly deregulated in sporadic breast tumors. more...
Organism:
Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Mus musculus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Rattus norvegicus; Murid gammaherpesvirus 4; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
38 Samples
Download data: TXT
Series
Accession:
GSE32922
ID:
200032922
10.

Gene and miRNA expression data in the DU145-LN metastatic cell series

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Murid gammaherpesvirus 4; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human polyomavirus 1
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL7723 GPL2700
14 Samples
Download data: TXT
Series
Accession:
GSE51756
ID:
200051756
11.

MicroRNA expression in DU145 sublines metastatic to lymph nodes

(Submitter supplied) Comparison of non-coding RNA profiling by array in sublines of DU145 human prostate cancer cell lines created by in vivo cycling Cell lines created by removal and growth of metastatic human DU145 tumor cells from mouse lymph node (metastasized from prostate xenograft) for LN cells and extracted from lung after intravenous injection (ivLU cells). Cell line numebr represented number of in vivo cycles of metastatic selection
Organism:
Rattus norvegicus; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Murid gammaherpesvirus 4; Human polyomavirus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
6 Samples
Download data: TXT
Series
Accession:
GSE51753
ID:
200051753
12.

MicroRNA profiling of bleomycin-induced pulmonary fibrosis in mice

(Submitter supplied) Pulmonary fibrosis is a disease characterized by inflammatory cell infiltration, scar formation, deposition of extracellular matrix, alveolar epithelial cell injury and hyperplasia. To determine if alterations in microRNA expression contribute to these phenotypes, microRNA expression profiling of the lungs from bleomycin treated C57Bl/6J mice, relative to that of untreated controls, was undertaken. Mice were treated at 8 weeks old with 100 Units/kg of bleomycin delivered subcutaneously with osmotic minipumps. At 42 days post treatment mice were euthanized and lung microRNA isolated. We identified 11 microRNA's to be significantly differentially expressed (FDR threshold of 0.01) in the lungs of bleomycin treated mice and confirmed these data with real time PCR measurements. These included bleomycin upregulated miR-34a, 335-5p, 207, 21, 301a, 146b, 199a-5p, and 449a and bleomycin downregulated miR-151-3p, 26a and 676. We have previously shown that 1558 genes are differentially expressed in the lungs of bleomycin treated mice. Of the 1412 targets of upregulated microRNAs, 142 were confirmed to be downregulated in the gene expression profile (GEP). Of the 583 targets of downregulated microRNAs, 53 were confirmed to be upregulated in the gene expression profile. Pathway analysis of the microRNA targets and GEP overlapping genes indicated that altered microRNA expression is associated with cellular development, cellular growth, cellular proliferation and changed tissue/cell morphology. Specific pathways include HGF signaling, Cholecystokinin/Gastrin-mediated signaling, Endothelin-1 signaling, RAR activation, Phospholipase C signaling and IGF1 signaling. We conclude that altered microRNA expression is a feature of pulmonary fibrosis which putatively influences components of the altered airway disease.
Organism:
Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Human alphaherpesvirus 1; Human gammaherpesvirus 4; Homo sapiens; Human betaherpesvirus 5; Murid gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
6 Samples
Download data: TXT
Series
Accession:
GSE45789
ID:
200045789
13.

MicroRNAs differentially expressed in MUC1 overexpressing cells

(Submitter supplied) To determine if overexpression of MUC1 alters the microRNA profile of pancreatic cancer cells S2.013. Comparison of miRNAs differentially regulated in pancreatic cancer cell line S2.013 with and without MUC1 overexpression.
Organism:
Murid gammaherpesvirus 4; Human polyomavirus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Rattus norvegicus; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
1 Sample
Download data: GPR, TXT
Series
Accession:
GSE48185
ID:
200048185
14.

miRNA expression profile in PC12 cells under NGF treatment and deprivation

(Submitter supplied) miRNA profiling of PC12 rat pheochromocytoma cells during NGF-induced differentiation and apoptosis of differentiated cells after 24h of NGF deprivation. miRNA expression in differentiating and deprivated cells was compared to untreated and terminally differentiated PC12 cells respectivelly.
Organism:
Mus musculus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Rattus norvegicus; Murid gammaherpesvirus 4; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
6 Samples
Download data: GPR
Series
Accession:
GSE46827
ID:
200046827
15.

1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of Toll-Like Receptor Signaling via Targeting MicroRNA-155-SOCS1 in Macrophages

(Submitter supplied) The negative feedback mechanism is essential to maintain effective immunity and tissue homeostasis. 1,25-dihydroxyvitamin D (1,25(OH)2D3) modulates innate immune response, but the mechanism remains poorly understood. Here we report that vitamin D receptor (VDR) signaling attenuates Toll-like receptor-mediated inflammation by enhancing the negative feedback inhibition. VDR inactivation leads to a hyperinflammatory response in mice and macrophage cultures when challenged with lipopolysaccharide (LPS) due to miR-155 overproduction that excessively suppresses SOCS1, a key regulator that enhances the negative feedback loop. more...
Organism:
Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Murid gammaherpesvirus 4; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
6 Samples
Download data: GPR
Series
Accession:
GSE43300
ID:
200043300
16.

MicroRNA expression profiling of highly purified CD4+ human T cell subsets

(Submitter supplied) The development and propagation of an adaptive immune response to an invading pathogen is a highly orchestrated process that involves the precise regulation of cytokine expression. Naïve CD4+ T lymphocytes give rise to T helper (Th) cell subsets with functions that are tailored to their respective roles in host defense. MicroRNAs are important regulators of most cellular processes, including many responses in the immune system. more...
Organism:
Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Murid gammaherpesvirus 4; Human polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
5 Samples
Download data: TXT
Series
Accession:
GSE33946
ID:
200033946
17.

Alteration of MicroRNA Expression Profile Linked to Microcystin-LR-Induced Tumorigenicity in Human WRL-68 Cell Line

(Submitter supplied) We report microcystin-LR, a cyclic heptapeptide that acts as a potent hepatotoxin and carcinogen, was used to induce the malignant transformation of the WRL-68 cell line and alterations in microRNA (miRNA) expression in the transformed cells.
Organism:
Human gammaherpesvirus 4; Murid gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Macaca mulatta polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1; Rattus norvegicus; JC polyomavirus
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
2 Samples
Download data: TXT
Series
Accession:
GSE30560
ID:
200030560
18.

Gene expression networks in COPD: microRNA and mRNA regulation

(Submitter supplied) 70 miRNAs and 2667 mRNAs were differentially expressed between lung tissue from subjects with COPD and smokers without COPD. miRNA and mRNA expression profiles enriched for biological pathways that may be relevant to the pathogenesis of COPD including the transforming growth factor b, Wnt and focal adhesion pathways. miR-223 and miR-1274a were the most affected miRNAs in subjects with COPD compared with smokers without obstruction. more...
Organism:
Human alphaherpesvirus 1; Macaca mulatta polyomavirus 1; Rattus norvegicus; JC polyomavirus; Murid gammaherpesvirus 4; Mus musculus; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Homo sapiens; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human immunodeficiency virus 1
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL4133 GPL7723
59 Samples
Download data
Series
Accession:
GSE38974
ID:
200038974
19.

Murine small intestinal crypt cell line IEC-6: control vs. TGF-beta stimulated

(Submitter supplied) microRNA profiling of rat small intestinal crypt cell IEC-6. Comparing control untreated with cells treated with transforming growth factor-beta (TGF-beta). TGF-beta stimulated cell differentiation, as observed in the stimulation of intestinal epithelial cell markers (alkaline phophotase, villin, aminopeptidase N, etc.).
Organism:
Mus musculus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8; Homo sapiens; Human polyomavirus 1; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Rattus norvegicus; Murid gammaherpesvirus 4
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
3 Samples
Download data: TXT, XLS
Series
Accession:
GSE20982
ID:
200020982
20.

Notch regulated miRNAs in human T-ALL cell line

(Submitter supplied) In an attempt to identify miRNAs regulated by oncogenic Notch signaling, we performed miRNA profiling of human T-cell acute lymphoblastic leukemia (T-ALL) cells with or without the treatment of γ-secretase inhibitor (GSI) to block Notch signaling. We found miR-223 levels to increase after GSI treatment suggesting that active Notch signaling represses miR-223 expression. We confirmed insulin-like growth factor-1 receptor (IGF1R) to be regulated by miR-223, but were unable to demonstrate functional effects on T-ALL cell growth by overexpression or knock-down of miR-223 alone.
Organism:
Rattus norvegicus; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Murid gammaherpesvirus 4; Human polyomavirus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
4 Samples
Download data: TXT
Series
Accession:
GSE35993
ID:
200035993
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