GEO DataSets

(Submitter supplied) The present experiments were performed to determine the roles of estrogen receptors α and β (ERα and ERβ) in normal and neoplastic development in the mouse mammary gland. In wild-type mice, in vivo administration of estradiol (E) + progesterone (P) stimulated mammary ductal growth and alveolar differentiation. Mammary glands from mice in which the ERβ gene has been deleted (βERKO mice) demonstrated normal ductal growth and differentiation in response to E + P. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8063

7 Samples

Download data: TXT

(Submitter supplied) Background: Constitutive activation of the alternative NF-κB pathway leads to marginal zone B cell expansion and disorganized spleen microarchitecture. Furthermore, uncontrolled alternative NF-κB signaling results in the development and progression of cancer. We aimed here to learn about the mechanisms how does the constitutively active alternative NF-κB pathway exert its effects in these malignant processes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8063

10 Samples

Download data: TXT

(Submitter supplied) The genetic defect underlying the human Smith-Lemli-Opitz dysmorphological disorder is loss-of-function mutations affecting the cholesterol synthesis enzyme dehydrocholesterol delta7 reductase, DHCR7. Dhcr7 knockout mice recapitulate the biochemical characteristics, but all knockout pups die within 14h of birth. Tissues of knockout mice accumulate the precursor sterol, 7-dehydrocholesterol, and show reduced levels of cholesterol (J. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8063

18 Samples

Download data: TXT

(Submitter supplied) This study analyses the gene expression profile of pre-osteoblastic C2C12 mice cells during osteodifferentiation in control and induced by rhBMP2 and rhBMP7 using DNA microarrays. Genes which were already known to be activated by BMP2, to be also activated by rhBMP7, indicating that BMP7 induces these genes in a similar fashion as BMP2. Moreover, we identified some new genes, such as Hoxc8, Glis1, Glis3, Ecsit, LrP6, Dvl1, Grn, BMP1, Ltbp2, Plod1, Htra1 and IGFBP-rP10, to be upregulated by both rhBMPs.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8063

3 Samples

Download data: TXT

(Submitter supplied) Gene expression profiles of Ngn3-overexpressing cultured hippocampal neurons was compared to the profile of the corresponding control populations. (neurons expressing GFP). Neurogenin3, a proneural transcription factor controlled by Notch receptor, is involved in hippocampal neuron differentiation and synapses, but little is known about the molecular bases of Ngn3 activity in neurons. Microarray analysis indicated that overexpression of Ngn3 upregulated a number of genes related with cytoskeleton dynamics. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8063

8 Samples

Download data: TXT

(Submitter supplied) We present a microdroplet-based method to isolate and pattern single cells from heterogeneous cell suspensions (10% target cell mixture), preserve viability of the extracted cells (97.0 ± 0.8%), and obtain genomic information from isolated cells compared to the non-patterned controls.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8063

6 Samples

Download data: TXT

(Submitter supplied) Stimulation of the mouse hindlimb via the sciatic nerve was used to induce contractions for 4 hours to investigate acute muscle gene activation in a model of muscle phenotype conversion. Initial force production (1.6 + 0.1 g/g body weight) declined 45% within 10 min and was maintained for the remainder of the experiment. Force returned to initial levels upon completion of the study. An immediate-early growth response was present in the EDL (FOS, JUN, ATF3, MAFK) with a similar but attenuated pattern in the soleus. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL8063 GPL6462

24 Samples

Download data: TIFF

(Submitter supplied) Stimulation of the mouse hindlimb via the sciatic nerve was used to induce contractions for 4 hours to investigate acute muscle gene activation in a model of muscle phenotype conversion. Initial force production (1.6 + 0.1 g/g body weight) declined 45% within 10 min and was maintained for the remainder of the experiment. Force returned to initial levels upon completion of the study. An immediate-early growth response was present in the EDL (FOS, JUN, ATF3, MAFK) with a similar but attenuated pattern in the soleus. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8063

10 Samples

Download data

(Submitter supplied) Peritoneal macrophages of Tyk2-/- and wildtype (wt) mice were compared before and after six hours of LPS treatment. Interferon responsive genes are lower expressed in Tyk2-/- macrophages at the basal level, metabolic genes higher before, but even more after LPS treatment.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8063

12 Samples

Download data: TXT

(Submitter supplied) http://www4.amershambiosciences.com/aptrix/upp01077.nsf/Content/codelink_user_protocols

Organism:

Mus musculus

9 Series

74 Samples

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